血清NSE、VILIP-1水平与新生儿缺氧缺血性脑病NBNA评分的相关性

doi:10.3969/j.issn.1671-7171.2022.11.019

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摘要【目的】探讨血清特异性神经元烯醇化酶(NSE)、视椎蛋白样蛋白1(VILIP-1)水平与新生儿缺氧缺血性脑病(HIE)行为神经评分法(NBNA)评分的相关性。【方法】选取2018年3月至2021年8月本院收治的126例HIE患儿(观察组),并选择同期在本院出生的83例健康新生儿(对照组)。比较两组及观察组不同病情程度患儿出生后24 h(T₁)、72 h(T₂)、7 d(T₃)血清NSE、VILIP-1水平及NBNA评分,分析血清NSE、VILIP-1水平与NBNA评分的相关性,分析血清NSE、VILIP-1水平诊断HIE的价值。【结果】观察组T₁、T₂、T₃血清NSE、VILIP-1水平高于对照组,随时间推移呈降低趋势,NBNA评分低于对照组,随时间推移呈升高趋势,差异有统计学意义(P<0.05)。不同病情程度患儿T₁时血清NSE、VILIP-1水平及NBNA评分比较,随着病情加重,血清NSE、VILIP-1水平呈升高趋势,NBNA评分呈降低趋势,差异有统计学意义(P<0.05)。经Pearson相关系数分析,T₁时血清NSE、VILIP-1水平与NBNA评分均呈负相关(r=－0.603、－0.589,均P<0.001)。T₁时血清NSE、VILIP-1诊断HIE的截断值分别为28.36 μg/L、0.61 μg/L,曲线下面积(AUC)分别为0.713、0.696,两者联合诊断HIE的AUC及敏感度、特异度均大于两者单独诊断(P<0.05)。【结论】血清NSE、VILIP-1水平与HIE患儿NBNA评分密切相关,动态监测可指导临床完善治疗方案。

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	韩波
	牟春燕

关键词 ：缺氧缺血,脑, 婴儿,新生,疾病, 磷酸丙酮酸水合酶/血液, 神经钙蛋白/血液

Abstract：【Objective】Objective To investigate the correlation between serum specific neuron enolase (NSE), optic vertebrae protein like protein 1 (VILIP-1) levels and neonatal hypoxic-ischemic encephalopathy (HIE) behavioral neurological score (NBNA). 【Methods】 From March 2018 to August 2021, 126 HIE children (observation group) were selected and 83 healthy newborns (control group) were selected.The levels of serum NSE, VILIP-1 and NBNA scores were compared between the two groups and the observation group at 24 h (T₁), 72 h (T₂) and 7 d (T₃) after birth, and the correlation between the levels of serum NSE, VILIP-1 and NBNA scores was analyzed. At the same time, the diagnostic value of serum NSE, VILIP-1 levels in HIE was analyzed. 【Results】The levels of NSE and VILIP-1 in serum of T₁, T₂, T₃ in the observation group were higher than those in the control group, showing a decreasing trend over time. The NBNA score was lower than that in the control group, showing a rising trend over time, with a statistically significant difference (P<0.05). Compared the serum NSE, VILIP-1 levels and NBNA scores at T₁ of children with different disease severity, the serum NSE, VILIP-1 levels showed an upward trend and NBNA scores showed a downward trend with the aggravation of the disease (P<0.05). Pearson correlation coefficient analysis showed that serum NSE, VILIP-1 levels at T₁ were negatively correlated with NBNA scores (r=-0.603, -0.589, both P<0.001). The cut-off values of serum NSE and VILIP-1 in diagnosing HIE at T₁ were 28.36 μg/L,0.61 μg/L respectively, the area under the curve (AUC) was 0.713 and 0.696 respectively. The AUC, sensitivity and specificity of combined diagnosis of HIE and HIE were higher than that of single diagnosis of HIE and HIE (P<0.05). 【Conclusion】The levels of serum NSE and VILIP-1 are closely related to the NBNA score of HIE children, and dynamic monitoring can guide clinical improvement of treatment.

Key words： Hypoxia-Ischemia,Brain Infant,Newborn,Diseases Phosphopyruvate Hydratase/BL Neurocalcin/BL

收稿日期: 2022-04-13

中图分类号:

R722.1

通讯作者: *E-mail:mcyyezi@126.com

引用本文:

韩波, 牟春燕. 血清NSE、VILIP-1水平与新生儿缺氧缺血性脑病NBNA评分的相关性[J]. 医学临床研究, 2022, 39(11): 1666-1668.
HAN Bo, MOU Chun-yan. Correlation between Serum NSE, VILIP-1 Levels and NBNA Scores in Neonates with Hypoxic-ischemic Encephalopathy. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1666-1668.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.11.019 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I11/1666

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