|
|
|
| Effect of Shenkang Injection on the Clinical Efficacy and the level of Inflammatory Factors in Patients with Chronic Glomerulonephritis |
| KONG Shu-min, SHENG Hua-ying |
| Dept. of Nephrology, the Second Affiliated Hospital of Suzhou University, Jiangsu 215004 |
|
|
|
|
Abstract Objective To investigate the effect of Shenkang injection on the clinical efficacy and the level of inflammatory factors in patients with chronic glomerulonephritis treatment. Methods Eighty-four cases of patients with chronic nephritis were random divided into two groups, 42 cases in each. The control group was treated with valsartan. On the basis of the control group, the observation group was treated with Shenkang injection. After three months of treatment, the clinical curative effect and TCM symptom integral, inflammatory factors and renal function were compared between the two groups. Results After 3 months of treatment, the total effective rate of the observation group was 83.33%(35/42), which was significantly higher than that of the control group 61.90%(26/42) (P<0.05); The 24hUPr,β2-MG ,TNF-α, IL-6 and IL-8 in the observation group were significantly lower than those in the control group (P<0.05);The TCM symptom score of the observation group was significantly lower than that of the control group and there was significant difference between the two groups (P<0.05). Conclusion Shenkang injection can improve the clinical curative effect of chronic nephritis patients, improve renal function and clinical symptoms, reduce inflammation with less adverse reactions, it is worthy of attention.
|
|
Received: 27 December 2016
|
|
|
|
|
|
[1] 景蕊.阿托伐他汀联合缬沙坦治疗慢性肾炎的疗效及对C反应蛋白的影响[J].解放军医学院学报,2014,35(4):335-337.
[2] 俞强.中西医结合治疗慢性肾盂肾炎疗效观察[J].新中医,2015,47(11):85-87.
[3] 王海燕.肾脏病学[M].第3版.北京:人民卫生出版社,2008:1256-1283.
[4] 郑宝林,李婷,余俊文,等.肾炎康复片联合氯沙坦钾治疗慢性肾炎的疗效观察[J].广州中医药大学学报,2014,31(1):32-34,39.
[5] 郑莜萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:156-160.
[6] 叶任高,陈裕盛,方敬爱.肾脏病诊断与治疗及疗效标准专题讨论纪要[J].中国中西医结合肾病杂志,2003,4(6):355-359.
[7] 梁文杰,马国平,梁丽娟,等.中药对慢性肾病肾组织炎性损伤的干预机制[J].中草药,2015,46(19):2946-2953.
[8] 米齐悦,杨丽平,陈静,等.占永立教授辨治慢性肾炎的思路[J].中国中西医结合肾病杂志,2015,16(7):572-574.
[9] Jepson RE,Vallance C,Syme HM,et al.Assessment of urinary N-acetyl-beta-D-glucosaminidase activity in geriatric cats with variable plasma creatinine concentrations with and without azotemia[J].Am J Vet Res,2010,71(2):241-247.
[10] 廉江平,韩珊,方志远,等.肾康注射液治疗慢性肾衰竭的有效性和安全性[J].中成药,2015,37(8):1677-1682.
[11] 楚加元.肾康注射液药理及临床研究进展综述[J].现代中药研究与实践,2014,28(2):76-78.
[12] Okada R,Kawai S,Naito M,et al.Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease[J].Am J Nephrol,2012,36(5):444-450.
|
|
|
|
2017, Vol. 34 
