CYP1A2*1F基因多态性与肺癌术后化疗疗效及预后的关系

doi:10.3969/j.issn.1671-7171.2017.05.025

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Abstract Objective To investigate the relationship between cytochrome P4501A2 (CYP1A2) *1F gene polymorphism and chemotherapy efficacy and prognosis in patients with lung cancer after operation. Methods CYP1A2 gene polymorphism was detected in 100 patients with lung cancer to analyze the correlation between CYP1A2*1F and chemotherapy effect and prognosis of lung cancer after operation. Results In the 100 patients, partial remission were found in 24 cases, 44 cases were stable, the clinical benefit rate was 68%. The genotype of patients with CYP1A2*1F was A/A mostly (49%), followed by A/C (38%);The proportion of A/A genotype in patients with clinical benefit was slightly higher than that in patients without benefit, but the difference was not significant (P>0.05); The total survival time of patients with CYP1A2*1F A/A genotype was slightly higher than those of type A/C and type C/C, but there was no significant difference between the groups (P>0.05). Conclusion There is no significant correlation between CYP1A2*1F mutation genotype and the efficacy of postoperative chemotherapy and prognosis in patients with lung cancer.

Key words： Cytochrome P-450 CYP1A2/GE Polymorphism, Genetic Lung Neoplasms/SU Lung Neoplasms/DT Prognosis

Received: 23 January 2017

PACS:

R734.2

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LI Wei-weng. Study on the Correlation Between CYP1A2*1F Gene Polymorphism and the Efficacy of Postoperative Chemotherapy and Prognosis in Patients with Lung Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 909-911.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.05.025 OR http://www.jcr.net.cn/EN/Y2017/V34/I5/909