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Quick Search     Adv Search 2023 Vol. 40, No. 8 Published: 2023-08-26 Review and lecture Original Articles          Original Articles 1124 Observation of Brain Visual Function Training and Occlusion Therapy in Clinical Treatment of Children Refractive Amblyopia SANG Ke-xin, ZHI Ying, DU Rui, et al DOI: 10.3969/j.issn.1671-7171.2023.08.002 【Objective】To observe the application effect of brain visual function training and occlusion therapy in the clinical treatment of children refractive amblyopia.【Methods】A total of 96 cases of children with refractive amblyopia admitted to our hospital were divided into two groups according to the random envelope method. In the control group,47 patients were treated with occlusion therapy combined with refine training,while 49 patients in the observation group were treated with occlusion therapy combined with brain visual function training. The total treatment effective rate,stereoscopic visual acuity (SA≤60"),corrected visual acuity,refraction,diopter,adjustment amplitude,adjustment flexibility,adjustment lag and the occurrence of adverse reactions were compared between the two groups. 【Results】The total effective rate in the observation group was 90.74% (49/54),which was higher than that in the control group (69.64%,39/56) (P<0.05). Comparison of the incidence of SA≤60" in the two groups before treatment,the difference was not statistically significant (P>0.05). The incidence of stereoacuity SA≤60" in the posttreatment observation group 75.51% (37/49)was higher than that in the control group 38.30% (18/49) (P<0.05). The comparison of corrected visual acuity and refraction diopter in the two groups before treatment did not show statistical difference (P>0.05); However,the corrected visual acuities in two groups were higher after 6 months and 12 months treatment; And it was even higher in the observation group than in the control group (P<0.05). After 6 months and 12 months treatment,the refraction diopters in both groups decreased,and the reduction in the observation group was greater than that in the control group (P<0.05). In terms of the adjustment amplitude,adjustment flexibility and adjustment lag,there were no statistically significant differences between two groups before treatment (P>0.05).The amplitude and flexibility of children in the two groups increased after treatment. And children in the observation group showed better results compared to the control group (P<0.05). Meanwhile,the adjustment lag of the two groups decreased compared to before treatment; And the adjustment lag of the observation group was even lower than that of the control group (P<0.05). The overall incidence of adverse reactions in two group was no difference (P>0.05). 【Conclusion】The occlusion therapy combined with brain visual function training refractive amblyopia treatment can significantly improve the vision of children,effectively improve the regulation function of the affected eye. It is very safe and is worth popularizing in clinical use. 2023 Vol. 40 (8): 1124-1127 [Abstract] ( 56 ) HTML (1 KB)  PDF (1189 KB)  ( 68 ) 1128 The Predictive Value of Serum T Lymphocyte Subsets,PLR,MLR and NLR for Peritoneal Dialysis Peritonitis LI Yi-su, HE Xue, XU Yong, et al DOI: 10.3969/j.issn.1671-7171.2023.08.003 【Objective】To investigate the predictive value of serum T lymphocyte subsets,neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR) and platelet-to-lymphocyte ratio(PLR) ratio for peritoneal dialysis-associated peritonitis (PDAP)diagnosis. 【Methods】A total of 119 peritoneal dialysis-associated patients who were hospitalized in our hospital from March 2018 to March 2022 were enrolled and divided into the peritonitis group and non-peritonitis group. The differences and correlations of T lymphocyte subsets (CD4+,CD8+,CD4+/CD8+) and various inflammatory indicators in each group were compared,and their predictive value for peritoneal dialysis peritonitis was analyzed. 【Results】The CD4+ and CD4+/CD8+ in the peritonitis group were higher than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). CD8+ and T lymphocyte counts in the peritonitis group were lower than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). There was no significant difference in the percentage of T lymphocytes between the two groups (P>0.05).However,NLR,MLR,PLR,hs-CRP,erythrocyte sedimentation rate(ESR) and procalcitonin(PCT) in the peritonitis group were higher than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). The CD4+/CD8+ was negatively correlated with NLR (r=-0.327,P<0.05),positively correlated with MLR (r=0.875,P<0.05),and positively correlated with hs-CRP (r=0.306,P<0.05). The AUC of serum CD4+,CD8+,CD4+/CD8+,PLR,NLR,MLR,hs-CRP,ESR,and PCT in predicting peritoneal dialysis-related peritonitis were 0.711,0.365,0.700,0.720,0.886,0.931,0.883,0.802,and 0.737,respectively. 【Conclusion】Serum T lymphocyte subsets,PLR,MLR,NLR,hs-CRP,ESR and PCT have good predictive value for peritoneal dialysis-associated peritonitis. Of which,NLR and MLR have the strongest specificity and higher clinical reference value. 2023 Vol. 40 (8): 1128-1131 [Abstract] ( 40 ) HTML (1 KB)  PDF (1289 KB)  ( 113 ) 1132 Efficacy of Bevacizumab Combined with Paclitaxel and its Effect on Patients&apos; Immune Function in the Treatment of Advanced Breast Cancer TAN Yue, LI Gang, LI Xue-lian, et al DOI: 10.3969/j.issn.1671-7171.2023.08.004 【Objective】To investigate the efficacy of bevacizumab combined with paclitaxel in the treatment of advanced breast cancer and its effect on patients&apos; immune function. 【Methods】Eighty patients with advanced breast cancer admitted to our hospital were randomly divided into two groups,with 40 patients in each group. The observation group was treated with paclitaxel + bevacizumab,while the control group was treated with paclitaxel alone. The clinical efficacy,serum-related markers [Vascular Endothelial Growth Factor (VEGF),Basic Fibroblast Growth Factor (bF-GF)],tumor markers [Serum Carcinoembryonic Antigen (CEA),Carbohydrate Antigen 125 (CA125)],and immune function indicators (CD3+,CD4+,CD4+/CD8+) level changes and the incidence of adverse reactions in both groups were compared. 【Results】The total remission rate of the observation group was 75.00% (30/40),which was significantly higher than 50.00% (20/40) of the control group. And the difference was statistically significant (P<0.05). After treatment,the levels of VEGF,bF-GF,CEA,and CA125 in both groups decreased compared to before treatment (P<0.05),and the aforementioned indicators in the observation group were lower than those in the control group (P<0.05). After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in both groups increased compared to before treatment (P<0.05),and the levels of CD3+,CD4+,and CD4+/CD8+ in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions in both groups showed no statistical difference (P>0.05). 【Conclusion】The use of bevacizumab combined with paclitaxel chemotherapy in advanced breast cancer can improve the immune function of patients,effectively reduce tumor markers and serum-related factors,and demonstrate good clinical efficacy. The combination treatment does not increase adverse reactions,which is worthy of clinical promotion and application. 2023 Vol. 40 (8): 1132-1135 [Abstract] ( 45 ) HTML (1 KB)  PDF (1190 KB)  ( 39 ) 1136 Correlation between Weight Change and Delayed Lactation in Pregnant Women with Diabetes GAO Dong-mei, WANG Fei-peng, HUI Jing DOI: 10.3969/j.issn.1671-7171.2023.08.005 【Objective】To explore the correlation between the weight change of pregnant women with diabetes and the delayed start of lactation.【Methods】The clinical data of 90 pregnant women with diabetes who were admitted to the Department of Obstetrics and Gynecology of the Xianyang Central Hospital in Shaanxi Province from January 2019 to January 2022 were retrospectively analyzed. According to whether there was a delay in the initiation of lactation,they were divided into delayed group (n=21) and non delayed group (n=69). We collected clinical data on the age of all pregnant women,whether insulin therapy was used,whether they had first delivery,pre pregnancy body mass index (BMI),weight gain during pregnancy,whether they had a cesarean section,whether they were premature,whether they were anxious or depressed,and the time of milk collection; Multiple logistic regression analysis was used to identify the risk factors for delayed lactation initiation in patients; Spearman rank correlation analysis was used to investigate the correlation between age,first birth,pre pregnancy BMI,depression score,anxiety score,and delayed lactation initiation.