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医学临床研究  2022, Vol. 39 Issue (11): 1669-1671    DOI: 10.3969/j.issn.1671-7171.2022.11.020
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氨磺必利联合高压氧对精神分裂症患者述情障碍及血液流变学的影响
苗天翼1, 闫军锋2, 苏琦1, 刘晓红2*
1.西北妇女儿童医院,陕西 西安 710061;
2.武警陕西省总队医院,陕西 西安 710054
Effect of Ambroxide Combined with Hyperbaric Oxygen on Alexithymia and Hemorheology in Patients with Schizophrenia
MIAO Tian-yi, YAN Jun-feng, SU Qi, et al
Northwest Women's and Children's Hospital,Xi'an Shaanxi 710061
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摘要 【目的】探讨氨磺必利联合高压氧对精神分裂症患者述情障碍及血液流变学的影响。【方法】回顾性分析2018年2月至2021年2月武警陕西省总队医院收治的118例精神分裂症患者的临床资料,根据治疗方法的不同将其分为观察组和对照组,每组59例。对照组给予氨磺必利治疗,观察组在对照组基础上给予高压氧治疗,均治疗2个月。比较两组疗效及治疗前、治疗2个月后阳性与阴性症状量表(PANSS)、简易精神状态量表(MMSE)、多伦多述情障碍量表(TAS-20)评分、血液流变学指标(全血低切还原黏度、全血高切还原黏度、纤维蛋白原),并统计不良反应发生情况。【结果】治疗2个月后,观察组总有效率为93.22%,高于对照组的79.66%(P<0.05);观察组PANSS、TAS-20评分均低于对照组,MMSE评分均高于对照组(P<0.05);观察组全血低切还原黏度、纤维蛋白原水平均低于对照组(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】氨磺必利联合高压氧治疗精神分裂症患者可减轻患者阳性与阴性症状、述情障碍,改善患者认知功能与血液流变学,且安全有效。
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苗天翼
闫军锋
苏琦
刘晓红
关键词 精神分裂症氨磺必利/治疗应用高压氧/方法血液流变学    
Abstract:【Objective】 To investigate the effects of sulfaapride combined with hyperbaric oxygen on alexithymia and hemorheology in patients with schizophrenia. 【Methods】 The clinical data of 118 schizophrenics admitted to Shaanxi Provincial Armed Police Corps Hospital from February 2018 to February 2021 were analyzed retrospectively. They were divided into observation group and control group according to different treatment methods, with 59 cases in each group. The control group was treated with ambroxide, and the observation group was treated with hyperbaric oxygen on the basis of the control group, both of which were treated for 2 months. The curative effect, positive and negative symptom scale (PANSS), simple mental state scale (MMSE), Toronto alexithymia scale (TAS-20) scores, blood rheology indexes (whole blood low shear reduction viscosity, whole blood high shear reduction viscosity, fibrinogen), and adverse reactions were compared between the two groups before and after treatment for 2 months. 【Results】 After 2 months of treatment, the total effective rate in the observation group was 93.22%, which was higher than that in the control group (79.66%, P<0.05); The PANSS and TAS-20 scores in the observation group were lower than those in the control group, and the MMSE scores were higher than those in the control group (P<0.05); The formal level of whole blood low shear reducing viscosity and fibrinogen in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P>0.05). 【Conclusion】The combination of ambroxide and hyperbaric oxygen therapy can reduce the positive and negative symptoms, alexithymia, improve cognitive function and hemorheology in patients with schizophrenia, and it is safe and effective.
Key wordsSchizophrenia    Amisulpride/TU    Hyperbaric Oxygenation/MT    Hemorheology
收稿日期: 2021-06-09     
中图分类号:  R749.3  
通讯作者: *E-mail:1327631097@qq.com   
引用本文:   
苗天翼, 闫军锋, 苏琦, 刘晓红. 氨磺必利联合高压氧对精神分裂症患者述情障碍及血液流变学的影响[J]. 医学临床研究, 2022, 39(11): 1669-1671.
MIAO Tian-yi, YAN Jun-feng, SU Qi, et al. Effect of Ambroxide Combined with Hyperbaric Oxygen on Alexithymia and Hemorheology in Patients with Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1669-1671.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.11.020     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I11/1669
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