Abstract:【Objective】 To comparatively analyze the application of disposcope and shikani optical stylet in tracheal intubation of general anesthesia for elderly hypertensive patients. 【Methods】 A total of 84 elderly hypertensive patients who planned to be treated with tracheal intubation general anesthesia were randomly divided into group A (disposcope) and group B (shikani optical stylet), with 42 cases in each group. Levels of HR, DBP, SBP, plasma cortisol (COR) and endothelin (ET) were compared between the two groups before anesthesia (T0), after induction of anesthesia (T1), immediately after intubation (T2) and 2min after intubation (T3). The success rate of tracheal intubation, intubation time and incidence of complications were compared between the two groups. 【Results】 There were no significant differences in the levels of HR, DBP, SBP, plasma COR and ET between the two groups at different time points (P>0.05). There were no significant differences in the success rates and failure rates of one-time tracheal intubation between group A and group B [90.48% (38/42) and 2.38% (1/42) vs 92.86% (39/42) and 0.00% (0/42)](P>0.05). Also, there was no significant difference between the two groups in the average intubation time (P>0.05). No complications such as snoring or sore throat happened in both groups. 【Conclusion】 The effect of disposcope tracheal intubation is similar to that of shikani optical stylet in elderly hypertensive patients under general anesthesia. They both can effectively maintain the stability of hemodynamics with mild stress response, and provide high success rate of one-time intubation and safety.