超前镇痛管理对非小细胞肺癌患者围手术期免疫功能、预后的影响分析

doi:10.3969/j.issn.1671-7171.2017.05.013

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Abstract Objective To explore effect of preemptive analgesia management on perioperative immune function and prognosis of patients with non-small cell lung cancer. Methods All patients were divided into experimental group (n=58) and control group (n=57) according to the principle of randomized, double-blinded assignment of 115 cases of non-small cell lung cancer admitted in our hospital from January 2015 to July 2016. Preemptive analgesia was used in the experimental group and conventional analgesia was used in the control group. Our goal was to observe the effect of different analgesia management on perioperative immune function and prognosis. Results The visual simulation scores (VAS) of the two groups were observed 6h, 1d, 3d after operation. The score of the experimental group was significantly lower than that of the control group (P<0.05). There was no significant difference in CD4⁺ and CD8⁺ levels between the two groups before operation (P>0.05). The levels of CD4⁺ and CD8⁺ in the two groups after surgery were significantly lower than those before operation, but the CD4⁺ and CD8⁺ levels in the experimental group were still higher than those in the control group, and the difference was statistically significant (P<0.05). The first time that patient got out the bed for activities in the experimental group was (2.72 ± 0.92) d,and the rate of lung infection, atelectasis, pleural effusion were 3.45 %, 0.00 %, 0.00 %, respectively, all significantly less than the control group (P<0.05). Conclusion Preemptive analgesia management can more effectively reduce the perioperative pain in patients with non-small cell lung cancer, protect the immune function, and improve the prognosis of postoperative effect. It is worth promoting.

Key words： Analgesia Carcinoma, Non-Small-Cell Lung/SU Carcinoma, Non-Small-Cell Lung/IM Intraoperative Period Prognosis

Received: 04 May 2016

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.05.013 OR http://www.jcr.net.cn/EN/Y2017/V34/I5/872

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