Abstract：【Objective】To investigate the effect of balloon dilatation combined with hormone in the treatment of esophageal cancer after radiotherapy. 【Methods】A total of 68 patients with esophageal cancer stenosis after radiotherapy were randomly divided into two groups, 34 cases in each group. The control group was treated with endoscopic balloon dilatation, while the observation group was treated with glucocorticoid. The curative effect, complications and dysphagia before and after treatment were compared between the two groups. Albumin (ALB), transferrin (TF), hemoglobin (Hb), lymphocyte count (TCL), body weight, nutritional status and immune function were compared between the two groups. 【Results】After intervention, the stenosis in the observation group was improved, and the total effective rate was 100%, which had no significant difference compared with 94.12% of the control group (P>0.05). The cure rate of the observation group was 79.41%, which was significantly higher than 55.88% of the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). At the time of reexamination, the proportion of grade 0, grade 1-2 in the two groups was significantly higher than that before treatment (P<0.05). The proportion of grade 0 in the observation group was significantly higher than that in the control group (P<0.05). The levels of ALB, TF, Hb and TCL in the two groups after intervention were higher than those before treatment, and the levels of ALB, TF and TCL in the observation group were significantly higher than those in the control group (P<0.05). The levels of CD4+, CD4+/CD8+ in the two groups were higher than those before treatment, and CD8+ was lower than that before treatment (P<0.05), and the levels of CD4+, CD4+/CD8+ and CD8+ in the observation group were higher than those in the control group (P<0.05). 【Conclusion】Endoscopic balloon dilatation combined with glucocorticoid in the treatment of esophageal cancer patients with stenosis after radiotherapy can improve the cure rate of stenosis, promote the further improvement of swallowing function, nutritional status and immune function.
朱超莽, 张群, 殷红梅, 李多杰. 内镜下球囊扩张联合糖皮质激素治疗食管癌放疗后狭窄的疗效[J]. 医学临床研究, 2020, 37(12): 1789-1792.
ZHU Chao-mang, ZHANG Qun, YIN Hong-mei, et al. Efficacy of Endoscopic Balloon Dilatation Combined with Glucocorticoid in the Treatment of Esophageal Cancer Stenosis after Radiotherapy. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1789-1792.
[1] Pietro MD, Canto MI, Fitzgerald RC. Endoscopic management of early adenocarcinoma and squamous cell carcinoma of the esophagus-screening, diagnosis, and therapy[J].Gastroenterology,2017, 154(2):421-436. [2] Okamura A, Watanabe M, Imamura Y, et al. Glycemic status and prognosis of patients with squamous cell carcinoma of the esophagus[J].World J Surg,2017, 41(10):2591-2597. [3] Oguma J, Ozawa S, Kazuno A, et al. Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus[J].Dis Esoph,2017, 30(12):1-5. [4] 岳天华,袁鹏,张兵, 等.小球囊在食管癌术后高位良性吻合口狭窄中的作用[J].实用放射学杂志,2016,32(9):1477-1478. [5] Parikh, Shan S, Blackwell, Daniel J, et al. Thyroid and glucocorticoid hormones promote functional T-tubule development in human-induced pluripotent stem cell-derived cardiomyocytes[J].Cire Res,2017, 121(12):1323-1330. [6] 高献书. 食管癌放射治疗指南[M]. 北京:中国医药科技出版社, 2011:104-108. [7] 黄子成, 黄安业. 食管癌伴吞咽困难患者行经皮内镜下胃造瘘肠内营养的临床效果观察[J].中华消化内镜杂志, 2015, 32(1):52-53. [8] Suzuki G, Yamazaki H, Aibe N, et al. Palliative radiotherapy in the local management of stage IVB esophageal cancer: factors affecting swallowing and survival[J].Anticancer Res,2017, 37(6):3085-3092. [9] 王献良, 孙忠源, 潘登, 等. 内镜下球囊扩张术治疗新生儿食管闭锁术后食管狭窄的临床研究[J].中华消化内镜杂志, 2019, 36(1):36-40. [10] 唐丽红, 戚静燕, 马香妹. 浙江省12家医院糖皮质激素应用分析[J].中国药房, 2015, 26(2):159-160. [11] 王德全, 王玉国, 刘保国,等. 糖皮质激素受体基因多态性与自身免疫性疾病相关性研究进展[J].河北医药, 2015, 37(12):1866-1868. [12] Vrana D,Matzenauer M,Aujesky R,et al. Potential predictive role of micrornas in the neoadjuvant treatment of esophageal cancer[J].Anticancer Res,2017, 37(2):403-412.
2020, Vol. 37 
