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Quick Search     Adv Search 2016 Vol. 33, No. 12 Published: 2016-12-15 Article          Article 2289 Analysis of More than 70 Thousands Allergy Specific IgE Tests In Children HE Xie-ling, TANG Jian-ping, WEI Zhu, et al DOI: 10.3969/j.issn.1671-7171.2016.12.001 【Objective】To analyze the common environmental and food allergens in children. 【Methods】The results of allergen specific IgE detection in children aged 0 ~ 16 years in the Allergic Reaction Laboratory of Department of Dermatology in our hospital were collected; the quantity, positive results and positive rate of different allergen specific IgE of the detection were counted; The subjects were divided into four groups according to age, and the positive rates of allergens in different groups .【Results】During the three years, 71,794 detections of serum allergen specific IgE in children were conducted, among them, 34,306 times were concerned with environment, accounting for 47.78%; 37,488 times with food , accounting for 52.22%. The detection of environmental allergen specific IgE were divided into 7 categories, the positive rate were 23.28% for dust mites, 8.52% for house dust, 7.85% for animal fur and chip, 4.24% for tree pollen ,2.04% for fungi, 1.78% for insects and 0.88% for grass pollen, respectively ; Detection of food allergen specific IgE were divided into 10 categories, the positive rates were 10.08% for milk, 8.97% for egg, 4.13% for fruit, 3.46% for wheat, 3.67% for peanut, 2.52% for other foods (including pork, chicken, mutton, beef, rice, tomatoes, etc.), 1.96% for soybean, 1.60% for fish, 1.59% for crabs and 1.09% for nut respectively .The positive rate of dust mite was the highest among the environmental allergens in different age groups of subjects. The positive rate of preschool group and school-age group was nearly two times higher than that of the infant group. In addition to dust mites, house dust, animal fur scraps and tree pollen were also positive common allergen in each age stage. The fungi positive rate of children in school age group was significantly higher than that of other age groups. In the detection of food allergens, the milk positive rate was the highest in all age groups. Among 0 ~ 4 months group, other food allergen positive was rare except for milk; from 4 to 12 months of age group, the positive rate of all kinds of food increased significantly.【Conclusion】 Dust mites, house dust, animal fur debris, cow's milk and eggs were the most common allergens in children. Primary allergen at different ages are not consistent. 2016 Vol. 33 (12): 2289-2293,2294 [Abstract] ( 154 ) HTML (1 KB)  PDF (1245 KB)  ( 118 ) 2292 Cognitive Function Comparison between Mirtazapine and Sertraline in First-episode Major Depression Treatment YU Yan, YANG Dong, PENG Hong-li,et al DOI: 10.3969/j.issn.1671-7171.2016.12.002 【Objective】To compare the efficacy of mirtazapine and sertraline on the cognitive function in first-episode depression patients. 【Method】A total of 198 first-episode major depression patients were randomly assigned to mirtazapine (n=98)or sertraline (n=100)for 6 weeks. The efficacies of patients were assessed by HAMD (Hamilton Depression Scale) and the cognitive functions were evaluated with Wisconsin card sorting test(WCST), trail marking test(TMT), verbal fluency task(VF), digital symbol and digital span【Results】 After 6 weeks of treatment, the effective rate of mirtazapine and sertraline were respectively 82.7% and 81.0%. There was no significant difference between two groups(P>0.05). After 6-weeks treatment, the two group patients had improvement in WSCT (in terms of right response numbers, classification, errors, continuous errors), reduced TMT times, and increased VF plus numbers and digital symbol(P<0.05). However, the digital span in two group patients had not obvious improvement after treatment(P>0.05). In the 6th weekend of treatment, the WSCT random errors and TMT-A times in the mirtazapine group were significantly lower than in the sertraline group(P<0.05). The VF numbers in the mirtazapine group were significantly higher than sertraline group(P<0.05). 【Conclusion】 Mirtazapine is as effective as sertraline, and is superior in improving cognitive functions than sertraline. 2016 Vol. 33 (12): 2292-2295 [Abstract] ( 134 ) HTML (1 KB)  PDF (1253 KB)  ( 92 ) 2295 Influence of Moxifloxacin on Serum Levels of PCT and sTREM-1 in Patients with Multiple Drug Resistance Tuberculosis ZHANG Qi-long GAO Long YANG Jun DOI: 10.3969/j.issn.1671-7171.2016.12.003 【Objective】To evaluate the effect of moxifloxacin intervention therapy on serum PCT and sTREM-1 in patients with multiple drug resistance tuberculosis(MDR-TB).【Methods】One hundred and forty patients with MDR-TB were enrolled in this study and randomly divided into two groups: the moxifloxacin group(n=70)and the control group. Dynamic changes of serum PCT and sTREM-1 levels and the clinical efficacy were observed in 2 and 6 months after treatment.【Results】After 6 months of treatment, the effective rate of the observation group was 85.7% (60/70), which was significantly higher than that of the control group 65.7% (46/70), and the difference was statistically significant (χ2=5.962,P=0.015<0.05). The levels of serum sTREM-1 and PCT were significantly decreased in the observation group after treatment, the serum sTREM-1 level was significantly lower than that of the control group at 2 and 6 months, and the difference was statistically significant (mean P<0.05 ); the serum PCT level was significantly lower than that the control group after 6 months of treatment, the difference was statistically significant (P<0.05). The differences of the serum PCT and sTREM-1 levels of Moxifloxacin group(both in the effective subgroup or ineffective subgroup ) were statistically significant 6 months before or after treatment (P<0.05); In the control group, PCT did not show a clear downward trend after treatment, while the level of sTREM-1 was decreased, but there was no significant difference(P>0.05).【Conclusion】Moxifloxacin can effectively reduce serum PCT and sTREM-1 levels in patients with MRD-TB and can improve the treatment efficiency. 2016 Vol. 33 (12): 2295-2299 [Abstract] ( 98 ) HTML (1 KB)  PDF (1249 KB)  ( 55 ) 2298 Analysis of the Causes of Thyroid Cancer to be Diagnosed as TI-RADS Grade 2-3 by Ultrasonography HUANG Shu-lin, LIU Liang, ZHANG Chao-jie DOI: 10.3969/j.issn.1671-7171.2016.12.004 【Objective】To evaluate the reasons why thyroid cancer was diagnosed as TI-RADS grade 2-3 by ultrasonography and to improve the diagnosis accuracy of atypical thyroid cancer and reduce unnecessary misdiagnoses. 【Methods】We retrospectively analyzed the clinic data and the ultrasound image characteristics of 30 thyroid cancers diagnosed as TI-RADS grade 2-3 by ultrasonography. 【Results】A total of 30 thyroid tumors that were diagnosed as TI-RADS 2-3 grade by preoperative ultrasound were pathological classified as 17 cases of papillary thyroid micro carcinoma,3 cases of papillary carcinoma, 6 cases of follicular carcinoma , and 4 cases of medullary carcinoma after surgery; out of these, Hashimoto's thyroiditis was found in 11 cases. 