血清T淋巴细胞亚群及PLR、MLR、NLR对尿毒症腹膜透析相关性腹膜炎患者的预测价值

doi:10.3969/j.issn.1671-7171.2023.08.003

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Abstract 【Objective】To investigate the predictive value of serum T lymphocyte subsets,neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR) and platelet-to-lymphocyte ratio(PLR) ratio for peritoneal dialysis-associated peritonitis (PDAP)diagnosis. 【Methods】A total of 119 peritoneal dialysis-associated patients who were hospitalized in our hospital from March 2018 to March 2022 were enrolled and divided into the peritonitis group and non-peritonitis group. The differences and correlations of T lymphocyte subsets (CD4⁺,CD8⁺,CD4⁺/CD8⁺) and various inflammatory indicators in each group were compared,and their predictive value for peritoneal dialysis peritonitis was analyzed. 【Results】The CD4⁺ and CD4⁺/CD8⁺ in the peritonitis group were higher than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). CD8⁺ and T lymphocyte counts in the peritonitis group were lower than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). There was no significant difference in the percentage of T lymphocytes between the two groups (P>0.05).However,NLR,MLR,PLR,hs-CRP,erythrocyte sedimentation rate(ESR) and procalcitonin(PCT) in the peritonitis group were higher than those in the non-peritonitis group,and the differences were statistically significant (P<0.05). The CD4⁺/CD8⁺ was negatively correlated with NLR (r=-0.327,P<0.05),positively correlated with MLR (r=0.875,P<0.05),and positively correlated with hs-CRP (r=0.306,P<0.05). The AUC of serum CD4⁺,CD8⁺,CD4⁺/CD8⁺,PLR,NLR,MLR,hs-CRP,ESR,and PCT in predicting peritoneal dialysis-related peritonitis were 0.711,0.365,0.700,0.720,0.886,0.931,0.883,0.802,and 0.737,respectively. 【Conclusion】Serum T lymphocyte subsets,PLR,MLR,NLR,hs-CRP,ESR and PCT have good predictive value for peritoneal dialysis-associated peritonitis. Of which,NLR and MLR have the strongest specificity and higher clinical reference value.

Key words： Peritonitis Uremia Peritoneal Dialysis T-Lymphocyte Subsets

Received: 27 February 2023

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R656.41

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.08.003 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I8/1128

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