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Quick Search     Adv Search 2017 Vol. 34, No. 5 Published: 2017-05-30 Article          Article 833 Effect of Shenkang Injection on the Clinical Efficacy and the level of Inflammatory Factors in Patients with Chronic Glomerulonephritis KONG Shu-min, SHENG Hua-ying DOI: 10.3969/j.issn.1671-7171.2017.05.001 Objective To investigate the effect of Shenkang injection on the clinical efficacy and the level of inflammatory factors in patients with chronic glomerulonephritis treatment. Methods Eighty-four cases of patients with chronic nephritis were random divided into two groups, 42 cases in each. The control group was treated with valsartan. On the basis of the control group, the observation group was treated with Shenkang injection. After three months of treatment, the clinical curative effect and TCM symptom integral, inflammatory factors and renal function were compared between the two groups. Results After 3 months of treatment, the total effective rate of the observation group was 83.33%(35/42), which was significantly higher than that of the control group 61.90%(26/42) (P<0.05); The 24hUPr,β2-MG ,TNF-α, IL-6 and IL-8 in the observation group were significantly lower than those in the control group (P<0.05);The TCM symptom score of the observation group was significantly lower than that of the control group and there was significant difference between the two groups (P<0.05). Conclusion Shenkang injection can improve the clinical curative effect of chronic nephritis patients, improve renal function and clinical symptoms, reduce inflammation with less adverse reactions, it is worthy of attention. 2017 Vol. 34 (5): 833-835 [Abstract] ( 124 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 836 Clinical study on the Expression of Inflammatory Factors and Classification of Thoracic Trauma Severity Score in Patients with Chest Trauma WU Yi-bin, LI Yi-ren, YANG Yi,et al DOI: 10.3969/j.issn.1671-7171.2017.05.002 Objective To study the relationship between the expression of inflammatory factors (like TNF-α) and classification of thoracic trauma severity score (TTS) in patients with thoracic trauma, and to investigate its role in the early prediction and assessment of clinical prognosis of patients. Method Sixty-four cases of hospitalized chest trauma patients in Department of Thoracic Surgery of our hospital from January 2014 to January 2016 were selected for the study. According to the thoracic trauma severity score (TTS score, total score 5~25 points), patients were classified as group A (35 severe cases with 16~25 points) and group B (29 mild cases with 5~15 points ). At the same time period, 40 cases of healthy volunteers were selected as the control group (group C). Collection of venous blood in group A and B were harvested on the onset of the first day, third day, and seventh day, and blood samples were collected in the control group as well at the same times. The inflammatory factors Hs-CRP and TNF-αwere detected and arterial blood characteristics including pH,PaCO2,PaO2 and SaO2 concentrations in blood gas were monitored in all three groups.The ELISA method was used to detect the dynamic changes of TNF- alpha index. Statistical software SAS9.3 was applied for data processing. Results The levels of hs-CRP and TNF-αin group A and group B showed a dynamic increasing within 24~72 hours after injury. The changes in group A were dramatically higher than those in group B. Three single factors were found by the statistical analysis including TTS scores, the serum TNF- level within 24 hours of onset and serum TNF- levels on the third day. They had significant predictive value in thoracic trauma patients who suffered multiple organ dysfunction syndrome (MODS).TTS scores combined with serum TNF-αlevels at 72 h showed the highest predictive value for thoracic trauma patients with MODS(AUC=0.9089). Indicators of pH, PaCO2, PaO2 and SaO2 in group A and B were significantly different from the control group C, there were also significant differences between group A and B in terms of PaCO2, PaO2 and SaO2 (P<0.05). Conclusion The severity of chest trauma can be evaluated by the TTS scores. The prediction value of thoracic trauma patients with MODS occurring can be improved significantly by the analysis of TTS scores combined with serum TNF-α levels. 2017 Vol. 34 (5): 836-839 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 840 Clinical Diagnostic Value of Focussed Assessment Sonograph in Emergency Abdominal Closed Trauma HOU Ren-fang, LI He-li, HUANG Li DOI: 10.3969/j.issn.1671-7171.2017.05.003 Objective To investigate the clinical diagnosis of emergency abdominal closed trauma measured by focussed assessment sonograph trauma (FAST). Methods The clinical data of 200 patients with abdominal closed trauma were selected from June 2015 to August 2016. All patients had FAST first, then went to the CT room for abdominal CT examination after vital signs were stable. The diagnostic results and the detection rate of the two methods (FAST and CT) were compared. Results The detection rate of FAST test for liver rupture, renal injury,s plenic rupture, peritoneal, and hemorrhage was 86.49%, 88.24%, 85.92% and 73.91%, respectively.the detection rate of FAST + CT was 97.30%, 97.10% and 97.10%, and 95.65%, respectively. Renal injury and peritoneal hemorrhage diagnostic rates between FAST and FAST+CT were statistically significant (P<0.05). FAST exam time period (4.12±0.85)min was significantly shorter than that of CT (26.13 ± 1.27) min; the difference was statistically significant (P<0.05). The positive detection rate of FAST examination for abdominal injury was 85.00% (170 /200,P<0.05) and the missed rate was 0%. The positive detection rate of FAST+CT was 96.00% (192/200) and the rate of missed diagnosis was 0%. The difference between the two methods was statistically significant(χ2=14.0739,P=0.0002＜0.05). Conclusion FAST ultrasound examination as a common inspection equipment has advantage of having a simple procedure, being easy to use, and able to complete the diagnosis in a shorter time with a high detection rate for emergency abdominal closed trauma. In combination with CT examination, it can further improve the diagnosis with higher clinical application value. 