【Conclusion】The reasons for thyroid cancer to be misdiagnosed as TI-RADS 2-3 grade are lumps within the complicated thyroid background, micro-cancer lesions associated with multiple benign nodules, and single atypical thyroid medullary carcinoma manifestation. Therefore,atypical thyroid nodules need further fine needle aspiration. 2016 Vol. 33 (12): 2298-2301 [Abstract] ( 190 ) HTML (1 KB)  PDF (1658 KB)  ( 225 ) 2301 Observation of the Curative Effect of Cervical Cerclage Combined with Mesh Patch Type Strengthening in the Treatment of Cervical Incompetence YOU Yi-ping, JIANG Yu-rong DOI: 10.3969/j.issn.1671-7171.2016.12.005 【Objective】To investigate the curative effect of emergency cervix cerclage with mesh patch type strengthening in the treatment of mid-pregnancy cervical incompetence.【Methods】Twelve cases of second trimester cervical incompetence from January 2013 to December 2014 were collected. Emergency cervical cerclage surgery with mesh patch type reinforcement was performed on these patients and the impact of this procedure on pregnancy outcomes was analyzed. 【Results】After mesh patch type strengthening cervical cerclage, the average gestational age was prolonged to 12.65±3.82 weeks in the 12 cases of pregnant women. Eight out of twelve pregnant women had babies that survived, and the success rate was 67.67%. Unfortunately, inevitable abortion occurred to the remaining 4 cases,3 cases of spontaneous abortion due to premature water breaking, 1 case of pregnancy terminated because of bacterial growth of vaginal secretions, blood and increased abnormal C-reactive protein (CRP) infection. 【Conclusion】The use of mesh patch type reinforcement of emergency cervical cerclage can prolong gestational age and improve the new surgical outcome of pregnancy with cervical incompetence. 2016 Vol. 33 (12): 2301-2304 [Abstract] ( 69 ) HTML (1 KB)  PDF (1606 KB)  ( 61 ) 2304 Therapeutic Observation: Sequential Therapy of TACE Combined with RFA and 125I Particle Implantation for Unresectable Hepatocellular Carcinoma SUN Qiong ,XU Bin, MA Yan-yan, et al DOI: 10.3969/j.issn.1671-7171.2016.12.006 【Objective】To discuss the clinical efficacy of the combined treatment of transcatheter aiterial chemoembolization (TACE), CT-guided radiofrequency ablation (RFA) and radioactive 125I particle implantation for unresectable hepatocellular carcinoma (HCC).【Methods】Twenty patients with HCC were collected from March 2014 to February 2016 (a total of 32 cancer foci, 3~12 cm). All cancers were inicially treated with TACE, 1 week later with RFA guided by CT, and with 125I particle implantation under CT guidance another week later. 125I particle implantation was performed by preoperative TPS and intraoperative CT guided coaxial method, The prescription dose (PD) of particle implantation was 80~100 Gy, CT detection was transferred into TPS immediately after operation to verify the quality of particle implantation. The changes of clinical symptoms, alpha fetoprotein (AFP), liver function, imaging (tumor volume) and the clinical efficacy, tumor recurrence and related complications were observed through follow-up.【Results】20 patients were significantly relieved after treatment, AFP was significantly decreased compared with the conditions before treatment, the difference was statistically significant(P<0.05);ALT, TBIL and ALB were all decreased, but there was no significant difference (P>0.05); The imaging examination showed that the tumor necrosis, iodized oil deposition at different degree and the tumor volume were significantly reduced compared with those before treatment (P<0.05), and there was no obvious enhancement after enhancement; the immediate TPS verification after 125I particle implantation showed that the technical success rate was 100%, that was, the quality of particle implantation was very good, D90 > MPD, CI=1 in 1 case, the dose inhomogeneity of implanted particles was 20%PD. The follow-up time was 3~ 24 months (mean, 12.7 months), the complete necrosis rate of the whole group was 93.75% (30/32), the median survival time was 11.2 months, and the half year and the 1 year survival rates were 95% and 75%, respectively. No serious complications occurred.【Conclusion】The recent curative effect of TACE, RFA combined with 125I particle implantation in the treatment of unresectable HCC is obvious, and it is expected to be a more effective therapy model for HCC. 2016 Vol. 33 (12): 2304-2309 [Abstract] ( 93 ) HTML (1 KB)  PDF (2369 KB)  ( 86 ) 2309 Association between Mean Platelet Volume and Embolism in Elderly Patients with Atrial Fibrillation WANG Mu-qiu, GAO Min DOI: 10.3969/j.issn.1671-7171.2016.12.007 【Objective】 To study the application values of mean platelet volume (MPV) and embolism risk assessment in elderly patients with atrial fibrillation . 【Methods】Simple atrial fibrillation (39 cases, negative group) and atrial fibrillation combined with vascular lesions or embolization (48 cases, positive group) were collected. General clinical data of patients and routine blood MPV values of the two groups were compared and analyzed. 【Results】The CHA2DS2-VASc method was used for the evaluation, i.e. congestive heart failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular disease, age 65~74, and sex (female). The CHA2DS2-VASc score(2.38±1.18) of the negative group was lower than that of the positive group (3.77±1.28), and the difference was statistically significant (P<0.05). Even after 3 points (1 for vascular disease and 2 for stroke/TIA) were subtracted from the score of the positive group, its CHA2DS2-VASc score (2.98±1.25)was still higher than that of the negative group (P<0.05). The MPV value in the negative group (10.39±1.07)fL was lower than that in the positive group (11.58±1.24)fL. The difference in the two groups was statistically significant (P<0.05). The area under the ROC curve was 0.773, which predicted high-risk embolism in elderly patients with atrial fibrillation. According to the ROC curve, the cutoff value of MPV was set at 11.1/11.2 fL. Then, the maximum index approached 0.446 with its sensitivity and specificity rate being 64.6% and 82.1%, respectively. 【Conclusion】 MPV is one of the effective indicators to assess the risk of embolism in elderly patients with atrial fibrillation. It has high sensitivity and specificity, and it is worthy application in the clinic. 2016 Vol. 33 (12): 2309-2313 [Abstract] ( 75 ) HTML (1 KB)  PDF (1365 KB)  ( 66 ) 2312 Changes of MeCP2 in Cochlea of BALB/c Mice with Age-Related Hearing Loss JIANG La-mei, WU Wei-jing, CHEN Yong DOI: 10.3969/j.issn.1671-7171.2016.12.008 【Objective】To investigate the variance of the methyl-CpG-binding protein 2 (MeCP2) expression in the cochlea of BALB/c mice with age-related hearing loss and its clinical significance. 【Methods】On the basis of research on auditory function of BALB/c mice in different months, the morphological study of cochlea and immunohistochemical expression of MeCP2 protein in cochlea, the expression of MeCP2 mRNA gene was detected in 3, 6, 12, 18 months old rats in the cochlea through the method of semi quantitative reverse transcription polymerase chain reaction. 【Results】MeCP2 was expressed in 4 mice groups in the cochlea of BALB/c with different months of age, the expression level of MeCP2 mRNA decreased gradually with the increase of month age, the difference was statistically significant (P<0.01).