Abstract：【Objective】To investigate the value of tumor markers in preoperative evaluation of gastric cancer and indications for endoscopic treatment. 【Methods】A total of 79 patients with gastric cancer admitted to our hospital from March 2016 to March 2019 was divided into two groups according to the indication of endoscopic submucosal dissection (ESD) (n=38) and not according to the indication of ESD (n=51). Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 724 (CA724), alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA), and to analyze the relationship between them and the clinical characteristics of patients, and to analyze the value of each index in ESD.【Results】 The positive rate of CA19-9 was related to TNM stage and lymph metastasis (P<0.05); the positive rate of CA724 was related to TNM stage, depth of invasion and distant metastasis (P<0.05); the positive rate of AFP was related to TNM stage and distant metastasis (P<0.05); the positive rate of CEA was related to TNM stage, depth of invasion and distant metastasis (P<0.05). The levels of CA19-9, CA724 and CEA in the non ESD group were significantly higher than those in the ESD group (P<0.05). ROC curve analysis showed that the difference was statistically significant (Z=4.153, P=0.001;Z=3.375, P=0.029); the difference was not statistically significant (P>0.05) when CA19-9 and CA724 were detected alone, and the sensitivity and specificity of combined detection were better than that of single detection (P<0.05). 【Conclusion】CA19-9, CA724, CEA and AFP detection have certain clinical application value in preoperative evaluation of gastric cancer patients and indications of endoscopic treatment. Combined detection can improve sensitivity and specificity, which is worthy of clinical reference.
白艳锋, 南建东. 肿瘤标志物检测在胃癌术前评估及内镜治疗适应证中的应用[J]. 医学临床研究, 2020, 37(6): 863-865.
BAI Yan-feng, NAN Jian-dong. Application Value of Tumor Markers Detection in Preoperative Evaluation and Endoscopic Treatment of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 863-865.
[1] 杨朝美,杨晏. PGR与血清肿瘤标记物联合检测在胃癌诊断的临床意义[J].中国普通外科杂志,2018,27(4):523-527.
[2] 刘夏炎,余安运,刘益,等. 血清胃蛋白酶原及相关肿瘤标志物与胃癌的相关性研究[J].现代检验医学杂志,2018,33(5):108-110.
[3] 覃刚,吴莉莉,袁宏,等. 肿瘤标记物联合智能染色内镜对早期胃癌的诊断价值[J].中国肿瘤临床与康复,2017,24(4):443-446.
[4] Ichinose M, Hikichi T, Kanno Y, et al .A case of gastric lipoma resected by endoscopic submucosa dissection with difficulty in preoperative diagnosis[J].Fukushima J Med Sci,2017,63(3):160-164.
[5] 黄平,匡久树. 胃癌患者手术治疗前后血清CEA、CA242、CA72-4和CA19-9检测的临床意义[J].放射免疫学杂志,2009,22(6):598-599.
[6] 程畅,叶乐平,汪胡根,等. 早期胃癌浸润深度影响因素及DPS对浸润深度的预测价值[J].山东医药,2017,57(29):16-19.
[7] Zeng XY, Yin YP, Xiao H, et al .Clinicopathological characteristics and prognosis of hepatoid adenocarcinoma of the stomach: evaluation of a pooled case series[J].Curr Med Sci,2018,38(6):1054-1061.
[8] 张云,刘春海,栗瑞敏,等. 肿瘤标志物联合检测对胃部病变的临床诊断价值[J].国际检验医学杂志,2017,38(18):2593-2595.
[9] Chen T, Xu L, Dong X, et al .The roles of CT and EUS in the preoperative evaluation of gastric gastrointestinal stromal tumors larger than 2 cm[J].Eur Radiol,2019,29(5):2481-2489.
[10] 马逸云,蒋华,马元麟. 腹腔镜辅助全胃切除术对胃癌患者术后胃肠功能恢复及血清CEA、CA50、CA19-9水平的影响[J].国际消化病杂志,2017,37(4):259-262.
[11] Suenaga Y, Kanda M, Ito S, et al .Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer[J].World J Gastrointest Oncol,2019,11(1):17-27.
[12] 王警,吴齐,孙利,等. 术前小探头超声内镜检查在早期胃癌治疗方式选择中的作用[J].中国内镜杂志,2016,22(2):15-21.
2020, Vol. 37 