2017 Vol. 34 (5): 840-843 [Abstract] ( 104 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 843 Effect of Fetal Electrocardiogram Combined with Echocardiography for the Improvemet of the Diagnostic Accuracy of Pre Fetal Contractions YAN Xue-mei, LIU Zhi-yu, YAN Zhi-qiong, et al DOI: 10.3969/j.issn.1671-7171.2017.05.004 Objective To study the effect of fetal electrocardiogram combined with echocardiography for the improvemet of the diagnostic accuracy of pre fetal contractions. Methods Those prenatally diagnozed as Pre fetal contraction by fetal electrocardiogram (FECG) and fetal echocardiography (FUCG) were selected as the research subjects. the consistency of the two detection methods and their sensitivity and specificity for the diagnosis of pre fetal contractions were evaluated. Results FECG findings showed that pre systole accounted for 36.8% of fetal arrhythmias, and FUCG showed premature contraction accounted for 35.5% of fetal arrhythmias, and the consistency of the two methods was 0.972; The sensitivity and specificity of FECG combined with FUCG in the diagnosis of supraventricular premature contractions were 95.95% and 89.17% respectively, The sensitivity and specificity of ventricular premature contraction were 93.55% and 96.50%, respectively. Conclusion There was good agreement between FECG and FUCG in determining pre fetal contractions; To judge the nature of pre contraction, FECG combined with FUCG test can make up for their deficiency so as to improve the accuracy of fetal pre systolic judgment. 2017 Vol. 34 (5): 843-845 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 846 Effect of Bone Cement Diffusion in Osteoporotic Vertebral Fracture Line on Percutaneous Vertebroplasty WU Jin-wei, ZOU Wei-min, LV Hai DOI: 10.3969/j.issn.1671-7171.2017.05.005 Objective To investigate the effect of bone cement diffusion in osteoporotic vertebral fractures line on percutaneous vertebroplasty (PVP). Methods Fifty-two patients with osteoporotic vertebral compression fractures (OVCF) from September 2014 to March 2016 in our hospital were recruited in the research. All patients underwent PVP treatment. According to multiplanar reconstruction CT or MRI evaluation, 39 cases were considered good dispersion of bone cement (good dispersion group)and 13 cases were considered poor dispersion of bone cement ( poor dispersion group).Visual analogue scale (VAS) score, Oswestry disability index (ODI) and local kyphosis Cobb angle were measured in the two groups. Results Bone mineral density of the good dispersion group was (-3.20±1.13) T, which was significantly lower than that of the poor dispersion group (P<0.05). The VAS and ODI scores on d4 post-operation in the good dispersion group were (2.60±0.55) points and (12.82±1.41) points, respectively, which were significantly lower than those in the poor dispersion group (P<0.05).There were no significant differences between the two groups in terms of VAS score and ODI score preoperatively and at the final follow-up after surgery (P>0.05).In the good dispersion group, local kyphosis Cobb angle on d4 post-operative and the final follow-up were (6.30±2.11)° and(6.51±1.84)° , respectively, which were significantly lower than those in the poor dispersion group (P<0.05). Refracture incidence rates in the good dispersion and poor dispersion group were 5.13% and 7.69%,respectively; the difference was not statistically significant (P>0.05); Vertebral collapse incidence rates in the good dispersion group was 10.26%, which was significantly lower than that in the poor dispersion group (38.46%); the difference was statistically significant (P<0.05). Conclusion PVP can improve the function of patients with osteoporotic vertebral compression fractures. Poor dispersion of bone cement in the fracture line will affect the short-term efficacy, which may lead to postoperative kyphosis deformity. 2017 Vol. 34 (5): 846-849 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 850 Expression of Soluble Advanced Glycosylatio End Product Receptor and its Significance in Patents with Polycystic Ovary Syndrome LIU Li-li DOI: 10.3969/j.issn.1671-7171.2017.05.006 Objective To investigate the expression of solube receptor for advanced glycation end products (sRAGE) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods From January 2015 to April 2016, 80 patients with PCOS were enrolled in the reproductive center of our hospital. PCOS patients were divided into four groups according to whether or not accompanied by hyperandrogenism / insulin resistance (IR). Group A: PCOS+ without NHA + without high insulin resistance (NIR); Group B: PCOS+IR; Group C: PCOS+HA; Group D: PCOS+HA+IR, 20 cases in each group. 20 healthy women were selected as the normal control group (group E). The levels of luteinizing hormone (LH), testosterone (T) and fasting insulin (FINS) were detected by electrochemiluminescence assay, Fasting serum glucose (fasting, blood, glucose, FBG) and ELISA were used to detect serum sRAGE levels by sugar kinase method; the degree of IR was evaluated by HOMA-IR. The correlation between sRAGE and indexes was analyzed. Results sRAGE value from high to the bottom were group E, group A, group C, group B, group D (P<0.05), the difference between the two groups was statistically significant (P<0.05); sRAGE was negatively related to LH, T, FBG, FINS and HOME-IR. Conclusion sRAGE can combine with the ligand of RAGE competitively , weaken the pathological role caused, has potential protective effect in PCOS. 2017 Vol. 34 (5): 850-853,856 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 853 Short-Term Effects of Ticagrelor and Clopidogrel on Inflammatory Factor Levels of Diabetic Patients Complicated with non-ST-elevation Acute Coronary Syndromes after Early Percutaneous Coronary Intervention YOU San-li, WANG Zhao DOI: 10.3969/j.issn.1671-7171.2017.05.007 Objective To observe the short-term effects of ticagrelor and clopidogrel on the Inflammatory factor levels of diabetic patients complicated with non-ST-elevation acute coronary syndromes (NSTE-ACS) after early percutaneous coronary intervention (PCI). Methods A total of 117 cases of type II diabetic mellitus patients (T2DM) with NSTE-ACS who were hospitalized and underwent early PCI in Hunan Province's Neuro Hospital from September 2015 to February 2017 were incorporated into our study. According to the prescription of antiplatelet drug administration, the patients were divided into two groups: clopidogrel group(n=72)and ticagrelor group(n=45). Patients in the two groups were given conventional treatment with 300mg of aspirin before PCI followed by 100mg each day after PCI. In addition, clopidogrel group was given 300mgclopidogrel before PCI followed by 75mg per day administered once a day.The ticagrelor group was given 180mg ticagrelor before PCI followed by 90mg per day administered twice a day. The levels of high sensitive C reactive protein(hs-CRP), interleukin-6(IL-6),interleukin-1β ( IL-1β),and soluble CD40 ligand ( sCD40L) were detected before operationand 6h,24h,3d,7d post operation. Results The levels of hs-CRP,IL-6,IL-1β,and sCD40L in the two groups were not significantly different before PCI operation(P>0.05); 6h post operation ,the levels of hs-CRP, IL-6, IL-1β , and sCD40L were higher than those before operation in both groups(P<0.05).More importantly, the level changes in the ticagrelor group were lower than those in the clopidogrel group(P<0.05). Postoperative 6h,24h,3d, and 7d ,the levels of hs-CRP,IL-6,IL-1β,and sCD40L decreased(P<0.05); the decreases in the ticagrelor group were lower than those in the clopidogrel group(P<0.05). Conclusion Both ticagrelor or clopidogrel can effectively inhibit early inflammatory response of diabetic patients complicated with non-ST-elevation acute coronary syndromes after PCI.It is important to note that ticagrelor exhibits better inhibitive effects than clopidogrel. 