Abstract：【Objective】 To investigate the relationship between the symptoms of emotional retardation and mismatch negativity (MMN) in event-related potential (ERP) in schizophrenia.【Methods】 Fifteen schizophrenic patients with and without affective retardation symptoms and 15 healthy subjects were selected as the subjects without medication or withdrawal for more than four weeks. The ERP data of all subjects under the auditory oddball paradigm were recorded, and the differences of MMN latency and amplitude among the three groups were compared. 【Results】 (1) MMN amplitude: in frontal region, the amplitude of MMN in the non affective group was lower than that in the healthy control group, while the MMN amplitude in the frontal region in the emotional retardation group was lower than that in the former two groups. In central area, left side and right side, only the MMN amplitude of patients with affective retardation was lower than that of healthy control group; in the middle, MMN amplitude of patients with and without affective retardation was lower than that of healthy control group, but there was no significant difference between the two groups. (2) There was no significant difference in MMN latency among the three groups.【Conclusions】 This study found that the process of pre attention processing is impaired in schizophrenic patients, and the degree of impairment is more serious in patients with emotional retardation.
唐佩茜, 孙巧玲, 谭立文. 有情感迟钝精神分裂症患者的失匹配负波研究[J]. 医学临床研究, 2020, 37(8): 1128-1132.
TANG Pei-xi, SUN Qiao-ling, TAN Li-wen. A study of Mismatch Negativity in Schizophrenic Patients with Affective Retardation. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1128-1132.
[1] 陆林. 沈渔邨精神病学[M].第6版.北京:人民卫生出版社,2020:300-301. [2] 周振和,袁国棋,朱红梅,等.喹硫平对儿童少年期精神分裂症患者失匹配性负波电位的影响[J].中华行为医学与脑科学, 2009,18(6):508-510. [3] Mathalon DH, Ford JM, Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study [J].Biol Psychiatry,2000, 47(5):434-449. [4] Jan S, Juran SA, Nele WW, et al. Auditory change detection in schizophrenia: sources of activity, related neuropsychological function and symptoms in patients with a first episode in adolescence, and patients 14 years after an adolescent illness-onset[J].BMC Psychiatry,2006,6:7. [5] Youn T, Park HJ, Kim JJ, et al. Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity[J].Schizophr Res,2003,59(2-3):253-260. [6] 高存友, 甘景梨, 孔素丽,等.Ⅰ、Ⅱ型精神分裂症事件相关电位对比及相关性研究[J].中国民康医学, 2007,19(5):168-169. [7] 刘青雷,黄宝晨,孙吉林.实用临床电生理学[M].北京:中国科学技术出版社,2006:95-108. [8] Minah Kim. Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis[J].Clin Neurophysiol,2016, 128(2):331-339. [9] 张明岛,陈兴时.脑诱发电位学[M].第5版.上海:科技教育出版社,2016:801-809. [10] Christian K rgel, Sartory G, Kariofillis D, et al. Mismatch negativitylatency and cognitive function in schizophrenia[J].PLoS One,2014, 9(4):e84536. [11] Ales Urban, Jan Kremlácek, Jan Libiger. Mismatch negativity in patients with schizophrenia[J].Acta Medica,2007, 50(1):23-28. [12] 张李娜. 精神分裂症患者事件相关电位MMN对照研究[J].山西医科大学学报, 2012, 43(010):780-782. [13] 陈兴时,徐一峰,唐云翔.脑电生理学技术在精神分裂症中的应用:现状、发展及展望[J].中华医学杂志,2010,90(29):2017-2019. [14] 郝伟, 于欣. 精神病学[M].第7版.北京:人民卫生出版社,2013:97-99. [15] Nagai T, Tada M, Kirihara K, et al. Mismatch negativity as a "translatable" brain marker toward early intervention for psychosis: a review[J].Front Psychiatry,2013,4:115. [16] Fishman YI. The mechanisms and meaning of the mismatch negativity[J].Brain Topogr,2014,27(4):500-526. [17] Jordanov T,Popov T,Weisz N,et al. Reduced mismatch negativity and increased variability of brain activity in schizophrenia[J].Clin Neurophysiol,2011,122(12): 2365-2374. [18] 楼翡璎,陈兴时,张明岛,等.精神分裂症患者失匹配负波(MMN)研究[J].现代电生理学杂志,2006,13(3):131-133. [19] N t nen Risto, K hk nen Seppo. Central auditory dysfunction in schizophrenia as revealed by the mismatch negativity (MMN) and its magnetic equivalent MMNm: a review[J].Int J Neuropsychopharmacol,2009,(1):125-135. [20] N t nen R,Gaillard AW,M ntysalo S. Early selective-attention effect on evoked potential reinterpreted[J].Acta Psychol,1978, 42(4):313-329. [21] Opitz B.Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results[J].Neuroimage,2002, 15(1):167-174. [22] Erickson MA, Ruffle A, Gold JM. A Meta-Analysis of Mismatch Negativity in Schizophrenia: From Clinical Risk to Disease Specificity and Progression[J].Biol Psychiatry,2016, 79(12):980-987.
2020, Vol. 37 
