Effects of Loading dose of Tegranolol before PCI on Coronary Blood Flow, Myocardial Zymogram and Hcy, FGF23, Klotho Protein in Patients with Acute Myocardial Infarction
CAI Hai-jun, ZHANG Pei
Ankang Hospital of Traditional Chinese Medicine,Ankang Shaanxi 725000
Abstract：【Objective】 To investigate the effects of loading dose tegrilol before early percutaneous coronary intervention (PCI) on coronary blood flow, myocardial zymogram, homocysteine (Hcy), fibroblast growth factor 23 (FGF23) and Klotho protein in patients with acute myocardial infarction (AMI). 【Methods】The clinical data of 180 AMI patients treated with PCI in our hospital from January 2017 to March 2019 were retrospectively analyzed. They were divided into control group (n=89) and observation group (n=91) according to different treatment methods. The myocardial blood perfusion immediately after operation, the peak time of five postoperative myocardial enzymes, the levels of Hcy, FGF23, Klotho protein at admission and 12 weeks after operation, cardiovascular events and adverse events were compared between the two groups. 【Results】The corrected TIMI blood flow frame number (cTFC) and the incidence of no reflow or slow blood flow after operation in the observation group were significantly lower than those in the control group (P<0.05);The peak time of Creatine kinase isoenzyme (CK-MB), creatine kinase phosphate (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), α-Hydroxybutyrate dehydrogenase(α-HBD) was significantly earlier than that of the control group (P<0.05). The levels of serum Hcy and FGF23 in the observation group were lower than those in the control group (P<0.05), and the level of Klotho protein was higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse events between the two groups during treatment (P>0.05). After 12 weeks of follow-up, the incidence of cardiovascular events in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】The loading dose of tegranolol before PCI can effectively improve the coronary blood flow in patients with AMI, better alleviate the injury of myocardial cells, and reduce the incidence of cardiovascular events.
蔡海军, 张培. PCI术前负荷剂量替格瑞洛对急性心肌梗死患者冠脉血流、心肌酶谱及Hcy、FGF23、Klotho蛋白的影响[J]. 医学临床研究, 2022, 39(7): 1047-1050.
CAI Hai-jun, ZHANG Pei. Effects of Loading dose of Tegranolol before PCI on Coronary Blood Flow, Myocardial Zymogram and Hcy, FGF23, Klotho Protein in Patients with Acute Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1047-1050.
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2022, Vol. 39 