【Conclusion】 The expression level of MeCP2 in the cochlea of BALB/c mice with age-related hearing loss decreased with the increase of the age of mice, which may be related to the aging of cochlea and the occurrence of presbycusis. 2016 Vol. 33 (12): 2312-2315 [Abstract] ( 102 ) HTML (1 KB)  PDF (1674 KB)  ( 40 ) 2315 Effect of Long-Term Antiviral Therapy on General Test Indexes and Hepatic Perfusion Parameters in Patients with Compensated Hepatitis B Cirrhosis DUAN Jing-shan, ZHANG Jun-xiong DOI: 10.3969/j.issn.1671-7171.2016.12.009 【Objective】To investigate the effect of long-term antiviral therapy on general test indexes and hepatic perfusion parameters in patients with compensated hepatitis B (HBV) cirrhosis. 【Methods】Sixty-nine patients with compensated hepatitis B cirrhosis treated between June 2012 and January 2015 were studied. All received long-term antiviral therapy, including 45 cases that received entecavir therapy and 24 cases that received adefovir dipivoxil therapy. The medication lasted for 144 weeks. The changes of liver function indexes, hepatitis B virus gene (HBV-DNA), Child-Pugh scores, liver tissue inflammation activity and liver fibrosis stage before and after medication were compared. In addition, CT hepatic perfusion scan was performed before and after medication. The changes of hepatic arterial perfusion (HAP) and total liver perfusion (TLP) were observed; the incidence of adverse drug reactions was recorded. 【Results】 After 144 weeks of medication, the levels of total bilirubin (TBIL), aspartate aminotransferase (AST), alanine transaminase (ALT), prothrombin time (PT), HBV-DNA and Child-Pugh score were significantly lower while albumin (Alb) level was significantly higher than that before medication(P<0.05). After 144 weeks of medication, liver tissue inflammation activity and liver fibrosis stage were significantly improved (P<0.05). There were significant differences in total liver perfusion (TLP), hepatic arterial perfusion (HAP), hepatic venous perfusion (HPP) and hepatic arterial perfusion index (HPI) before medication and after 114 weeks of medication (P<0.05). There were no obvious adverse reactions. 【Conclusion】Long-term antiviral therapy can significantly improve general test indexes of liver function and hepatic perfusion parameters in patients with compensated hepatitis B cirrhosis. 2016 Vol. 33 (12): 2315-2319 [Abstract] ( 77 ) HTML (1 KB)  PDF (1245 KB)  ( 37 ) 2318 Impact of the Endoscopic Injection of Tissue Glue for Gastric Varices Bleeding on Portal Hypertensive Gastropathy HU Hua-hua, XU Jie-hong, YI Hong DOI: 10.3969/j.issn.1671-7171.2016.12.010 【Objective】 To study the impact of the endoscopic injection of tissue glue for gastric varices bleeding on portal hypertensive gastropathy (PHG) .【Methods】The clinical data of 30 patients from January 2008 to April 2012 were retrospectively analyzed. The patients were treated with endoscopic injection of tissue glue for gastric varices bleeding (Group A).Compared with other 30 patients (B Group) with gastric varices bleeding treated by conventional drug, the incidence of severe PHG was observed after 6 months.【Results】The incidence of severe PHG of the Group A was 63.33% (19/30) 6 months after treatment, which was significantly higher than that in the Group B (10/30) 30.33% , and the difference was statistically significant (P<0.05).【Conclusion】Endoscopic injection of tissue glue for gastric varices bleeding may lead to a significant severity of illness on PHG. 2016 Vol. 33 (12): 2318-2321 [Abstract] ( 92 ) HTML (1 KB)  PDF (1247 KB)  ( 126 ) 2321 Clinical Importance of Methylation Status of Gene Promoter HOXA5 and HOXA10 in Gastric Cancer FANG Zhi-xue, HUANG Zhong-cheng DOI: 10.3969/j.issn.1671-7171.2016.12.011 【Objective】To investigate the methylation status of the gene promoters HOXA5 and HOXA10 and its relationship with clinical pathology in gastric cancer. 【Methods】Methylation status of gene promoters HOXA5 and HOXA10 in 51 of cases of gastric cancer tissues and normal mucosa tissues were detected by methylation-specific PCR (MSP). 【Results】 1.The methylation rate of HOXA5 gene promoter in gastric cancer tissues (74.5%) was higher than that in normal mucosa tissues (37.3%),the difference was statistically significant (χ2=14.356,P=0.000). The methylation rate of HOXA5 gene promoter was negatively related to the tumor grade (χ2=4.311,P=0.038), the degree of invasion (χ2=5.669,P=0.017), the lymphatic metastasis (χ2=9.349,P=0.002) and tumor stage (χ2=16.023,P=0.000), but was not related to age or gender (mean P>0.05); 2. The methylation rate of HOXA10 gene promoter in gastric cancer tissues (68.6%)was higher than that in the normal mucosa tissues (41.2%),the difference was statistically significant (χ2=7.761,P=0.009). The methylation rate of HOXA10 gene promoter was negatively related to the tumor grade (χ2=5.304,P=0.021), the degree of invasion (χ2=15.457,P=0.000) and lymphatic metastasis (χ2=6.157,P=0.013), but was not related to the tumor stage, the age nor the gender (mean P>0.05); 3.The methylation status of HOXA5 gene promoter was negatively associated with its protein expression(r=-0.495,P=0.000), and so was HOXA10 (r=-0.343,P=0.000). There was a positively relationship between the methylation rate of two gene promoters (r=0.751,P=0.000). 【Conclusion】HOXA5 and HOXA10 gene promoters were highly methylated in gastric cancer tissues and were negatively related with their protein expression. DNA methylation may be one of important regulatory mechanisms underlying gene expression changes. 2016 Vol. 33 (12): 2321-2326 [Abstract] ( 77 ) HTML (1 KB)  PDF (1445 KB)  ( 126 ) 2326 Effect of Different Segmental Fixation of Posterior Pedicle Screw in Treatment of Severe Thoracolumbar Spine Fracture JIANG Shi-lin, NI Cheng, DU Liang,et al DOI: 10.3969/j.issn.1671-7171.2016.12.012 【Objective】To investigate the clinical effect of different segmental fixation of posterior pedicle screw in the treatment of severe thoracolumbar spine fracture.【Methods】The clinical data of 67 cases of severe thoracolumbar fractures from January 2012 to December 2014 in our hospital were retrospectively analyzed and divided into the observation group (n=36) and the control group (n=31) according to the different operation, the control group underwent posterior short segment pedicle screw fixation, and the observation group was treated with posterior long segment pedicle screw fixation. The operation condition, , nerve function, vertebral body anterior compression and Cobb angle were compared between the two groups. 【Results】The operation time of the observation group was (158.7±33.9 ) min, significantly longer than (113.6±24.2) min (P<0.05); The amount of intraoperative bleeding was (386.4±122.9) mL, significantly higher than that of the control group (+ 183.7 ±57.8) mL (P<0.05); 3 months after operation, the spinal cord nerve function Frankel grade of the patients in both groups increased significantly (P<0.05), but there was no significant difference between the two groups (P>0.05);12 months after operation, the vertebral compression degree and Cobb angle of the patients in the two groups were significantly better than those before surgery (P<0.05); Cobb angle, Cobb angle correction rate, Cobb angle correction loss, vertebral leading edge correction loss of the observation group were significantly lower than those of the control group; but the vertebral anterior compression degree and vertebral anterior compression correction rate were significantly higher than those of the control group (P<0.05).