2017 Vol. 34 (5): 853-856 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 857 Prognostic Value of Interleukin-18 with NIHSS and mRS Scores in Patients with Acute Cerebral Infarction ZHAO Yan, CHEN Xiang-dong, ZHANG Yan-mei,et al DOI: 10.3969/j.issn.1671-7171.2017.05.008 Objective To investigate the prognostic value of serum interleukin-18 with NIHSS (National Institutes of Health Stroke Scale) and mRS (modified Rankin scale) in patients with actual cerebral infarction (ACI). Methods A total of 100 cases of ACI patients from August 2013 to December 2014 in our hospital were chosen as the subjects of the study.All were diagnosed as ACI by head CT or MRI based on the guidelines of China Ischemic Stroke Treatmentin 2010. According to the score of NIHSS, patients were divided into mild group(NIHSS score<7), moderately severe group (NIHSS score 7～15) and severe group (NIHSS scor >15).At same time period, sixty healthy volunteers were collected as control.Serum interleukin-18 levels were measured within 24hamong all patients in ACI and control group. The relevance and relationship between serum interleukin-18 levels and Alberta CT (ASPECT) scores plus NIHSS scores were analyzed. All patients were followed up on the day of 90 and 180; neurological impairment was assessed by mRS score; the correlation between plasma interleukin-18 levels and prognosis were analyzed. Results Patients'serum interleukin-18 levels 24h after hospitalization were significantly higher than that in the healthy control group (P<0.05). The interleukin-18 levels were (526.36±26.82)ng/L,(439.24±26.45)ng/L,and (385±34.26)ng/L,respectively, in severe group, moderate severe group and mild group. The differences among the three groups were statistically significant (P<0.05). Interleukin-18 level in the poor prognosis group was significantly higher than the good prognosis group(P<0.05). Serum interleukin-18 levels were positively correlated betweenwith ASPECT scores and NIHSS scores. Univariate Logistic regression analysis showed that the age, ASPECT score, NIHSS score, and interleukin-18 levels were prognostic factors of ACI patients (P<0.05). Area under the receiver's work curve (ROC) analysis showed that the predictive value of serum interleukin-18 was no significant difference with NIHSS score and ASPECT score in predicting outcomes of ACIpatients . Conclusion Plasma interleukin-18 levels were significantly elevated in patients with acute ACI; there is a significant positive correlation between serum interleukin-18 levels within 24 hours with neurologic impairment severity and prognosis in ACI patients. Serum interleukin-18 levels has great value in assessing the severity and prognosis in patients with ACI. 2017 Vol. 34 (5): 857-860 [Abstract] ( 85 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 860 Application of Neoadjuvant Chemotherapy in Sequential Treatment of Stage Ⅲ Esophageal Cancer ZHANG Li, ZHANG Jing, WANG Yuan,et al DOI: 10.3969/j.issn.1671-7171.2017.05.009 Objective To investigate the application value of neoadjuvant chemotherapy in sequential treatment of stage Ⅲ esophageal cancer. Methods One hundred patients with stage Ⅲ esophageal cancer were divided into radical radiotherapy group (control group,n=42) and the neoadjuvant sequential chemotherapy group (observation group) according to the treatment methods. The tumor control, treatment effect, safety and quality of life were compared between the two groups. Results The overall remission rate, tumor control rate followed up for 1~3 years, and follow-up survival rate of the observation group were not significantly different compared with those of the control group (P>0.05);Ⅰ~Ⅳ gastrointestinal reaction and the incidence of radiation esophagitis atⅠ~Ⅱgrade of the observation group were lower than those of the control group (P<0.05); There was no significant difference in quality of life between the two groups before treatment (P>0.05). The quality of life scores of the two groups were increased at different times (P<0.05), the quality of life scores of 1~2 year - followed-up were higher than those in the control group (P<0.05). Conclusion The efficacy of neoadjuvant chemotherapy sequential treatment and concurrent radiotherapy /chemotherapy is similar in the treatment of patients with esophageal cancer , but neoadjuvant sequential chemoradiotherapy regimen is safe and can improve the long-term quality of life. 2017 Vol. 34 (5): 860-862 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 863 Clinical Value of Noninvasive Intracranial Pressure Monitoring in the Treatment of Traumatic Acute Diffuse Brain Swelling LIU Yu, XIAO Can, SHI Lei,et al DOI: 10.3969/j.issn.1671-7171.2017.05.010 Objective To investigate the clinical value of noninvasive intracranial pressure monitoring in the treatment of posttraumatic acute diffuse brain swelling (PADBS) and to evaluate its significance to the prognosis. Methods A retrospective analysis of the clinical data of 69 patients with PADBS treated by neurosurgery from January 2009 to December 2014 in the 163 Hospital of People's Liberation Army was performed. All patients were in ICU ward within 2~24 hours after injury and were monitored by noninvasive intracranial pressure monitor (MICP-1A, flash visual evoked potential noninvasive intracranial pressure detection analyzer). Patients were divided into mild, moderate, and severe intracranial hypertension according to the value of noninvasive intracranial pressure monitoring and were treated accordingly based on their symptoms and brain CT examination. The Glasgow prognosis scores were evaluated for patients' prognosis among different types of PADBS. Results The overall accurate prognosis rate was 43.5% (30/69) and poor prognosis rate was 56.5% (39/69). The mortality rate was 31.8% (22/69). The accurate prognosis rates of mild, moderate, and severe intracranial hypertension patients were 90.1% (10 / 11), 65.22% (15/23), and 14.29% (5/35), respectively. The accurate prognosis of patients with mild intracranial hypertension was significantly higher than that of moderate and severe intracranial hypertension. The difference was statistically significant (P<0.05). The proportion of death in patients with severe intracranial hypertension was significantly higher than that in patients with mild to moderate intracranial hypertension; the difference was statistically significant (P<0.05). Conclusion The value of noninvasive intracranial pressure monitor was closely related to the prognosis of PADBS patients. Continuous monitoring can provide an important indicator for the treatment of posttraumatic acute diffuse brain swelling. 