急性缺血性脑卒中患者PLR、NLR与认知功能的关系

doi:10.3969/j.issn.1671-7171.2023.12.009

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Abstract 【Objective】To investigate the relationship of cognitive function with levels of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR)in patients with acute ischemic stroke (AIS). 【Methods】Among 80 AIS patients, 54 with cognitive impairment were classified as group A, and 26 with normal cognitive function were classified as group B. The general data, as well as the levels of PLR, NLR, interleukin-1β (IL-1β), and interleukin-18(IL-18) in both groups were compared. The value of these indicators in predicting cognitive impairment in AIS patients was analyzed using the receiver operating characteristic (ROC) curve analysis. Multifactorial Logistic regression analysis was used to clarify the risk factors for cognitive dysfunction. 【Results】There were no statistically significant differences between the two groups in terms of gender, age, comorbidity with hypertension, diabetes, hyperlipidemia and coronary heart disease, history of alcohol consumption, and severity of stroke (P>0.05). The levels of PLR, NLR, IL-1β, and IL-18 in the group A were significantly higher than those in the group B (P<0.05). ROC analysis confirmed that the serum levels of PLR, NLR, IL-1β, and IL-18 could be used to predict cognitive impairment in AIS patients, with areas under the curve of 0.707, 0.769, 0.827, and 0.929 respectively (all P<0.05). Multifactorial Logistic regression analysis confirmed that PLR>3.355, NLR>6.598, IL-1β>28.565 pg/mL, and IL-18>22.554 pg/mL are risk factors for cognitive impairment in AIS patients. 【Conclusion】Changes in the levels of PLR, NLR, IL-1β, and IL-18 are closely related to the occurrence and development of cognitive dysfunction after AIS and they are risk factors for cognitive impairment in patients.

Key words： Brain Ischemia Stroke Acute Disease Odds Ratio Lymphocytes Neutrophils

Received: 06 October 2022

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R743

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	NING Wenjun
	HU Weibing

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NING Wenjun,HU Weibing. Study on the Relationship of Cognitive Function with PLR and NLR in Patients with Acute Ischemic Stroke[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1854-1856.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.12.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I12/1854

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