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| Study on Efficacy of Methionine and Vitamin B1 in the treatment of Liver Cirrhosis |
| ZHANG Xue-qin,WANG Qian |
| Department of Gastroenterology, the First People ‘s Hospital of Qujing City, Yunnan Province, China 655000 |
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Abstract Objective To study on the efficiency of methionine and vitaminB1 in the treatment of hepatic cirrhosis and their effects on liver function, symptoms and complications . Methods From March 2013 to March 2016, there were 80 patients with hepatocirrhosis treated in our hospital. Their clinical data were analyzed retrospectively. Among them, 38 patients were treated by the traditional method (the control group). On the basis of traditional method, 42 patients received Methionine and VitaminB1 treatment (the experimental group). The effects of these treatments were observed and compared between the two groups. Results (1) Before treatment, there were no significant differences in liver function (i.e. TBIL, ALT, CHE, FN) and serum liver fibrosis (HA、PCⅢ、LN、cⅣ) between the experimental and controls (P<0.05). After treatment, the indicators stated above in the experimental group were significantly lower than those in the control group (P<0.05); (2) The total effective rate of the experimental group was higher than that of the control group (85.71% VS 71.05%) (P<0.05); (3) The incidence of complications (liver and kidney syndrome, hepatic encephalopathy, spontaneous bacterial peritonitis) in the experimental group was significantly lower than that in the control group (9.52% VS 26.32%)
(P<0.05). Conclusion Methionine and VitaminB1 can significantly improve the liver function and symptoms. The treatment is safe and effective. Therefore, this method is worthy of further promotion and use in clinic.
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Received: 07 November 2016
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[1] 王燕.恩替卡韦治疗慢性乙型肝炎和乙肝肝硬化高胆红素血症60例[J].陕西医学杂志,2012,41(8):1060-1062.
[2] 王松贤.慢性乙型肝炎患者肝组织学检查的意义[J].实用肝脏病杂志,2014,9(3):297- 298.
[3] 连晓明,覃舒扬,莫金荣.阿德福韦醋联合拉米夫定与恩替卡韦单药治疗乙肝肝硬化疗效比较[J].海南医学,2013,24(22):3303-3305.
[4] 李佑桥,张亚琳.复方鳖甲软肝片联合恩替卡韦治疗乙肝后肝硬化疗效观察[J].实用中医药杂志,2011,27(7):456-457.
[5] 贾红宇,马葵芬,吕国才,等.初始拉米夫定联合阿德福韦酯与恩替卡韦单药治疗乙肝肝硬化疗效比较[J].中国药学杂志,2012,47(18):1453-1456.
[6] Ye XG, Su QM. Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis [J]. World J Gastroenterol, 2013, 19 (39): 6665-6678.
[7] 耿建章,范晓红,李静,等.乙型肝炎肝硬化初始联合抗病毒治疗的疗效观察[J].临床肝胆病杂志,2011,27(8):837-843.
[8] 韩莹,丁惠国.抗病毒治疗乙型肝炎肝硬化的过去、现在和将来[J].实用肝脏病杂志, 2015,6(5):453-456.
[9] 耿建章,陈翠英,王素平.甲硫氨酸维B1联合苦黄注射液治疗慢性乙型肝炎肝内胆汁淤积的疗效观察[J].河北医药,2008,30(9):1372.
[10] 李太平.腺苷蛋氨酸联合苦参碱治疗病毒性肝炎高胆红素血症疗效[J].临床荟萃,2015, 7(1):108-110.
[11] 张钊,龚建平.S-腺苷蛋氨酸对内毒素性肝损害的保护作用[J].第三军医大学学报,2010, 32(11):1145-1149.
[12] 徐蜀远.维生素B1治疗慢性乙型肝炎感染[J].国外医学:内科学分册,2002,29(2):87- 88.
[13] Pellanda H. Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver[J]. Clin Chem Lab Med, 2013, 51(3): 617-621.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(4): 741-743. |
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2017, Vol. 34 