2017 Vol. 34 (5): 863-865 [Abstract] ( 43 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 866 Comparison of the Selective Lumbar Plexus Combined with Sciatic Nerve Block and Lumbar Plexus Combined with the First Posterior Sacral Foramen Block in Hip Replacement for the Elderly JI Miao DOI: 10.3969/j.issn.1671-7171.2017.05.011 Objective To compare the application of selective lumbar plexus combined with sciatic nerve block and lumbar plexus combined with the first posterior sacral foramen block in hip replacement for the elderly. Methods Sixty elderly patients who needed to be treated with hip replacement were divided into Group A (lumbar plexus and sciatic nerve block) and B group (lumbar plexus combined with the first posterior sacral foramen block) according to different anesthesia methods, 30 cases in each group. The hemodynamic changes, the success rate of block, anesthetic effect and adverse reactions in the two groups were recorded. Results There was no significant difference in HR, SBP and DBP in the Group A at different time points (P>0.05). In the Group B, 10 min ,20 min after the start of operation, the SBP decreased compared with the previous block, and the difference was significant (P<0.05); There were no significant differences in HR and DBP at each time point (P>0.05). 30 min after injection, skin needling sensation block success rate in the lumbosacral plexus nerve skin area of the Group A was 98%~100%, and that of the Group B was 92%~100%. The excellent rate of anesthesia in the Group A was 100%, higher than that in the Group B, but there was no significant difference between the two groups (P>0.05) (93.3%). No local anesthetic poisoning occurred in the two groups. Conclusion Compared with the first posterior sacral foramen block, HR, SBP and DBP of patients receiving lumbar plexus and sciatic nerve block are relatively stable, the success rates of different block levels are higher with better anesthetic effect. It is a better choice for hip replacement. 2017 Vol. 34 (5): 866-868 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 869 Study on Efficacy of Methionine and Vitamin B1 in the treatment of Liver Cirrhosis ZHANG Xue-qin,WANG Qian DOI: 10.3969/j.issn.1671-7171.2017.05.012 Objective To study on the efficiency of methionine and vitaminB1 in the treatment of hepatic cirrhosis and their effects on liver function, symptoms and complications . Methods From March 2013 to March 2016, there were 80 patients with hepatocirrhosis treated in our hospital. Their clinical data were analyzed retrospectively. Among them, 38 patients were treated by the traditional method (the control group). On the basis of traditional method, 42 patients received Methionine and VitaminB1 treatment (the experimental group). The effects of these treatments were observed and compared between the two groups. Results (1) Before treatment, there were no significant differences in liver function (i.e. TBIL, ALT, CHE, FN) and serum liver fibrosis (HA、PCⅢ、LN、cⅣ) between the experimental and controls (P<0.05). After treatment, the indicators stated above in the experimental group were significantly lower than those in the control group (P<0.05); (2) The total effective rate of the experimental group was higher than that of the control group (85.71% VS 71.05%) (P<0.05); (3) The incidence of complications (liver and kidney syndrome, hepatic encephalopathy, spontaneous bacterial peritonitis) in the experimental group was significantly lower than that in the control group (9.52% VS 26.32%) (P<0.05). Conclusion Methionine and VitaminB1 can significantly improve the liver function and symptoms. The treatment is safe and effective. Therefore, this method is worthy of further promotion and use in clinic. 2017 Vol. 34 (5): 869-871 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 872 Effect of Preemptive Analgesia Management on Perioperative Immune Function and Prognosis of Patients with Non-Small Cell Lung Cancer LIU Gao-qiong, WU Dan, TAO Hong, et al DOI: 10.3969/j.issn.1671-7171.2017.05.013 Objective To explore effect of preemptive analgesia management on perioperative immune function and prognosis of patients with non-small cell lung cancer. Methods All patients were divided into experimental group (n=58) and control group (n=57) according to the principle of randomized, double-blinded assignment of 115 cases of non-small cell lung cancer admitted in our hospital from January 2015 to July 2016. Preemptive analgesia was used in the experimental group and conventional analgesia was used in the control group. Our goal was to observe the effect of different analgesia management on perioperative immune function and prognosis. Results The visual simulation scores (VAS) of the two groups were observed 6h, 1d, 3d after operation. The score of the experimental group was significantly lower than that of the control group (P<0.05). There was no significant difference in CD4+ and CD8+ levels between the two groups before operation (P>0.05). The levels of CD4+ and CD8+ in the two groups after surgery were significantly lower than those before operation, but the CD4+ and CD8+ levels in the experimental group were still higher than those in the control group, and the difference was statistically significant (P<0.05). The first time that patient got out the bed for activities in the experimental group was (2.72 ± 0.92) d,and the rate of lung infection, atelectasis, pleural effusion were 3.45 %, 0.00 %, 0.00 %, respectively, all significantly less than the control group (P<0.05). Conclusion Preemptive analgesia management can more effectively reduce the perioperative pain in patients with non-small cell lung cancer, protect the immune function, and improve the prognosis of postoperative effect. It is worth promoting. 