Abstract：【Objective】 To investigate the expressions and significance of presepsin and interleukin (IL-6) in plasma of patients with acute pyelonephritis. 【Methods】 A total of 113 patients with acute pyelonephritis admitted to our hospital from October 2018 to May 2020 were selected as the observation group. According to the difference in clinical symptoms, they were divided into in the early group (91 cases) and in the late group (22 cases). Volunteers of 115 cases with health examination personnel were selected as the control group. The expression of presepsin and IL-6 was detected, the correlation between the levels of presepsin and IL-6 and glomerular filtration rate (GFR) was analyzed, and the predictive value of plasma presepsin and IL-6 in patients with early acute pyelonephritis was analyzed by ROC curve. 【Results】 Compared with those in the control group, the levels of WBC, C-reactive protein (CRP), Cystatin C (CysC), procalcitonin (PCT), serum creatinine (SCr), presepsin and IL-6 in the observation group were significantly higher (P<0.05), while the GFR was lower (P<0.05). compared to the early group, the expression levels of plasma presepsin and IL-6 in the late group were higher (P<0.05). The levels of plasma presepsin and IL-6 in patients with acute pyelonephritis were positively correlated with WBC, CRP and SCr (P<0.05), and negatively correlated with GFR (P<0.05). The area under the curve of plasma presepsin and IL-6 in patients with early acute pyelonephritis was 0.928, the sensitivity was 81.82% and the specificity was 90.11%.【Conclusion】 The high expressions of presepsin and IL-6 in plasma of patients with acute pyelonephritis are related to the levels of WBC, CRP, and SCr, which may be used as potential markers for early acute pyelonephritis.
姜肖肖, 叶丽丽. 急性肾盂肾炎患者血浆中presepsin、IL-6的表达水平及其意义[J]. 医学临床研究, 2022, 39(5): 750-752.
JIANG Xiao-xiao, YE Li-li. Expression and Significance of Plasma Presepsin and IL-6 in Patients with Acute Pyelonephritis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 750-752.
[1] ENIKEEV DV, GLYBOCHKO P, ALYAEV Y, et al. Imaging technologies in the diagnosis and treatment of acute pyelonephritis[J].Urologia,2017, 84(3):179-184. [2] BAS S, GAUTHIER BR, SPENATO U, et al. CD14 is an acute-phase protein[J].J Immunol,2004, 172(7):4470-4479. [3] TAMBO M, TAGUCHI S, NAKAMURA Y, et al. Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis[J].BMC Urol,2020, 20(1):1-7. [4] 陈兵, 王荣. 肾盂肾炎的诊治进展[J].临床内科杂志, 2018, 35(7):443-447. [5] TSUJIMOTO K, HATA A, FUJITA M, et al. Presepsin and procalcitonin as biomarkers of systemic bacterial infection in patients with rheumatoid arthritis[J].Int J Rheum Dis,2018, 21(7):1406-1413. [6] 黄珠晏, 韦升市, 廖翠媚,等. 血清Presepsin、PCT、IL-6水平联合检测对儿童脓毒症的诊断和预后评估的临床意义[J].中国免疫学杂志, 2019, 35(20):2527-2531. [7] 辛少军, 高敏, 张宗新. presepsin在急性阑尾炎的诊断及病情评估中的价值[J].中国卫生检验杂志, 2017, 27(1):82-84. [8] TANIMURA S, FUJIEDA Y, KONO M, et al. Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus[J].Mod Rheumatol,2018, 28(5):865. [9] 陈万义,张庆民.急性滑膜炎患者血清CRP、PCT和IL-6表达及临床特点[J].检验医学与临床, 2020, 17(8):1090-1092.
2022, Vol. 39 