【Conclusion】 Long segment posterior pedicle screw internal fixation can effectively correct kyphosis of severe thoracolumbar spinal fracture and restore vertebral body height, and prevent the long-term correction loss, It is worthy of clinical application. 2016 Vol. 33 (12): 2326-2330,2331 [Abstract] ( 70 ) HTML (1 KB)  PDF (1838 KB)  ( 94 ) 2329 Analysis of the Relationship between Premature Respiratory Secretions of Ureaplasma Urea Original Body and Neonatal Lung Injury FAN Li-ying, ZHOU Li-ping DOI: 10.3969/j.issn.1671-7171.2016.12.013 【Objective】To research the relationship between premature respiratory secretions of ureaplasma urea original body and neonatal lung injury.【Method】 A total of 246 cases of premature infants with respiratory symptoms in the neonatal intensive care unit in the Maternal and Child Health Hospital of Hunan Province from January 2014 to August 2015 were selected as the research object. The clinical data of each child was recorded in detail. According to the test results of fluorescent quantitative PCR detection of Uu nucleic acid with stomach and, pharyngeal airway secretions which were taken when they were admitted to this hospital, the patients were categorized into a positive group and a negative group. Basic clinical characteristics, infection markers, neonatal respiratory distress syndrome (RDS), congenital pneumonia, and the incidence of bronchial pulmonary dysplasia (BPD) and the length of hospital stay of the two groups were compared.【Result】 In the 246 cases of premature infants, 59 cases of Uu were positive and 187 cases of Uu were negative. In the Uu positive group, incidence of neonatal respiratory distress syndrome was 32.2% (19/59), while in the negative group, it was 45.5% (85/187). Incidence of congenital pneumonia in the Uu positive group was 35.6% (21/59), while incidence in the negative group was 21.9% (46/187). After more than 28 days in the hospital, the incidence of bronchial pulmonary dysplasia in the Uu positive group was 16.9% (10/59), while incidence in the negative group was 8.02% (15/187). The length of hospitalization in the Uu positive group was obviously longer than in the Uu negative groups; the difference had statistical significance.【Conclusions】 For preterm infants, Uu positivity in respiratory secretions increased the incidence of congenital pneumonia and bronchial pulmonary dysplasia, which extended the length of hospital stay. So, it is a protective factor of neonatal respiratory distress syndrome. 2016 Vol. 33 (12): 2329-2332 [Abstract] ( 83 ) HTML (1 KB)  PDF (1255 KB)  ( 142 ) 2332 Analysis of Pathological Features and Postoperative Complications in 80 Elderly Patients with Malignant Gastrointestinal Tumor ZHOU Ting-liang, CAO Ying DOI: 10.3969/j.issn.1671-7171.2016.12.014 【Objective】To analyze the clinical pathological features and postoperative complications in elderly patients with malignant gastrointestinal tumors. 【Methods】A retrospective analysis of clinical data was carried out on 80 elderly (age >65 years) patients with malignant gastrointestinal tumors who received surgery in our hospital. According to the occurence of postoperative complications, patients were divided into the complication group (n=26) and non-complication group (n=54). Clinical pathological characteristics of patients between the two groups were analyzed to explore the related influencing factors of postoperative complications. 【Results】① In the 80 elderly patients with malignant gastrointestinal tumor, 26 patients had postoperative complications (32.50%). The complications were mainly infections of the incisional wound, pulmonary infections, and angiocardiopathy. Other complications included liver and kidney dysfunction and anastomotic leakage. ② Male patients made up a significantly higher proportion of the postoperative complications group, and their operative time and age were significantly greater than non-complication group. There were significant differences in frequency of complications, TNM staging, pathologic differentiation, lymph nodes cleanliness, and lymphatic metastasis between the two groups (P<0.05). ③ Multivariate regression analysis showed that age, operation time, preoperative complications, lymph node dissection type, and pathologic differentiation were all independent risk factors which influenced postoperative complications of patients with malignant gastrointestinal tumor (P<0.05). 【Conclusion】Age, gender, pathologic differentiation, lymph node dissection, and preoperative complications are independent risk factors which influence postoperative complications of elderly patients with malignant gastrointestinal tumor-indicating preparation for prevention and treatment of complications in clinic. 2016 Vol. 33 (12): 2332-2335 [Abstract] ( 70 ) HTML (1 KB)  PDF (1247 KB)  ( 105 ) 2335 Clinical Effects of Diseased Segment Fixation in Treatment of Patients with Spinal Tuberculosis YANG Fan, HAN Cui-yu, YANG Wen,et al DOI: 10.3969/j.issn.1671-7171.2016.12.015 【Objective】To explore the clinical effects of diseased segment fixation in the treatment of patients with spinal tuberculosis. 【Methods】Retrospectively 84 cases with spinal tuberculosis in our hospital from January 2009 to December 2014 were analyzed according to different operation methods , and they were divided into diseased segment fixation group (fixed in lesions involving individual neurons, 38 cases) and non-diseased segment fixation group (using long and short segmental fixation, 46 cases). The intraoperative blood loss, operative time during the surgery, the ESR and preoperative and postoperative CRP level , CRP ,VAS score, Franke l classification and Cobb Angle of the two groups were observed and analyzed.【Results】Blood loss and operation time of diseased segment fixation group were superior than diseased non-segment fixation group, the difference was statistical significance (P<0.05); ESR and CRP of two groups reduced to normal levels 6 months after surgery, but there was no statistical difference between two groups(P＜0.05).VAS score at the last follow-up of the two groups were decreased ,and VAS score of the diseased segment fixation group was lower than that of the non-diseased segment fixation group (P<0.05);The Frankel function classification of the two groups were obviously recovered ;Cobb angle at the last follow-up of the two groups were less than that before surgery, but the correction of Cobb's angle and angle loss of preoperative and postoperative and the last follow-up of two groups were not statistically different. 【Conclusion】Diseased segment fixation in the treatment of patients with spinal tuberculosis is a safe and effective therapy, which can effectively preserve normal vertebral motion nerve unit adjacent to diseased segment with its advantage of less intraoperative bleeding and shorter operation time. 2016 Vol. 33 (12): 2335-2339 [Abstract] ( 48 ) HTML (1 KB)  PDF (2034 KB)  ( 70 ) 2339 Analysis of the Risks of Allergic Rhinitis in Smokers HUA He-lai, JIANG Zi-kang, LIN Wei, et al DOI: 10.3969/j.issn.1671-7171.2016.12.016 【Objective】 To study the medical evidence of the related risks on smokers and allergic rhinitis by analyzing the published SCI study involved.