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| Predictive Value of Serum IAP,Progesterone,Estradiol,and PAPP-A Levels in Early Pregnant Embryo Arrest |
| ZENG Bang-zhi, YANG Hai-rong |
| Department of Laboratory Medicine,Ankang Maternal and Child Health Hospital,Ankang Shaanxi 725000 |
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Abstract 【Objective】This study aims to explore the predictive value of serum immune-suppressive acid protein (IAP),progesterone (P),estradiol (E2),and pregnancy-associated plasma protein-A (PAPP-A) levels in predicting embryo arrest in early pregnancy. 【Methods】Seventy pregnant women with early pregnant embryo arrest admitted to Ankang Maternal and Child Health Hospital were included in the observation group,while 50 normal early pregnant women who underwent prenatal examination in the same period at the hospital were selected as the control group. Serum levels of P,E2,PAPP-A,and IAP were measured at gestational weeks 8,10,and 12 in both groups,and the differences in serum levels of P,E2,PAPP-A,and IAP between the two groups at gestational weeks 8,10,and 12 were compared. 【Results】At gestational week 8,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2 and PAPP-A were significantly lower than those in the control group (P<0.05). At gestational week 10,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2,and PAPP-A were significantly lower than those in the control group (P<0.05). At gestational week 12,the IAP level in the observation group was significantly higher than that in the control group (P<0.05),while the levels of P,E2,and PAPP-A were significantly lower than those in the control group (P<0.05). 【Conclusion】The serum levels of P,E2,and PAPP-A in pregnant women with early pregnancy embryo arrest were significantly lower than those in normal pregnant women,while the IAP level was significantly higher. These indicators have important implications for the pregnancy process and can serve as predictive markers for embryo arrest in early pregnancy.
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Received: 04 July 2022
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2023, Vol. 40 
