Abstract：【Objective】To explore the clinical effect and mechanism of zopiclone in the treatment of schizophrenia with sleep disorders. 【Methods】The clinical data of 90 patients with schizophrenia complicated with sleep disorder treated in our hospital from February 2019 to February 2020 were retrospectively analyzed. According to different treatment methods, they were divided into control group and observation group, with 45 cases in each group. The control group was given oral aripiprazole + alprazolam, and the observation group was given oral aripiprazole + zopiclone. The clinical efficacy, sleep quality(PSQI), serum serotonin(5-HT) and nuclear transcription factor were compared between the two groups before and after treatment-κB(NF-κB). The adverse reactions of the two groups were observed and recorded. 【Results】After one week of treatment, the PSQI score of the observation group was lower than that of the control group(P<0.05); There was no significant difference in PSQI scores between the two groups before treatment, 2 weeks and 3 weeks of treatment(P>0.05). The effective rate of the observation group was 75.56%(34/45), which was significantly higher than 55.56%(25/45) of the control group(χ2 =3.986,P=0.046＜0.05). After treatment, serum NF-κB , the level of was lower than that before treatment, and the level of 5-HT was higher than that before treatment, and there was significant difference between the observation group and the control group(P<0.05). The incidence of adverse reactions in the observation group was 24.44%(11/45), which was lower than 44.44%(20/45) in the control group(P<0.05).【Conclusion】Zopiclone can better improve the sleep quality of schizophrenic patients with sleep disorders, and the incidence of adverse reactions is less. It may be related to the regulation of serum 5-HT and NF-κB by zopiclonelevel.
李英, 安国松. 佐匹克隆治疗精神分裂症合并睡眠障碍患者的临床疗效及对相关神经因子水平的影响[J]. 医学临床研究, 2021, 38(7): 1011-1013.
LI Ying, AN Guo-song. Clinical Efficacy of Zopiclone in the Treatment of Schizophrenia Complicated with Sleep Disorder and its Effect on the Level of Related Nerve Factors. JOURNAL OF CLINICAL RESEARCH, 2021, 38(7): 1011-1013.
2021, Vol. 38 
