卵巢早衰方中西药联合治疗卵巢早衰患者的疗效观察

doi:10.3969/j.issn.1671-7171.2020.12.009

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摘要 【目的】探讨卵巢早衰方中西药联合治疗卵巢早衰患者的临床疗效及对患者血清促卵泡生长激素(FSH)、血清抑制素B(INHB)、雌二醇(E₂)表达水平的影响。【方法】回顾性分析2015年8月至2018年8月在本院诊治的卵巢早衰患者102例的临床资料,根据治疗方法不同分为观察组和对照组。对照组给予芬吗通治疗,观察组在对照组基础上给予卵巢早衰方治疗,比例两组患者临床疗效。【结果】观察组总有效率为92.16%(47/51),显著高于对照组的76.47%(39/51),其差异有统计学意义(χ²=4.744,P=0.029)。两组患者治疗前血清FSH、INHB、E₂水平和Kupperman评分比较差异无统计学意义(P>0.05);治疗3个月、6个月后,观察组患者血清INHB和E₂水平均显著高于对照组,FSH水平、Kupperman评分显著低于对照组,其差异均有统计学意义(P<0.05)。观察组6个月复发率为9.80%(5/51),显著低于对照组的33.33%(17/51),其差异有统计学意义(χ²=9.346,P=0.004)。【结论】卵巢早衰方中西药联合治疗卵巢早衰患者,疗效显著,可改善患者血清FSH、INHB、E₂的表达水平,减轻病程程度,且复发率低,值得临床推广应用。

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	陆梅艳
	马晓红
	安沛兴
	陆春艳

关键词 ：原发性卵巢功能不全/药物疗法, 原发性卵巢功能不全/中药疗法, 药物疗法, 联合

Abstract：【Objective】To study the therapeutic effect of Chinese medicine (Ovarian Zaoshuai Recipe) combined with Fimotong on follicular growth hormone (FSH), serum inhibin B (INHB) and estrogen (E₂) in patients with premature ovarian failure. 【Methods】 A total of 102 patients with premature ovarian failure treated in our hospital from August 2015 to August 2018 were divided into two groups according to different treatment methods. The control group was treated with Fimotong, while the observation group was treated with ovariectomy recipe on the basis of Finmotong. The clinical efficacy of the two groups after treatment was analyzed. 【Results】The total effective rate was 92.16% (47/51) in the observation group and 76.47% (39/51) in the control group. The total effective rate in the observation group was higher than that in the control group (P<0.05). There were no significant differences in FSH, INHB and E₂ level between the two groups before treatment (P>0.05). However, 3 and 6 months after treatment, serum INHB and E₂ levels of the observation group were significantly higher than those of the control group, and the FSH level in the observation was significantly lower than that in the control group. The differences were statistically significant (P<0.05). There was no significant difference in Kupperman score between the two groups before treatment (P>0.05). While the Kupperman score in the observation group was lower than that in the control group at 3 months and 6 months after treatment. The recurrence rate was 9.80% in the observation group and 33.33% (17/51) in the control group. The recurrence rate in the observation group was lower than that in the control group (P<0.05). 【Conclusion】The treatment of premature ovarian failure with Chinese medicine combined with Western medicine can improve the expression of FSH, INHB, and E₂, reduce the course of disease, improve the curative effect, and result in a low recurrence rate.

Key words： Primary Ovarian Insufficiency/DT Primary Ovarian Insufficiency/ZD Drug Therapy, Combination

收稿日期: 2019-09-23

PACS:

R711.75

引用本文:

陆梅艳, 马晓红,安沛兴, 陆春艳. 卵巢早衰方中西药联合治疗卵巢早衰患者的疗效观察[J]. 医学临床研究, 2020, 37(12): 1793-1795.
LU Mei-yan, MA Xiao-hong, AN Pei-xing, et al. Observation of the Curative Effect of Chinese Medicine Combined with Fimotong in the Treatment of Patients with Premature Ovarian Failure. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1793-1795.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.12.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I12/1793