Abstract：【Objective】 To investigate the correlation between the expression levels of serum interleukin-1β(IL-1β) and interleukin-6 (IL-6) and pregnancy outcome in patients with pregnancy complicated with schizophrenia. 【Methods】 A total of 37 pregnant women with schizophrenia (observation group) and 28 normal pregnant women (control group) who delivered in the obstetrics department of the Affiliated Hospital of Yan'an University from January 2020 to December 2020 were selected. The expression levels of serum IL-1β and IL-6 in all subjects were detected by enzyme-linked immunosorbent assay (ELISA); Pearson was used to analyze the correlation between the expression levels of IL-1β and IL-6 and the correlation between the expression levels of IL-1β and IL-6 and adverse pregnancy outcomes; ROC curve was used to analyze the predictive value of IL-1β and IL-6 expression levels on adverse pregnancy outcomes. 【Results】 Compared with the control group, the expression levels of serum IL-1βand IL-6 in the observation group increased (P<0.05); There was a positive correlation between the expression of serum IL-β1 and IL-6 (r=0.54, P<0.05); The incidence of premature delivery, premature rupture of membranes, placental abruption and postpartum hemorrhage in the observation group was significantly higher than that in the control group (P<0.05); The incidence of low fetal weight, fetal malformation, fetal distress, perinatal death and severe asphyxia in the control group were significantly higher than those in the control group (P<0.05); The expression of serum IL-1β and IL-6 was positively correlated with adverse pregnancy outcome (P<0.05); ROC curve analysis showed that the area under the curve (AUC) of serum IL-1β and IL-6 in predicting adverse pregnancy outcomes were 0.883 and 0.864 respectively, and the AUC of combined prediction of adverse pregnancy outcomes was 0.891. 【Conclusion】 Pregnancy complicated with schizophrenia can increase the incidence of adverse pregnancy outcomes. Serum IL-1β and IL-6 are highly expressed in the serum of patients with pregnancy complicated with schizophrenia, which are closely related to the adverse pregnancy outcomes of patients with pregnancy complicated with schizophrenia, which can provide a basis for the condition monitoring of pregnancy complicated with schizophrenia.
张瑞, 白瑜. 妊娠合并精神分裂症患者血清中IL-1β、IL-6的表达水平及其与妊娠结局的相关性[J]. 医学临床研究, 2022, 39(5): 740-742.
ZHANG Rui, BAI Yu. Correlation between the Expression Levels of Serum IL-1β and IL-6 and Pregnancy Outcome in Patients with Pregnancy Complicated with Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 740-742.
2022, Vol. 39 
