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Quick Search     Adv Search 2023 Vol. 40, No. 12 Published: 2023-12-26   1825 The Effects of miR-181a and miR-138 on the Proliferation of Chondrosarcoma Cells ZENG Xukai,HE Pan,WANG Zhijun DOI: 10.3969/j.issn.1671-7171.2023.12.001 【Objective】 To investigate the effects of miR-181a and miR-138 on the proliferation of chondrosarcoma cells. 【Methods】A total of 20 samples of osteosarcoma and 20 samples of chondrosarcoma tissues were collected. qRT PCR was used to detect the expression levels of miR-181a and miR-138. miRNA mimetics were used to promote the expression of miR-181a and miR-138 in chondrosarcoma cells SW1353. Cell counting was used to detect the effects of miR-181a or miR-138 overexpression alone or in combination on the growth ability of SW1353 cells. The binding sites of miR-181a, miR-138 and RAS family associated domain protein 8 (RASSF8) were predicted using the TargetScan database, and gene experiments were validated using dual luciferase reporter technology.【Results】Compared with chondrosarcoma tissue, the expression of miR-181a and miR-138 was significantly upregulated in chondrosarcoma tissue (P<0.05); Compared with the negative control group, the cell growth ability of the miR-181a and miR-138 overexpression groups was significantly increased (P<0.05), and the combined overexpression group of miR-181a and miR-138 showed the most significant upregulation of cell growth ability; According to predictions, both miR-181a and miR-138 have binding sites with RASSF8; Compared with the cotransfected wild-type RASSF8+scaffold group, the luciferase activity in the cotransfected wild-type RASSF8+miR-181a group and wild-type RASSF8+miR-138 group was significantly reduced (P<0.05); Compared with the cotransfected mutant RASSF8+scaffold group, there was no significant change in luciferase activity in the cotransfected mutant RASSF8+miR-181a group and the mutated RASSF8+miR-138 group (P>0.05). 【Conclusions】miR-181a and miR-138 may promote the growth of chondrosarcoma cells by inhibiting RASSF8. 2023 Vol. 40 (12): 1825-1828 [Abstract] ( 70 ) HTML (1 KB)  PDF (1557 KB)  ( 26 ) 1829 Clinical Efficacy of Intramuscular Injection of Sodium Dimercaptosulfonate and Oral Administration of Dimercaptosuccinic Acid Capsules in the Treatment of Patients with Chronic Arsenic Poisoning YANG Yimei,HUANG Lei,WU Zhimin,et al DOI: 10.3969/j.issn.1671-7171.2023.12.002 【Objective】 To explore the clinical efficacy of intramuscular injection of sodium dimercaptosulfonate and oral administration of dimercaptosuccinic acid capsules in the treatment of patients with chronic arsenic poisoning. 【Methods】 A retrospective analysis was conducted on the clinical data of 206 patients with chronic arsenic poisoning admitted to our hospital from January 2020 to December 2022. According to different treatment methods, they were divided into a control group (treated with dimercaptosuccinic acid) and an observation group (treated with intramuscular injection of sodium dimercaptosulfonate), with 103 patients in each group. The two groups of patients were treated continuously for 3 courses of treatment. We compared the clinical efficacy and arsenic concentration in hair and urine between two groups of patients before and after treatment.【Results】After treatment, the arsenic concentration in the hair and urine of the two groups of patients was significantly lower than before treatment, and the arsenic concentration in the hair and urine of the observation group was significantly lower than that of the control group, with statistical significance (P<0.05). The total effective rate of the observation group was 68.93% (71/103), significantly higher than the control group's 41.75% (43/103), and the difference was statistically significant (P<0.05). 【Conclusion】Early diagnosis and elimination of arsenic in the body are important measures in the treatment of chronic arsenic poisoning; Compared with dimercaptosuccinic acid, sodium dimercaptopropylsulfonate can significantly improve the overall effective rate of patients with chronic arsenic poisoning. 2023 Vol. 40 (12): 1829-1831 [Abstract] ( 59 ) HTML (1 KB)  PDF (1216 KB)  ( 37 ) 1832 Effects of Dexmedetomidine Combined with Ultrasound-Guided Nerve Block Anesthesia on Diabetic Foot Gangrene Surgery ZHENG Minghui,SHI Tao DOI: 10.3969/j.issn.1671-7171.2023.12.003 【Objective】To explore the effects of dexmedetomidine (Dex) combined with ultrasound-guided nerve block anesthesia on diabetic foot gangrene surgery. 【Methods】Eighty patients undergoing diabetic foot gangrene surgery were randomly divided into two groups, with 40 patients in each. The control group underwent ultrasound-guided nerve block anesthesia, while the observation group received anesthesia with Dex combined on the basis of the control group. The sensory and motor nerve block time of the two groups was compared, along with hemodynamic changes [heart rate (HR), blood oxygen saturation (SpO2)] at different time points before and after anesthesia. Serum immune function indicators [CD4+, CD8+, CD4+/CD8+] before anesthesia and after surgery were measured, and the incidence of adverse reactions was recorded as well. 【Results】The onset and completion time of sensory and motor blockade in the observation group were shorter than those in the control group (P<0.05); the duration of sensory and motor blockade in the observation group was longer than that in the control group (P<0.05). The HR after anesthesia in the observation group was significantly higher than that in the control group (P<0.05); the HR at the start of surgery in the observation group was lower than after anesthesia in the same group (P<0.05); the HR after anesthesia in the control group was significantly lower than before anesthesia in the same group (P<0.05). The levels of CD4+ and CD4+/CD8+ after surgery in the control group were significantly lower than before anesthesia in the same group (P<0.05); the levels of CD4+ and CD4+/CD8+ after surgery in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The use of Dex combined with ultrasound-guided nerve block anesthesia for diabetic foot gangrene surgery significantly improves the anesthetic effect, effectively prolongs the nerve block time, maintains stable hemodynamic levels, and does not increase adverse reactions. 2023 Vol. 40 (12): 1832-1834 [Abstract] ( 47 ) HTML (1 KB)  PDF (1278 KB)  ( 50 ) 1835 Clinical Efficacy of Auricle Orthosis in Treatment of Congenital Auricle Deformity XIE Lihua,ZHAO Sijun,WANG Min,et al DOI: 10.3969/j.issn.1671-7171.2023.12.004 【Objective】To explore the effect of noninvasive ear model on infants with congenital auricle malformation of different ages by comparing the auricle morphology data before and after treatment.【Methods】A total of 86 healthy children aged from 2 weeks to 24 weeks who only suffered from unilateral congenital auricle morphological malformation (the malformations showed helix malformation, hidden ear and cup ear) were treated with earwell auricle orthosis. After treatment, the changes of ear morphological data were compared and the curative effect was evaluated combined with various evaluation indexes. 【Results】All children were successfully treated without serious complications. After treatment, facial ear length, morphological ear width, facial ear width and morphological ear length were all longer than before treatment, and the vertical distance between cranial and ear was shorter than before treatment. The differences were statistically significant (P<0.05), However, there was no significant difference in auriculocranial Angle before and after treatment (P>0.05).There were statistically significant differences in treatment cycles, doctors' ratings of efficacy, VAS score of parents' satisfaction and the occurrence of adverse reactions in different age groups (P<0.05). 【Conclusion】The noninvasive ear mold treatment can effectively correct the congenital auricle deformity of infants. And the best effect of wearing ear mold appliance is within 6 weeks after birth. 2023 Vol. 40 (12): 1835-1838 [Abstract] ( 40 ) HTML (1 KB)  PDF (1369 KB)  ( 27 ) 1839 Value of Ultrasonic Parameters and ET-1 on Arteriovenous Fistula Maturity in Patients Post Arteriovenous Fistula Surgery WANG Lei,BIAN Lili DOI: 10.3969/j.issn.1671-7171.2023.12.005 【Objective】To explore the evaluative value of ultrasonic parameters in conjunction with Endothelin-1(ET-1) on the maturity of arteriovenous fistulas in patients with post arteriovenous fistula surgery. 【Methods】A retrospective analysis was conducted on the clinical data of 82 patients who underwent arteriovenous fistula surgery at The Fifth Hospital of Yulin City from August 2020 to August 2022. Patients were divided into the mature group (71 cases) and the immature group (11 cases) based on the maturity of the fistula. Preoperative and postoperative 8-week radial artery hemodynamic indicators [Peak Systolic Velocity (PSV), End-Diastolic Velocity (EDV), Resistive Index (RI)], radial artery diameter (RAD) and blood flow volume (RVF), cephalic vein diameter (CVD) and blood flow volume (CVF), and ET-1 levels were compared between the two groups. The predictive value of RAD, RVF, PSV, EDV, ET-1,and RI on the maturity of arteriovenous fistulas post-surgery was analyzed using the Receiver Operating Characteristic (ROC) curve. The predictive efficacy of the combination of RAD, RVF, PSV, EDV, RI, and ET-1 on arteriovenous fistula maturity was assessed using consistency analysis. 