|
|
|
| Prognostic Value of Interleukin-18 with NIHSS and mRS Scores in Patients with Acute Cerebral Infarction |
| ZHAO Yan, CHEN Xiang-dong, ZHANG Yan-mei,et al |
| Departmeng of Neurology,Inner Mongolia Autonomous Region Hospital,Huhhot 010050,China |
|
|
|
|
Abstract Objective To investigate the prognostic value of serum interleukin-18 with NIHSS (National Institutes of Health Stroke Scale) and mRS (modified Rankin scale) in patients with actual cerebral infarction (ACI). Methods A total of 100 cases of ACI patients from August 2013 to December 2014 in our hospital were chosen as the subjects of the study.All were diagnosed as ACI by head CT or MRI based on the guidelines of China Ischemic Stroke Treatmentin 2010. According to the score of NIHSS, patients were divided into mild group(NIHSS score<7), moderately severe group (NIHSS score 7～15) and severe group (NIHSS scor >15).At same time period, sixty healthy volunteers were collected as control.Serum interleukin-18 levels were measured within 24hamong all patients in ACI and control group. The relevance and relationship between serum interleukin-18 levels and Alberta CT (ASPECT) scores plus NIHSS scores were analyzed. All patients were followed up on the day of 90 and 180; neurological impairment was assessed by mRS score; the correlation between plasma interleukin-18 levels and prognosis were analyzed. Results Patients'serum interleukin-18 levels 24h after hospitalization were significantly higher than that in the healthy control group (P<0.05). The interleukin-18 levels were (526.36±26.82)ng/L,(439.24±26.45)ng/L,and (385±34.26)ng/L,respectively, in severe group, moderate severe group and mild group. The differences among the three groups were statistically significant (P<0.05). Interleukin-18 level in the poor prognosis group was significantly higher than the good prognosis group(P<0.05). Serum interleukin-18 levels were positively correlated betweenwith ASPECT scores and NIHSS scores. Univariate Logistic regression analysis showed that the age, ASPECT score, NIHSS score, and interleukin-18 levels were prognostic factors of ACI patients (P<0.05). Area under the receiver's work curve (ROC) analysis showed that the predictive value of serum interleukin-18 was no significant difference with NIHSS score and ASPECT score in predicting outcomes of ACIpatients . Conclusion Plasma interleukin-18 levels were significantly elevated in patients with acute ACI; there is a significant positive correlation between serum interleukin-18 levels within 24 hours with neurologic impairment severity and prognosis in ACI patients. Serum interleukin-18 levels has great value in assessing the severity and prognosis in patients with ACI.
|
|
Received: 22 January 2016
|
|
|
|
|
|
[1] Ghandehari K.Challenging comparison of stroke cacles[J].J Res Med Sci,2013,18(10):906-910.
[2] Fann DY,Lee SY,Manzanero S,et al.Pathogenesis of acute stroke and the role of inflammasomes[J].Ageing Res Rev,2013,12(4):941-946.
[3] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-153.
[4] 段洪连,刘美云,张拥波,等.缺血性脑卒中常用评估量表及其最新研究进展[J].中国全科医学,2011,35:4018-4021.
[5] 金灿,王苇. ASPECT评分的临床应用进展[J].国际医学放射学杂志,2015,05:418-422.
[6] Oh SH,Kim OJ,Shin DA,et al. Alteration of immunologic responses on peripheral blood in the acute phase of ischemic stroke: blood genomic profiling study[J].J Neuroimmunol,2012, 249(1-2):60-65.
[7] Amantea D,Micieli G2,Tassorelli C3,et al.Rational modulation of the innate immune system for neuroprotection in ischemic stroke[J].Front Neurosci,2015,9(2):147-152.
[8] Shimizu K,Shimomura K,Tokuyama Y,et al.Association between inflammatory biomarkers and progression of intracranial large artery stenosis after ischemic stroke[J].J Stroke Cerebrovasc Dis,2013,22(3):211-217.
[9] Piazza O,Scarpati G,Cotena S,et al.Thrombin antithrombin complex and IL-18 serum levels in stroke patients[J].Neurol Int,2010,2(1):e1.
|
|
|
|
2017, Vol. 34 
