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| Expression and Significance of GDF-15 microRNAs in Serum of Patients with Cervical Cancer |
| HUANG Jiang-mei, XIAO Fang, ZHAO Min, et al |
| Department of Pathology,Qinhuangdao First Hospital, Qinhuangdao Hebei 066000 |
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Abstract 【Objective】 To investigate the expression and significance of growth differentiation factor 15 (GDF-15) miRNA in serum of patients with cervical cancer.【Methods】 Sixty-four patients with cervical cancer (cervical cancer group) and 54 patients with cervical intraepithelial neoplasia (CIN) (CIN group) were enrolled in our hospital from May 2012 to March 2016. Forty-six healthy subjects in the hospital were used as a control group.The expression of GDF-15 miRNA in serum of three groups was detected by RT-PCR, and the relationship between GDF-15 miRNA expression and clinical pathology and prognosis of cervical cancer patients was analyzed.【Results】 The expression of serum GDF-15 miRNA in cervical cancer patients was (3.12±1.11), which was higher than 1.97±0.53 in the CIN group and 1.07±0.37 in the healthy control group.The expression of serum GDF-15 miRNA in cervical cancer patients was not correlated with age, pathological type and tumor size (P>0.05), and was associated with FIGO stage, lymph node metastasis and differentiation (P<0.05).Sixty-four patients with cervical cancer were followed up for 3 years. 45 patients (70.31%) survived, 19 patients (9.69%) died, and the average survival time was (29.39±1.36) months.The total survival time of patients with GDF-15 miRNA>3.12 cervical cancer was 25.87(±2.27) months, which was significantly less than that of GDF-15 miRNA≤3.12 (32.50±1.39 months) , the difference was statistically significant (P<0.05). 【Conclusion】 The expression of serum GDF-15 microRNAs increases in cervical cancer patients, which is related to FIGO staging, lymph node metastasis and differentiation. Monitoring GDF-15 is helpful to evaluate the prognosis of cervical cancer patients.
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Received: 06 November 2018
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[1] 洪宇.血清miR-130a、HMGA1及SCC-Ag在宫颈癌患者中的表达及其临床意义[J].医学临床研究,2018,35(3):453-455.
[2] Griner SE, Joshi JP, Nahta R. Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion[J].Biochem Pharmacol,2013,85(1):46-58.
[3] 黎晔,吴共发,陈勍.GDF-15在子宫内膜样腺癌中的表达及意义[J].中国组织化学与细胞化学杂志,2014,23(2):180-184.
[4] 刘琦芳. C14ORF166蛋白在宫颈癌组织中的表达及其意义[J].医学临床研究, 2017, 34(11):2235-2237.
[5] Wongjampa W, Ekalaksananan T, Chopjitt P,et al.Suppression of miR-22, a tumor suppressor in cervical cancer, by human papillomavirus 16 E6 via a p53/miR-22/HDAC6 pathway[J].PLoS One,2018,13(10):e0206644.
[6] 黎晔,吴共发,林俊汕,等.生长分化因子15蛋白在宫颈上皮内瘤变和鳞癌中的表达及意义[J].实用医学杂志,2015,31(2):201-203.
[7] 熊慧,刘平,邹文,等.局部中晚期宫颈癌同步放化疗临床疗效及预后影响因素分析[J].中国全科医学,2018,21(17):2053-2058. |
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2019, Vol. 36 
