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| Study of the Relationship Between the Efficacy of Cisplatin Chemotherapy in Combination with Radiotherapy and Expression levels of RRM1 in Cervical Cancer |
| DING Ding, KONG Wei-min, HAN Chao,et al |
| Department of Obstetrics and Gynecology, Lidu Branch, Meizhongyihe Women and Children Hospital, Beijing 100015, China |
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Abstract 【Objective】To explore the application value of cisplatin chemotherapy combined with radiotherapy in the treatment of cervical cancer, and to analyze the relationship between clinical efficacy and expression levels of ribonucleotide reductase M1 (RRM1) in patients with cervical cancer. 【Methods】Ninety-eight patients with cervical cancer were divided into group A and group B by the random number table method, 49 cases in each group. Group B was given pelvic external radiotherapy combined with brachytherapy. On that basis, group A was given cisplatin chemotherapy. The short-term effects and incidence of side effects were compared between the two groups, and changes of the maximum transverse diameter of tumor and expression of RRM1 in cervical lesions before and after the treatment were recorded. According to short-term effects, Group A was further divided into the good to excellent and poor to medium groups. The expression of RRM1 in cervical lesions was compared between the two groups, and Pearson correlation analysis was used to analyze the relationship between the clinical effect and expression of RRM1 in cervical lesions. 【Results】The overall effective rate, incidence rates of Ⅲ~Ⅳ level gastrointestinal reactions, Ⅰ~Ⅱ level bone marrow suppression, radiocystitis, and factitial proctitis in group A were significantly higher than those in group B (P<0.05). After treatment, the maximum transverse diameter of tumor and RRM1 high expression rates were significantly lower than those before treatment, and those in group A were lower than group B (P<0.05). The RRM1 low expression rate in excellent and good group was significantly higher than that in the medium and poor group (57.7% vs 16.7%) (P<0.05). Pearson correlation analysis showed that the clinical effect of cisplatin chemotherapy combined with radiotherapy was positively correlated with RRM1 low expression in cervical lesions (P<0.05). 【Conclusion】Cisplatin chemotherapy combined with radiotherapy improves the short-term effects of patients with cervical cancer, and its efficacy is inversely correlated with RRM1 expression.
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Received: 01 July 2016
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2016, Vol. 33 