【Results】 Preoperatively and at 8 weeks postoperatively, the mature group had significantly higher levels of RAD, RVF, PSV, EDV, and ET-1 (P<0.05), and a significantly lower RI (P<0.05) compared to the immature group. ROC curve analysis confirmed that RAD, RVF, PSV, EDV, RI 、ET-1 could be used to predict the maturity of fistulas with areas under the curve of 0.757, 0.814, 0.841, 0.762, 0.789, 0.855, respectively. Furthermore, the area under the curve, sensitivity and specificity of the combined prediction were 0.918, 0.986 and 0.909, respectively. The efficiency of the all indexes combined prediction was higher than that of the single detection. 【Conclusion】Ultrasonic measurement parameters combined with ET-1 can be used for the assessment of arteriovenous fistula maturity post-surgery and have clinical applicative value. 2023 Vol. 40 (12): 1839-1841 [Abstract] ( 54 ) HTML (1 KB)  PDF (1354 KB)  ( 37 ) 1842 Effectiveness of Transitional Care Model in The Rehabilitation of Elderly Patients after Total Hip Arthroplasty BU Qiaomei,LIU Yuehui,TAN Haitao,et al DOI: 10.3969/j.issn.1671-7171.2023.12.006 【Objective】To explore the effect of transitional care model on the rehabilitation of elderly patients after total hip arthroplasty. 【Methods】From November 2020 to August 2022, 136 patients with artificial total hip arthroplasty admitted to the Department of Traumatology and Arthroplasty of our hospital were selected as the study subjects and divided into experimental and control groups using the random number table method, with 68 patients in each group. In the control group, conventional treatment and care were used, while in the experimental group ( the observation group), a transitional care model was applied. The Harris Hip Function Score and Barthel Index were compared between the two groups. 【Results】There was no statistically significant difference in the preoperative Harris hip function scores between the two groups of patients (P>0.05). The Harris hip function scores of the two groups of patients at each time point after discharge were higher than those before surgery, and the scores in the observation group was higher than those in the control group, and the difference was statistically significant (P<0.05). The Barthel index scores of the two groups of patients at each time point after discharge were higher than those before surgery, and the scores in the observation group was higher than those in the control group, and the difference was statistically significant (P<0.05).【Conclusion】The transitional care model can significantly improve the functional rehabilitation and self-care ability of the hip joint in the elderly patients after total hip arthroplasty. 2023 Vol. 40 (12): 1842-1845 [Abstract] ( 35 ) HTML (1 KB)  PDF (1700 KB)  ( 37 ) 1846 The Application Value of Iterative Image Reconstruction Algorithm Based on Machine Learning in MRI Scanning in Skeletal System HU Jiayuan,YANG Xiangxiong DOI: 10.3969/j.issn.1671-7171.2023.12.007 【Objective】To explore the application value of iterative image reconstruction algorithms based on machine learning in magnetic resonance imaging (MRI) scanning of the skeletal system. 【Methods】87 patients with skeletal system diseases who underwent 1.5T MRI scans at The Second Xiangya Hospital, Central South University were selected. First, routine sequence scans were performed, and then the sequence protocols of T1WI and T2WI were modified with parameters such as voxel size and excitation frequency. The scanning time was reduced before scanning. The images obtained after scanning were imported into the iterative image reconstruction algorithm software IQMR based on machine learning for processing. The obtained images were statistically analyzed using both quantitative and qualitative methods.【Results】After processing the sequence with a 30% reduction in scanning time using an iterative image reconstruction algorithm based on machine learning, there was no statistically significant difference in image quality between the skeletal system and conventional imaging sequences (P>0.05). 【Conclusion】The iterative image reconstruction algorithm based on machine learning can not only achieve fast imaging of bone systems, but also obtain image quality similar to conventional imaging sequences, thereby improving work efficiency. 2023 Vol. 40 (12): 1846-1849 [Abstract] ( 37 ) HTML (1 KB)  PDF (1516 KB)  ( 59 ) 1850 Analysis of Predictive Value of Combined Detection of Serum Cystatin C and Total Bilirubin in the Prognosis of High-risk Non-ST-segment Elevation Myocardial Infarction GU Jianing,LIU Dan,DI Ruomin,et al DOI: 10.3969/j.issn.1671-7171.2023.12.008 【Objective】To explore the prognostic value of combined detection of serum cystatin C (cys C) and total bilirubin (TBIL) in the prognosis of high-risk non-ST-segment elevation myocardial infarction (NSTEMI). 【Methods】 The clinical data of 173 patients with NSTEMI who underwent percutaneous coronary intervention (PCI) treatment in our hospital from November 2018 to November 2020 were retrospectively analyzed. Serum cys C and TBIL levels were detected before PCI. Patients were followed up for 28 days to record the incidence of the patients' major adverse cardiovascular events (MACE). According to whether the patients had MACE at 28 days after operation, they were divided into the occurrence group (occurrence of MACE) and non-occurrence group (non-occurrence of MACE). General patient information was collected. Logistic regression analysis was used to analyze the risk factors of MACE in NSTEMI patients within 28 days after PCI. The receiver operating characteristic curve (ROC) was drawn, and the area under curve (AUC) was used to evaluate the predictive value. 【Results】Within 28 days after the operation, 29 of the 173 patients had MACE. The incidence of MACE was 16.76%. The age of > 65 years old, Killip grade (Ⅲ-Ⅳ), the proportion of cases with culprit blood vessels ≥2, and the pre-PCI blood levels of creatinine, N-terminal B-type brain natriuretic peptide (NT-proBNP), uric acid (UA), serum cys C and TBIL in the occurrence group were higher than those in the non-occurring group (P<0.05). Logistic regression analysis showed that age>65 years old, number of culprit blood vessels ≥2, serum cys C and TBIL levels before PCI were risk factors for MACE in NSTEMI patients within 28 days after PCI (P<0.05).ROC results showed that the serum cys C and TBIL levels before PCI, and the combination of both cys C and TBIL detection for predicting the AUC values of MACE in NSTEMI patients within 28 days after PCI were 0.785, 0.744,and 0.915 (all P<0.05). 【Conclusion】The detection of both serum cys C and TBIL levels before PCI has a certain value in predicting the occurrence of MACE in NSTEMI patients within 28 days after PCI, while the combined detection of cys C and TBIL has even higher predictive value. 2023 Vol. 40 (12): 1850-1853 [Abstract] ( 35 ) HTML (1 KB)  PDF (1269 KB)  ( 53 ) 1854 Study on the Relationship of Cognitive Function with PLR and NLR in Patients with Acute Ischemic Stroke NING Wenjun,HU Weibing DOI: 10.3969/j.issn.1671-7171.2023.12.009 【Objective】To investigate the relationship of cognitive function with levels of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR)in patients with acute ischemic stroke (AIS). 【Methods】Among 80 AIS patients, 54 with cognitive impairment were classified as group A, and 26 with normal cognitive function were classified as group B. The general data, as well as the levels of PLR, NLR, interleukin-1β (IL-1β), and interleukin-18(IL-18) in both groups were compared. The value of these indicators in predicting cognitive impairment in AIS patients was analyzed using the receiver operating characteristic (ROC) curve analysis. Multifactorial Logistic regression analysis was used to clarify the risk factors for cognitive dysfunction. 【Results】There were no statistically significant differences between the two groups in terms of gender, age, comorbidity with hypertension, diabetes, hyperlipidemia and coronary heart disease, history of alcohol consumption, and severity of stroke (P>0.05). The levels of PLR, NLR, IL-1β, and IL-18 in the group A were significantly higher than those in the group B (P<0.05). ROC analysis confirmed that the serum levels of PLR, NLR, IL-1β, and IL-18 could be used to predict cognitive impairment in AIS patients, with areas under the curve of 0.707, 0.769, 0.827, and 0.929 respectively (all P<0.05). Multifactorial Logistic regression analysis confirmed that PLR>3.355, NLR>6.598, IL-1β>28.565 pg/mL, and IL-18>22.554 pg/mL are risk factors for cognitive impairment in AIS patients. 【Conclusion】Changes in the levels of PLR, NLR, IL-1β, and IL-18 are closely related to the occurrence and development of cognitive dysfunction after AIS and they are risk factors for cognitive impairment in patients. 2023 Vol. 40 (12): 1854-1856 [Abstract] ( 33 ) HTML (1 KB)  PDF (1304 KB)  ( 35 ) 1857 Relationship of MoCA Score with Serum Levels of PKC, IGF-1, and BNDF in Epilepsy Patients DU Aimin,TUO Zhen,SUN Sha,et al DOI: 10.3969/j.issn.1671-7171.2023.12.010 【Objective】To explore the relationship of Montreal Cognitive Assessment (MoCA) score with serum levels of protein kinase C (PKC), insulin-like growth factor-1 (IGF-1), and brain-derived neurotrophic factor (BNDF) in epilepsy patients. 【Methods】Based on the MoCA scores, 80 epilepsy patients treated in our hospitals were divided into the cognitive impairment group (group A with MoCA score <26) and the non-cognitive impairment group (Group B with MoCA score ≥26). The basic information, electroencephalogram results, and serum indicators [PKC, IGF-1, BNDF, Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)] of the two groups were compared. The relationship of cognitive impairment with serum PKC, IGF-1, and BNDF levels was analyzed using Receiver Operating Characteristic (ROC) curve analysis. Multivariate Logistic regression analysis was used to identify the risk factors for cognitive impairment in epilepsy patients. 