【Methods】Relevant literature on MEDLINE, PUBMED, EMBASE, WOS(2004~2015) were retrieved , and the quality of the study involved was evaluated by the JADA score so as to aquire or calculate the relevant research involved in the RR, 95% credible period. The relationship between the risk of allergic rhinitis in smokers was comprehensively analyzed.【Results】The risk of allergic rhinitis in smokers was as follows compared with that of non-smokers: 1. Smokers Vs non-smokers: RR=1.11, 95%CI (1.09, 1.21),P=0.00, the difference was statistically significant; 2. Active smokers vs non-smokers: RR=1.04, 95%CI (1, 1.09),P=0.038, the difference was not statistically significant;3. Passive smokers vs non-smokers: RR=1.12, 95%CI (1.10, 1.13),P=0.00, the difference was statistically significant.【Conclusion】 Both active and passive smokers will increase the risk of allergic rhinitis. 2016 Vol. 33 (12): 2339-2343,2345 [Abstract] ( 58 ) HTML (1 KB)  PDF (1549 KB)  ( 56 ) 2342 Study of the Relationship Between the Efficacy of Cisplatin Chemotherapy in Combination with Radiotherapy and Expression levels of RRM1 in Cervical Cancer DING Ding, KONG Wei-min, HAN Chao,et al DOI: 10.3969/j.issn.1671-7171.2016.12.017 【Objective】To explore the application value of cisplatin chemotherapy combined with radiotherapy in the treatment of cervical cancer, and to analyze the relationship between clinical efficacy and expression levels of ribonucleotide reductase M1 (RRM1) in patients with cervical cancer. 【Methods】Ninety-eight patients with cervical cancer were divided into group A and group B by the random number table method, 49 cases in each group. Group B was given pelvic external radiotherapy combined with brachytherapy. On that basis, group A was given cisplatin chemotherapy. The short-term effects and incidence of side effects were compared between the two groups, and changes of the maximum transverse diameter of tumor and expression of RRM1 in cervical lesions before and after the treatment were recorded. According to short-term effects, Group A was further divided into the good to excellent and poor to medium groups. The expression of RRM1 in cervical lesions was compared between the two groups, and Pearson correlation analysis was used to analyze the relationship between the clinical effect and expression of RRM1 in cervical lesions. 【Results】The overall effective rate, incidence rates of Ⅲ~Ⅳ level gastrointestinal reactions, Ⅰ~Ⅱ level bone marrow suppression, radiocystitis, and factitial proctitis in group A were significantly higher than those in group B (P<0.05). After treatment, the maximum transverse diameter of tumor and RRM1 high expression rates were significantly lower than those before treatment, and those in group A were lower than group B (P<0.05). The RRM1 low expression rate in excellent and good group was significantly higher than that in the medium and poor group (57.7% vs 16.7%) (P<0.05). Pearson correlation analysis showed that the clinical effect of cisplatin chemotherapy combined with radiotherapy was positively correlated with RRM1 low expression in cervical lesions (P<0.05). 【Conclusion】Cisplatin chemotherapy combined with radiotherapy improves the short-term effects of patients with cervical cancer, and its efficacy is inversely correlated with RRM1 expression. 2016 Vol. 33 (12): 2342-2345 [Abstract] ( 72 ) HTML (1 KB)  PDF (1277 KB)  ( 59 ) 2346 Effects of Liraglutide on the Injury of Neonatal Rat Cardiomyocytes Induced by Hypoxia / Reoxygenation ZHOU Xue, LI Ben, ZHANG Wen-juan,et al DOI: 10.3969/j.issn.1671-7171.2016.12.018 【Objective】To observe the effects of a new antidiabetic drug Liraglutide on injury of neonatal rat cardiomyocytes induced by hypoxia / reoxygenation(H/R).【Method】 Wistar rat myocardial cells were cultured in vitro and were divided into three groups: simple H/R group(group A ), Liraglutide + H/R group(group B ), and normal control group (group C). In addition to the normal control group, the remaining two groups were injured by H/R. Dehydrogenase (LDH), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and apoptotic cardiomyocytes were detected in the three groups. 【Results】Compared with group C, MDA, LDH levels, and apoptosis rate in group A were significantly higher, and the activity of SOD was lower (P<0.01). Compared with group A, the LD H, MDA level, and cell apoptosis rate in group B was significantly lower (P<0.01), but was still higher than those in group C (P<0.01). Compared with groups B and C, the SOD activity was significantly higher in group A (P<0.01). 【Conclusion】H/R can damage of myocardial cells and increase cell apoptosis. As glucagon like peptide-1 analogue, Liraglutide shows potential cardioprotective effects by directly acting on myocardial cells, which includes reducing myocardial cell injury and inhibiting the apoptosis caused by H/R. 2016 Vol. 33 (12): 2346-2349 [Abstract] ( 64 ) HTML (1 KB)  PDF (1735 KB)  ( 42 ) 2349 Effects of Different Methods of Labor Analgesic Administration on Primiparas in the Second Stage of Labor YI Li-sheng, LI Li-ping DOI: 10.3969/j.issn.1671-7171.2016.12.019 【Objective】To compare the effects of two different ways of drug administrations in labor analgesia for primiparas during the second stage of labor time .【Methods】A total of 32 cases of primiparas who required painless childbirth were divided according to the random number table method into an experimental group and a control group, with 16 cases in each group. Primiparas in the experimental group were given anesthesia according to a high added dosage with low background dosage method also known as the 8-2-20-8 administration method: In the first dosage, patients were given 8 ml of a mixture of ropivacaine and fentanyl. The background dose was 2ml/h mixture. Every 20 minutes, an additional 8ml of the mixture was rapidly injected. Meanwhille, in the control group, primiparas were given anesthesia according to a low added dosage and high background dosage method also known as the 8-6-20-3 administration method: The ropivacaine and fentanyl mixture was given at a first dosage of 8ml. The background dosage was 6ml/h mixture. Every 20 minutes, an additional 3ml of the mixture was rapidly injected. VAS scores before labor analgesia and during the second stage of labor of the two groups of primiparas were evaluated, and the length of the second stage of labor was recorded. The lactate value of every infant was determined. 【Results】The VAS scores of the two groups before labor analgesia and during the second stage and the lactate values of the infants showed no difference (P>0.05). The length of the second stage of labor in the experimental group was significantly shorter than that in the control group (P<0.05).【Conclusion】Compared to the high dosage of background and low additional dosage method of drug delivery, the low background dosage and high additional dosage method can shorten the length of the second stage of labor. It also has no obvious adverse reactions in babies. So, it is suitable as the method of delivery of labor analgesia for primiparas. 