【Results】There was no statistically significant difference (P>0.05) between the two groups in terms of whether insulin therapy was used,whether cesarean section was performed,preterm delivery,and milk collection time; The delayed group had significantly higher rates of age ≥ 35 years old,initial delivery,pre pregnancy BMI ≥ 30.0 kg/m2,excessive weight gain during pregnancy,and anxiety or depression compared to the non delayed group (P<0.05); Multivariate logistic regression analysis showed that age ≥ 35 years old,first birth,pre pregnancy BMI ≥30.0 kg/m2,excessive weight gain during pregnancy,depression or anxiety were the risk factors for delayed lactation in pregnant women with diabetes; Age,first birth,BMI before pregnancy,weight gain during pregnancy,depression or anxiety of pregnant women with diabetes were positively correlated with delayed lactation (P<0.05).【Conclusion】The risk factors of delayed lactation initiation in pregnant women with diabetes are elderly parturient,primipara,obesity,excessive weight gain during pregnancy,depression or anxiety. 2023 Vol. 40 (8): 1136-1138 [Abstract] ( 49 ) HTML (1 KB)  PDF (1166 KB)  ( 34 ) 1139 Effect of Remimazolam on Hemodynamics during General Anesthesia Induction in Elderly Hypertensive Patients WU Li-hui, LIU Song-hua DOI: 10.3969/j.issn.1671-7171.2023.08.006 【Objective】To explore the sedative effect and hemodynamic impact of remimazolam toluenesulfonate on anesthesia induction in elderly hypertensive patients.【Methods】A total of 100 elderly hypertensive patients who underwent elective general anesthesia and required tracheal intubation at the Changsha Central Hospital from October 2021 to October 2022 were randomly divided into an observation group (using remimazolam anesthesia) and a control group (using etomidate anesthesia) using a random number table method,with 50 patients in each group. The time from the onset of wakefulness to BIS values less than 60 was recorded,and the changes in mean arterial pressure (MAP),heart rate (HR),and BIS values were recorded at four time points: before induction (T0),after induction to BIS<60 (T1),1 minute after intubation (T2),and 5 minutes after intubation (T3). Blood samples were collected at these four time points to compare the serum levels of norepinephrine (NE) between the two groups of patients. The incidence of adverse events such as muscle spasms,tachycardia,bradycardia,hypertension,and hypotension during anesthesia induction was compared between two groups.【Results】The HR at T1 and T2 in the observation group was higher than that at T0,and the MAP at T0 and T2 was higher than that at T1,with a statistically significant difference (P<0.05); The MAP and HR of the control group at T0 and T2 were higher than those of T1,with statistically significant differences (P<0.05); The MAP and HR of the observation group at T1 were higher than those of the control group,and the difference was statistically significant (P<0.05). The serum NE levels at T0 and T2 in the observation group and the control group were higher than those at T1,and the difference was statistically significant (P<0.05); The serum NE levels in the observation group at T2 and T3 were lower than those in the control group,with a statistically significant difference (P<0.05). The onset time of anesthesia induction in the observation group was longer than that in the ET group,and the incidence of muscle fibrillation,hypotension,and bradycardia was lower than that in the control group,with a statistically significant difference (P<0.05).【Conclusion】The use of remimazolam during the induction period of general anesthesia in elderly hypertensive patients can stabilize hemodynamic indicators,and the incidence of adverse reactions such as muscle spasms,hypotension,and bradycardia during the induction period is relatively low. 2023 Vol. 40 (8): 1139-1142 [Abstract] ( 50 ) HTML (1 KB)  PDF (1193 KB)  ( 29 ) 1143 Expression and Significance of miR-21,SP-A and SP-D in Serum and MRC-5 Cells of Patients with Pulmonary Fibrosis LI Zhi, CHEN Jun-yi DOI: 10.3969/j.issn.1671-7171.2023.08.007 【Objective】To explore the significance and relationship of pulmonary fibrosis with miR-21 and SP-A,SP-D in serum and MRC-5 cells of pulmonary fibrosis patients.【Methods】From October 2020 to June 2021,30 patients with Pulmonary fibrosis (the pulmonary fibrosis group) and 30 healthy volunteers (the healthy group) were recruited in our hospital for the study. The expression levels of miR-21,SP-A,and SP-D in serum of the two groups were detected and compared. Meanwhile,MRC-5 cells were divided into an empty virus control group (transfected with meaningless miRNA lentivirus),a miR-21 overexpression group (transfected with miR-21 mimetic vector),and a miR-21 silencing group (transfected with inhibitor lentivirus vector). The expression levels of miR-21,SP-A,and SP-D mRNA in MRC-5 cells in each group were measured and compared. 【Results】 Serum levels of miR-21,SP-A and SP-D in the pulmonary fibrosis group were higher than those in the healthy group (P<0.05). In the cell experiment,levels of SP-A and SP-D in the miR-21 overexpression group were significantly higher than those in the empty virus control group (P<0.05). After silencing miR-21,the levels of SP-A and SP-D were significantly lower than those of the empty virus group (P<0.05). 【Conclusion】miR-21,SP-A and SP-D can be used as biomarkers of pulmonary fibrosis. And the expression of SP-A and SP-D decreases by inhibiting miR-21,which can inhibit the occurrence and development of pulmonary fibrosis. 2023 Vol. 40 (8): 1143-1145 [Abstract] ( 38 ) HTML (1 KB)  PDF (1167 KB)  ( 29 ) 1146 Study on the Correlation between Back Strength and Nutritional Status in Maintenance Hemodialysis Patients ZHANG Xiao-yuan, SUN Pei, LI Yue DOI: 10.3969/j.issn.1671-7171.2023.08.008 【Objective】To explore the correlation between maintenance hemodialysis (MHD) patients' back strength and nutritional status. 【Methods】A total of 105 MHD patients admitted to two hospitals were selected in the study. The patients were divided into two groups (high and low back strength) according to their back strength levels. Then,the Modified Quantitative Subjective Global Assessment (MQSGA),Malnutrition-Inflammation Score (MIS),serum protein levels' detection and nutritional index detection were used to evaluate the nutritional status of the two groups of patients. The nutritional status scores,molecular nutritional status,and overall nutritional status were observed in the two groups,and the correlation between back strength and nutritional status were analyzed. 【Results】The scores of MQSGA and MIS in the high back strength group were higher than those in the low back strength group (P<0.05). Levels of Albumin (ALB),Prealbumin (PAB),Transferrin (TRF),and Total Protein (TP) in the high back strength group were higher than those in the low back strength group (P<0.05). The Body Mass Index (BMI),Triceps Skinfold (TSF) and Arm Muscle Circumference (AMC) of the patients in the high back strength group were greater than those in the low back strength group (P<0.05). Spearman rank correlation analysis showed that the back strength of maintenance hemodialysis patients was negatively correlated with nutritional status score,and positively correlated with molecular level and overall nutritional status indicators (P<0.05). 【Conclusion】There is a close relationship between the back strength of MHD patients and the nutritional status. Therefore development of personalized nutritional support programs based on the patient's condition is of great significance for improving back strength and improving the quality of life. 2023 Vol. 40 (8): 1146-1149 [Abstract] ( 34 ) HTML (1 KB)  PDF (1188 KB)  ( 28 ) 1150 Influence of Combined Spinal-epidural Anesthesia and General Anesthesia on Adverse Events of Cesarean Section and Prognosis of Mother and Infant in Pregnant Women with Hypertension HAN Ming, LIU Miao, ZHANG Dan DOI: 10.3969/j.issn.1671-7171.2023.08.009 【Objective】To investigate the impact of combined spinal-epidural anesthesia (CSEA) and general anesthesia on adverse events during cesarean section and maternal-infant outcomes in pregnant women with hypertension. 