2017 Vol. 34 (5): 872-875,878 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 875 Effect of Laparoscopic Ovarian Cyst Removal on Ovarian Reserve Function in Female Patients FU Jie, CHEN Hui-juan, LUAN Ying, et al DOI: 10.3969/j.issn.1671-7171.2017.05.014 Objective To investigate the effect of laparoscopic ovarian cystectomy on ovarian reserve function in women with endometriosis. Methods Eighty-four patients with endometriosis cysts who were admitted to the obstetrics and gynecology department in our hospital between from April 2013 and to March 2015 were selected as the study subjects and were randomized into the observation group (n=42) and the control group (n=42) according to the order of admission. The control group was treated with laparoscopic open reduction of cyst, and the observation group was treated with laparoscopic ovarian cyst removal. All patients were treated with gonadotropin releasing hormone (GnRH-a) after operation. The changes of ovarian function indexes such as serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estrogen (E2) levels, basic number of follicles and ovarian volume in the two groups were recorded before operation and at 6 months after operation. The status of fertility, including the rate of successful re-pregnancy and recurrence rate in 1 year after operation and menstruation were compared between the two groups. Results At six months after operation, levels of LH and E2 were significantly lower than those before operation, and the levels LH and E2 in observation group were significantly lower than those in control group (P<0.05). There were no significant changes of FSH at 6 months after operation (P>0.05); The basic number of follicles and aveareg ovarian volume were significantly lower than those before operation (P<0.05). There was no significant difference in menstrual period and menstrual cycle between the two groups before operation and at 1 year after operation (P>0.05). The pregnancy rate of observation group in 1 year after operation was significantly higher than that of control group while the recurrence rate was significantly lower than that in the control group (P<0.05). Conclusion The ovarian reserve function is affected in a short time after laparoscopic ovarian cystectomy, Compared with traditional laparotomy, laparoscopic ovarian cystectomy still has obvious advantages in terms of pregnancy rate, postoperative recovery and recurrence rate. 2017 Vol. 34 (5): 875-878 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 879 Correlation between Fractional Exhaled Nitric oxide (FeNO) and Blood Eos, Eos%, Serum TIgE in Patients with Bronchial Asthma LIU Nian, LUO Hong, LIU Zhi-guang DOI: 10.3969/j.issn.1671-7171.2017.05.017 Objective To explore the correlation between fractional exhaled nitric oxide (FeNO) , blood eosinophilic granulocyte (Eos)and Eos% with serum total immunoglobulin E (TIgE) in patients with bronchial asthma. Methods Eighty bronchial asthma patients hospitalized in our hospital from October, 2014 to September,2015 were selected as the observation group; meanwhile, 80 check-up volunteers in the above-mentioned hospital were selected randomly as the control group. Exhaled FeNO, blood Eos, Eos% and TIgE levels were compared between the two groups to analyze the correlation between FeNO levels and other indicators. Results The level of FeNO in the observation group (51.48±13.09) was significantly higher than that of the control group(11.29±4.37)ppb, while the score of ACT in the observation group (15.39±3.21) was significantly lower than that of the control group(23.64±4.29), with statistically significant differences between the two groups( P<0.05). The levels of Eos, Eos% and TIgE in the observation group were (264.28±32.19)×106/L,(6.39±1.21)% and(134.38±19.73)kU/L respectively, which were all significantly higher than those of the control group [(67.49±9.74) ×106/L、(1.21±0.59)%、(92.10±11.49)kU/L](P＜0.05). Regression analysis showed that the level of FeNO did not correlated with the level of TIgE (P>0.05), and positively correlated with Eos count and Eos% level (P<0.05). Conclusions As a noninvasive examination, the test results FeNO detection can directly reflect the situation of chronic airway inflammation of allergic asthma patients, especially in the inflammatory response of Eos, and it is also conducive to accurately evaluate the severity of allergic asthma. Therefore, it is worthy of clinical application. 2017 Vol. 34 (5): 879-882,885 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 882 Rosiglitazone's Protective Effects on Multiple Organ Dysfunction Syndrome Induced by Double-Hit in Rabbits GU Chang-wei, QIAO Wan-hai, LIU Zhong DOI: 10.3969/j.issn.1671-7171.2017.05.016 Objective To investigate the PPAR-γ,NF-κB,TNF-α, IL-10 expression,blood gas and the biochemical changes in double-hit rabbit animal model of multiple organ dysfunction syndrome (MODS). The effects of rosiglitazone and GW9662 were evaluated. Methods In this study, we prepared double-hit MODS rabbit model through fluid resuscitation after hemorrhagic shock and LPS stimulation. We used PPAR-γ agonist rosiglitazone and PPAR-γ antagonist GW9662 to regulate the expression of PPAR-γ. We detected the expression of PPAR-γ, NF-κB, TNF-α, and IL-10 in liver 24 hour after the double-hit MODS model was established. Biochemical and blood gas analysis at the same time were detected as well. Results The expressions of PPARγ mRNA in T-H group and D-H-S group were significant lower than that in sham group (P<0.05). In the D-H group, the expression of PPARγ mRNA with rosiglitazone application was higher than that in control group (P<0.05) whilethe expression of PPARγ mRNA with GW9662 application was significant lower than that in rosiglitazone-treated group(P<0.05). In the T-H group, the expressions of NF-κB and TNF-α increased significantly (P<0.05).However, the expressions of IL-10 in the T-H group did not change significantly as compared to sham group (P>0.05). In D-H-S group, the expressions of NF-κB and TNF-α increased significantly as compared to T-H group (P<0.05). The expressions of IL-10 in D-H-S group increased significantly as compared to sham group (P<0.05), but it did not change significantly compared to T-H group (P>0.05). In D-H -R group, the expressions of NF-κB and TNF-α decreased significantly compared with D-H-S group (P<0.05). The expressions of IL-10 increased significantly compared with D-H-S group (P<0.05). In D-H-G group, the expressions of NF-κB and TNF-α increased significantly compared with D-H-R group (P<0.05). The expressions of IL-10 decreased significantly compared with D-H-R group (P<0.05). In the T-H group, blood gas and biochemical parameters did not change significantly compared with sham group. In the D-H-S group, blood gas and biochemical parameters increased significantly compared with sham group and T-H group (P<0.05). In the D-H-R group, blood gas and biochemical parameters ameliorated significantly compared with D-H-S group (P<0.05). In the D-H-G group, blood gas and biochemical parameters deteriorated significantly compared with D-H-R group (P<0.05). Conclusion As the agonist of PPAR-γ, Rosiglitazone could improve the organ function in MODS rabbit induced by double-hit. 2017 Vol. 34 (5): 882-885 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 886 Effects of Stage Health Education on Negative Emotions, Pain and Delivery Modes of Primipara ZHAO Bao-yu DOI: 10.3969/j.issn.1671-7171.2017.05.017 Objective To explore the effect of stage health education on negative emotion, pain and mode of delivery in primipara. Methods A total of 128 cases of pregnant