【Results】Among the 80 patients, 52 (65.00%) cases had cognitive impairment and were categorized into the group A, while 28 (35.00%) cases did not have cognitive impairment and were categorized into the group B. The proportion of patients with generalized seizures and epileptiform waves on electroencephalogram in Group A was higher than that in Group B. The levels of PKC, IGF-1, and BNDF in Group A were lower than in Group B (P<0.05). There were no significant differences in age, gender, duration of illness, family history of epilepsy, history of febrile seizures, IL-6, and TNF-α levels between the two groups (P>0.05). ROC analysis confirmed that the levels of PKC, IGF-1, and BNDF could be used to predict cognitive impairment, with area under the curve (AUC) values of 0.927, 0.732, and 0.862, respectively (all P<0.05). Multivariate Logistic regression analysis showed that generalized seizures, epileptiform waves on electroencephalogram, PKC<3.015 pg/mL, IGF-1<126.57 μg/L, and BNDF<7.635 μg/L were risk factors for cognitive impairment (P<0.05). 【Conclusion】MoCA scores in epilepsy patients are positively correlated with serum levels of PKC, IGF-1, and BNDF. Lower scores of MoCA indicate more severe cognitive impairment and lower serum levels of PKC, IGF-1 and BNDF. Generalized seizures, epileptiform waves on electroencephalogram, PKC<3.015 pg/mL, IGF-1<126.57 μg/L, and BNDF<7.635 μg/L are all risk factors for cognitive impairment in epilepsy patients, which should be given clinical attention. 2023 Vol. 40 (12): 1857-1860 [Abstract] ( 37 ) HTML (1 KB)  PDF (1269 KB)  ( 33 ) 1861 Expression Level and Clinical Significance of Endothelial Cell Microparticles in Patients with Carotid Atherosclerotic Plaques YU Fulin,ZHANG Hongwei DOI: 10.3969/j.issn.1671-7171.2023.12.011 【Objective】To investigate the expression level and clinical significance of endothelial cell microparticles (EMPs) in patients with carotid atherosclerotic plaques (carotid plaques). 【Methods】A total of 82 patients with carotid plaques attended to outpatient clinics of two hospitals were assigned to the observation group, while 82 healthy individuals undergoing routine health check-ups during the same period were designated as the control group. Related clinical data and EMPs levels between the two groups were compared. The diagnostic value of EMPs for carotid plaques was evaluated using receiver operating characteristic (ROC) curves, and multivariate logistic regression analysis was applied to identify factors influencing carotid plaques. 【Results】The observation group exhibited significantly higher levels of low-density lipoprotein cholesterol (LDL-C) and EMPs, while significantly lower level of high-density lipoprotein cholesterol (HDL-C) compared to the control group (all P<0.05).Multivariate logistic regression analysis showed that LDL-C, HDL-C, and EMPs were associated with carotid plaques, with odds ratios (OR) (95%CI) of 1.88 (1.42-2.50), 0.65 (0.32-0.97), and 2.17 (1.49-3.16), respectively.The ROC curve indicated that the area under the curve (AUC) (95%CI) for EMPs diagnosing carotid plaques was 0.80 (0.74-0.87).Patients in the high EMPs subgroup had significantly higher carotid intima-media thickness (IMT) and plaque scores compared to those in the low EMPs subgroup (P<0.05). 【Conclusion】EMPs are potential diagnostic indicators for carotid plaques and it is a risk factor for carotid plaques development. 2023 Vol. 40 (12): 1861-1863 [Abstract] ( 33 ) HTML (1 KB)  PDF (1299 KB)  ( 158 ) 1864 Prognostic Value of EOS, PCT and CRP in Peripheral Blood of Meprednisolone-treated Elderly Patients with COPD Complicated with Pulmonary Infection GONG Lei,FENG Jinmei DOI: 10.3969/j.issn.1671-7171.2023.12.012 【Objective】To explore the predictive value of blood eosinophils (EOS), C-reactive protein (CRP), and serum procalcitonin (PCT) levels in elderly patients with chronic obstructive pulmonary disease (COPD) and pulmonary infection treated with methylprednisolone. 【Methods】A total of 78 elderly patients with COPD and pulmonary infection admitted to Xi'an Fifth Hospital from november 2019 to December 2022 were selected as the study subjects. The expression levels of EOS, CRP, and PCT in the peripheral blood of all patients were measured. Patients received intravenous infusion of methylprednisolone in addition to conventional treatment, and they were divided into the effective and ineffective groups based on their clinical efficacy. Logistic regression was used to analyze the relevant factors that affected methylprednisolone treatment effectiveness of elderly COPD patients with pulmonary infection. The receiver operating characteristic (ROC) curve to evaluate the predictive value of EOS, CRP, and PCT in methylprednisolone treatment of elderly COPD patients with pulmonary infection. 【Results】Among 78 elderly COPD patients with pulmonary infection, 52 patients (in the effective group) were treated effectively, accounting for 66.67%.The remaining 26 cases were ineffective (in the ineffective group), accounting for 33.33%. The levels of serum EOS, CRP and PCT in the effective group were lower than those in the ineffective group. The differences were statistically significant (P<0.05). Logistic regression analysis showed that serum EOS, CRP and PCT levels were all influencing factors of the efficacy of methylprednisolone in the treatment of elderly COPD patients with pulmonary infection (P<0.05). ROC analysis showed that the area under the curve (AUC) of serum EOS, CRP, PCT levels and their combination to predict methylprednisolone-treated efficacy of elderly COPD patients with pulmonary infection were 0.815, 0.831, 0.795 and 0.894, respectively. 【Conclusion】The levels of EOS, CRP, and PCT are all related factors that affect the efficacy of methylprednisolone in elderly COPD patients with pulmonary infection. The levels of EOS, CRP, and PCT can predict the clinical prognosis of methylprednisolone treatment in elderly COPD patients with pulmonary infection. 2023 Vol. 40 (12): 1864-1867 [Abstract] ( 69 ) HTML (1 KB)  PDF (1270 KB)  ( 54 ) 1868 Correlation Analysis between Fetal Thymus Parameters and Gestational Age Measured ZHOU Zhuo,WANG Shan,DUAN Xiaoxia,et al DOI: 10.3969/j.issn.1671-7171.2023.12.013 【Objective】To investigate the correlation between fetal thymus parameters and gestational age in the third trimester. 【Methods】From January 2022 to January 2023, 200 pregnant women in the third trimester were selected from Northwestern University First Hospital, of which 48 were from 29 to 31 weeks, 43 were from 32 to 34 weeks, 54 were from 35 to 37 weeks, and 55 were from 38 to 40 weeks. All pregnant women underwent two-and three-dimensional ultrasonography to measure the anterior and posterior diameter, transverse diameter, circumference and transverse area of fetal thymus at the section of three vessels and the section of left innominate vein, respectively, and the volume of thymus was measured by three-dimensional volumetric imaging. The diameter, transverse diameter, circumference, transverse area and volume of thymus in different gestational weeks were compared. Pearson correlation coefficient was used to analyze the relationship of gestational age with anterior and posterior diameter, transverse diameter, circumference, transverse area and volume of thymus. 【Results】The anterior and posterior diameter, transverse diameter, circumference and transverse area of thymus measured at the section of the three blood vessels and the section of the left innominate vein at weeks 29 to 31, 32 to 34, 35 to 37 and 38 to 40 increased sequentially, and the differences between groups were statistically significant (P<0.05). The volume of fetal thymus from 29 to 31 weeks, 32 to 34 weeks, 35 to 37 weeks and 38 to 40 weeks increased in sequence, and the differences between groups were statistically significant (P<0.05). Pearson correlation coefficient analysis showed that the anterior and posterior diameter, transverse diameter, circumference, transverse area and volume of thymus were positively correlated with gestational age (P<0.05). 【Conclusion】The anteroposterior diameter, transverse diameter, circumference, transverse area and volume of thymus increased with the increase of gestational weeks, and the anteroposterior diameter, transverse diameter, circumference, transverse area and volume of thymus were positively correlated with gestational week. 2023 Vol. 40 (12): 1868-1870 [Abstract] ( 34 ) HTML (1 KB)  PDF (1280 KB)  ( 33 ) 1871 Application Evaluation of Three-dimensional Printed Tooth Model Combined with PRF in Molar Autologous Tooth Transplantation LI Mei,CAO Li DOI: 10.3969/j.issn.1671-7171.2023.12.014 【Objective】To study the effect of three-dimensional printed tooth model combined with platelet rich fibrin (PRF) in molar autologous tooth transplantation.【Methods】One hundred and ninety-two patients who underwent molar autogenous tooth transplantation in our hospital from February 2018 to February 2021 were randomly divided into routine group and study group, with ninety-six cases in each group. The conventional group used three-dimensional printed tooth model combined with bovine bone substitute (Bio-oss), and the study group used three-dimensional printed tooth model combined with PRF. The success rate of transplanted teeth, periodontal indexes [plaque index (PLI), gingival sulcus bleeding index (GBI), clinical attachment loss, periodontal probing depth], masticatory function (bite force and masticatory efficiency) and complications of the two groups were compared, and the patient satisfaction was evaluated one year after operation.