利拉鲁肽对缺氧/复氧诱导的乳鼠心肌细胞损伤的影响

doi:10.3969/j.issn.1671-7171.2016.12.018

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Abstract 【Objective】To observe the effects of a new antidiabetic drug Liraglutide on injury of neonatal rat cardiomyocytes induced by hypoxia / reoxygenation(H/R).【Method】 Wistar rat myocardial cells were cultured in vitro and were divided into three groups: simple H/R group(group A ), Liraglutide + H/R group(group B ), and normal control group (group C). In addition to the normal control group, the remaining two groups were injured by H/R. Dehydrogenase (LDH), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and apoptotic cardiomyocytes were detected in the three groups. 【Results】Compared with group C, MDA, LDH levels, and apoptosis rate in group A were significantly higher, and the activity of SOD was lower (P<0.01). Compared with group A, the LD H, MDA level, and cell apoptosis rate in group B was significantly lower (P<0.01), but was still higher than those in group C (P<0.01). Compared with groups B and C, the SOD activity was significantly higher in group A (P<0.01). 【Conclusion】H/R can damage of myocardial cells and increase cell apoptosis. As glucagon like peptide-1 analogue, Liraglutide shows potential cardioprotective effects by directly acting on myocardial cells, which includes reducing myocardial cell injury and inhibiting the apoptosis caused by H/R.

Key words： Hypoglycemic Agents/TU Myocytes, Cardiac Anoxia Wounds and Injuries Apoptosis

Received: 19 September 2016

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R542.2

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2016.12.018 OR http://www.jcr.net.cn/EN/Y2016/V33/I12/2346