狼疮性肾炎合并急性肾损伤患者血清中肿瘤坏死因子-α、降钙素原水平与预后的关系

doi:10.3969/j.issn.1671-7171.2022.06.016

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摘要【目的】探讨狼疮性肾炎(LN)合并急性肾损伤(AKI)患者血清中肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)水平与预后的关系。【方法】LN患者136例,根据是否发生AKI分为AKI组(84例)和非AKI组(52例),同时选取本院体检健康者85例作为对照组。检测所有受试者PCT、TNF-α、同型半胱氨酸(Hcy),血清肌酐(SCr)水平,同时检测LN患者24 h尿蛋白量并分析LN患者序贯器官衰竭评分(SOFA)状况。对AKI组患者随访3个月,根据生存情况分为生存组和死亡组。应用二元Logistic回归分析相关指标与患者预后的关系。【结果】与对照组相比,AKI组、非AKI组患者血清PCT、TNF-α、SCr、Hcy水平较高(P<0.05);与非AKI组相比,AKI组患者24 h尿蛋白量、SOFA评分和血清PCT、TNF-α、SCr、Hcy水平较高(P<0.05)。与生存组相比,死亡组患者血清PCT、TNF-α水平显著升高(P<0.05)。Logistic回归分析结果显示:血清PCT、TNF-α高为LN合并AKI预后的危险因素(P<0.05)。【结论】LN合并AKI患者血清中PCT、TNF-α水平升高,可为预测患者预后提供参考依据。

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	张沛
	曹绥琳

关键词 ：狼疮肾炎/并发症, 肾/损伤, 急性病, 降钙素/血液, 肿瘤坏死因子α/血液

Abstract：【Objective】To explore the relationships of prognosis with levels of serum tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) in patients with lupus nephritis (LN) complicated with acute renal injury (AKI). 【Methods】According to whether AKI occurred,136 patients with LN were divided into the AKI group (n=84) and the non-AKI group (n=52). Meanwhile,85 healthy volunteers in our hospital were selected as the control group. PCT,TNF-α,homocysteine (Hcy) and serum creatinine (SCr) levels were measured in all subjects. The 24-hour urinary protein level of LN patients was detected by urine analyzer and the sequential organ failure score (SOFA) of LN patients was evaluated. Patients in the AKI group were followed up for 3 months:they were divided into the survival group and the death group according to the survival situation. Bivariate Logistic regression was used to analyze the relationship between related indicators and prognosis. 【Results】Compared to the control group,the serum levels of PCT,TNF-α,SCr and Hcy in both AKI group and non-AKI group were higher (P<0.05). compared with the non-AKI group,24-hour urinary protein,SOFA score and serum PCT,TNF-α,SCr and Hcy levels in the AKI group were higher (P<0.05). Compared with the survival group,the levels of serum PCT and TNF-α in the death group increased significantly (P<0.05). Using bivariate logistic regression analysis,serum PCT and TNF-α were risk factors for prognosis of lupus nephritis complicated with AKI (P<0.05). 【Conclusion】The levels of serum PCT and TNF-α in patients with lupus nephritis who complicated with AKI are much higher,which may provide a reference for predicting the prognosis of patients.

Key words： Lupus Nephritis/CO Kidney/IN Acute Disease Calcitonin/BL Tumor Necrosis Factor-alpha/BL

收稿日期: 2021-12-07

中图分类号:

R593.242

通讯作者: *E-mail:13991180985@163.com

引用本文:

张沛, 曹绥琳. 狼疮性肾炎合并急性肾损伤患者血清中肿瘤坏死因子-α、降钙素原水平与预后的关系[J]. 医学临床研究, 2022, 39(6): 859-861.
ZHANG Pei, CAO Sui-lin. Relationships of Prognosis with Levels of Serum Tumor Necrosis Factor-α and Procalcitonin in Patients with Lupus Nephritis Complicated with Acute Renal Injury. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 859-861.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.06.016 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I6/859