women from January 2015 to December 2015 were divided into the observation group (n=64) and the control group (n=64) by the stratified sampling method. The control group were treated with routine nursing. The observation group were applied with intervention of the stage health education during in perinatal period. The negative emotion of the two groups were used with self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before and after the intervention. The pain, labor, and outcome of the two groups were recorded. Results The SAS and SDS scores of the observation group were lower than those of the control group (P<0.05). The pain score in the observation group was lower than that in the control group (P<0.05). The time of the first stage of labor and the time of the second stage of labor were shorter than those of the control group (P<0.05). The incidence of postpartum hemorrhage, cesarean section and puerperal depression in the observation group were lower than those in the control group (P<0.05), while the breastfeeding rate and maternal satisfaction rate within the 42 days after labor were higher than those in the control group (P<0.05). Conclusion Stage health education can effectively improve the anxiety and depression of primiparas, shorten maternal labor, relieve childbirth pain, reduce the incidence of maternal cesarean section and postpartum depression and improve maternal breastfeeding rate and satisfaction rate. 2017 Vol. 34 (5): 886-888 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 889 Correlation Between PTPN22 Gene Polymorphism and Susceptibility of Idiopathic Thrombocytopenic Purpura in Children LI Fang-fang, LI Tian-yu, XU Da-ming,et al DOI: 10.3969/j.issn.1671-7171.2017.05.018 Objective To analyze the correlation between non-receptor protein tyrosine phosphatase 22 (PTPN22) gene polymorphism and the susceptibility of idiopathic thrombocytopenic purpura (ITP) in children. Methods Gene polymorphism of PTPN22-1123G>C (rs2488457) in 120 children with ITP (the observation group) and 80 normal children (the control group) was determined by PCR-MALDI-TOF MS method. Results The C frequency of PTPN22-1123G > C allele in the observation group was 62.50% ,which was significantly lower than that in the control group (71.25%) (P<0.05), while there were no significant differences in genotypes between the two groups (P>0.05). The allele frequency showed significant differences in boys in the two groups (P<0.05), while there were no significant differences in girls (P>0.05). There were no significant differences in genotypes in children with the same gender (P>0.05). Conclusion The PTPN22-1123G>C polymorphism is associated with susceptibility of ITP in children. C is the dominant allele while G is the risk allele. The allele frequencies of PTPN22-1123G > C may be related to the gender of children. 2017 Vol. 34 (5): 889-892 [Abstract] ( 45 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 892 Correlation between the Expression of PVT1 and Her-2 Genes and Clinical Pathology in Patients with Advanced Gastric Cancer XU Li DOI: 10.3969/j.issn.1671-7171.2017.05.019 Objective To investigate the correlation between the expression of human plasmacytoma transformation and migration gene 1 (PVT1) and human epidermal growth factor receptor -2 (Her-2) and clinical pathology in patients with advanced gastric cancer. Methods Eighty cases of advanced gastric cancer diagnosed by pathology and the expression level of PVT1 and Her-2 in normal tissues adjacent to cancer were detected by immunohistochemical staining. Results The high expression rate of PVT1 and the positive expression rate of Her-2 in gastric cancer tissues were significantly higher than those in the adjacent tissues (P<0.05). The high expression rate of PVT1 and positive rate of Her-2 in patients with signet ring cells (81.25%, 75.00%) were significantly higher than those in patients with papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma (P<0.05). Spearman correlation analysis showed that high expression of PVT1 and positive expression of Her-2 were positively correlated with TNM stage of gastric cancer and lymph node metastasis(P＜0.05), and negatively correlated with the degree of cell differentiation , but there was no correlation with gender and age (P>0.05). Conclusion The expression levels of PVT1 and Her-2 in patients with advanced gastric cancer are significantly correlated with TNM stage of gastric cancer, lymph node metastasis, cell differentiation and clinical pathology. 2017 Vol. 34 (5): 892-894 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 895 Evaluation of the Risk of Foot Ulcers in Diabetic Patients by Vibration Perception Threshold LIN Zhan DOI: 10.3969/j.issn.1671-7171.2017.05.020 Objective To study the risk of diabetic foot ulcers (DFU) in diabetes using vibration perception threshold (VPT). Methods Sixty cases of diabetic patients without diabetic foot ulcers in our hospital from April 2014 to March 2015 were collected. All patients were given vibration sense threshold detection. According to the value of vibration perception thresholds that patients felt, patients were divided into the normal group (VPT≤10) and the higher vibration perception thresholds group (VPT>10). Patients' age, course of disease, triglyceride (TG), total cholesterol (TC), glycosylated hemoglobin(HbA1c), fasting blood glucose (FBG), and body mass index (MBI) were measured and compared between the two groups. Results In those 60 cases of diabetic patients, 30 patients had VPT≤10 (the control group) and 30 patients had higher vibration sense (the observation group). Out of 30 cases with VPT>10, 6 cases were low risk (VPT 11~15 V), 16 cases were moderate risk (VPT 16~25 V), and 8 cases were high risk (VPT ≥26 V).Patients'age(64.87±3.29 year), course of disease (7.84±1.21year), and fasting blood glucose(9.61±0.71mmol/L) of the observation group were significantly higher than those of the control group(60.43±3.21)year,(4.22±0.76)year, and (8.52±0.62)mmol/L, respectively (P<0.05). There were no significant difference in triglyceride, total cholesterol, glycosylated hemoglobin, and body mass index in the two groups (P>0.05). The risk of diabetic foot ulcers was greater in patients with age≥62 year and course ≥5year. Conclusion Based on the vibration perception thresholds detection, diabetic peripheral neuropathy can be found earlier, the risk of diabetic foot ulcers in patients with diabetes should be objective evaluation as soon as possible. 