Abstract：【Objective】 To investigate the effect of personalized peptide mesh combined with barrier membrane in guided bone regeneration (GBR) for alveolar bone defect repair. 【Methods】A total of 106 patients with alveolar bone defects with missing upper anterior teeth who were diagnosed and treated in our hospital from January 2019 to October 2020 were randomly divided into observation group and control group,with 53 cases in each group. GBR technique was used to repair alveolar bone defects in both groups,conventional barrier membrane was used in the control group,and personalized peptide net was given in the observation group on the basis of the control group. The bone increment,gingival aesthetics,periodontal index and postoperative complications were compared between the two groups. 【Results】 Six months after operation,the width of alveolar bone in the observation group was greater than that in the control group (P<0.05),the change of alveolar bone width was lower than that in the control group (P<0.05),and the total score of red aesthetic index (PES) of implant repair was higher than that in the control group (P<0.05); There was no significant difference in the total score of white aesthetic index (WES) between the two groups (P>0.05). The depth of detection (PD) and the level of adhesion (AL) of the two groups at 6 months after operation were lower than those before operation (P<0.05). There was no significant difference in PD and Al between the two groups at 6 months after operation (P>0.05). There was no significant difference between the two groups in the incidence of total complications one month after operation (P>0.05). 【Conclusion】 The use of personalized peptide net and barrier membrane in GBR repair of alveolar bone defects can increase the bone mass and red aesthetic effect of alveolar bone defects,provide a stable implant environment,and have good safety.
孟文侠, 胡亚利. 个性化钛网联合屏障膜在引导骨再生修复牙槽骨缺损中的应用效果[J]. 医学临床研究, 2022, 39(6): 862-865.
MENG Wen-xia, HU Ya-li. Application of Personalized Peptide Net Combined with Barrier Membrane in Guided Bone Regeneration for Alveolar Bone Defect Repair. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 862-865.
[1] TOLEDANO-SERRABONA J,SANCHEZ-GARCES M A,SANCHEZ-TORRES A,et al. Alveolar distraction osteogenesis for dental implant treatments of the vertical bone atrophy:A systematic review[J].Med Oral Patol Oral Cir Bucal,2019,24(1):70-75.
[2] MONJE A,PONS R,INSUA A,et al. Morphology and severity of peri-implantitis bone defects[J].Clin Implant Dent Relat Res,2019,21(4):635-643.
[3] RITTER A,ROZENDORN N,AVISHAI G,et al. Preoperative maxillary sinus imaging and the outcome of sinus floor augmentation and dental implants in asymptomatic patients[J].Ann Otol Rhinol Laryngol,2020,129(3):209-215.
[4] KIM Y K,KU J K. Guided bone regeneration[J].J Korean Assoc Oral Maxillofac Surg,2020,46(5):361-366.
[5] SABADO-BUNDO H,SANCHEZ-GARCES M A,GAY-ESCODA C. Bone regeneration in diabetic patients. A systematic review[J].Med Oral Patol Oral Cir Bucal,2019,24(4):425-432.
[6] JENG M D,CHIANG C P. Autogenous bone grafts and titanium mesh-guided alveolar ridge augmentation for dental implantation[J].J Dent Sci,2020,15(3):243-248.
[7] 刘宇飞,易建国. 口腔修复学[M].河南:郑州大学出版社,2012:45-98.
[8] POUR N N,GHAEDI B,SOHRABI M. Soft-tissue esthetic outcome of single implants:Immediate placement in fresh extraction sockets versus conventional placement in healed sockets[J].J Indian Soc Periodontol,2018,22(3):249-253.
[9] AL-DOSARI A,AL-ROWIS R,MOSLEM F,et al. Esthetic outcome for maxillary anterior single implants assessed by different dental specialists[J].J Adv Prosthodont,2016,8(5):345-353.
[10] DE OLIVEIRA E L,DE CARVALHO P S P,DA SILVA T B. Histological and histomorphometric evaluation of efficacy of a polypropylene barrier in guided bone regeneration and modified guided bone regeneration in critical defects in rodent cranial vaults[J].J Indian Soc Periodontol,2019,23(4):351-355.
[11] EOM K S. Single-stage reconstruction with titanium mesh for compound comminuted depressed skull fracture[J].J Korean Neurosurg Soc,2020,63(5):631-639.
[12] TAKATSU Y,YOSHIDA R,YAMAMURA K,et al. Three-dimensional gradient-echo is effective in suppressing radiofrequency shielding by a titanium mesh[J].Magn Reson Med Sci,2021,20(2):182-189.
[13] TAMBURINI N,GROSSI W,SANNA S,et al. Chest wall reconstruction using a new titanium mesh:a multicenters experience[J].J Thorac Dis,2019,11(8):3459-3466.
[14] KU J K,LEEM D H. Vestibuloplasty covering titanium mesh with grafted free gingiva on anterior mandible:technical report and rationale[J].J Korean Assoc Oral Maxillofac Surg,2019,45(6):369-373.
2022, Vol. 39 
