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| Changes of MeCP2 in Cochlea of BALB/c Mice with Age-Related Hearing Loss |
| JIANG La-mei, WU Wei-jing, CHEN Yong |
| School of Medicine, Hunan Normal University, Changsha 410013, Hunan, China |
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Abstract 【Objective】To investigate the variance of the methyl-CpG-binding protein 2 (MeCP2) expression in the cochlea of BALB/c mice with age-related hearing loss and its clinical significance. 【Methods】On the basis of research on auditory function of BALB/c mice in different months, the morphological study of cochlea and immunohistochemical expression of MeCP2 protein in cochlea, the expression of MeCP2 mRNA gene was detected in 3, 6, 12, 18 months old rats in the cochlea through the method of semi quantitative reverse transcription polymerase chain reaction. 【Results】MeCP2 was expressed in 4 mice groups in the cochlea of BALB/c with different months of age, the expression level of MeCP2 mRNA decreased gradually with the increase of month age, the difference was statistically significant (P<0.01).【Conclusion】 The expression level of MeCP2 in the cochlea of BALB/c mice with age-related hearing loss decreased with the increase of the age of mice, which may be related to the aging of cochlea and the occurrence of presbycusis.
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Received: 29 August 2016
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2016, Vol. 33 