【Results】The success rate of transplanted teeth in the study group was 94.79%, which was higher than 84.38% in the routine group (P<0.05). The periodontal indexes PLI, GBI, clinical attachment loss and periodontal probing depth in the study group were lower than those in the routine group (P<0.05). The bite force and masticatory efficiency of the study group were higher than those of the routine group (P<0.05). The incidence of complications in the study group was 3.13%, which was lower than 12.50% in the routine group(P<0.05). The satisfaction of patients in the study group was 95.83% which was higher than 87.50% in the routine group (P<0.05).【Conclusion】The application of three-dimensional printed tooth model combined with PRF in molar autologous tooth transplantation can improve the success rate of transplanted teeth, improve periodontal indexes and masticatory function, reduce the incidence of complications and improve patient satisfaction. 2023 Vol. 40 (12): 1871-1874 [Abstract] ( 31 ) HTML (1 KB)  PDF (1237 KB)  ( 80 ) 1875 Correlation between Serum NF-κB Inflammatory Signaling Pathway and Renal Function Indicators in Patients with Type 2 Diabetic Nephropathy CHEN Jinghe,JIA Xinna DOI: 10.3969/j.issn.1671-7171.2023.12.015 【Objective】To investigate the correlation between serum nuclear factor-kappa B (NF-κB) inflammatory signaling pathway and renal function indicators such as blood urea nitrogen (BUN), serum creatinine (Scr), urinary albumin excretion rate (UAER), β2-microglobulin (β2-MG), and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetic nephropathy (T2DN). 【Methods】Eighty-seven newly diagnosed T2DN patients (Group A), eighty patients with primary type 2 diabetes mellitus without nephropathy (Group B), and seventy healthy volunteers (Group C) were enrolled in the study. Clinical data, renal function indicators, and serum levels of NF-κB, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β),interleukin-6(IL-6), and high-sensitivity C-reactive protein (hs-CRP) were compared among the three groups. Pearson correlation analysis was used to analyze the relationship of renal function indicators with serum levels of NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP, in T2DN patients.【Results】Fasting blood glucose and 2-hour postprandial blood glucose in both group A and group B were higher than those in group C (P<0.05). Other clinical data showed no significant difference among the three groups (P>0.05). Levels of BUN, Scr, UAER, and β2-MG in group A were higher than those in groups B and C (P<0.05), while level of eGFR in group A was lower than that in groups of B and C (P<0.05). There were no significant differences in these above indicators between group B and group C (P>0.05). Serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in group A were higher than those in Groups B and C (P<0.05); The above indicators of group B also were higher than those of group C (P<0.05). Pearson correlation analysis showed that serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in T2DN patients were positively correlated with levels of BUN, Scr, UAER, and β2-MG (P<0.05), while they were negatively correlated with eGFR level (P<0.05). 【Conclusion】Activation of the NF-κB inflammatory signaling pathway mediates the pathogenesis of T2DN. NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP are significantly correlated with renal function indicators. 2023 Vol. 40 (12): 1875-1877 [Abstract] ( 32 ) HTML (1 KB)  PDF (1291 KB)  ( 34 ) 1878 Analysis of the Predictive Value of Peripheral Blood miR-155 Levels for the Clinical Efficacy of Immunoglobulin Therapy in Children with Kawasaki Disease GONG Haitao,MA Xiaomiao DOI: 10.3969/j.issn.1671-7171.2023.12.016 【Objective】To explore the predictive value of peripheral blood miR-155 levels for the clinical efficacy of immunoglobulin therapy in children with Kawasaki disease.【Methods】A total of 187 children with KD admitted to the hospital from October 2018 to March 2021 were selected as the study subjects. They were divided into a sensitive group (n=162) and a non responsive group (n=25) based on their clinical efficacy within 14 days after treatment. The factors affecting the clinical efficacy of KD children were analyzed, and the predictive value of the relative expression level of miR-155 in peripheral blood before treatment on the clinical efficacy of immunoglobulin therapy in KD children was analyzed. 【Results】After treatment, 25 out of 187 children with KD (13.37%) showed no response to immunoglobulin. Non reactive group alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase,total bilirubin,the relative expression levels of hypersensitive C-reactive protein, erythrocyte sedimentation rate, troponin I, N-terminal B-type brain natriuretic peptide(NT-proBNP), and miR-155 were higher in the sensitive group than in the sensitive group (P<0.05). Logistic regression analysis showed that the relative expression level of miR-155 and NT-proBNP were related factors affecting the clinical efficacy of immunoglobulin therapy in children with KD (P<0.05). ROC curve analysis showed that the optimal cutoff point, sensitivity, specificity, and area under the curve for evaluating the clinical efficacy of immunoglobulin therapy in KD children with peripheral blood miR-155 relative expression were 3.01%, 76.00%, 80.25%, and 0.785, respectively (P<0.05). 【Conclusion】Children with KD have a high risk of immunoglobulin non response, and miR-155 is associated with the clinical efficacy of immunoglobulin therapy in KD patients. miR-155 has a higher predictive effect on the clinical efficacy of immunoglobulin therapy in KD patients. 2023 Vol. 40 (12): 1878-1881 [Abstract] ( 27 ) HTML (1 KB)  PDF (1295 KB)  ( 19 ) 1882 The Significance of Serum Neurotrophic and Inflammatory Factor Levels in Patients with Acute Spinal Cord Injury of Different Severity LI Wang,ZHANG Wei DOI: 10.3969/j.issn.1671-7171.2023.12.017 【Objective】To explore the significance of serum neurotrophic and inflammatory factor levels in patients with acute spinal cord injuries of varying severity. 【Methods】A total of 120 patients with acute spinal cord injury were divided into the complete injury group (Group A, 52 cases) and the incomplete injury group (Group B, 68 cases), based on the severity of neurological function injury. Additionally, 65 healthy individuals undergoing physical examination in the same period were selected as the control group. Serum levels of B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were compared among the three groups. The correlation between these serum indicators and the degree of injury in patients was analyzed. 【Results】The serum Bcl-2 level in both group A and B were significantly higher than that in the control group, while Bax level in both groups was significantly lower than that in the control group (P<0.05). Group A had higher Bcl-2 level and lower Bax level than group B (P<0.05). The levels of serum BDNF, NT-3, NT-4, IL-6, and TNF-α in patients of group A and group B were significantly higher than those in the control group (P<0.05); And group A had higher levels of serum BDNF, NT-3, NT-4, IL-6, and TNF-α than group B (P<0.05). Pearson correlation analysis showed that serum levels of Bcl-2, BDNF, NT-3, NT-4, IL-6, and TNF-α in patients were positively correlated with the severity of spinal cord injury (P<0.05), while Bax level was negatively correlated (P<0.05). 【Conclusion】The levels of serum inflammatory factors in patients with acute spinal cord injury are elevated with the severity of the injury, which makes them potential indicators for assessing the degree of injury. 2023 Vol. 40 (12): 1882-1884 [Abstract] ( 30 ) HTML (1 KB)  PDF (1277 KB)  ( 14 ) 1885 Comparison of the Efficacy of BEP and ACM Chemotherapy Regimens in the Treatment of Patients with Trophoblastic Tumors LIU Liying,ZHAI Yao,ZHANG Hengyu DOI: 10.3969/j.issn.1671-7171.2023.12.018 【Objective】To compare the efficacy and impact on pregnancy outcome of combination chemotherapy (BEP) with bleomycin (BLM), etoposide (VP-16), and cisplatin (DDP) with sequential chemotherapy (ACM) with actinomycin D (Act-D), cyclophosphamide (CTX), and methotrexate (MTX) in the treatment of patients with gestational trophoblastic neoplasia (GTN). 【Methods】A total of 102 patients with GTN admitted to our hospital from February 2020 to May 2021 were randomly divided into a BEP group (treated with BEP) and an ACM group (treated with ACM) according to a random number table method, with 51 patients in each group.The clinical efficacy, recovery time of sexual life, sexual function score, incidence of adverse reactions, pregnancy outcome, and ovarian function indicators [estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH)] before and after treatment were compared between the two groups. 【Results】After treatment, there was no significant difference in the total effective rate between the two groups (χ2=1.041,P=0.308). After treatment, the levels of E2, LH, and FSH in both groups decreased (P<0.05), but the levels of E2, LH, and FSH in the ACM group were higher than those in the BEP group (P<0.05). There was no significant difference in the recovery time of sexual life and sexual function score between the two groups after chemotherapy (t=0.293, 1.814, P=0.770, 0.073). The total incidence of adverse reactions in the two groups was similar (χ2=1.055, P=0.316). The pregnancy success rate in the ACM group was higher than that in the BEP group (χ2=4.767, P<0.05).