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| The Effects of Carvedilol on Oxidative Stress Response and Endothelial Function in Elderly Hypertensive Patients with Coronary Heart Disease |
| WANG Yuan, ZHAO Lidan |
| Xi'an Ninth Hospital, Xi'an Shaanxi 710000 |
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Abstract 【Objective】 To explore the effects of carvedilol on oxidative stress response and endothelial function in elderly hypertensive patients with coronary heart disease. 【Methods】A total of 84 elderly patients with hypertension and coronary heart disease admitted to our hospital from March 2019 to March 2022 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 42 cases in each group. The control group was given metoprolol, while the observation group was given carvedilol on the basis of the control group. Compare two sets of cardiac function indicators[Heart rate (HR), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDD), cardiac output (CO)].Two sets of oxidative stress indicators, levels of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-P) were detected and compared. We compared the levels of two groups of vascular endothelial function indicators [adrenal medulla (AM), endothelin-1 (ET-1), and nitric oxide (NO)], and observed the occurrence of adverse reactions between the two groups.【Results】After treatment, the average levels of HR and LVDD in the two groups were lower than before treatment, while LVEF and CO were higher than before treatment. In addition, the HR and LVDD in the observation group were lower than those in the control group, while LVEF and CO were higher than those in the control group, with statistical significance (P<0.05); The levels of SOD and GSH-P in the two groups were higher than before treatment, while the levels of MDA were lower than before treatment. In addition, the levels of SOD and GSH-P in the observation group were higher than those in the control group, and the levels of MDA were lower than those in the control group, with statistical significance (P<0.05); The levels of AM and ET-1 in the two groups were lower than before treatment, and the levels of NO were higher than before treatment. In addition, the levels of AM and ET-1 in the observation group were lower than those in the control group, and the levels of NO were higher than those in the control group, with statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 16.67% (7/42), while in the control group it was 23.81% (10/42), with no statistically significant difference(χ2=0.664, P>0.05). 【Conclusion】 Carvedilol can effectively improve patient cardiac and endothelial function, alleviate oxidative stress response, and has safety and clinical application value.
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Received: 13 July 2022
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[1] KAMAL A. Determinants of Blood Pressure Variability in Individuals with Essential Hypertension: A Survey-Based Study[J].World J Cardiovascular Dis,2022, 12(5):259-276.
[2] PARK S, HAN K, LEE S, et al. Cardiovascular or mortality risk of controlled hypertension and importance of physical activity[J].Heart,2021,107(18):1472-1479.
[3] ALLO M, BOQUETE C, MORETTON M, et al.Development of subcutaneous implants of controlled release formulations of carvedilol for sustained blood pressure reduction in experimental models of hypertension[J].Revista Argentina de Cardiol,2020,88(2):125-129.
[4] 刘安邦,姜成,尹晗,等.游离三碘甲状腺原氨酸与冠心病患者合并抑郁状态的相关性研究[J].中国全科医学,2022,25(14):1707-1712.
[5] 曲歌乐,张仲迎,曹若瑾.血脂相关指标对血压达标中老年高血压患者动脉僵硬度的影响[J].山东医药,2021,61(11):32-36.
[6] 刘同波,李瑶,姚思宇,等.个体化降压干预异常血压昼夜节律对高血压合并冠心病患者血压及左室肥厚的影响[J].中华医学杂志,2019,99(13):977-982.
[7] 徐宝华,李楠,朱家庭.冠状动脉粥样硬化性心脏病慢性心力衰竭患者血清microRNA-499水平及与心功能和心肌重构的相关性[J].中国现代医学杂志,2020,30(2):104-108.
[8] WANG K L, FANG C Y, LAI W T, et al. Extended-Release Carvedilol in the Treatment of Hypertension: A Double-Blind, Randomized, Placebo-Controlled Trial[J].Acta Cardiologica Sinica,2021, 37(2):186-194.
[9] SILVA J, ALVES J, SILVA-NETO J, et al. Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation-implications in atherosclerosis[J].Clin Sci,2021, 135(15):1845-1858.
[10] 刘岩,安硕,王晓霞,等.卡维地洛分别联合降压药对难治性高血压患者血压控制及内皮功能、炎症因子水平的影响[J].中国老年学杂志,2019,39(16):3863-3866.
[11] 肖景华,李亚妮.叶酸、维生素D辅助治疗对妊娠期高血压患者血管内皮功能及Th1/Th2细胞因子表达的影响[J].现代免疫学,2021,41(2):129-133.
[12] 孙瑜,李慧,赵智儒.盐酸伊伐布雷定联合卡维地洛治疗心绞痛的疗效及心功能的影响[J].中华保健医学杂志,2022,24(1):11-14.
[13] 刘旭光,陈晨,谭安安,等.卡维地洛联合托拉塞米对慢性充血性心力衰竭病人CX3CR1、miR-423-5p表达的影响[J].中西医结合心脑血管病杂志,2022,20(10):1857-1860. |
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2023, Vol. 40 
