Effects of Repetitive Transcranial Magnetic Stimulation Combined with Amisulpride Treatment on Cognitive Function and Blood Cytokine Levels in Patients with Schizophrenia
LI Juan, CAO Jing
Yan'an Third People's Hospital,Yan'an Shaanxi 716000
Abstract 【Objective】This study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with amisulpride treatment on cognitive function and serum cytokine levels in patients with schizophrenia. 【Methods】Ninety-six patients with schizophrenia were randomly divided into two groups,with 48 patients in each group. The control group received oral amisulpride treatment,while the observation group received rTMS in addition to amisulpride treatment. The Wisconsin Card Sorting Test (WCST) scores,Positive and Negative Syndrome Scale (PANSS) scores,serum markers [interleukin-1β (IL-1β),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α)],and occurrence of adverse reactions were compared between the two groups before and after treatment. 【Results】After treatment,both groups showed higher scores in the number of categories completed and total correct responses and lower scores in the total number of responses,perseverative errors,and total errors compared to before treatment (P<0.05). Moreover,the observation group had significantly better scores in all these measures compared to the control group (P<0.05). After treatment,both groups had lower scores in positive symptoms,negative symptoms,general psychopathology,and total PANSS scores compared to before treatment (P<0.05); And the observation group showed significantly lower scores in all these measures compared to the control group (P<0.05). After treatment,both groups had decreased levels of serum IL-1β,IL-6,and TNF-α compared to before treatment (P<0.05),while the observation group had lower levels of serum IL-6 and TNF-α compared to the control group (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】rTMS combined with amisulpride treatment in patients with schizophrenia is beneficial in suppressing IL-6 and TNF-α levels,reducing symptoms,and improving cognitive function. It has good clinical application value.
LI Juan,CAO Jing. Effects of Repetitive Transcranial Magnetic Stimulation Combined with Amisulpride Treatment on Cognitive Function and Blood Cytokine Levels in Patients with Schizophrenia[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1186-1189.
[1] 沈文婧,高威,岳静,等.小剂量氨磺必利配合奥氮平对难治性精神分裂患者睡眠及认知功能影响研究[J].中国药师,2019,22(1):102-105. [2] 邓顺顺,平军娇,杨建明.精神分裂症伴高同型半胱氨酸血症患者治疗前后尿酸与糖脂代谢变化的研究[J].检验医学与临床,2020,17(3):347-349. [3] 侯建春,程奥博,李小宁,等.氨磺必利与氯丙嗪、氟哌啶醇对首发精神分裂症患者认知功能的影响及疗效分析[J].精神医学杂志,2019,32(4):268-272. [4] KUMAR N,VISHNUBHATLA S,WADHAWAN AN,et al.A randomized,double blind,sham-controlled trial of repetitive transcranial magnetic stimulation (rTMS) in the treatment of negative symptoms in schizophrenia[J].Brain Stimul,2020,13(3):840-849. [5] 中华医学会精神病学分会. 中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188. [6] 赵虎,陈平.小剂量氨磺必利对长期住院精神分裂症患者阴性症状及认知功能影响分析[J].国际精神病学杂志,2022,49(1):28-30. [7] 张英辉,杨梅,王德燧,等.精神分裂症患者血清β2微球蛋白、神经营养因子、白细胞介素-6水平及其与临床症状的关系[J].临床精神医学杂志,2019,29(4):273-275. [8] LIMONGI R,MACKINLEY M,DEMPSTER K,et al. Frontal-striatal connectivity and positive symptoms of schizophrenia: implications for the mechanistic basis of prefrontal rTMS[J].Eur Arch Psychiatry Clin Neurosci,2021,271(1):3-15. [9] LIPPMANN B,BARMASHENKO G,FUNKE K. Effects of repetitive transcranial magnetic and deep brain stimulation on long-range synchrony of oscillatory activity in a rat model of developmental schizophrenia[J].Eur J Neurosci,2021,53(8):2848-2869. [10] WAGNER E,HONER W G,SOMMER I E,et al. Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine[J].World J Biol Psychiatry,2021,22(1):14-26. [11] GUPTA P,SAHU A,PRASAD S,et al. Memory changes following adjuvant temporo-parietal repetitive transcranial magnetic stimulation in schizophrenia[J].Indian J Psychiatry,2021,63(1):66-69. [12] 崔航涛,周志强,樊华,等.齐拉西酮联合低频重复经颅磁刺激对老年重症精神分裂症病人BNDF、IL-6、Hcy水平与认知功能障碍的影响[J].蚌埠医学院学报,2020,45(11):1521-1524. [13] 张涛,赵春龙,陈玉齐,等.奥氮平联合重复经颅磁刺激对以阴性症状为主的精神分裂症的疗效及血浆GABA和Glu水平的影响[J].海南医学,2021,32(24):3170-3172. [14] LANG X,TRIHN T H,WU H E,et al. Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia[J].Aging (Albany NY),2020,12(2):1433-1445.
2023, Vol. 40 