2016 Vol. 33 (12): 2349-2352 [Abstract] ( 91 ) HTML (1 KB)  PDF (1223 KB)  ( 148 ) 2351 Study of the Clinical Efficacy and Safety of Different Doses of Valsartan in the Treatment of Chronic Glomerulonephritis Patients with Hypertension WEI Jin-xi, LIU Zhen-jiang, ZHANG Chao,et al DOI: 10.3969/j.issn.1671-7171.2016.12.020 【Objective】To study the dose and effect of Valsartan in the treatment of chronic glomerulonephritis (CG) patients with hypertension. 【Methods】 A total of 96 CG patients complicated with hypertension were selected in the Department of Nephrology in our hospital treated. They were divided according to the random table method into a high-dose group (320 mg/d Valsartan oral) and a conventional-dose group (160mg / d Valsartan oral), with 48 cases in each group. Clinical effects were collected and evaluated after six months of continuous medication. 【Results】Before treatment, the levels of 24h urine protein, SCr, GFR, serum K+, α1-MG, NAG, and CysC were not statistically significant difference between the two groups level group (P<0.05). After 6-month treatment, the high dose group patients showed lower levels of 24h urine protein, SCr, α1-MG, NAG and CysC and a higher level of GFR compared to the conventional dose group; the differences were statistical significance (P<0.05). The incidence of adverse reactions was 14.58% in the high-dose group and 4.17% in the conventional dose group, but the difference was not statistically significant (P> 0.05). 【Conclusion】High doses of Valsartan treatment in chronic glomerulonephritis patients with hypertension is conducive to delaying the process of deterioration of renal function. It has certain clinical and practical value. 2016 Vol. 33 (12): 2351-2354 [Abstract] ( 73 ) HTML (1 KB)  PDF (1252 KB)  ( 78 ) 2354 Analysis of Related Risk Factors of Nosocomial Infection for Ipatients with Aute Leukemia LI Fang, HUANG Li-hua DOI: 10.3969/j.issn.1671-7171.2016.12.021 【Objective】To explore the related risk factors of nosocomial infection for the inpatients with acute leukemia so as to provide scientific evidence for effective prevention and control of nosocomial infection. 【Methods】Clinical data of 315 inpatients with acute leukemia at Hematology Department in our hospital from January 2011 to December 2013 were analyzed retrospectively. 【Results】Nosocomial infection rate in the group was 37%. Respiratory infection was the main infection site, followed by bloodstream infection, skin infection, gastrointestinal infection and perianal infection; Multivariate logistic regression analysis showed that the invasive operation, hospitalization time more than 15 days, combined with other diseases were independent risk factors of nosocomial infection in patients with acute leukemia.【Conclusion】 The incidence of nosocomial infection in patients with acute leukemia is fairly high.Clinical work should be focused on hospital risk factors, and take reasonable and effective measures to reduce the incidence of nosocomial infection so as to improve the treatment effect and quality of life of hospitalized patients with acute leukemia. 2016 Vol. 33 (12): 2354-2357 [Abstract] ( 53 ) HTML (1 KB)  PDF (1371 KB)  ( 35 ) 2357 Effects of Shenmai Injection Combined with Interleukin-2 on the Immune Function and Life Quality of Lung Cancer Patients Underwent Postoperative Chemotherapy YAO Yang, WANG Xiao-hua, ZHOU Qiang DOI: 10.3969/j.issn.1671-7171.2016.12.022 【Objective】To explore the effects of Shenmai injection combined with interleukin-2 on immune function, chemotherapy toxicity and quality of life in patients with lung cancer undergoing postoperative chemotherapy. 【Methods】Eighty-two patients with non small cell lung cancer treated in our hospital were divided into the observation group and the control group . Based on the operation, the control group was treated with postoperative chemotherapy and intrapleural injection of IL-2 , while the observation group recieved IL-2 intrapleural injection combimed with Shenmai injection. The clinical efficacy were compared between the two groups. 【Results】The total response rate in the treatment of pleural effusion in the observation group was 83.3%, higher than that in the control group (62.5%) (P<0.05). There were no significant differences in immune function and quality of life scores between the two groups before treatment (P>0.05); After treatment, there were no significant changes in the control group (P>0.05).The function scale CD3+、CD4+、CD4+/CD8+, the overall quality of life scale score of the observation group after treatment were higher; Symptom scale, single scale score and CD8+ were lower than those before treatment and those of the control group after treatment (P<0.05). The incidence of nausea and vomiting Ⅲ in the observation group was 4.8% (2/42) and 7.1% (3/42), which was lower than that in the control group 20.0% (8/40) and 30% (12/40), and the difference was significant (P<0.05). There was no significant difference in the incidence of other adverse reactions between the two groups (P > 0.05).【Conclusion】The application of Shenmai injection combined with interleukin-2 in the treatment of lung cancer can effectively alleviate pleural effusion, enhance patient's immune ,improve patient's tolerance and reduce the toxic and side effects. 2016 Vol. 33 (12): 2357-2361,2363 [Abstract] ( 79 ) HTML (1 KB)  PDF (1245 KB)  ( 52 ) 2360 Effect of Motivational Interviewing on Functional Exercise in Patients with Rheumatoid Arthritis HU Fang, SUN Jiang-yan DOI: 10.3969/j.issn.1671-7171.2016.12.023 【Objective】To explore the effect of motivational interviewing on functional exercise in patients with rheumatoid arthritis . 【Methods】A total of 148 cases in our hospital with rheumatoid arthritis (RA) were selected from October 2014 to December 2015, the patients were randomly divided into intervention group and control group by random number table. The control group received routine follow-up guidance, health education, rehabilitation training daily guidance and set up electronic records with follow-up according to plan; The intervention group added motivational interviewing on the basis of control group, In 6 months, the hospital discharge and morning stiffness duration of the two groups of patients, pain score, ADL score and patient compliance were evaluated and compared.【Results】 Morning stiffness duration, pain score, ADL score and the effect of compliance at discharge were not statistically significant (P>0.05).Six months after discharge, morning stiffness, pain score, ADL score of the patients in the intervention group were significantly lower than those of the control group , the compliance was significantly higher than that of the control group, the difference was statistically significant (P<0.05).【Conclusion】Motivational interviewing has significant effect on the functional exercise of patients with rheumatoid arthritis and has important clinical application value. 