【Methods】A total of 84 pregnant women with pregnancy induced hypertension (preeclampsia) admitted to our hospital were randomly divided into two groups,with 42 cases in each group. All women underwent cesarean section,with the control group receiving general anesthesia and the observation group receiving CSEA. The anesthesia conditions and perioperative hemodynamic changes were compared between the two groups. Apgar scores at 1 minute and 5 minutes after birth and umbilical artery blood gas parameters of newborns were compared. The occurrence of anesthesia-related adverse events and maternal-infant outcomes during hospitalization were compared between the two groups. 【Results】 The onset time of anesthesia and the time from anesthesia initiation to delivery were longer in the observation group than in the control group (P<0.05). At the time of fetal delivery (T1),both groups showed a significant decrease in heart rate and mean arterial pressure compared to before anesthesia (T0) (P<0.05). At the end of surgery (T2),heart rate in both groups increased compared to T0 and T1,while mean arterial pressure was lower than T0 and higher than T1,with statistically significant differences (P<0.05). The heart rate and mean arterial pressure at T1 and T2 were higher in the observation group than in the control group (P<0.05). Apgar scores at 1 minute and 5 minutes after birth in the observation group were higher than that in the control group (P<0.05). The observation group had lower carbon dioxide partial pressure (PCO2) and higher oxygen partial pressure (PO2) in newborns compared to the control group (P<0.05). There was no statistically significant difference in the occurrence rate of overall anesthesia-related adverse reactions and maternal adverse events between the two groups (P>0.05),while the occurrence rate of adverse events in newborns was lower in the observation group than in the control group (P<0.05). 【Conclusion】Both CSEA and general anesthesia have advantages and disadvantages in cesarean section for pregnant women with preeclampsia due to hypertension. General anesthesia has minimal impact on maternal hemodynamics and provides rapid onset of anesthesia but may adversely affect neonatal outcomes. Compared to general anesthesia,CSEA can more effectively ensure the safety of newborns. 2023 Vol. 40 (8): 1150-1153 [Abstract] ( 36 ) HTML (1 KB)  PDF (1188 KB)  ( 48 ) 1154 Effects of Dexmedetomidine and Midazolam on Agitation during Recovery from Intravenous Inhalation Anesthesia in Children LAN Xia, YAO Yu-liang, XU Ting DOI: 10.3969/j.issn.1671-7171.2023.08.010 【Objective】To analyze the effect of dexmedetomidine (Dex) and midazolam on prevention of agitation (EA) during anesthesia recovery in children with intravenous inhalation combined anesthesia. 【Methods】A total of 60 children in our hospital who received intravenous inhalation compound anesthesia from March 2020 to March 2021 were selected and divided into two groups according to anesthesia drugs,the control group (30 cases with Mida anesthesia) and the observation group (30 cases with Dex anesthesia). The anesthesia time,operation time,recovery time and the incidence of agitation at different time points during the recovery period were compared between the two groups. 【Results】The anesthesia time,operation time and recovery time of the two groups were not statistically significant difference (P>0.05). The incidence of agitation at 5 min,10 min,15 min and 20 min after extubation in the observation group was lower than that in the control group (P< 0.05). The incidence of agitation immediately and 30 min after extubation between the observation group and the control group was not statistically significant difference (P>0.05). 【Conclusion】Dexmedetomidine is better than midazolam in preventing agitation in children with intravenous inhalation combined anesthesia. 2023 Vol. 40 (8): 1154-1156 [Abstract] ( 39 ) HTML (1 KB)  PDF (1165 KB)  ( 19 ) 1157 Clinical Efficacy of Intermittent Isotretinoin Capsules Combined with Clindamycin Metronidazole in Treatment of Moderate to Severe Acne MA Xiao-hong, ZHANG Ya-qin DOI: 10.3969/j.issn.1671-7171.2023.08.011 【Objective】To investigate the clinical efficacy of intermittent therapy with isotretinoin capsules combined with clindamycin metronidazole in treating moderate to severe acne. 【Methods】Eighty patients with moderate to severe acne admitted to our hospital from January 2019 to January 2022 were selected as research subjects. Patients were randomly divided into the observation group and control group,with 40 cases each. The observation group was treated with isotretinoin capsule intermittent therapy combined with clindamycin metronidazole topical treatment,while the control group was treated with clindamycin metronidazole topical treatment. The clinical efficacy,the severity (tenderness,flushing) and quantity (pustules,cysts,nodules,blackheads) scores of skin lesions before and after treatment,changes in inflammation factors [tumor necrosis factor-alpha (TNF-α),interleukin-8 (IL-8),Toll-like receptors (TLR)] levels before and after treatment,changes in hormone levels [testosterone (T),progesterone (P),estradiol (E2)] before and after treatment,and the incidence of drug side effects were compared between the two groups. 【Results】The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The severity and quantity scores of skin lesions in both groups were lower after treatment than before (P<0.05),and the scores in the observation group were lower than those in the control group (P<0.05). After treatment,the levels of TNF-α,IL-8 and TLR in both groups were lower than those before treatment (P<0.05); And their levels in the observation group were lower than those in the control group (P<0.05). The levels of T and P in both groups after treatment were lower than those before treatment,and E2 levels of posttreatment groups were higher than those of pretreatment groups (P<0.05); While posttreatment levels of T and P in the observation group were lower than those in the control group,and E2 level in the observation group was higher than that in the control group (P<0.05). There was no significant difference in the incidence of drug side effects between the two groups (P>0.05). 【Conclusion】The combination of intermittent isotretinoin capsules with clindamycin metronidazole has a significant effect on the treatment of moderate to severe acne. It can effectively reduce the degree of skin lesions,decrease inflammation,adjust hormone levels,and does not significantly increase adverse reactions. Thus it is recommended for clinical application. 2023 Vol. 40 (8): 1157-1160 [Abstract] ( 41 ) HTML (1 KB)  PDF (1188 KB)  ( 204 ) 1161 Predictive Value of Serum IAP,Progesterone,Estradiol,and PAPP-A Levels in Early Pregnant Embryo Arrest ZENG Bang-zhi, YANG Hai-rong DOI: 10.3969/j.issn.1671-7171.2023.08.012 【Objective】This study aims to explore the predictive value of serum immune-suppressive acid protein (IAP),progesterone (P),estradiol (E2),and pregnancy-associated plasma protein-A (PAPP-A) levels in predicting embryo arrest in early pregnancy. 【Methods】Seventy pregnant women with early pregnant embryo arrest admitted to Ankang Maternal and Child Health Hospital were included in the observation group,while 50 normal early pregnant women who underwent prenatal examination in the same period at the hospital were selected as the control group. Serum levels of P,E2,PAPP-A,and IAP were measured at gestational weeks 8,10,and 12 in both groups,and the differences in serum levels of P,E2,PAPP-A,and IAP between the two groups at gestational weeks 8,10,and 12 were compared. 【Results】At gestational week 8,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2 and PAPP-A were significantly lower than those in the control group (P<0.05). At gestational week 10,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2,and PAPP-A were significantly lower than those in the control group (P<0.05). At gestational week 12,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2,and PAPP-A were significantly lower than those in the control group (P<0.05). 【Conclusion】The serum levels of P,E2,and PAPP-A in pregnant women with early pregnancy embryo arrest were significantly lower than those in normal pregnant women,while the IAP level was significantly higher. These indicators have important implications for the pregnancy process and can serve as predictive markers for embryo arrest in early pregnancy. 