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| Study of the Clinical Efficacy and Safety of Different Doses of Valsartan in the Treatment of Chronic Glomerulonephritis Patients with Hypertension |
| WEI Jin-xi, LIU Zhen-jiang, ZHANG Chao,et al |
| Department of internal medicine, Pixian people's Hospital, Chengdu 611730, Sichuan |
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Abstract 【Objective】To study the dose and effect of Valsartan in the treatment of chronic glomerulonephritis (CG) patients with hypertension. 【Methods】 A total of 96 CG patients complicated with hypertension were selected in the Department of Nephrology in our hospital treated. They were divided according to the random table method into a high-dose group (320 mg/d Valsartan oral) and a conventional-dose group (160mg / d Valsartan oral), with 48 cases in each group. Clinical effects were collected and evaluated after six months of continuous medication. 【Results】Before treatment, the levels of 24h urine protein, SCr, GFR, serum K+, α1-MG, NAG, and CysC were not statistically significant difference between the two groups level group (P<0.05). After 6-month treatment, the high dose group patients showed lower levels of 24h urine protein, SCr, α1-MG, NAG and CysC and a higher level of GFR compared to the conventional dose group; the differences were statistical significance (P<0.05). The incidence of adverse reactions was 14.58% in the high-dose group and 4.17% in the conventional dose group, but the difference was not statistically significant (P> 0.05). 【Conclusion】High doses of Valsartan treatment in chronic glomerulonephritis patients with hypertension is conducive to delaying the process of deterioration of renal function. It has certain clinical and practical value.
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Received: 19 August 2016
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2016, Vol. 33 
