Abstract Objective To investigate the changes of serum interleukin-1β(IL-1β)、IL-10、IL-18 and tumor necrosis factor alpha (TNF-) expression in patients with irritable bowel syndrome (IBS) and their roles in the pathogenesis of IBS. Methods Seventy-two patients with IBS were divided into diarrhea type group IBS (group A) and constipation type IBS group (B group) according to the symptom type. The levels of cytokines IL-1β, IL-10, IL-18 and TNF-αin serum were detected by ELISA. Results The expression of IL-1β、IL-10、IL-18 and TNF-αin serum of the Group A and the Group B was significantly higher than those of the control group, and the difference was significant (P<0.05). The level of TNF-αin the Group A was higher than that in the Group B, and the difference was significant (P<0.05). There was no significant difference in the expression of IL-1β, IL-10, IL-18 in serum between the two groups (P>0.05). Conclusion The imbalance between proinflammatory cytokines and anti-inflammatory cytokines may be related to the clinical symptoms such as diarrhea, abdominal distension, and changes in bowel habits in IBS patients.
ZENG Ming-xi,KANG Chang-ming,CHEN Xiao-hong, et al. Study on the Relationship the Expression of Interleukin and Tumor Necrosis Factor with Irritable Bowel Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 901-903,906.
2017, Vol. 34 