2023 Vol. 40 (8): 1161-1163 [Abstract] ( 36 ) HTML (1 KB)  PDF (1170 KB)  ( 32 ) 1164 The Application Value of Combined Detection of Serum miR21,miR155-5P,and miR20a in the Early Diagnosis of Cervical Cancer WANG Yan-yan, ZHONG Rong DOI: 10.3969/j.issn.1671-7171.2023.08.013 【Objective】To explore the application value of combined detection of serum microribonucleic acid 21 (miR21),microribonucleic acid 155-5P (miR155-5P),and microribonucleic acid 20a (miR20a) in the early diagnosis of cervical cancer. 【Methods】 A retrospective analysis was conducted on the clinical data of 41 patients with cervical cancer (cervical cancer group) and 41 patients with cervical intraepithelial neoplasia (CIN) who received treatment at the Xi'an North Hospital from May 2018 to May 2022. Two sets of baseline data and serum indicators [carbohydrate antigen-125 (CA-125),miR21,miR155-5P,and miR20a] were compared; The diagnostic value of combined detection of miR21,miR155-5P,and miR20a in cervical cancer was analyzed using the receiver operating characteristic (ROC) curve; Multiple logistic regression analysis was used to identify the risk factors for cervical cancer. 【Results】There was no statistically significant difference (P>0.05) between the two groups in terms of age,body mass index (BMI),smoking history,menopausal status,clinical staging,family history of gynecological tumors,past history of gynecological diseases,past history of sexually transmitted diseases,pregnancy,childbirth,miscarriage frequency,imaging cervical abnormalities,and serum CA-125 levels;The proportion of HPV infection,age of first sexual intercourse<20 years old,and serum levels of miR21,miR155-5P,and miR20a in the cervical cancer group were higher than those in the CIN group (P<0.05). The ROC curve analysis results show that serum miR21,miR155-5P,and miR20a can all be used for the diagnosis of cervical cancer,with areas under the curve of 0.949,0.930,and 0.889,respectively. Combined diagnosis can obtain higher areas under the curve. Multivariate logistic regression analysis confirmed that HPV infection,age of first sexual intercourse<20 years old,miR21 ≥2.285,miR155-5P ≥2.335,and miR20a ≥2.445 were all risk factors for cervical cancer. 【Conclusions】Serum miR21,miR155-5P,and miR20a are all involved in the occurrence and development of cervical cancer,and their expression is of great significance for the early diagnosis of cervical cancer; Patients with HPV infection,age of first sexual activity<20 years old,miR21 ≥ 2.285,miR155-5P ≥ 2.335,and miR20a ≥ 2.445 are risk factors for cervical cancer and should be given clinical attention. 2023 Vol. 40 (8): 1164-1167 [Abstract] ( 33 ) HTML (1 KB)  PDF (1241 KB)  ( 62 ) 1168 The Effect of Atorvastatin on Angiogenesis and VEGF Expression in Rats with Chronic Subdural Hematoma LI Jing, HE Qing, HUANG Bo DOI: 10.3969/j.issn.1671-7171.2023.08.014 【Objective】To investigate the effect of atorvastatin on angiogenesis and the expression of vascular endothelial growth factor (VEGF) in chronic subdural hematoma (CSDH) rats. 【Methods】Thirty SPF grade SD rats were randomly divided into sham surgery group,model group,and atorvastatin group,with 10 rats in each group. After the successful establishment of the CSDH model,rats in the atorvastatin group were treated with atorvastatin by gavage for 7 consecutive days. The sham operated group and model group were gived with the same amount of physiological saline at the same time. Immunohistochemistry was used to detect microvascular density (MVD) in the outer membrane tissue of hematoma in rats of each group. Real time fluorescence quantitative PCR was used to detect the expression level of VEGF mRNA in the brain tissue of rats of each group. Immunoblotting was used to detect the changes in VEGF protein levels in the brain tissue of rats of each group. 【Results】As time passed,the volume of intracranial hematoma in the model group and atorvastatin group of rats was lower than that on day 3,and the atorvastatin group was lower than the model group,with a statistically significant difference (P<0.05). Compared with the sham surgery group,the levels of MVD-CD34 in the brain tissue of the model group and atorvastatin group were both increased (P<0.05),while the atorvastatin group was lower than the model group (P<0.05). Compared with the sham surgery group,the levels of VEGF mRNA in the brain tissue of the model group and atorvastatin group were both increased,while the atorvastatin group was lower than the model group,with a statistically significant difference (P<0.05). Compared with the sham surgery group,the levels of VEGF protein in the brain tissue of the model group and atorvastatin group were both increased,while the atorvastatin group was lower than the model group (P<0.05). 【Conclusion】Atorvastatin may inhibit neovascularization in brain tissue by down regulating VEGF expression,thereby inhibiting the occurrence and development of CSDH. 2023 Vol. 40 (8): 1168-1171 [Abstract] ( 33 ) HTML (1 KB)  PDF (1402 KB)  ( 30 ) 1172 Effects of Different Restoration Materials on Inflammation and Osteoclastic Cytokines of GCF in Anterior Teeth PFM Restoration Patients MA Qing-yun, LI Hui-bin, DUAN Feng, et al DOI: 10.3969/j.issn.1671-7171.2023.08.015 【Objective】To compare the effects of different restoration materials on inflammation and osteoclastic cytokines in gingival sulcus fluid (GCF) in patients with anterior tooth porcelain fused metal (PFM) full crown restoration. 【Methods】A total of 180 patients with anterior tooth PFM restoration admitted to the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2019 to June 2022 were randomly divided into three groups:Group A(n=60),Group B(n=60),and Group C(n=60). Group A was remediated using nickel-chromium materials,Group B was remediated using cobalt-chromium materials,and Group C was remediated using gold deposited materials. The gum condition,GCF inflammatory factor level,GCF osteoclastic regulator level and restoration integrity rate before and after repair were compared between the three groups. 【Results】After restoration,the GCF volume and gingival groove exploration depth (GCD) were higher than those before restoration,while the gingival index (GI) was lower than that before restoration (P<0.05). After restoration,the above indexes in group A were higher than those in groups B and C (P<0.05),but there was no significant difference between group B and group C (P>0.05). Levels of inflammatory factors in GCF of the three groups after restoration were higher than those before restoration (P<0.05); And the GCF inflammatory factor levels in group A after restoration were higher than those in groups B and C (P<0.05),but the comparison between group B and group C was not significant (P>0.05). The levels of RANKL (receptor activator of nuclear factor κB ligand) and RANKL/OPG (osteoprotegerin) in the three groups after restoration were higher than those before restoration,while the OPG was lower than that before restoration (P<0.05).After restoration,the nuclear factor κB receptor activating factor ligand (RANKL) and RANKL/osteoprotectin (OPG) in group A were higher than those in groups B and C,and its OPG was lower than that in the group B and group C (P<0.05).However,there was no significant difference of OPG between the two groups of B and C (P>0.05). The restoration integrity rate among the three groups did not show significant differences (P>0.05). 【Conclusion】Compared with nickel-chromium alloy,cobalt-chromium alloy and gold deposition in PFM restoration have significantly lower levels of inflammatory factors,less influence on osteoclasts,and higher biocompatibility and stability of restored teeth. 2023 Vol. 40 (8): 1172-1175 [Abstract] ( 36 ) HTML (1 KB)  PDF (1547 KB)  ( 46 ) 1176 The Application Value of Dual Energy CT in Identifying the Components of Urinary Calculi in Vivo WU Xi-hui, LIU Dan, ZENG Miao, et al DOI: 10.3969/j.issn.1671-7171.2023.08.016 【Objective】To explore the application value of dual energy CT in identifying the components of urinary calculi in vivo. 【Methods】 A total of 106 patients with urinary tract stones admitted to the Shaoyang Central Hospital from October 2020 to October 2021 were selected and subjected to 80 kV/140 kV dual energy scanning and data collection. The composition of urinary tract stones was analyzed,and infrared spectroscopy was used as the gold standard to draw the receiver operating characteristic (ROC) curve for dual energy CT analysis. The sensitivity,specificity,and accuracy of dual energy CT diagnosis were analyzed. 