2017 Vol. 34 (5): 895-898 [Abstract] ( 98 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 898 Value of Serum Procalcitonin, Lactic Acid and Brain Natriuretic Peptide in the Diagnosis and Prognosis of Elderly Patients with Community-acquired Pneumonia ZHAUG Zhi, ZHU Can-hong, LI Rong, et al DOI: 10.3969/j.issn.1671-7171.2017.05.021 Objective To evaluate the value of serum procalcitonin (PCT), lactic acid (LA) and brain natriuretic peptide (BNP) in the diagnosis and prognosis of community-acquired pneumonia. Methods From May 2015 to July 2016, 82 elderly patients with community-acquired pneumonia were enrolled in this study as the pneumonia group. Eighty healthy volunteers were selected as the control group. Serum levels of procalcitonin, lactate and BNP were measured in two groups. Results The levels of plasma procalcitonin (0.99 ± 0.42) μg/L, lactic acid (3.90±1.09) mmol/L and BNP (159.26±19.80) pg/ml in pneumonia group were significantly higher than those in control group, (0.17±0.31) μg/L , (0.92±0.33) mmol/L and (50.01 ±13.40) pg/ml, respectively. There were significant differences between the two groups (P<0.05). Of the 82 patients with pneumonia, 10 (12.20%) died. The levels of procalcitonin (1.85±0.47) μg / L, lactate (6.20±1.21) mmol/L and BNP (278.78±25.80) pg/mL in the death group were significantly higher than those in the survivors group, (0.87±0.39) (3.58±0.98) mmol/L and (142.66±17.46) pg/ml, respectively. The difference was significant (P<0.05). ROC analysis showed that the sensitivity and specificity of the detection order was: calcitonin>lactate> BNP. Combination of calcitonin,lactate,and BNP was higher than single index (P<0.05). Conclusion The levels of serum procalcitonin, lactate and BNP are closely related to the development and prognosis of community-acquired pneumonia in elderly patients. Combined use of these three indexes can further improve the application value. 2017 Vol. 34 (5): 898-900 [Abstract] ( 47 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 901 Study on the Relationship the Expression of Interleukin and Tumor Necrosis Factor with Irritable Bowel Syndrome ZENG Ming-xi, KANG Chang-ming, CHEN Xiao-hong,et al DOI: 10.3969/j.issn.1671-7171.2017.05.022 Objective To investigate the changes of serum interleukin-1β(IL-1β)、IL-10、IL-18 and tumor necrosis factor alpha (TNF-) expression in patients with irritable bowel syndrome (IBS) and their roles in the pathogenesis of IBS. Methods Seventy-two patients with IBS were divided into diarrhea type group IBS (group A) and constipation type IBS group (B group) according to the symptom type. The levels of cytokines IL-1β, IL-10, IL-18 and TNF-αin serum were detected by ELISA. Results The expression of IL-1β、IL-10、IL-18 and TNF-αin serum of the Group A and the Group B was significantly higher than those of the control group, and the difference was significant (P<0.05). The level of TNF-αin the Group A was higher than that in the Group B, and the difference was significant (P<0.05). There was no significant difference in the expression of IL-1β, IL-10, IL-18 in serum between the two groups (P>0.05). Conclusion The imbalance between proinflammatory cytokines and anti-inflammatory cytokines may be related to the clinical symptoms such as diarrhea, abdominal distension, and changes in bowel habits in IBS patients. 2017 Vol. 34 (5): 901-903,906 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 903 Comparison of Fentanyl and Oxycodone Respectively Combined with Propofol in Hysteroscopic Surgery LI Yun-yun DOI: 10.3969/j.issn.1671-7171.2017.05.023 Objective To compared the effects of fentanyl and oxycodone respectively combined with propofol in hysteroscopic surgery. Methods Eighty-eight patients who underwent elective hysteroscopic surgery were randomly divided into the control group and the observation group with 44 cases in each group. The control group was treated with fentanyl combined with propofol anesthesia, while the observation group was treated with oxycodone combined with propofol. The changes of heart rate (HR), mean arterial pressure (MAP) and blood oxygen saturation (SpO2), condition of surgery, postoperative sedation scores and incidence of adverse reactions were compared between groups. Results ①HR, MAP and SpO2 at the end of injection (T1), uterine dilation (T2), 5min after the beginning of surgery (T3) and withdrawal of vagina dilator (T4) were lower than those before anesthesia (T0), and after recovery (T5), MAP were lower than those at T0 (P<0.05). At T2, T3 and T4, SpO2 of observation group were higher than those of the control group (P<0.05). ②There were no significant differences in the surgical time, recovery time and Ramsay sedation score between the two groups (P>0.05). The dosage of propofol in the observation group was lower than that in the control group during surgery (P<0.05). ③The incidence of adverse reactions in the observation group was slightly lower than that in the control group, but the difference was not significant (P>0.05). Conclusion The sedative effects of both oxycodone and fentanyl combined with propofol are good in hysteroscopic surgery, but oxycodone combined with propofol has little effect on the respiratory inhibition in patients with less dosage of propofol and higher safety. 2017 Vol. 34 (5): 903-905 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 906 Effect of General Anesthesia Combined with Regional Nerve Block on Stress Response in Patients with Colorectal Cancer Surgery and Analgesia SHEN Xue-yong, XIE Shao-jie, CHEN Ren-jun DOI: 10.3969/j.issn.1671-7171.2017.05.024 Objective To investigate the effect of general anesthesia combined with regional nerve block on stress response, inflammatory response and analgesic effect in patients with malignant gastrointestinal tumors after laparoscopic operation. Methods Ninety patients with malignant gastrointestinal tumors were randomly divided into A, B and C groups, 30 cases in each group. The Group A was treated with intravenous anesthesia, the Group B received general anesthesia combined with epidural anesthesia, and the Group C underwent general anesthesia combined with transversus abdominis plane block. Comparison of three groups were made on anesthesia, skin incision of three groups (T0), 5min after skin incision (T1) and the mean arterial pressure (MAP) at the end of operation (T2), heart rate (HR), intra/postoperative cortisol (Cor) and inflammatory factors (IL-6, tumor necrosis factors) levels, postoperative pain and complications. Results The hospitalization time and lying in bed time of the three groups were the Group C>the Group B and the Group A (P<0.05); the increase of MAP and HR in T0~T2 time range was smaller than that in group A (P<0.05); after operation ,the Cor, IL-6, TNF-αof the Group C increased significantly compared with the Group B and the Group A (P<0.05); 6h, 12h after operation, VAS were less than that of the Group A and the Group B (P<0.05); complication rate of the Group C was 3.33%, significantly lower than that in the Group A 23.33% and the Group B 20% (P<0.05). Conclusion General anesthesia combined with regional nerve block can obviously reduce the stress response, inflammatory response, pain with less dosage of anesthetics in patients with malignant gastrointestinal tumors. 