2016 Vol. 33 (12): 2360-2364 [Abstract] ( 49 ) HTML (1 KB)  PDF (1268 KB)  ( 78 ) 2364 Correlations of Nanog Expression in Lung Adenocarcinoma Tissue with Chemotherapy Response and Prognosis YAO Su-mei, HE Hai-yan, CHEN Jin-liang,et al DOI: 10.3969/j.issn.1671-7171.2016.12.024 【Objective】To investigate the expression of Nanog in cancer tissue before chemotherapy in advanced lung adenocarcinoma and its influence on the chemotherapeutic effect and prognosis.【Methods】 Pathological data of fifty-six advanced lung adenocarcinoma cases confirmed by histopathology between January 2010 and December 2013 in our hospital was collected. All patients completed at least four cycles of pemetrexed chemotherapy combined with cisplatin. The expression of Nanog was detected by immunohistochemistry in all cancer tissues.【Results】 High expression of Nanog protein in cancer tissue occurred in 29 cases (51.8%) out of 56 cases of advanced lung adenocarcinoma, low expression in 27 cases (48.2%); There was no correlation between the expression level and the gender of the patients (P=0.643), age (P=0.143) and clinical stage (P=0.096); the efficiency of chemotherapy (24.1%) in the Nanog high expression group was lower than that of the low expression group (70.4%), the difference was statistically significant (P<0.05). Univariate analysis showed that clinical stage and Nanog expression levels were associated with clinical prognosis in patients with lung adenocarcinoma (P mean <0.05); Multivariate analysis showed that Nanog expression was an independent prognostic factor in patients with lung adenocarcinoma (P<0.05).【Conclusion】 Nanog high expression may indicate a poor response to pemetrexed chemotherapy combined with cisplatin in patients with lung adenocarcinoma, and even a worse clinical outcome. 2016 Vol. 33 (12): 2364-2368 [Abstract] ( 56 ) HTML (1 KB)  PDF (1845 KB)  ( 38 ) 2368 Study on Contrast-Enhanced Ultrasound Value in the Differential Diagnosis of Uterine Fibroids and Adenomyosis ZHENG Yuan-yuan, ZHONG Zhi-fang, LIU Min, et al DOI: 10.3969/j.issn.1671-7171.2016.12.025 【Objective】To explore the value of contrast-enhanced ultrasound value in the differential diagnosis of uterine fibroids and adenomyosis. 【Methods】Contrast-enhanced ultrasound was used to observe the perfusion characteristics of 105 cases of uterine local lesions. Single uterine fibroids, multiple uterine fibroids, single adenomyosis, multiple adenomyosis and the adenomyosis of myoma underwent differential diagnosis. The sensitivity, specificity, and positive and negative predictive value by contrast-enhanced ultrasound were compared with those by conventional ultrasound and postoperative pathological diagnosis. 【Results】 Compared to the conventional ultrasound group, the contrast-enhanced ultrasound group had significantly higher detection rates of single myoma, multiple myoma, single adenomyosis, multiple adenomyosis and adenomyosis of myoma. The difference between contrast-enhanced ultrasound group and conventional ultrasound group was 93.3% (98/105) versus 59% (62/105), respectively, which showed statistically significant (χ2=4.941,P=0.022). The sensitivity, specificity, positive predictive value and negative predictive value of contrast-enhanced ultrasound were 97.5%, 97.1%, 98.7% and 94.4%, respectively, significantly higher than those of the conventional ultrasound group 65%, 60%, 78.8% and 42.9%, respectively. In the contrast-enhanced ultrasound group, the time of onset, peak time and peak intensity of uterine leiomyoma were significantly higher than those of adenomyosis (P<0.05). 【Conclusion】Compared to conventional ultrasound, contrast-enhanced ultrasound has a high diagnostic rate in the differential diagnosis of uterine fibroids and adenomyosis and is worthy of clinical application. 2016 Vol. 33 (12): 2368-2371 [Abstract] ( 51 ) HTML (1 KB)  PDF (1505 KB)  ( 40 ) 2371 Effect of Bevacizumab Combined with FOLFOX on the Expression of VEGF, MMPs and COX-2 in Patients with Advanced Colorectal Cancer XIAO Qi, WANG Xiao-jie, XIE Ming-shui DOI: 10.3969/j.issn.1671-7171.2016.12.026 【Objective】 To investigate the effect of bevacizumab combined with 5- fluorouracil (5-Fu) + oxaliplatin (L-OHP) + leucovorin (LV) (FOLFOX) chemotherapy on the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMPs) and cyclooxygenase-2 (COX-2) in patients with advanced colorectal cancer. 【Methods】A total of 90 patients with advanced colorectal cancer were equally divided into the control group and the observation group, with 45 cases in each. Both groups were treated with FOLFOX chemotherapy; however, the observation group was additionally treated with bevacizumab. The therapeutic effect was compared between the two groups. The changes in serum VEGF, MMPs and COX-2 were determined before and after treatment. The changes in quality of life before and after treatment were evaluated according to the European Organization for Research and Treatment of Cancer Quality of Life (EORTC QLC-CR37) scale. The incidence rates of side effects in the two groups were statistically analyzed. 【Results】① The total remission rate of the observation group was higher than that of the control group (P<0.05). ② After treatment, the expression levels of VEGF, COX-2, MMP-2 and MMP-9 in both groups were decreased, and the decrease in the observation group was significantly greater than that in the control group (P<0.05). ③ After treatment, the quality of life scores in both groups were increased (P<0.05), and the increase in the observation group was greater than that in the control group (P<0.05). ④ The main side effects in the two groups were grade Ⅰ~Ⅱ leukopenia, gastrointestinal reactions and anemia. There was no case of grade Ⅲ~Ⅳ side effects in the observation group. The incidence rates of different grades of side effects were slightly lower in the observation group than those in control group (P>0.05). 【Conclusion】The total remission rate of bevacizumab combined with FOLFOX chemotherapy is higher than that of routine FOLFOX treatment. The expression of VEGF, COX-2, MMP-2 and MMP-9 is significantly down-regulated. Patient life quality can be improved significantly and the drug tolerance is high as well. 2016 Vol. 33 (12): 2371-2375 [Abstract] ( 48 ) HTML (1 KB)  PDF (1250 KB)  ( 45 ) 2374 Clinical Study of Laparoscopic Devascularization Combined with Endoscopic Esophageal Varix Ligation and Laparoscopic Modified Sugiura Surgery for Treatment of Portal Hypertension FENG Yi-bin, ZHANG Guang-ya, BIE Yu-kun,et al DOI: 10.3969/j.issn.1671-7171.2016.12.027 【Objective】To explore the clinical effect of laparoscopic devascularization combined with endoscopic esophageal varix ligation(EVL) and laparoscopic modified Sugiura surgery for the treatment of portal hypertension.【Methods】A total of 103 patients with portal hypertension was randomly divided into two groups: ,the Group A (underwent laparoscopic devascularization combined with endoscopic esophageal varix ligation(EVL) (n=55) and the Group B (underwent laparoscopic Sugiura operatio(n=48). The operation time, postoperative anal exhaust time, postoperative hospital stay, liver function Child-Pugh grade and esophageal varices were compared between the two groups.