【Results】 Dual energy CT was used to analyze the composition of 126 urinary tract stones in 106 patients,including 30 urate stones and 96 non urate stones. 32 urate stones and 94 non urate stones were diagnosed by in vitro infrared spectroscopy. There was no statistically significant difference in the evaluation of different components of stones using dual energy CT and infrared spectroscopy (χ2=0.228,P>0.05). The effective atomic number of uric acid stones was 7.06 ± 0.68,while the effective atomic number of non uric acid stones was 12.87 ± 2.53,with a statistically significant difference (t=-11.00,P<0.001). The sensitivity,specificity,and accuracy of dual energy CT analysis of stone components were 87.5%,97.9%,and 95.2%,respectively. 【Conclusions】 Dual energy CT can accurately analyze the in vivo composition of urinary calculi,which helps guide clinical physicians to choose appropriate treatment methods. 2023 Vol. 40 (8): 1176-1178 [Abstract] ( 42 ) HTML (1 KB)  PDF (1450 KB)  ( 28 ) 1179 Clinical Efficacy of Locking Intramedullary Nailing in the Treatment of Limb Fractures WANG Fu-shun, LI Xing DOI: 10.3969/j.issn.1671-7171.2023.08.017 【Objective】To explore the effect of locking intramedullary nailing on the limb function and postoperative complications in patients with limb fractures. 【Methods】A total of 110 patients with limb fractures admitted to Baoji Central Hospital from January 2020 to January 2022 were selected and randomly divided into an observation group and a control group,with 55 cases in each group. The control group was treated with dynamic compression plate internal fixation,while the observation group was treated with interlocking intramedullary nail internal fixation. Two groups of patients were compared in terms of perioperative indicators (including surgery time,intraoperative bleeding volume,hospital stay,and fracture healing time),postoperative joint function recovery,incidence of complications,and serum levels of inflammatory factors [interleukin-6 (IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein (CRP)] before and after surgery.【Results】The observation group had shorter surgical time,intraoperative bleeding,hospital stay,and fracture healing time than the control group,with statistically significant differences (P<0.05). The postoperative recovery of joint function in the observation group was better than that in the control group,with a statistically significant difference (P<0.05). There was no statistically significant difference in serum IL-6,TNF-α,and CRP levels between the two groups of patients before and after surgery (P>0.05); The postoperative serum levels of IL-6,TNF-α,and CRP in both groups of patients were higher than those in the same group before surgery,and the difference was statistically significant (P<0.05). The incidence of complications in the observation group (12.73%) was significantly lower than that in the control group (29.09%),with a statistically significant difference (P<0.05). 【Conclusions】 Compared with dynamic compression plate fixation,locking intramedullary nailing in treating limb fractures results in faster fracture healing,better recovery of limb motor function after surgery,and a lower incidence of complications. 2023 Vol. 40 (8): 1179-1182 [Abstract] ( 39 ) HTML (1 KB)  PDF (1190 KB)  ( 40 ) 1183 Relationship of Postoperative Cognitive Dysfunction with ApoE Gene and Clinical Features in Elderly Patients after General Anesthesia LU Zhi-fang, LIU Xiao-bing DOI: 10.3969/j.issn.1671-7171.2023.08.018 【Objective】To study the relationship of postoperative cognitive dysfunction(POCD) with apolipoprotein E (ApoE) gene and clinical features in elderly patients after general anesthesia. 【Methods】A total of 122 elderly patients underwent general anesthesia with propofol in our hospital. All patients were tested for ApoE gene and genotype,while mini mental state examination (MMSE) was used to assess the incidence of postoperative cognitive dysfunction. The relationship between ApoE gene and cognitive dysfunction after propofol-induced general anesthesia in elderly patients was analyzed. 【Results】 The MMSE score was (28.51 ± 1.12) before operation. While the MMSE score was (26.01 ± 1.32) at 24 hours after operation,the MMSE score was (26.81 ± 1.05) at 72 hours after operation,and the MMSE score was (27.41 ± 1.06) on 7 days after operation. The results showed that 36 cases (29.51%) had POCD and 86 cases (70.49%) had no POCD. The age and ApoE gene carrying frequency (epsilon 3/4 and epsilon 4 gene) of the POCD group were significantly higher than those of the non POCD group (P<0.05). However,the epsilon 3/3 genotype carrying frequency of the POCD group was significantly lower than that of the non POCD group (P<0.05). Multivariate logistic regression analysis showed that age,epsilon 3/3,epsilon 3/4 and epsilon 4 were independent influencing factors of POCD after propofol anesthesia induction in the elderly patients (P<0.05). 【Conclusion】The distribution of ApoE gene may be related to the mechanism of POCD dysfunction induced by propofol anesthesia in the elderly patients. 2023 Vol. 40 (8): 1183-1185 [Abstract] ( 41 ) HTML (1 KB)  PDF (1167 KB)  ( 34 ) 1186 Effects of Repetitive Transcranial Magnetic Stimulation Combined with Amisulpride Treatment on Cognitive Function and Blood Cytokine Levels in Patients with Schizophrenia LI Juan, CAO Jing DOI: 10.3969/j.issn.1671-7171.2023.08.019 【Objective】This study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with amisulpride treatment on cognitive function and serum cytokine levels in patients with schizophrenia. 【Methods】Ninety-six patients with schizophrenia were randomly divided into two groups,with 48 patients in each group. The control group received oral amisulpride treatment,while the observation group received rTMS in addition to amisulpride treatment. The Wisconsin Card Sorting Test (WCST) scores,Positive and Negative Syndrome Scale (PANSS) scores,serum markers [interleukin-1β (IL-1β),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α)],and occurrence of adverse reactions were compared between the two groups before and after treatment. 【Results】After treatment,both groups showed higher scores in the number of categories completed and total correct responses and lower scores in the total number of responses,perseverative errors,and total errors compared to before treatment (P<0.05). Moreover,the observation group had significantly better scores in all these measures compared to the control group (P<0.05). After treatment,both groups had lower scores in positive symptoms,negative symptoms,general psychopathology,and total PANSS scores compared to before treatment (P<0.05); And the observation group showed significantly lower scores in all these measures compared to the control group (P<0.05). After treatment,both groups had decreased levels of serum IL-1β,IL-6,and TNF-α compared to before treatment (P<0.05),while the observation group had lower levels of serum IL-6 and TNF-α compared to the control group (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】rTMS combined with amisulpride treatment in patients with schizophrenia is beneficial in suppressing IL-6 and TNF-α levels,reducing symptoms,and improving cognitive function. It has good clinical application value. 2023 Vol. 40 (8): 1186-1189 [Abstract] ( 47 ) HTML (1 KB)  PDF (1192 KB)  ( 33 ) 1190 Effect of Single Load with Low Dose Esmolol on Hemodynamic Parameters in Elderly Patients Undergoing Painless Gastroscopy LI Hu, LI Hai-ying DOI: 10.3969/j.issn.1671-7171.2023.08.020 【Objective】To investigate the effect of single load with small dose esmolol on hemodynamic parameters of the elderly patients undergoing painless gastroscopy. 【Methods】A total of 160 elderly patients underwent painless gastroscopy were randomly divided into the observation group and the control group,with 80 cases in each group. The observation group was given a low dose of esmolol 0.3 mg/kg intravenously,while the control group was given a high dose of esmolol 0.5 mg/kg intravenously. The injection time of the two groups was administrated within 15 to 30 seconds. Hemodynamic parameters [heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP) and oxygen saturation (SpO2)] before and after examination were compared between the two groups. After examination,the length of hospital observation,the duration of anesthesia wakefulness,the score of the Simple Mental State Assessment Scale (MMSE),the amount of anesthesia and the occurrence of adverse reactions between the two groups were compared as well. 