【Conclusion】 The efficacy of combination chemotherapy (BEP) and sequential chemotherapy (ACM) for the treatment of gestational trophoblastic neoplasia (GTN) is comparable, and the incidence of adverse reactions is similar, but sequential chemotherapy (ACM) has less impact on the ovarian function of patients with GTN, which is beneficial to improving the pregnancy success rate after treatment. 2023 Vol. 40 (12): 1885-1888 [Abstract] ( 35 ) HTML (1 KB)  PDF (1242 KB)  ( 29 ) 1889 Analysis of Red Blood Cell Distribution width in Patients with Type H Hypertension and Carotid Atherosclerosis YUAN Tingting,GAO Xiaofang DOI: 10.3969/j.issn.1671-7171.2023.12.019 【Objective】To investigate the changes of red blood cell distribution width (RDW) in patients with type H hypertension complicated with carotid atherosclerosis. 【Methods】A total of 168 patients with type H hypertension admitted to our hospital from May 2019 to December 2020 were prospectively selected and randomly divided into an observation group (with carotid atherosclerosis) and a control group (without carotid atherosclerosis) according to whether they had carotid atherosclerosis. There were 84 patients in each group. The general data and RDW levels of the two groups of patients were compared, and the carotid atherosclerosis in patients with type H hypertension with different RDW levels was compared. Pearson correlation analysis was used to analyze the correlation between RDW and clinical indicators.【Results】The proportion of patients in the observation group with hypertension grade 3, 24-hour dynamic systolic blood pressure (24hSBP), RDW, and homocysteine (Hcy) were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). The 24hSBP, hemoglobin (Hb), and Hcy levels in the high RDW subgroup were higher than those in the low RDW subgroup, and the differences were statistically significant (P<0.05). The number and area of carotid plaque and carotid intima-media thickness (IMT) in the high RDW subgroup were significantly higher than those in the low RDW subgroup (P<0.05). Pearson correlation analysis showed that RDW was positively correlated with 24hSBP(r=0.419), Hcy (r=0.327), atherosclerotic plaque area (r=0.506) and IMT (r=0.238) (all P<0.05). 【Conclusion】RDW is the influencing factor of carotid atherosclerosis in patients with type H hypertension. Clinicians can evaluate the carotid atherosclerosis in patients with type H hypertension according to the changes of RDW. 2023 Vol. 40 (12): 1889-1891 [Abstract] ( 37 ) HTML (1 KB)  PDF (1222 KB)  ( 24 ) 1892 The Effect of Neoadjuvant Radiotherapy and Chemotherapy on the Expression of ki-67, CD44v6, and PD-1/PD-L1 after Esophageal Cancer Surgery GONG Xiangping,SHI Yongtie DOI: 10.3969/j.issn.1671-7171.2023.12.020 【Objective】 To explore the effects of neoadjuvant radiotherapy and chemotherapy on the expression of nuclear protein (ki-67), integrated membrane glycoprotein (CD44v6), and programmed cell death protein-1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) in postoperative esophageal cancer patients. 【Method】A total of 76 patients with esophageal cancer were randomly divided into an observation group and a control group, with 38 cases in each group. Both groups of patients underwent routine esophageal cancer radical surgery, while the observation group received neoadjuvant chemotherapy before surgery. We compared perioperative indicators, clinical efficacy, postoperative ki-67, CD44v6, PD-1/PD-L1 expression levels, and incidence of complications between two groups of patients. 【Results】There was no statistically significant difference in intraoperative bleeding, surgical time, and pleural fluid volume between the two groups of patients (P>0.05); The length of hospital stay in the observation group was less than that in the control group (P<0.05). The objective effective rate of the observation group patients was 76.32% (29/38), significantly higher than the control group's 52.63% (20/38) (P<0.05). The positive expression rate of ki-67 protein and the levels of CD44v6 and PD-1/PD-L1 in the observation group were lower than those in the control group after surgery (P<0.05). There was no statistically significant difference in the total incidence of complications between the two groups of patients (P>0.05). 【Conclusion】Preoperative neoadjuvant radiotherapy and chemotherapy can effectively improve the clinical efficacy and immune function of esophageal cancer patients, with high safety. 2023 Vol. 40 (12): 1892-1894 [Abstract] ( 38 ) HTML (1 KB)  PDF (1280 KB)  ( 39 ) 1895 The Predictive Value of Improved DORSSSP Scoring System Combined with NLR Level for Postoperative Complications in Elderly Patients with Hip Fractures HUANG Junfeng,YANG Le,YANG Sen DOI: 10.3969/j.issn.1671-7171.2023.12.021 【Objective】To explore the predictive value of the modified Daping Orthopaedic Surgery Risk Scoring System (DORSSSP) score combined with neutrophil to lymphocyte ratio (NLR) level for postoperative complications in elderly patients with hip fractures. 【Methods】A total of 160 elderly patients with hip fractures admitted to our hospital from January 2019 to December 2022 were enrolled in this study. After admission, all patients underwent surgical treatment, and a 3-month follow-up was conducted to record the occurrence of postoperative complications. According to the occurrence of postoperative complications, patients were divided into the complication group and the non-complication group. Relevant clinical data of patients such as gender, age, body mass index, the modified DORSSSP score and the NLR level were collected. Single factor and multivariate logistic regression were used to analyze the factors influencing the occurrence of postoperative complications in patients. The predictive value of the modified DORSSSP score combined with NLR level detection for postoperative complications in patients was evaluated using the subject performance characteristic (ROC) curve. 【Results】The postoperative complication rate of elderly patients with hip fracture was 31.88% (51/160). The results of univariate analysis showed that there were no statistical differences in gender, body mass index (BMI), fracture location, surgical method, ASA grade, comorbid hypertension, and operative time between the two groups (P>0.05). Age, proportion of comorbid diabetes mellitus, C-reactive protein (CRP) level, and white blood cell count (WBC) level were significantly higher in the complication group than in the non-complication group (P<0.05). The modified DORSSSP scores and NLR level of the patients in the complication group were significantly higher than those in the uncomplicated group (P<0.05). Multivariate logistic regression analysis showed that high modified DORSSSP score (OR=1.755), high NLR level (OR=2.147), advanced age (OR=2.658), and high CRP (OR=2.324) level were independent risk factors for the development of postoperative complications (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of the modified DORSSSP score, NLR level and the combined prediction of both DORSSSP score and NLR for postoperative complications in elderly hip fracture patients were 0.686, 0.714 and 0.898, respectively. 【Conclusion】The modified DORSSSP score and NLR level are risk factors for postoperative complications in elderly patients with hip fractures. The combination of both modified DORSSSP scoring and NLR level provides better predictive value for the evaluation of the occurrence of postoperative complications in patients. 2023 Vol. 40 (12): 1895-1898 [Abstract] ( 26 ) HTML (1 KB)  PDF (1257 KB)  ( 19 ) 1899 Efficacy of Traditional Chinese Medicine Fumigation in Treating Rheumatoid Arthritis and its Impact on Cytokines YAN Jialing DOI: 10.3969/j.issn.1671-7171.2023.12.022 【Objective】To investigate the effect of traditional Chinese medicine fumigation on alleviating joint symptoms of rheumatoid arthritis (RA) patients and its impact on cytokines.【Methods】A total of 114 RA patients were randomly divided into two groups. Patients in the control group received methotrexate tablet treatment, while patients in the observation group received additional traditional Chinese medicine fumigation therapy. The changes in joint symptoms, Disease Activity Score of 28 joints (DAS28), erythrocyte sedimentation rate (ESR), cyclic citrullinated peptide antibodies (CCP-AB), C-reactive protein (CRP), rheumatoid factor (RF), α1-acid glycoprotein (α1-AGP), interleukin-35 (IL-35), and interleukin-17(IL-17) levels before and after treatment in both groups were compared. 【Results】There were no significant differences in any of the indices between the two groups before treatment (P>0.05). After treatment, the scores of joint symptoms and DAS28 in both groups significantly decreased compared to before treatment (P<0.05). These scores in the observation group were lower than those in the control group (P<0.05). Post-treatment, IL-35 levels in both groups significantly increased (P<0.05), while level of IL-35 in the observation group was higher than that in the control group (P<0.05).CCP-AB, ESR, CRP, RF, α1-AGP, and IL-17 levels significantly decreased after treatment in both groups, and levels of ESR and CCP-AB were significantly lower in the observation group compared to the control group (P<0.05). 【Conclusion】TCM fumigation can reduce the expression of ESR, CRP, and RF in RA patients through improving symptoms such as joint pain, swelling, tenderness, and functional impairment. 2023 Vol. 40 (12): 1899-1901 [Abstract] ( 36 ) HTML (1 KB)  PDF (1219 KB)  ( 63 ) 1902 Study on the Influencing Factors of Thrombolytic Therapy Efficacy in Patients with Acute Cerebral Infarction GUO Jing,YANG Jinsuo,CHAI Lihong DOI: 10.3969/j.issn.1671-7171.2023.12.023 【Objective】To investigate the factors affecting the efficacy of thrombolytic therapy in patients with Acute Cerebral Infarction (ACI). 