2017 Vol. 34 (5): 906-909 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 909 Study on the Correlation Between CYP1A2*1F Gene Polymorphism and the Efficacy of Postoperative Chemotherapy and Prognosis in Patients with Lung Cancer LI Wei-weng DOI: 10.3969/j.issn.1671-7171.2017.05.025 Objective To investigate the relationship between cytochrome P4501A2 (CYP1A2) *1F gene polymorphism and chemotherapy efficacy and prognosis in patients with lung cancer after operation. Methods CYP1A2 gene polymorphism was detected in 100 patients with lung cancer to analyze the correlation between CYP1A2*1F and chemotherapy effect and prognosis of lung cancer after operation. Results In the 100 patients, partial remission were found in 24 cases, 44 cases were stable, the clinical benefit rate was 68%. The genotype of patients with CYP1A2*1F was A/A mostly (49%), followed by A/C (38%);The proportion of A/A genotype in patients with clinical benefit was slightly higher than that in patients without benefit, but the difference was not significant (P>0.05); The total survival time of patients with CYP1A2*1F A/A genotype was slightly higher than those of type A/C and type C/C, but there was no significant difference between the groups (P>0.05). Conclusion There is no significant correlation between CYP1A2*1F mutation genotype and the efficacy of postoperative chemotherapy and prognosis in patients with lung cancer. 2017 Vol. 34 (5): 909-911 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 912 Effect of Continuous ACB or FNB Analgesia on Pain and Early Functional Training after Total Knee Arthroplasty YANG Shun-min DOI: 10.3969/j.issn.1671-7171.2017.05.026 Objective To comparatively analyze the effect of continuous adductor canal block (ACB) and femoral nerve block (FNB) analgesia on pain and early functional training after total knee arthroplasty (TKA). Methods A total of 76 patients undergoing TKA were divided into ACB group and FNB group by the random number table method. The numeric rating scale (NRS) and early functional training associated indicators in resting and active state were compared between the two groups at different time points, and adverse reactions during analgesia were statistically analyzed. Results At 2h, 6h, 12h, 24h and 48h after surgery, the NRS scores in resting and active state showed no significant differences between the two groups (P<0.05), and quadriceps femoris muscle strength of the affected limbs of the ACB group was significantly lower than that before surgery (P<0.05). 24h, 48h and 72h after surgery, the knee range of motion of the affected limb was significantly smaller than that before surgery (P<0.05). The quadriceps femoris muscle strength and knee range of motion of the affected limbs were better in the ACB group than the FNB group at different time points after surgery (P<0.05). Conclusion The analgesic effects and adverse reactions of continuous ACB and FNB are similar after TKA but the effect of continuous ACB on quadriceps femoris muscle strength is significantly less, and the knee range of motion is significant greater, which is good for the early functional training. 2017 Vol. 34 (5): 912-914,916 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 914 Correlation between Renal Insufficiency and the Prognosis of Patients with Acute Myocardial Infarction during Hospitalization HE Jing-dong, TIAN Zhong, XIE Jia-ping DOI: 10.3969/j.issn.1671-7171.2017.05.027 Objective To explore the correlation between renal insufficiency and the prognosis of patients with acute myocardial infarction (AMI) during hospitalization. Methods One hundred hospitalized patients with AMI were divided into the normal renal function group (A group,n=37), the mild renal insufficiency group (B group, n=30) and the moderate renal insufficiency group (C group,n=33) according to the glomerular filtration rate (GFR). The clinical characteristics, incidence of cardiovascular events during hospitalization, mortality rate and related risk factors were observed. Results Compared to A group, B group and C group had older patients and more female patients, combined with hypertension, heart failure, stroke or history of cerebral ischemia, and cardiac function Fillip grade ≥ grade Ⅱ; the differences were significantly significant (P<0.05). The mortality rates in the hospital and the incidence rates of cardiovascular events in B group and C group were significantly higher than those in A group (P<0.05). Multivariate logistic regression analysis showed that renal insufficiency was a risk factor for mortality in the hospital and cardiovascular events in patients with AMI. Conclusion Renal insufficiency is a common complication in patients with AMI, and it can increase mortality in the hospital and the incidence of cardiovascular events. Renal function detection is of great importance in evaluating the clinical outcomes of patients with AMI. 2017 Vol. 34 (5): 914-916 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 917 Analysis of E2F-1 Expression in Gastric Cancer Tissues and Its Relationship with Prognosis XI Cheng, WANG Yi-bo DOI: 10.3969/j.issn.1671-7171.2017.05.028 Objective To investigate the expression of E2F-1 in gastric cancer tissues and its relationship with prognosis. Methods Eighty patients with gastric cancer in our hospital were enrolled in the study. The expression of E2E-1 in gastric cancer tissues and adjacent normal tissues was detected, and the clinicopathological features and prognosis were analyzed. Results The positive expression rate of E2F-1 in gastric cancer tissues (71.25%) was significantly higher than that in adjacent normal tissues (23.75%) (P<0.05). There were no significant differences in positive and negative expressions of E2F-1 in relation to gender, age, histological type, tumor location, differentiation, TNM stage and lymph node metastasis in patients (P>0.05). The 2-year survival rate of patients with positive expression of E2F-1 (47.37%) was lower than that of patients with negative expression (73.91%), and the difference was statistical significant (P<0.05). Cox model univariate analysis showed that tumor location, differentiation degree, TNM stage and lymph node metastasis were related to the overall survival time of patients with gastric cancer (P<0.05). Multivariate analysis showed that lymph node metastasis and positive expression of E2F-1 were the independent risk factors influencing the survival time of patients with gastric cancer. Conclusion E2F-1 is one of the signs of malignant behavior for gastric cancer and is an important influencing factor for poor prognosis. 2017 Vol. 34 (5): 917-919 [Abstract] ( 44 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )

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