急性心肌梗死患者血清lncRNA MALAT1水平与心肌损伤标志物、凝血功能指标的相关性研究

doi:10.3969/j.issn.1671-7171.2022.04.021

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摘要【目的】探讨急性心肌梗死(AMI)患者血清长链非编码RNA-肺腺癌转移相关转录因子1(lncRNA MALAT1)水平与心肌损伤标志物、凝血功能指标的相关性。【方法】选取2017年1月至2019年11月本院收治的103例AMI患者(观察组),另选取同期在本院体检的103例健康志愿者(对照组)。采用实时荧光定量聚合酶链反应检测血清中lncRNA MALAT1水平,比较两组心肌损伤标志物及凝血因子水平,并分析lncRNA MALAT1水平与心肌损伤标志物及凝血功能相关性。【结果】观察组血清N末端脑钠肽前体(NT-proBNP)、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK),心肌钙蛋白I(cTnI)、lncRNA MALAT1、肌红蛋白(MYO)、纤维蛋白原(FIB)、血管性血友病因子(vWF)、纤溶酶原激活物抑制物(PAI-1)水平均高于对照组,部分凝血酶原时间(PT)、活化部分凝血酶时间(APTT)及国际标准化比值(INR)均低于对照组,差异有统计学意义(P<0.05)。观察组患者血清lncRNA MALAT1水平与NT-proBNP、CK-MB、cTnI、vWF及PAI-1水平呈正相关(P<0.05),与PT、APTT呈负相关(P<0.05)。NT-proBNP高水平、CK-MB高水平、APTT低水平、vWF高水平及lncRNA MALAT1高水平是AMI发生的危险因素(P<0.05)。【结论】AMI患者血清中lncRNA MALAT1表达水平显著升高,可能通过影响心肌标志物及凝血指标变化导致AMI发生。

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	王星
	胡亚红

关键词 ：心肌梗死, 急性病, RNA,长链非编码, 心肌/病理学, 血液凝固

Abstract：【Objective】To detect the expression level of long non-coding RNA-lung adenocarcinoma metastasis-associated transcription factor 1 (IncRNA MALAT1) in serum of patients with acute myocardial infarction and analyze its relationships with marks of myocardial injury and coagulation function in actual myocardial infarction (AMI). 【Methods】A total of 103 patients with acute myocardial infarction admitted to our hospital from January 2017 to January 2019 were selected as the observation group, and 103 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The level of lncRNA MALAT1 in serum was detected by qRT-PCR and the levels of myocardial injury markers and coagulation factors were detected by ELISA. The correlations of the level of lncRNA MALAT1 with myocardial injury and coagulation function were analyzed. 【Results】The levels of NT-proBNP, CK-MB, CK, cTnI, MYO, coagulation indexes such as PT, APTT, INR, FIB, vWF, PAI-1 and serum lncRNA MALAT1 in acute myocardial infarction group were significantly higher than those in healthy control group (all P<0.05), while the values of PT, APTT and INR were lower than those in the control group, and the differences were statistically significant. (P<0.05). Serum lncRNA MALAT1 was positively correlated with NT-proBNP, CK-MB, cTnI, vWF and PAI-1 in patients with acute myocardial infarction (P<0.05), and IncRNA MALAT1 level was negatively correlated with PT and APTT (P<0.05). High NT-proBNP level, high CK-MB level, low APTT level, high vWF level and high lncRNA MALAT1 level were risk factors for acute myocardial infarction (all P<0.05). 【Conclusion】The expression level of serum lncRNA MALAT1 of patients with acute myocardial infarction was significantly increased, which may promote the occurrence of acute myocardial infarction by influencing the changes of myocardial markers and coagulation indexes.

Key words： Myocardial Infarction Acute Disease RNA, Long Noncoding Myocardium/PA Blood Coagulation

收稿日期: 2021-12-07

中图分类号:

R542.22

通讯作者: *E-mail:937833620@qq.com

引用本文:

王星, 胡亚红. 急性心肌梗死患者血清lncRNA MALAT1水平与心肌损伤标志物、凝血功能指标的相关性研究[J]. 医学临床研究, 2022, 39(4): 553-556.
WANG Xing, HU Ya-hong. Study on Correlation of Serum lncRNA MALAT1 Level with Markers of Myocardial Injury and Coagulation Function in Patients with Acute Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 553-556.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.04.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I4/553

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