Abstract：【Objective】 To evaluate the clinicopathologic features of adenocarcinoma with gastrointestinal stromal tumor (GIST) in the stomach. 【Methods】 The clinical data of 703 gastric cancer (GC) patients (546 Han, 122 Uygur, and 35 Hui) admitted to the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital) were collected. Clinicopathologic features of 16 cases of adenocarcinoma with gastrointestinal stromal tumor (GIST) from those 703 cases of gastric cancer were analyzed. 【Results】 Among 703 gastric cancer patients, 16 cases (2.28%) of GIST with synchronous carcinoma were diagnosed preoperatively, including 12 males and 4 females. The age of the patients ranged from 35 to 80 years old (average age 63.5 years old). All cases were invasive adenocarcinoma of no special type,which mean diameter was 4.6 cm. Meanwhile, 16 cases of GISTs were single nodule in the stomach, with an average diameter of 0.96 cm; And the histomorphological examinations all showed spindle cell type. Most GISTs were in the early phase and had low risk of malignance:14 cases were of very low risk, 1 case of low risk, and 1 case of moderate risk. The positive rate of CD117 and SDH-B proteins expression were 100%, Dog-1 were 87.5% (14/16), CD34 were 75% (12/16), the Ki-67 proliferative index was lower than 5%. The mutation detection rate of C-KIT exons 11 and 9 were 56.25% (9/16),18.75% (3/16), respectively, while 4 cases were no mutations. There were no correlated with different ethnic groups in adenocarcinoma with GIST in the stomach(P>0.05). All the patients with gastric cancer were undernent radical gastrectomy. At a median follow-up of 29 months,10 cases were alive without evidence of recurrence or distant metastases, whereas 3 cases had gastric adenocarcinoma distant metastases. 【Conclusion】 In our study, there is no difference of incidence rate among nationalities . There is no high risk grading in synchronous GIST,and no patients have GIST relapse. The cytologically of all GIST cases are bland spindle shaped cells. Decisions about surgical extent and further management should likely be made mainly according to GC in the occurrence synchronous tumors.
2023, Vol. 40 