【Methods】A retrospective analysis was conducted on the clinical data of 120 patients with ACI who underwent thrombolytic therapy in our hospital. Based on the therapeutic effect of thrombolysis, patients were divided into a good prognosis group and a poor prognosis group. Differences in relevant data between the two groups were compared, and multivariate logistic regression analysis was used to analyze the independent risk factors affecting the thrombolytic effect in ACI patients. 【Results】Out of the 120 ACI patients treated with thrombolysis, 34 cases (28.33%) had poor prognosis and were categorized into the poor group; the remaining 86 cases (71.67%) had good prognosis and were categorized into the good group. There were no significant differences between the two groups in terms of Body Mass Index (BMI), time from onset to thrombolysis, time from onset to the first Transcranial Doppler (TCD) examination, blood lipid and coagulation index levels, gender, and comorbidities (P>0.05). The age and National Institutes of Health Stroke Scale (NIHSS) scores in the poor prognosis group were higher than those in the good prognosis group (P<0.05), while the Thrombolysis in Brain Ischemia (TIBI) grading and vascular recanalization rate in the poor prognosis group were lower than those in the good prognosis group(P<0.05). Multivariate logistic regression analysis showed that TIBI grading (OR=2.658), vascular recanalization rate (OR=6.532), and NIHSS score (OR=8.712) were independent risk factors affecting the efficacy of thrombolytic therapy in ACI patients (P<0.05). 【Conclusion】TIBI grading, vascular recanalization rate, and NIHSS score are risk factors for poor prognosis in patients with ACI undergoing thrombolytic therapy. 2023 Vol. 40 (12): 1902-1904 [Abstract] ( 31 ) HTML (1 KB)  PDF (1282 KB)  ( 35 ) 1905 Efficacy of Acupuncture Combined with Electrical Stimulation and Swallowing Training in the Treatment of Stroke Patients with Dysphagia LIU Ying,ZHU Jie DOI: 10.3969/j.issn.1671-7171.2023.12.024 【Objective】To investigate the efficacy of acupuncture combined with electrical stimulation and swallowing training in treating patients with stroke-related dysphagia. 【Methods】A total of 94 stroke patients with dysphagia were randomly divided into the observation group and the control group, each consisting of 47 patients. The control group received neural electrical stimulation and swallowing training intervention, while the observation group received acupuncture treatment in addition to the aforementioned therapies. Clinical efficacy was compared between the two groups. Swallowing function was assessed before and after the intervention using the Wada Water Swallowing Test and the Gugging Swallowing Function Assessment Scale (GUSS). The Swallowing Quality of Life questionnaire (SWAL-QOL), Pittsburgh Sleep Quality Index (PSQI), and Hamilton Depression Rating Scale (HAMD) were used to assess and compare the quality of life, sleep quality, and psychological status before and after the intervention in both groups. The incidence of complications was also compared. 【Results】The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). After the intervention, the proportion of Grade Ⅰ in the Wada Water Swallowing Test in the observation group was significantly higher than that of the control group (P<0.05), while Grades Ⅱ, Ⅲ, and Ⅳ in the observation group were significantly lower those in the control group (P<0.05). GUSS scores of both groups increased post-intervention, with the observation group scoring was higher than the control group (P<0.05). Post-intervention, SWAL-QOL scores improved (P<0.05), while PSQI and HAMD scores decreased in both groups (P<0.05), with the observation group showing better scores than the control group (P<0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05). 【Conclusion】Acupuncture combined with electrical stimulation and swallowing training effectively treats stroke-induced dysphagia through improving patients' swallowing function and quality of life while maintaining high safety. 2023 Vol. 40 (12): 1905-1908 [Abstract] ( 27 ) HTML (1 KB)  PDF (1243 KB)  ( 48 ) 1909 The Expression Level and Clinical Significance of FLT-1 and YKL-40 in Serum of Children with Respiratory Syncytial Virus Positive YE Wen-juan,WANG Yu DOI: 10.3969/j.issn.1671-7171.2023.12.025 【Objective】To investigate the expression level and clinical significance of human vascular endothelial growth factor receptor-1 (FLT-1) and human chitinase protein 40 (YKL-40) in the serum of children with respiratory syncytial virus (RSV) positive.【Methods】From March 2019 to April 2021, 82 children with RSV positive were treated in Baoji Hospital affiliated to Xi'an Medical College. All children were given recombinant human interferon α-2b For injection therapy, RSV positive children were divided into effective group and ineffective group according to the clinical efficacy. The general data of the two groups of children were collected, and the factors influencing the clinical efficacy of RSV positive children were analyzed by Logistic multivariate regression, and the predictive value of serum FLT-1 and YKL-40 levels on the clinical efficacy of RSV positive children was analyzed by using the subject working characteristic (ROC) curve.【Results】 Among 82 cases of RSV positive children in this study, 59 cases (71.95%) in the effective group and 23 cases (28.05%) in the ineffective group; The children in the effective group were older than those in the ineffective group, and the levels of FLT-1 and YKL-40 were lower than those in the ineffective group, the difference was statistically significant (P<0.05); Multivariate regression analysis showed that young children and high serum levels of FLT-1 and YKL-40 were risk factors for ineffective treatment in RSV positive children (P<0.05); The ROC curve analysis results showed that the area under the ROC curve (AUC) of serum FLT-1 and YKL-40 levels predicting the clinical efficacy of RSV positive children were 0.803(95%CI:0.710-0.895) and 0.778 (95%CI:0.669-0.888), respectively. 【Conclusion】The young RSV positive children with high serum FLT-1 and YKL-40 levels are more likely to have poor clinical efficacy, and both have certain predictive value for the clinical efficacy of RSV positive children. 2023 Vol. 40 (12): 1909-1911 [Abstract] ( 34 ) HTML (1 KB)  PDF (1365 KB)  ( 45 ) 1912 Observation of Myocardial Injury Markers and No Risk of Reflow in Patients with Acute ST Segment Elevation Myocardial Infarction with Different Electrocardiogram Manifestations MAO Cun DOI: 10.3969/j.issn.1671-7171.2023.12.026 【Objective】 To explore the correlation between electrocardiogram ischemic grading, myocardial injury markers, and no reflow in patients with acute ST segment elevation myocardial infarction. 【Methods】A retrospective analysis was conducted on the clinical data of 80 patients with acute ST segment elevation myocardial infarction admitted to our hospital from January 2019 to January 2022. According to the electrocardiogram ischemic grading, they were divided into grade Ⅱ ischemic group (n=32) and grade Ⅲ ischemic group (n=48). We compared the levels of two groups of myocardial injury biomarkers [high-sensitivity troponin (hs-cTnI), N-terminal B-type brain natriuretic peptide(NT-proBNP), and creatine kinase isoenzyme (CK-MB)], and used receiver operating characteristic (ROC) curves to analyze the value of myocardial injury biomarker indicators in predicting grade Ⅲ ischemia in acute ST segment elevation myocardial infarction. Logistic multiple factor stepwise regression was used to analyze the influencing factors of electrocardiogram ischemia grade Ⅲ in patients with acute ST segment elevation myocardial infarction. 【Results】The proportion of patients in the grade Ⅱ ischemic group without reflow was lower than that in the grade Ⅲ ischemic group, and the levels of hs-cTnI and NT-proBNP were lower than those in the grade Ⅲ ischemic group. The levels of CK-MB were higher than those in the grade Ⅲ ischemic group (P<0.05). ROC curve analysis showed that hs-cTnI, NT-proBNP, and CK-MB levels can all be used for predicting grade Ⅲ ischemia in acute ST segment elevation myocardial infarction, with areas under the curves of 0.861, 0.706, and 0.792 (P<0.05), respectively. Multivariate logistic regression analysis showed that no reflow, hs-cTnI ≥ 1.545 ng/mL, NT-proBNP ≥ 1075.005 ng/mL, and CK-MB<38.253 ng/mL were risk factors for ischemic grade Ⅲ on electrocardiogram in acute ST segment elevation myocardial infarction (P<0.05). 【Conclusion】There are differences in the levels of myocardial injury markers and reflow in patients with acute ST segment elevation myocardial infarction with different electrocardiographic ischemic grades, and myocardial injury markers and no reflow can be used to predict the ischemic grade of acute ST segment elevation myocardial infarction electrocardiograms. 2023 Vol. 40 (12): 1912-1915 [Abstract] ( 49 ) HTML (1 KB)  PDF (1265 KB)  ( 44 ) 1916 A Study on the Correlation between Psychological State and Dysbiosis of Gut Microbiota and Gastrointestinal Motility in Patients with Functional Dyspepsia YANG Ting,LIU Wenqing,LIU Jinzhi,et al DOI: 10.3969/j.issn.1671-7171.2023.12.027 【Objective】 To explore the correlation between the psychological state of patients with functional dyspepsia (FD) and the imbalance of gut microbiota and gastrointestinal motility. 