Abstract：【Objective】To investigate the expression level and clinical significance of serum microrna-98(miR-98) and interleukin-13(IL-13) in elderly patients with acute attack of asthma. 【Methods】A total of 360 elderly patients with asthma diagnosed in the Ankang Central Hospital from March 2017 to January 2020 was selected, including 200 cases in the acute attack group (90 cases in the mild group, 80 cases in the moderate group and 30 cases in the severe group) and 160 cases in the remission group; In addition, 90 elderly people who underwent physical examination in the Ankang Central Hospital in the same period were selected as the health group. The relative expression of serum miR-98 was detected by real-time fluorescence quantitative PCR (Quantitative Real-time PCR,qRT-PCR), the level of serum IL-13 was detected by enzyme-linked immunosorbent assay, and the first second forced expiratory volume (FEV1) and maximum peak expiratory flow rate (PEF) in acute attack group were detected and compared by pulmonary function instrument. 【Results】 The expression of serum miR-98 in the acute attack group was significantly lower than that in the remission group and the healthy group, and decreased successively with the aggravation of acute attack (P<0.05); The expression of serum IL-13 was higher than that in the remission group and the healthy group, and increased successively with the aggravation of acute attack (P<0.05). FEV1 and PEF in the mild group, the moderate group and the severe group decreased successively with the aggravation of the disease(P<0.05). The relative expression of miR-98 in serum of patients with the acute attack group was positively correlated with FEV1 and PEF(P<0.05), and negatively correlated with IL-13(P<0.05); The expression level of IL-13 in serum was negatively correlated with FEV1 and PEF (P<0.05).【Conclusion】The abnormal expression of serum miR-98 and IL-13 in patients with acute attack of asthma is related to the degree of attack and the indexes of pulmonary function FEV1 and PEF. It can be used as a potential index to evaluate the elderly asthma.
李超, 张军艳. miR-98、IL-13在老年哮喘急性发作期患者血清中的表达水平及其临床意义[J]. 医学临床研究, 2022, 39(3): 415-418.
LI Chao, ZHANG Jun-yan. Expression and Clinical Significance of Serum MiR-98 and IL-13 in Elderly Patients with Acute Attack of Asthma. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 415-418.
2022, Vol. 39 
