MTHFR基因C677T多态性与冠心病患者病情程度、合并症的相关性研究

doi:10.3969/j.issn.1671-7171.2023.08.022

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Abstract 【Objective】To investigate the correlation between the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and the severity and comorbidities of coronary heart disease patients. 【Methods】A total of 496 patients with coronary heart disease admitted to our hospital from January 2021 to January 2022 were selected and divided into CC group (n=139),CT group (n=211),and TT group (n=146) based on the MTHFR gene C677T polymorphism detection results. The severity of coronary heart disease,plasma homocysteine (Hcy),blood pressure,and serum total cholesterol (TC),triglyceride (TG),and glycosylated hemoglobin (HbA1c) were compared among the three groups,and the incidence of H-type hypertension,hypertension,diabetes,and hyperlipidemia in the three groups were statistically analyzed; We analyzed the correlation between MTHFR gene C677T polymorphism typing and Gensini score,Hcy,TC,TG,HbA1c. 【Results】 The differences in Hcy,SBP,DBP,TC,TG,HbA1c,and Gensini scores among the three groups of patients were statistically significant (P<0.05). The incidence rate of H-type hypertension,hypertension,diabetes and hyperlipidemia complications in the three groups were statistically significant (P<0.05). 【Conclusion】The C677T polymorphism of MTHFR gene is associated with the severity,Hcy,blood lipid and blood glucose levels of patients with coronary heart disease. Among them,patients with TT genotype coronary heart disease have a higher probability of severity,and have a higher risk of combining H-type hypertension,hypertension,diabetes and hyperlipidemia.

Key words： Coronary Disease Gene Expression Polymorphism,Genetic Patient Acuity Correlation of Data

Received: 21 July 2022

PACS:

R541.4

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	BAI Zhi-sheng
	LYU Yong-hui

Cite this article:

BAI Zhi-sheng,LYU Yong-hui. The Correlation between the C677T Polymorphism of MTHFR Gene and the Severity and Comorbidities of Coronary Heart Disease Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1197-1199.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.08.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I8/1197

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