【Methods】Eighty FD patients admitted to our hospital from May 2020 to April 2021 were selected as the study subjects. Depression levels, Lactobacillius, Enterococcus, and 6-hour postprandial gastric emptying rate were evaluated using the Self Rating Depression Scale (SDS), quantitative and qualitative detection of fresh fecal specimens, and small barium X-ray gastric emptying test, respectively. Pearson correlation analysis was used to examine the relationship between psychological status, gut microbiota imbalance, and gastrointestinal motility in FD patients. 【Results】The SDS score of FD patients was (59.41±4.85) points, the Lactobacillus count was (6.45±1.27) lgCFU/g, the Enterococcus count was (7.41±1.04) lgCFU/g, and the gastric emptying rate at 6 hours after meals was (88.36±6.74)%. Pearson correlation analysis showed that SDS score was positively correlated with Enterococcus count (r=0.594, P<0.05), negatively correlated with postprandial gastric emptying rate at 6 hours (r=-0.721, P<0.05), and negatively correlated with Lactobacillus count (r=-0.622, P<0.05); Lactobacillus count was positively correlated with postprandial gastric emptying rate at 6 hours (r=0.580, P<0.05), and negatively correlated with Enterococcus (r=-0.491, P<0.05). The count of Enterococcus was negatively correlated with the gastric emptying rate at 6 hours after meals (r=-0.784, P<0.05). 【Conclusion】 Patients with functional digestion have a negative psychological state of depression, and clinical physicians should develop positive and reasonable psychological treatment methods to correct the patient's negative psychology, which can help improve the patient's gastrointestinal function and promote early recovery. 2023 Vol. 40 (12): 1916-1918 [Abstract] ( 34 ) HTML (1 KB)  PDF (1218 KB)  ( 45 ) 1919 Analysis of Influencing Factors of Early Brain Injury in High-grade Aneurysmal Subarachnoid Hemorrhage YANG Lisha DOI: 10.3969/j.issn.1671-7171.2023.12.028 【Objective】To explore the influencing factors of early brain injury (EBI) in patients with high-grade aneurysmal subarachnoid hemorrhage (aSAH). 【 Methods 】 A retrospective analysis was conducted on the clinical data of 182 high-grade aSAH patients admitted to our hospital from March 2017 to March 2022. They were divided into EBI group (n=90) and non EBI group (n=92) based on the occurrence of EBI. We collected and compared baseline data from two groups of patients, and used multivariate logistic regression analysis to identify independent risk factors for EBI in high-grade aSAH patients.【Results】 The EBI group had a higher proportion of age, hyperglycemia, hypomagnesemia, hyponatremia, and Fisher's grade Ⅲ-Ⅳ than the non EBI group (P<0.05), and higher levels of serum periosteal protein, IL-6, and S100B protein than the non EBI group (P<0.05). Multivariate logistic regression analysis showed that age ≥ 60 years old, hyperglycemia, hypomagnesemia, hyponatremia, Fisher's grading (Ⅲ-Ⅳ), periosteal protein≥270.00 ng/mL, IL-6≥47.10 pg/mL, S100B protein ≥ 2.05 μg/L was an independent risk factor for EBI in high-grade aSAH patients (P<0.05).【Conclusion】 There are many risk factors for EBI in high-grade aSAH patients, which are not only related to age, hyperglycemia, hypomagnesemia, hyponatremia, and Fisher's grading, but also to serum periosteal protein, IL-6, and S100B protein levels. In clinical practice, these risk factors should be identified as early as possible and targeted preventive measures should be taken. 2023 Vol. 40 (12): 1919-1921 [Abstract] ( 30 ) HTML (1 KB)  PDF (1283 KB)  ( 110 ) 1922 Effect of Supervised Pelvic Floor Rehabilitation Training Combined with Neuromuscular Electrical Stimulation on Urinary Dynamics in Postpartum Stress Urinary Incontinence Patients ZHANG Renping,LI Xiaohong DOI: 10.3969/j.issn.1671-7171.2023.12.029 【Objective】To investigate the effect of supervised pelvic floor rehabilitation training combined with neuromuscular electrical stimulation on urinary dynamics in postpartum stress urinary incontinence (SUI) patients. 【Methods】A total of 260 postpartum SUI patients from two hospitals were randomly divided into two groups, with 130 patients in each group. The patients in the control group received supervised pelvic floor rehabilitation training, while patients in the observation group received supervised pelvic floor rehabilitation training combined with neuromuscular electrical stimulation. The treatment outcomes, incidence of complications, changes in functional urethral length (LES), maximum urethral closure pressure (PMUC), maximum urethral measurement pressure (PMU), progesterone (P), luteinizing hormone (LH), estradiol (E2), as well as the scores of the Incontinence Quality of Life Questionnaire (I-QOL) and Female Sexual Function Index (FSFI) were compared between the two groups. 【Results】The total effective rate in the observation group was 90.77%(118/130), which was significantly higher than 78.46%(102/130) in the control group. After treatment, the levels of LES, PMUC, PMU, P, LH, E2, I-QOL scores, and FSFI scores in both groups were significantly higher than those before treatment(P<0.05). Furthermore, the observation group after treatment showed higher levels of the above parameters than those in the control group after treatment (P<0.05). The incidence of complications in the observation group was 10.77%(14/130), which was significantly lower than the 20.00%(26/130) in the control group (P<0.05). 【Conclusion】Supervised pelvic floor rehabilitation training combined with neuromuscular electrical stimulation can more effectively improve urinary dynamic indicators in postpartum SUI patients to result in better treatment outcomes. 2023 Vol. 40 (12): 1922-1925 [Abstract] ( 37 ) HTML (1 KB)  PDF (1242 KB)  ( 187 ) 1926 Observation of Myocardial Injury Markers and T Lymphocyte Subsets in Children with Rotavirus Enteritis ZHANG Xiaomei,ZHAO Yunai DOI: 10.3969/j.issn.1671-7171.2023.12.030 【Objective】To explore the myocardial injury and changes in T lymphocytes in children with rotavirus enteritis and their correlation. 【Methods】 A retrospective analysis was conducted on 80 children with rotavirus enteritis admitted to our hospital from January 2019 to January 2022 (observation group). According to the severity of dehydration, the observation group was divided into non dehydration group (n=26), mild dehydration group (n=32), and moderate dehydration group (n=22). Another 80 children with enteritis who tested negative for rotavirus and were admitted to our hospital during the same period were selected as the control group. Myocardial injury biomarkers between two groups and cases with different degrees of dehydration [Creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH)] levels and T lymphocyte subpopulations (CD3+, CD4+, CD8+, and calculate the CD4+/CD8+ ratio) were compared.【Results】The levels of CK, CK-MB, LDH, and α-HBDH in the observation group were significantly higher than those in the control group, with statistical significance (P<0.05). The levels of CK, CK-MB, LDH, and α-HBDH in the mild and moderate groups of children were higher than those in the non dehydration group, while those in the moderate group were higher than those in the mild group, with statistical significance (P<0.05). The CD8+ in the observation group was higher than that in the control group, and the CD3+, CD4+, and CD4+/CD8+ values were lower than those in the control group, with statistical significance (P<0.05). The CD8+ levels in the mild and moderate groups were higher than those in the non dehydrated group, and the levels of CD3+, CD4+, and CD4+/CD8+ were lower than those in the non dehydrated group. Moreover, the above indicators in the mild group were significantly different from those in the moderate group (P<0.05). 【Conclusion】Myocardial injury markers and T lymphocyte subsets can accurately evaluate the dehydration status of children with early-stage viral enteritis, which is of great significance for guiding clinical treatment in the later stage. 2023 Vol. 40 (12): 1926-1928 [Abstract] ( 31 ) HTML (1 KB)  PDF (1277 KB)  ( 64 ) 1929 The Effect of Ultrasound-guided RFA and Open Surgery on Thyroid Function in Patients with Thyroid Micropapillary Carcinoma CHEN Shanshan,CAI Yongsheng,HE Ning DOI: 10.3969/j.issn.1671-7171.2023.12.031 【Objective】To investigate the impact of ultrasound-guided radiofrequency ablation (RFA) and open surgery on thyroid function in patients with thyroid micropapillary carcinoma. 【Methods】A total of 90 patients with thyroid micropapillary carcinoma admitted to our hospital from March 2020 to February 2022 were selected and divided into an observation group and a control group according to different surgical procedures, with 45 cases in each group.The control group underwent open surgery, while the observation group underwent ultrasound-guided RFA treatment.Perioperative indicators were compared between the two groups, as well as thyroid function before and after surgery [thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4)].The levels of serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP)] were compared before and after surgery, as well as the incidence of complications. 【Results】The operation time, intraoperative blood loss, hospitalization time, and hospitalization costs in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The postoperative TSH level in the control group was significantly higher than that in the same group before surgery, while the FT3 and FT4 levels were lower than those in the same group before surgery, and the difference was statistically significant (P<0.05). The postoperative TSH level in the observation group was significantly lower than that in the same group before surgery, and the difference was statistically significant (P<0.05). The postoperative TSH level in the observation group was significantly lower than that in the control group, while the FT3 and FT4 levels were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). The levels of serum IL-6, TNF-α, and CRP in both groups were higher than those before surgery, and the difference was statistically significant (P<0.05). The postoperative serum IL-6, TNF-α, and CRP levels in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】Ultrasound-guided RFA treatment for thyroid micropapillary carcinoma has less impact on thyroid function, with fewer postoperative complications and high safety. 