Abstract 【Objective】To compare the efficacy and impact on pregnancy outcome of combination chemotherapy (BEP) with bleomycin (BLM), etoposide (VP-16), and cisplatin (DDP) with sequential chemotherapy (ACM) with actinomycin D (Act-D), cyclophosphamide (CTX), and methotrexate (MTX) in the treatment of patients with gestational trophoblastic neoplasia (GTN). 【Methods】A total of 102 patients with GTN admitted to our hospital from February 2020 to May 2021 were randomly divided into a BEP group (treated with BEP) and an ACM group (treated with ACM) according to a random number table method, with 51 patients in each group.The clinical efficacy, recovery time of sexual life, sexual function score, incidence of adverse reactions, pregnancy outcome, and ovarian function indicators [estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH)] before and after treatment were compared between the two groups. 【Results】After treatment, there was no significant difference in the total effective rate between the two groups (χ2=1.041,P=0.308). After treatment, the levels of E2, LH, and FSH in both groups decreased (P<0.05), but the levels of E2, LH, and FSH in the ACM group were higher than those in the BEP group (P<0.05). There was no significant difference in the recovery time of sexual life and sexual function score between the two groups after chemotherapy (t=0.293, 1.814, P=0.770, 0.073). The total incidence of adverse reactions in the two groups was similar (χ2=1.055, P=0.316). The pregnancy success rate in the ACM group was higher than that in the BEP group (χ2=4.767, P<0.05).【Conclusion】 The efficacy of combination chemotherapy (BEP) and sequential chemotherapy (ACM) for the treatment of gestational trophoblastic neoplasia (GTN) is comparable, and the incidence of adverse reactions is similar, but sequential chemotherapy (ACM) has less impact on the ovarian function of patients with GTN, which is beneficial to improving the pregnancy success rate after treatment.
LIU Liying,ZHAI Yao,ZHANG Hengyu. Comparison of the Efficacy of BEP and ACM Chemotherapy Regimens in the Treatment of Patients with Trophoblastic Tumors[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1885-1888.
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2023, Vol. 40 
