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| Correlation between the Expression of PVT1 and Her-2 Genes and Clinical Pathology in Patients with Advanced Gastric Cancer |
| XU Li |
| The People‘s Hospital of Jiangsu 210029 |
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Abstract Objective To investigate the correlation between the expression of human plasmacytoma transformation and migration gene 1 (PVT1) and human epidermal growth factor receptor -2 (Her-2) and clinical pathology in patients with advanced gastric cancer. Methods Eighty cases of advanced gastric cancer diagnosed by pathology and the expression level of PVT1 and Her-2 in normal tissues adjacent to cancer were detected by immunohistochemical staining. Results The high expression rate of PVT1 and the positive expression rate of Her-2 in gastric cancer tissues were significantly higher than those in the adjacent tissues (P<0.05). The high expression rate of PVT1 and positive rate of Her-2 in patients with signet ring cells (81.25%, 75.00%) were significantly higher than those in patients with papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma (P<0.05). Spearman correlation analysis showed that high expression of PVT1 and positive expression of Her-2 were positively correlated with TNM stage of gastric cancer and lymph node metastasis(P＜0.05), and negatively correlated with the degree of cell differentiation , but there was no correlation with gender and age (P>0.05). Conclusion The expression levels of PVT1 and Her-2 in patients with advanced gastric cancer are significantly correlated with TNM stage of gastric cancer, lymph node metastasis, cell differentiation and clinical pathology.
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Received: 10 January 2017
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2017, Vol. 34 
