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| Expression of TFF1 and MCP-1 in Urine of Patients with Renal calculi and its Significance |
| ZHANG Jian, CHEN Zhi-qiang, SUN Guo-liang,et al |
| The Central Hospital of Chengde, Chengde 067000 |
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Abstract 【Objective】To investigate the levels and significance of trilobal factor 1 (TFF1) and monocyte chemoattractant protein 1 (MCP 1) in urine of patients with renal calculi. 【Methods】From January 2017 to April 2018, 103 patients with renal calculi were selected as observation group and 100 healthy volunteers as control group, serum biochemical parameters such as serum calcium and creatinine in two groups were detected, urine TFF1, MCP-1 and urinary calcium level were detected. 【Results】There was no significant difference in serum calcium, creatinine, uric acid and urea nitrogen between the observation group and the control group (P>0.05). The levels of TFF1 in urine of the observation group were significantly lower than those of the control group, while the levels of MCP-1 and urinary calcium were significantly higher than those of the control group (P<0.05). The estimated glomerular filtration rate (eGFR) of the observation group was (88.10±32.20)[mL/(min·1.73 m2)]. The correlation analysis of urine TFF1, MCP-1, urine calcium and eGFR in the observation group showed that urine TFF1 was negatively correlated with urine calcium (r=-0.433, P<0.05), urine MCP-1 was positively correlated with urine calcium (r=0.404, P<0.05), and negatively correlated with eGFR (r=-0.362, P<0.05).【Conclusion】The level of TFF1 in urine of patients with renal calculi decreases, while the level of MCP-1 increases, which is correlated with urinary calcium and eGFR in patients with renal calculi.
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Received: 15 October 2018
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2019, Vol. 36 
