Abstract：【Objective】To explore the clinical value of D-dimer combined with N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) in predicting the risk of recent death in patients with acute heart failure (AHF).【Methods】 A total of patients with AHF admitted to our hospital from June 2017 to December 2020 were selected. All patients were followed up for 3 months. They were divided into survival group (n=65) and death group (n=21) according to their survival conditions. The levels of D-dimer and NT-proBNP in serum were measured by immunoturbidimetry of latex and electrochemiluminescence. The influencing factors of recent death in AHF patients were analyzed by multivariate logistic regression. The clinical value of D-dimer combined with NT-proBNP in predicting the risk of recent death was analyzed by receiver operating characteristic curve (ROC curve).【Results】 Compared with the survival group,the AHF family history rate in the death group was higher (P<0.05). The levels of NT-proBNP and D-dimer in serum of death group were higher than those of survival group (P<0.05). Multivariate logistic regression analysis showed that D-dimer and NT-proBNP were the risk factors of recent death in AHF patients (P<0.05). The AUC of D-dimer combined with NT-proBNP in predicting the recent death of AHF patients was 0.917 (95%CI:0.860~0.974). The sensitivity and specificity were 98.90% and 66.70% respectively. 【Conclusion】 D-dimer and NT-proBNP are risk factors of recent death in AHF patients. Serum D-dimer combined with NT-proBNP has certain clinical value in predicting recent death in AHF patients.
何玲鸽, 戚凯. D-二聚体联合NT-proBNP预测急性心力衰竭患者近期死亡风险的临床价值[J]. 医学临床研究, 2022, 39(6): 869-872.
HE Ling-ge, QI Kai. Clinical Value of D-dimer Combined with NT-proBNP in Predicting Short-term Mortality Risk in Patients with Acute Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 869-872.
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2022, Vol. 39 