2023 Vol. 40 (12): 1929-1932 [Abstract] ( 37 ) HTML (1 KB)  PDF (1239 KB)  ( 35 ) 1933 Risk Factors of Postoperative Incision Infection after Laparoscopic Cholecystectomy QI Meng,SUN Yalan,JIA Wencheng,et al DOI: 10.3969/j.issn.1671-7171.2023.12.032 【Objective】To explore the related influencing factors of postoperative incisional infection after laparoscopic cholecystectomy (LC).【Methods】A retrospective analysis of 80 patients treated with LC in our hospital from April 2020 to April 2022. Patients were divided into the incision infection group (n=20) and the incision non-infection group (n=60) based on whether postoperative incision infection occurred. General data of patients in the incision infection group were compared to those in the incision non-infection group. Logistic multiple regression analysis was then performed on single factors with statistical significance, and the receiver operating characteristic (ROC) curve was used to analyze the clinical value of relevant influencing factors in predicting postoperative incisional infection after LC.【Results】The proportion of patients with incision infection in terms of age >55 years old, surgery time>60 minutes, emergency surgery, and gallbladder rupture in the incision infection group was significantly higher than that in the incision non-infection group; and the difference was statistically significant (P<0.05). The results of logistic multiple regression analysis showed that surgical time, emergency surgery, and gallbladder rupture were the influencing factors of incision infection after LC surgery (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of surgical time, emergency surgery, and gallbladder rupture for predicting incision infection after LC surgery were 0.758, 0.733, and 0.808, respectively. While their Youden Index was 0.467, 0.441, and 0.617, respectively. 【Conclusion】The risk factors for incision infection during laparoscopic cholecystectomy are the operation time,emergency surgery and gallbladder rupture. Clinically, targeted treatment plans need to be formulated for such patients. 2023 Vol. 40 (12): 1933-1935 [Abstract] ( 34 ) HTML (1 KB)  PDF (1291 KB)  ( 91 ) 1936 The Effect of Levosimendan Combined with Tofacilitaxel in the Treatment of Acute Decompensated HFpEF MA Rui,LEI Xueting DOI: 10.3969/j.issn.1671-7171.2023.12.033 【Objective】To explore the clinical efficacy of levosimendan combined with tofacilitan in patients with acute decompensated ejection fraction preserved heart failure (HFpEF). 【Methods】A total of 78 patients with acute decompensated HFpEF admitted to Shaanxi Aerospace Hospital from March 2020 to November 2021 were selected and randomly divided into an observation group and a control group using a random number table method, with 39 cases in each group. The control group was treated with Tovastatin tablets, while the observation group was treated with a combination of levosimendan on the basis of the control group. Both groups of patients were evaluated for cardiac function indicators [left ventricular end diastolic/systolic diameter (LVEDD/LVESD) and left ventricular ejection fraction (LVEF)], myocardial injury related indicators [heart type fatty acid binding protein (hFABP) and N-terminal B-type brain natriuretic peptide(NT-proBNP)], and cardiac function related inflammatory factor indicators [high-sensitivity C-reactive protein (hs-CRP) and hypoxia inducible factor 1α (HIF-1α)] before and 1 week after treatment Hemodynamic indicators [heart rate (HR), stroke output (SV)] and 24-hour urine output levels, and adverse drug reactions were recorded.【Results】After treatment, LVEDD and LVESD in both groups were lower than before treatment, and LVEF was higher than before treatment. LVEDD and LVESD in the observation group were lower than those in the control group, and LVEF was higher than those in the control group, with statistical significance (P<0.05); The serum levels of hFABP, NT-proBNP, hs-CRP, and HIF-1α in two groups of patients were lower than before treatment, and the observation group was lower than the control group (P<0.05); The SV and 24-hour urine output of the two groups of patients were higher than before treatment, while the HR was lower than before treatment. The observation group had higher SV and 24-hour urine output than the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). 【Conclusion】The combined use of levosimendan and tofapetam in the treatment of acute decompensated HFpEF patients is beneficial for the recovery of cardiac function, stable hemodynamics, and good safety. 2023 Vol. 40 (12): 1936-1939 [Abstract] ( 29 ) HTML (1 KB)  PDF (1241 KB)  ( 32 ) 1940 Prognostic Value of Serum NF-κB and Nrf2 Levels in Type 2 Diabetes Nephropathy ZHANG Yong,WANG Xinlei DOI: 10.3969/j.issn.1671-7171.2023.12.034 【Objective】To explore the prognostic value of serum levels of nuclear factor-κB (NF-κB) and nuclear factor E2 related factor (Nrf2) in patients with type 2 diabetes nephropathy.【Methods】The clinical data of 118 patients with type 2 diabetes nephropathy admitted to the NO.215 Hospital of Shaanxi Nuclear Industry from April 2020 to April 2022 were retrospectively analyzed. According to the prognosis of patients, they were divided into poor prognosis group (renal failure, uremia or death, n=48) and good prognosis group (n=70). The prognostic factors of type 2 diabetes nephropathy patients and the predictive value of NF-κB and Nrf2 on the prognosis of type 2 diabetes nephropathy patients were analyzed.【Results】The levels of NF-κB, serum creatinine (Scr), and urinary protein excretion rate (UAER) in the poor prognosis group were higher than those in the good prognosis group, while Nrf2 and glomerular filtration rate (eGFR) were lower than those in the good prognosis group (P<0.05). Logistic analysis showed that the increase of NF-κB, Scr, UAER, Nrf2 and eGFR were all risk factors for poor prognosis of type 2 diabetes nephropathy patients (P<0.05). The analysis of ROC curve of subjects showed that the area under the curve (AUC) of serum NF-κB, Nrf2 and their combination to predict the prognosis of type 2 diabetes nephropathy patients were 0.713, 0.706 and 0.801, respectively. 【Conclusion】The combination of serum NF-κB and Nrf2 is effective in predicting the prognosis of patients with type 2 diabetes nephropathy. 2023 Vol. 40 (12): 1940-1942 [Abstract] ( 32 ) HTML (1 KB)  PDF (1303 KB)  ( 57 ) 1943 The Effects of Carvedilol on Oxidative Stress Response and Endothelial Function in Elderly Hypertensive Patients with Coronary Heart Disease WANG Yuan,ZHAO Lidan DOI: 10.3969/j.issn.1671-7171.2023.12.035 【Objective】 To explore the effects of carvedilol on oxidative stress response and endothelial function in elderly hypertensive patients with coronary heart disease. 【Methods】A total of 84 elderly patients with hypertension and coronary heart disease admitted to our hospital from March 2019 to March 2022 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 42 cases in each group. The control group was given metoprolol, while the observation group was given carvedilol on the basis of the control group. Compare two sets of cardiac function indicators[Heart rate (HR), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDD), cardiac output (CO)].Two sets of oxidative stress indicators, levels of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-P) were detected and compared. We compared the levels of two groups of vascular endothelial function indicators [adrenal medulla (AM), endothelin-1 (ET-1), and nitric oxide (NO)], and observed the occurrence of adverse reactions between the two groups.【Results】After treatment, the average levels of HR and LVDD in the two groups were lower than before treatment, while LVEF and CO were higher than before treatment. In addition, the HR and LVDD in the observation group were lower than those in the control group, while LVEF and CO were higher than those in the control group, with statistical significance (P<0.05); The levels of SOD and GSH-P in the two groups were higher than before treatment, while the levels of MDA were lower than before treatment. In addition, the levels of SOD and GSH-P in the observation group were higher than those in the control group, and the levels of MDA were lower than those in the control group, with statistical significance (P<0.05); The levels of AM and ET-1 in the two groups were lower than before treatment, and the levels of NO were higher than before treatment. In addition, the levels of AM and ET-1 in the observation group were lower than those in the control group, and the levels of NO were higher than those in the control group, with statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 16.67% (7/42), while in the control group it was 23.81% (10/42), with no statistically significant difference(χ2=0.664, P>0.05). 【Conclusion】 Carvedilol can effectively improve patient cardiac and endothelial function, alleviate oxidative stress response, and has safety and clinical application value. 2023 Vol. 40 (12): 1943-1946 [Abstract] ( 32 ) HTML (1 KB)  PDF (1243 KB)  ( 52 )

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