医学临床研究
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医学临床研究  2020, Vol. 37 Issue (3): 400-402    DOI: 10.3969/j.issn.1671-7171.2020.03.023
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ERAT对阑尾炎患者PCT、sICAM-1水平影响及安全性分析
郑东林, 陈远能, 农长深, 袁海锋, 黄徽徽
广西中医药大学附属瑞康医院,广西 南宁 530011
Effect of ERAT on the Level of PCT and sICAM-1 in Patients with Appendicitis and its Safety Analysis
ZHENG Dong-lin, CHEN Yuan-neng, NONG Chang-shen, et al
Ruikang Hospital Affillated to Guangxi University of Chinese Medicine,Guangxi 530011
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摘要 【目的】探讨内镜逆行阑尾炎治疗术(ERAT)对阑尾炎患者血清降钙素原(PCT)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响及安全性。【方法】回顾性分析2016年10月至2018年3月本院收治的128例阑尾炎患者的临床资料,根据手术方法不同分为对照组(采用腹腔镜阑尾切除术治疗)和观察组(ERAT手术方法治疗),每组各64例。观察两组患者PCT、sICAM-1、脂氧素A4(LXA4)、可溶性P选择素(sP-s)水平变化,比较两组手术时间、术后卧床时间、白细胞恢复正常时间、住院时间及术后并发症发生情况。【结果】观察组患者手术时间、术后卧床时间、白细胞恢复正常时间及住院时间短于对照组,住院费用少于对照组,差异有统计学意义(P<0.05)。术前,两组患者PCT、sICAM-1、LXA4、sP-s水平比较,差异无统计学意义(P>0.05)。术后72 h,观察组血清PCT、sICAM-1、LXA4、sP-s水平低于对照组,差异有统计学意义(P<0.05)。观察组消化道出血1例,对照组消化道出血、腹腔脓肿、肠梗阻各1例,观察组并发症发生率为1.56%(1/64)低于对照组的4.69%(3/64),差异无统计学意义(χ2=1.032,P=0.310>0.05)。【结论】ERAT治疗阑尾炎创伤小,炎症反应轻,患者术后恢复快,并发症少,安全性高,值得临床推广应用。
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关键词 阑尾炎/外科学内窥镜检查降钙素    
Abstract:【Objective】To analyze the effect and safety of endoscopic retrograde appendicitis therapy (ERAT) on the levels of procalcitonin (PCT) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with appendicitis. 【Methods】The clinical data of 128 patients with appendicitis admitted to our hospital from October 2016 to March 2018 were analyzed retrospectively. According to the different operation methods, the patients were divided into control group (treated with laparoscopic appendectomy) and observation group (treated with ERAT operation), 64 cases in each group. The changes of PCT, sICAM-1, lipoxygenase A4 (LXA4) and soluble P-selectin (sP-s) in the two groups were observed, and the operation time, bed time, time of leukocyte recovery, hospitalization time and postoperative complications were compared.【Results】 The operation time, bed time, WBC recovery time and hospitalization time in the observation group were shorter than those in the control group, and the hospitalization cost was less than that in the control group, with a statistically significant difference (P<0.05). Before operation, there was no significant difference in PCT, sICAM-1, LXA4 and sP-s between the two groups (P>0.05). 72 hours after operation, the levels of serum PCT, sICAM-1, LXA4 and sP-s in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05).There was 1 case of gastrointestinal hemorrhage in the observation group, 1 case of gastrointestinal hemorrhage, 1 case of abdominal abscess and 1 case of intestinal obstruction in the control group. The incidence of complications in the observation group was 1.56% (1/64) lower than that in the control group (4.69% (3/64). The difference was not statistically significant (χ2=1.032,P=0.310>0.05).【Conclusion】 ERAT treatment of appendicitis has the advantages of less trauma, less inflammatory reaction, quick postoperative recovery, less complications and high safety, which is worthy of clinical application.
Key wordsAppendicitis/SU    Endoscopy    Procalcitonin
收稿日期: 2018-11-06     
PACS:  R574.61  
引用本文:   
郑东林, 陈远能, 农长深, 袁海锋, 黄徽徽. ERAT对阑尾炎患者PCT、sICAM-1水平影响及安全性分析[J]. 医学临床研究, 2020, 37(3): 400-402.
ZHENG Dong-lin, CHEN Yuan-neng, NONG Chang-shen, et al. Effect of ERAT on the Level of PCT and sICAM-1 in Patients with Appendicitis and its Safety Analysis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 400-402.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.03.023     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I3/400
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