医学临床研究
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JOURNAL OF CLINICAL RESEARCH  2023, Vol. 40 Issue (8): 1132-1135    DOI: 10.3969/j.issn.1671-7171.2023.08.004
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Efficacy of Bevacizumab Combined with Paclitaxel and its Effect on Patients' Immune Function in the Treatment of Advanced Breast Cancer
TAN Yue, LI Gang, LI Xue-lian, et al
Department of Oncology,Minhang Branch,Fudan University Affiliated Cancer Hospital,Shanghai 200240
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Abstract  【Objective】To investigate the efficacy of bevacizumab combined with paclitaxel in the treatment of advanced breast cancer and its effect on patients&apos; immune function. 【Methods】Eighty patients with advanced breast cancer admitted to our hospital were randomly divided into two groups,with 40 patients in each group. The observation group was treated with paclitaxel + bevacizumab,while the control group was treated with paclitaxel alone. The clinical efficacy,serum-related markers [Vascular Endothelial Growth Factor (VEGF),Basic Fibroblast Growth Factor (bF-GF)],tumor markers [Serum Carcinoembryonic Antigen (CEA),Carbohydrate Antigen 125 (CA125)],and immune function indicators (CD3+,CD4+,CD4+/CD8+) level changes and the incidence of adverse reactions in both groups were compared. 【Results】The total remission rate of the observation group was 75.00% (30/40),which was significantly higher than 50.00% (20/40) of the control group. And the difference was statistically significant (P<0.05). After treatment,the levels of VEGF,bF-GF,CEA,and CA125 in both groups decreased compared to before treatment (P<0.05),and the aforementioned indicators in the observation group were lower than those in the control group (P<0.05). After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in both groups increased compared to before treatment (P<0.05),and the levels of CD3+,CD4+,and CD4+/CD8+ in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions in both groups showed no statistical difference (P>0.05). 【Conclusion】The use of bevacizumab combined with paclitaxel chemotherapy in advanced breast cancer can improve the immune function of patients,effectively reduce tumor markers and serum-related factors,and demonstrate good clinical efficacy. The combination treatment does not increase adverse reactions,which is worthy of clinical promotion and application.
Key wordsBreast Neoplasms/DT      Antibodies,Monoclonal/TU      Taxol/TU      Treatment Outcome     
Received: 16 May 2023     
PACS:  R737.9  
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TAN Yue
LI Gang
LI Xue-lian
et al
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TAN Yue,LI Gang,LI Xue-lian, et al. Efficacy of Bevacizumab Combined with Paclitaxel and its Effect on Patients&apos; Immune Function in the Treatment of Advanced Breast Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1132-1135.
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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.08.004     OR     http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I8/1132
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