【Results】Compared with those of the Group B, the operative time, hospital stay and postoperative exhaust time in the Group A were shorter ,the difference was statistically significant (P<0.05) and there was no significant difference in blood loss and volume of drainage between the two groups (P>0.05). Six months after the operation, the esophageal varices degree and Child-Pugh classification in the two groups were better than that of pre-operation. Patients with Child-Pugh classification grade A in the Group A were more than that in the Group B (P=0.0300), and the incidence of hepatic encephalopathy was lower than that of the Group B, the difference was statistically significant (P<0.05).【Conclusion】Laparoscopic devascularization combined with endoscopic esophageal varix ligation(EVL) for the treatment of portal hypertension has advantages of shorter operation time, better recovery of liver and intestinal function with lower incidence of hepatic encephalopathy after operation, It is worthy of clinical popularization and application. 2016 Vol. 33 (12): 2374-2377 [Abstract] ( 62 ) HTML (1 KB)  PDF (1250 KB)  ( 50 ) 2377 Comparison of Dose, Curative Rates, and Side Effects between Two Radiotherapy Plans XI Dan, PEI Hong-lei, GU Wen-dong,et al DOI: 10.3969/j.issn.1671-7171.2016.12.028 【Objective】To explore the differences in dose, curative rates, and side effects between volumetric modulated arc therapy (VMAT) and three dimensional conformal radiation therapy (3DCRT) after rectal cancer operation. 【Methods】Eighty patients with rectal cancer who underwent operation in our hospital were randomly divided into the VMAT group (A) and 3DCRT group (B) according to different postoperative radiotherapy plans. The dose, curative rates, and side effects of radiotherapy were compared between the two groups. 【Results】The values of Dmax, Dmean, Dmin, and HI (hompgenecity Index) in the A group were significantly lower than those in the B group, while the value of CI (Conformity Index) was significantly higher (P<0.01). The difference in V95% between the two groups was not significant (P>0.05). There were significant differences in the values of Dmax, Dmean, and V50 in the small intestine and bladder between the two groups(P<0.01), the Dmean values in the left and right femoral heads also showed significant differences(P<0.01). The treatment time of group A was significantly shorter than that of group B and the hop count of body was significantly lower than that of group B (P<0.01). The total remission rate in group A was 70%, while in group B was 65% (P>0.05). The total incidence of adverse reactions in group A (52.5%) was significantly lower than that in group B (75%) (P<0.05). 【Conclusion】During the process of radiotherapy after rectal cancer operation, the effects of both VMAT and 3DCRT are significant. However, the former is more consistent with metrology, and side effects are few, with short treatment time. It is of clinical significance. 2016 Vol. 33 (12): 2377-2381,2382 [Abstract] ( 108 ) HTML (1 KB)  PDF (1246 KB)  ( 166 ) 2380 Value of Action Research Method in Prevention and Control of Deep Venous Thrombosis in Patients after Hepatobiliary Surgery LIU Chun, HUANG Ping-ping DOI: 10.3969/j.issn.1671-7171.2016.12.029 【Objective】To explore the value of action research method of nursing intervention on prevention of deep venous thrombosis (DVT) in patients after operation.【Methods】Two hundred and eighty-eight patients who underwent surgical treatment in our hospital from December 2012 to April 2016 were selected. Among them, 144 patients who underwent surgical treatment in the Department of hepatobiliary surgery from December 2012 to November 2014 were selected as the observation group, and the patients underwent surgical treatment in our department from December 2014 to April 2016 were selected as the control group (n=144). Patients in the control group were treated with routine nursing care, and the patients in the observation group were treated through nursing intervention by the action research method to analyze the prevention and control of DVT in the Department of hepatobiliary surgery.The incidence of DVT, edema rate of lower extremity, length of stay, hospitalization cost, D-dimer levels and nursing satisfaction of patients in different time periods were observed in the two groups.【Results】The incidence of DVT and edema of lower limbs in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05); hospitalization time and hospitalization costs of the observation group were significantly lower than those in the control group; At 6 h after operation, the level of D-dimer in the observation group was significantly lower than that in the control group , the difference was statistically significant (P<0.05); The satisfaction rate of the observation group was 95.8%, which was significantly higher than that of the control group (81.3%), and the difference was statistically significant (P<0.05).【Conclusion】 The nursing intervention of action research method for postoperative patients of hepatobiliary surgery can intervene the high plasma coagulation state to some extent. It has some clinical significance in prevention and treatment of DVT. 2016 Vol. 33 (12): 2380-2383 [Abstract] ( 46 ) HTML (1 KB)  PDF (1249 KB)  ( 58 ) 2383 Expression Level of CD8+ and CD4+ Memory T cells and Its Diagnostic Value in Patients with Active Tuberculosis and TB Latent Infection YUAM Cheng-liang, LIU Zhao-hong, ZHANG Yao,et al DOI: 10.3969/j.issn.1671-7171.2016.12.030 【Objective】To investigate the expression and significance of CD8+ and CD4+ memory T cells in active pulmonary tuberculosis and TB latent infection. 【Methods】Patients diagnosed with active tuberculosis and latent infection in our hospital were chosen as the subject. There were 25 cases of active pulmonary tuberculosis patients (TB group), 25 cases of latent tuberculosis infection (latent infection group), and 30 cases of healthy people (healthy group). CD4+ and CD8+ memory T cells in peripheral blood were detected by flow cytometry. The results were compared with patients' high-resolution CT scores (HRCT) to analyze the correlation between the two. 【Results】The level of CD4+ Tcm and CD8+ Tcm in the latent infection group was higher than that of the active pulmonary TB group and healthy group; the difference was statistically significant (P<0.05). Also, the expression of CD4+ and CD8+ Tcm in TB group was higher than that of the healthy group with statistical significance (P<0.05). On the other hand, the level of CD4+ Tem and CD8+ Tem in TB group and latent infection group was significantly lower than that in the healthy group; the difference was statistically significant (P<0.05). However, the differential expression in CD4+ Tem and CD8+ Tem between the patients with pulmonary tuberculosis and the patients with latent infection was not statistically significant (P>0.05). Furthermore, the level CD4+ Tcm and CD8+ Tcm in TB patients had significant negative correlation with HRCT score (P<0.05). However, in TB patients, the level of CD4+ Tem and CD8+ Tem level had no significant correlation coefficient (P>0.05) with HRCT score. 【Conclusion】Levels of Central memory T cells of CD4+ Tcm and CD8+ Tcm in the active and latent tuberculosis infection patients were significantly increased, which may reflect the degree of injury of pulmonary tuberculosis. 2016 Vol. 33 (12): 2383-2386 [Abstract] ( 103 ) HTML (1 KB)  PDF (1249 KB)  ( 167 )

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