【Results】After examination,HR,SBP and DBP levels of the two groups were lower than those before examination (P<0.05),however,HR,SBP and DBP of the observation group were higher than those of the control group (P<0.05). There was no statistical significance in SpO2 between the two groups before and after examination (P>0.05). There were no significant differences in hospital observation time,anesthetic waking time,MMSE score and anesthetic dosage between the two groups (P>0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】Esmolol has a significant anesthetic effect in the elderly for painless gastroscopy,and small doses of esmolol are more conducive to stable blood circulation,and the adverse reactions are small,so it is recommended for clinical application. 2023 Vol. 40 (8): 1190-1192 [Abstract] ( 29 ) HTML (1 KB)  PDF (1166 KB)  ( 15 ) 1193 The Relationship between Hemodynamic Parameters Measured by Ultrasound and Perinatal Outcomes in Pregnant Women with Hypertension during Pregnancy MA Jing, WANG Juan DOI: 10.3969/j.issn.1671-7171.2023.08.021 【Objective】To explore the correlation between ultrasound-measured hemodynamic parameters and perinatal outcomes in pregnant women with hypertension. 【Methods】A total of 65 pregnant women with pregnancy-induced hypertension diagnosed in Baoji Maternal and Child Health Care Hospital from August 2018 to August 2021 were selected as the study subjects. Patients were divided into the mild group (n=33,systolic pressure 140-160 mmHg,diastolic pressure 90-110 mmHg) and the severe group (n=32,systolic pressure>160 mmHg,diastolic pressure>110 mmHg). During the same time period,normal pregnant women who received regular prenatal checkups in Baoji Maternal and Child Health Hospital were selected as the normal control group (n=21). The fetal hemodynamic parameters were detected by Doppler Ultrasonic testing. The fetal hemodynamic parameters with different pregnancy outcomes were analyzed. 【Results】Comparison of umbilical artery resistance index (RI),peak to valley ratio of blood flow velocity (S/D),and pulsation index (PI) parameters among three groups of fetuses showed: normal group<the mild group<the severe group (P<0.05). While comparison of PI,RI,and S/D parameters of middle cerebral artery among three groups showed: normal group>the mild group>the severe group (P<0.05). Results of the birth weight,placental weight,Apgar score,umbilical artery PH value,and gestational week at delivery showed the decreased order in normal group,the mild group and the severe group,while the rate of cesarean section increased in turn of normal group<mild group<severe group (P<0.05).Among the 86 pregnant women (including 65 patients with gestational hypertension and 21 normal pregnant women),56 cases had normal pregnancy outcome in the perinatal period,25 had mild adverse outcome,and 5 had severe adverse outcome. Comparison of the PI,RI,and S/D parameters of the umbilical artery among the three groups showed the order of adverse severity as the normal group<the mild adverse outcome<the severe adverse outcome (P<0.05). There were no statistically significant differences in the PI,RI,and S/D parameters of the middle cerebral artery among the three groups of pregnancy outcomes (P>0.05). The results of logistic regression analysis showed that the umbilical artery parameters of PI,RI,and S/D were all influencing factors for adverse pregnancy outcomes (OR=2.614,2.396,3.445,all P<0.05). 【Conclusion】The fetal hemodynamic parameters detected by ultrasonic testing can be used to predict the fetal intrauterine development status,and evaluate the progress of maternal conditions and adverse pregnancy outcomes in hypertensive women during pregnancy. 2023 Vol. 40 (8): 1193-1196 [Abstract] ( 36 ) HTML (1 KB)  PDF (1192 KB)  ( 19 ) 1197 The Correlation between the C677T Polymorphism of MTHFR Gene and the Severity and Comorbidities of Coronary Heart Disease Patients BAI Zhi-sheng, LYU Yong-hui DOI: 10.3969/j.issn.1671-7171.2023.08.022 【Objective】To investigate the correlation between the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and the severity and comorbidities of coronary heart disease patients. 【Methods】A total of 496 patients with coronary heart disease admitted to our hospital from January 2021 to January 2022 were selected and divided into CC group (n=139),CT group (n=211),and TT group (n=146) based on the MTHFR gene C677T polymorphism detection results. The severity of coronary heart disease,plasma homocysteine (Hcy),blood pressure,and serum total cholesterol (TC),triglyceride (TG),and glycosylated hemoglobin (HbA1c) were compared among the three groups,and the incidence of H-type hypertension,hypertension,diabetes,and hyperlipidemia in the three groups were statistically analyzed; We analyzed the correlation between MTHFR gene C677T polymorphism typing and Gensini score,Hcy,TC,TG,HbA1c. 【Results】 The differences in Hcy,SBP,DBP,TC,TG,HbA1c,and Gensini scores among the three groups of patients were statistically significant (P<0.05). The incidence rate of H-type hypertension,hypertension,diabetes and hyperlipidemia complications in the three groups were statistically significant (P<0.05). 【Conclusion】The C677T polymorphism of MTHFR gene is associated with the severity,Hcy,blood lipid and blood glucose levels of patients with coronary heart disease. Among them,patients with TT genotype coronary heart disease have a higher probability of severity,and have a higher risk of combining H-type hypertension,hypertension,diabetes and hyperlipidemia. 2023 Vol. 40 (8): 1197-1199 [Abstract] ( 39 ) HTML (1 KB)  PDF (1165 KB)  ( 87 ) 1200 Effect of Sevelamer Carbonate on TGF-β1/Smad Pathway in Elderly Patients with End-stage Renal Disease and Hyperphosphatemia CUI Ying-xue, CHEN Bo-ting, ZHANG Pan DOI: 10.3969/j.issn.1671-7171.2023.08.023 【Objective】To explore the effect of sevelamer carbonate on the transforming growth factor β1 (TGF-β1) / Smad pathway in elderly patients with end-stage renal disease (ESRD) complicated with hyperphosphatemia. 【Methods】Eighty-two elderly patients with ESRD and hyperphosphatemia were randomly divided into two groups,with 41 cases in each group. The control group was treated with calcium carbonate,while the observation group was treated with sevelamer carbonate. The levels of intact parathyroid hormone (iPTH),serum calcium ,serum phosphorus,lipid [total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)],renal function [serum creatinine (Scr),blood urea nitrogen (BUN)] and TGF-β1,Smad,and the occurrence rate of adverse reactions were compared between the two groups before and after treatment. 【Results】After treatment,the levels of serum calcium ,serum phosphorus,TG,TC,LDL-C,Scr,and BUN in both groups were lower than those before treatment (P<0.05),and these indicators in the observation group were lower than those in the control group (P<0.05). There were no significant differences in the levels of iPTH,HDL-C before and after treatment between the two groups (P>0.05). The levels of TGF-β1 were lower and the levels of Smad 7 were higher after treatment in both groups (P<0.05). The level of TGF-β1 in the observation group was lower than that in the control group,and the level of Smad 7 was higher than that in the control group (P<0.05). There was no significant difference in the occurrence rate of adverse reactions between the two groups (P>0.05). 【Conclusion】Sevelamer carbonate has a significant therapeutic effect on elderly patients with ESRD complicated with hyperphosphatemia. It can inhibit the expression of the TGF-β1/Smad signaling pathway,reduce the levels of blood calcium,phosphorus,and lipids,and is safe for medication use,hence it is worth promoting. 2023 Vol. 40 (8): 1200-1203 [Abstract] ( 37 ) HTML (1 KB)  PDF (1191 KB)  ( 26 ) 1204 Correlation Analysis of Lower Respiratory Tract Infection with PCT,CRP and AAG in Geriatric Patients with COPD YU Rui, XIE Jun DOI: 10.3969/j.issn.1671-7171.2023.08.024 【Objective】To investigate the association of lower respiratory tract infection with PCT (Procalcitonin),CRP (c-reactive protein) and AAG (αl acid glycoprotein) in geriatric patients with COPD.【Methods】Clinical profiles of 84 geriatric patients with COPD admitted to our hospital from January 2018 to December 2021 were retrospectively analysed. Lower respiratory tract infection stauts age,gender,BMI,comorbidity,blood lipid index,chronic obstructive pulmonary disease prevention and treatment (GOLD) grade,coagulation index,and level of PCT,CRP and AAG were collected. Multivariate logistic regression analysis was used to analyze the independent risk factors of lower respiratory tract infection in elderly patients with COPD; Spearman test was used to analyze the correlation of lower respiratory tract infection with PCT,CRP and AAG in elderly patients with COPD. 【Results】Among 84 elderly patients with COPD,50 patients (59.52%) were admitted as uninfected group with no lower respiratory tract infection and 34 patients (40.48%) were admitted to the infection group with lower respiratory tract infection. There was no statistically significant difference in age,gender,comorbidities,blood lipid indicators,BMI,coagulation indicators,GOLD grading,smoking history,and disease course between the two groups (P>0.05). The levels of PCT,CRP,and AAG in the infection group were higher than those in the non-infection group (P<0.05). Multivariate logistic regression analysis showed that CRP,PCT and AAG were independent risk factors for lower respiratory tract infection in elderly patients with COPD (P<0.05). Spearman test showed that serum levels of PCT,CRP and AAG were positively correlated with lower respiratory tract infection in elderly patients with COPD (P<0.05). 【Conclusion】PCT,CRP and AAG are the risk factors for lower respiratory tract infection in geriatric patients with COPD. With the increase of PCT,CRP and AAG levels,the risk of lower respiratory tract infection in elderly patients with COPD increases accordingly. 2023 Vol. 40 (8): 1204-1206 [Abstract] ( 40 ) HTML (1 KB)  PDF (1168 KB)  ( 20 ) 1207 The Effect of Underwater Exercise Training on Limb Motor Function and Daily Living Ability of Children with Cerebral Palsy BAI Tian-li, LI Yuan, FENG Zhou, et al DOI: 10.3969/j.issn.1671-7171.2023.08.025 【Objective】To explore the effect of underwater exercise training on limb motor function and daily living ability in children with cerebral palsy. 【Methods】A total of 80 children with cerebral palsy admitted to our hospital from January 2020 to February 2022 were selected and randomly divided into an observation group and a control group using a random number table method,with 40 cases in each group. The control group received routine comprehensive rehabilitation training,while the observation group received combined water sports training on the basis of the control group. We compared the clinical efficacy of two groups of children,including the Gross Motor Function Scale (GMFM) and Fine Motor Function Scale (FMFM) scores before and after treatment. We also compared the number and time of 10 meters of walking,as well as the Berg Balance Scale (Berg) score,Daily Activity Power Scale (ADL),and the Functional Independence Measure for Children (WeeFIM) scores before and after treatment. 【Results】The total effective rate of clinical efficacy in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05). After treatment,the GMFM scores and FMFM scores of the two groups of children were significantly higher than those of the same group before treatment,and the observation group was higher than the control group,with a statistically significant difference (P<0.05); The number of steps and time for walking 10 meters in both groups of children were shorter than before treatment in the same group,and the Berg score was higher than before treatment in the same group (P<0.05); After treatment,the number and time of walking 10 meters in the observation group were shorter than those in the control group,and the Berg score was higher than that in the control group (P<0.05); The ADL and the WeeFIM scores of the two groups of children were significantly higher than those of the same group before treatment,and the observation group was higher than the control group,with a statistically significant difference (P<0.05). 【Conclusion】 Underwater exercise training can effectively increase muscle strength,improve limb motor function,and improve daily living ability in children with cerebral palsy. 2023 Vol. 40 (8): 1207-1210 [Abstract] ( 38 ) HTML (1 KB)  PDF (1193 KB)  ( 79 ) 1211 The Expression and Clinical Significance of α1-AT/DNase Ⅰ,HBD-1,and SF in Children with Severe Community Acquired Pneumonia ZHOU Yu-yang, YANG Jun-jie DOI: 10.3969/j.issn.1671-7171.2023.08.026 【Objective】To investigate the expression and clinical significance of α1-antitrypsin (α1-AT)/DNase Ⅰ(DNase Ⅰ),β-Defensins 1 (HBD-1),and ferritin (SF) in children with severe community acquired pneumonia (SCAP). 【Methods】 A total of 98 children with SCAP admitted to Kaifeng Children's Hospital from January 2020 to May 2021 were selected as the observation group. They were divided into low risk group (n=15),medium risk group (n=52),and high risk group (n=31) based on the pneumonia severity index (PSI). According to the test results,they were divided into bacterial pneumonia group (n=50),mycoplasma pneumonia group (n=22),and viral pneumonia group (n=26). At the same time,62 healthy children who underwent physical examination in our hospital were selected as the control group. The serum levels of α1-AT/DNase Ⅰ,HBD-1,and SF were compared between different groups. The Spearman method was used to analyze the correlation between α1-AT/DNase Ⅰ,HBD-1,and SF and disease severity. The diagnostic value of the above for SCAP was evaluated using the receiver operating characteristic (ROC) curve.【Results】The serum levels of α1-AT/DNase Ⅰ,HBD-1,and SF in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05). Univariate analysis of variance showed that there was a statistically significant difference in serum α1-AT/DNase Ⅰ,HBD-1,and SF levels among SCAP patients with different disease severity levels (P<0.05). The serum levels of α1-AT/DNase Ⅰ,HBD-1,and SF in the medium and high-risk groups were higher than those in the low risk group,and the high-risk group was higher than the medium risk group,with statistical significance (P<0.05). The levels of α1-AT/DNase Ⅰ,HBD-1,and SF in the mycoplasma pneumonia group and viral pneumonia group were higher than those in the bacterial pneumonia group (P<0.05). There was no statistically significant difference between the mycoplasma pneumonia group and viral pneumonia group (P>0.05). Spearman correlation analysis showed that α1-AT/DNase Ⅰ,HBD-1,and SF were positively correlated with disease severity (rs=0.632,0.524,0.531,all P<0.01). ROC curve analysis showed that the AUC area,sensitivity,and specificity of α1-AT/DNase Ⅰ,HBD-1,and SF combined detection were significantly higher than those of single detection (P<0.05). 【Conclusion】 The serum levels of α1-AT/DNase Ⅰ,HBD-1,and SF in children with SCAP are abnormally elevated and related to the severity of the disease. Combined detection can improve the diagnostic value of SCAP. 2023 Vol. 40 (8): 1211-1213 [Abstract] ( 28 ) HTML (1 KB)  PDF (1172 KB)  ( 24 ) 1214 Application of Different Doses of Tigrillo in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention with Reischemia ZHANG Hui-qin, WANG Zhi-gang, WANG Xiao-ni DOI: 10.3969/j.issn.1671-7171.2023.08.027 【Objective】To investigate the clinical efficacy of different doses of Tigrillo in patients with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) for reperfusion.【Methods】A total of 64 AMI patients who underwent PCI surgery Xianyang Hospital of Yan&apos;an University from April 2020 to November 2021 were selected and divided into an observation group and a control group based on different treatment methods,with 32 patients in each group. Comparison of the two groups before and after treatment was conducted including platelet function [Platelet aggregation rate,platelet count,enzyme membrane glycoprotein 63 (CD63) α Granular membrane glycoprotein 62p (CD62p)],coronary artery blood flow parameters [Peak systolic blood flow (SPV),peak diastolic blood flow (DPV),coronary flow reserve (CFVR)],myocardial injury indicators[Ischemic modified albumin (IMA),cardiac troponin I (cTnI),myoglobin (Mb),creatine kinase isoenzyme (CK-MB) ],inflammatory factors [Hypersensitivity C-reactive protein (hs-CRP),intercellular adhesion molecule-1 (ICAM-1),macrophage derived chemokine (MDC),interleukin-10 (IL-10)],and the incidence of adverse reactions after treatment.【Results】After treatment,the platelet aggregation rate,platelet count,CD63,and CD62p in both groups of patients were lower than before treatment,and the observation group was lower than the control group (P<0.05); The DPV,SPV,and CFVR of both groups of patients were higher than before treatment,and the observation group was higher than the control group (P<0.05); The levels of IMA,cTnI,Mb,and CK-MB in both groups of patients were lower than before treatment,and the observation group was lower than the control group (P<0.05); The levels of hs-CRP,ICAM-1,MDC,and IL-10 in both groups were lower than before treatment,and the observation group was lower than the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).【Conclusion】The treatment of AMI patients with load dose Tigrillo can improve platelet function,coronary artery blood flow,alleviate myocardial injury,and reduce the expression level of inflammatory factors in patients with reperfusion after PCI,which is of great significance for improving patient prognosis. 2023 Vol. 40 (8): 1214-1217 [Abstract] ( 35 ) HTML (1 KB)  PDF (1193 KB)  ( 25 ) 1218 Analysis of Risk Factors for Placental Abruption in Pregnant Women with Gestational Hypertension WANG Wei, JIA Bao-ling DOI: 10.3969/j.issn.1671-7171.2023.08.028 【Objective】To explore the risk factors of placental abruption in pregnant women with hypertensive disorder complicating pregnancy (HDCP). 【Methods】 A total of 80 HDCP pregnant women admitted to the Obstetrics and Gynecology Department of the Lantian County People&apos;s Hospital from July 2018 to July 2021 were selected and divided into early exfoliation group (n=12) and non early exfoliation group (n=68) based on the examination results after admission. The age,pre pregnancy body mass index (BMI),weight gain during pregnancy,history of diabetes,number of pregnant fetuses,history of cesarean section,history of abortion,family history of hypertension,educational level and renal function index [serum urea nitrogen,serum creatinine,uric acid level,glomerular filtration rate] of the two groups were compared,Multiple regression analysis was used to identify the risk factors for placental abruption in HDCP pregnant women. 【Results】There was no significant difference in age,diabetes,multiple pregnancy,cesarean section,abortion,smoking,education,and serum urea nitrogen between the two groups (P>0.05); The pre pregnancy BMI,gestational weight gain,and glomerular filtration rate of the early exfoliation group were lower than those of the non early exfoliation group,while the proportion of individuals with a family history of hypertension,serum creatinine,and uric acid levels were higher than those of the non early exfoliation group (P<0.05). The ROC curve analysis results show that pre pregnancy BMI,gestational weight gain,serum creatinine,uric acid,and glomerular filtration rate can all predict the occurrence of placental abruption in HDCP pregnant women,with areas under the curves of 0.713,0.879,0.849,0.686,and 0.846,respectively. The results of multivariate analysis showed that pre pregnancy BMI<23.51 kg/m2,pregnancy weight gain<14.10 kg,family history of hypertension,and serum creatinine ≥ 66.13 μmol/L,uric acid ≥361.34 μmol/L and glomerular filtration rate<111.86 mL/min were risk factors for placental abruption in HDCP pregnant women (P<0.05). 【Conclusions】The impact of pre pregnancy BMI,gestational weight gain,family history of hypertension,serum creatinine,uric acid,and glomerular filtration rate on placental abruption in HDCP pregnant women needs to be strengthened in clinical practice to prevent the occurrence of placental abruption. 2023 Vol. 40 (8): 1218-1220 [Abstract] ( 41 ) HTML (1 KB)  PDF (1220 KB)  ( 21 ) 1221 The Correlation between ATX,RPR,miR-122 and Chronic Hepatitis B Liver Fibrosis ZHOU Xiao, WANG Xiao-mei DOI: 10.3969/j.issn.1671-7171.2023.08.029 【Objective】To investigate the correlation between autotaxin (ATX),RDW-to-Platelet Ratio,RPR (RPR),microRNA-122 (miR-122),and liver fibrosis in patients with chronic hepatitis B (CHB). 【Methods】 A total of 64 CHB patients admitted to our hospital from May 2019 to November 2021 were selected as the study subjects. According to Scheuer&apos;s grading criteria,they were divided into a non fibrosis group (S0 grade,n=12),a mild fibrosis group (S1-S2 grade,n=27),and a moderate to severe fibrosis group (S3-S4 grade,n=25). The levels of serum ATX,RPR,miR-122,liver fibrosis indicators [hyaluronic acid (HA),laminin (LN),N-terminal peptide of type Ⅲ procollagen (PⅢP),Ⅳ collagen (Ⅳ-C)],and liver hardness were compared among each group. We analyzed the correlation between serum indicators and liver fibrosis indicators,liver hardness,and their diagnostic value for liver fibrosis.【Results】Compared with the non fibrosis group,the levels of serum ATX and RPR in the mild fibrosis group and the moderate to severe fibrosis group increased,while the levels of HA,LN,P Ⅲ P,Ⅳ-C,and liver hardness increased. The expression of miR-122 decreased (P<0.05),and the differences in various indicators between the mild fibrosis group and the moderate to severe fibrosis group were statistically significant (P<0.05). ATX and RPR were positively correlated with HA,LN,PⅢP,Ⅳ-C,and liver hardness (P<0.05),while miR-122 was negatively correlated with HA,LN,PⅢP,Ⅳ-C,and liver hardness (P<0.05). The AUC of ATX,RPR,and miR-122 combined detection for liver fibrosis was higher than that of single detection (P<0.05); The risk of liver fibrosis in patients with high expression of ATX and RPR was 1.604 times and 1.738 times higher than that in patients with low expression (P<0.05),respectively. The risk of liver fibrosis in patients with low expression of miR-122 was 1.887 times higher than that in patients with high expression (P<0.05). 【Conclusion】 As the degree of liver fibrosis worsens in CHB patients,ATX and RPR increase,while miR-122 expression decreases,which is related to liver fibrosis indicators and liver hardness,and has important diagnostic value for the occurrence of liver fibrosis. 2023 Vol. 40 (8): 1221-1224 [Abstract] ( 36 ) HTML (1 KB)  PDF (1192 KB)  ( 28 ) 1225 Effect of Irbesartan Hydrochlorothiazide Combined with Jinkui Shenqi Pill on Hypertensive CHF and its Influence on NLRP3/NF-κB Pathway WANG Wen-jing DOI: 10.3969/j.issn.1671-7171.2023.08.030 【Objective】To investigate the clinical efficacy of irbesartan hydrochlorothiazide combined with the Jingui Shenqi Pill in the treatment of hypertensive chronic heart failure (CHF) and its impact on the nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3)/nuclear factor B (NF-κB) pathway. 【Methods】A total of 106 hypertensive CHF patients admitted to our hospital from May 2019 to May 2022 were randomly divided into an observation group (treated with irbesartan hydrochlorothiazide combined with the Jingui Shenqi Pill) and a control group (treated with irbesartan hydrochlorothiazide) using a random number table method,with 53 patients in each group. We compared the efficacy,traditional Chinese medicine syndrome scores,blood pressure levels,cardiac function [B-type brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD)],NLRP3/NF-κB pathway [NLRP3,NF-κB,interleukin-1 (IL-1β),interleukin-18 (IL-18),tumor necrosis factor-α(TNF-α)],and safety between two groups. 【Results】The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05); After treatment,the observation group had lower scores of traditional Chinese medicine syndromes such as chest tightness,palpitations,difficulty lying flat,lower limb edema,palpitations,dizziness,tinnitus,lack of qi and lazy speech,fatigue and fatigue compared to the control group (P<0.05); After treatment,the systolic and diastolic blood pressure in the observation group were lower than those in the control group (P<0.05); After treatment,BNP,LVEDD,and LVESD in the observation group were lower than those in the Western medicine group,while LVEF was higher than that in the control group (P<0.05); After treatment,the NLRP3,NF-κB,IL-1β,IL-18,and TNF-α levels in the observation group were lower than those in the control group (P<0.05); There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). 【Conclusions】The combination of Irbesartan Hydrochlorothiazide and the Jinkui Shenqi Pill in the treatment of hypertensive CHF can effectively improve clinical symptoms and signs,lower blood pressure levels,improve cardiac function,inhibit NLRP3/NF-κB pathway activation,and is safe and reliable. 2023 Vol. 40 (8): 1225-1228 [Abstract] ( 44 ) HTML (1 KB)  PDF (1192 KB)  ( 43 )

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