Abstract：【Objective】 To investigate the expression of Mucin 5AC protein in gastric polyps and its clinical significance. 【Methods】 A total of 160 patients with gastric polyps treated in our hospital from January 2017 to January 2018 were selected, meanwhile 87 normal gastric mucosa tissues and 90 gastric cancer tissues were enrolled as controls.Mucin 5AC protein expression was detected by immunohistochemical staining. 【Results】 The positive expression rate of Mucin 5AC protein in gastric polyps was 64.38% (103/160), which was significantly higher than that in gastric cancer (41.11%, P<0.05), but lower than that in normal gastric tissues (87%, P<0.05). The positive expression rate of Mucin 5AC protein in proliferative polyps was 71.43%, which was significantly higher than that in adenomatous polyps (53.23%, P<0.05); There were no significant difference in terms of the positive expression rate of Mucin 5AC protein in different age, gender, size and location of gastric polyps (P>0.05). 【Conclusion】 Mucin 5AC protein may be down-regulated during malignant transformation of gastric polyps, which deserves further study.
余智涛, 张磊, 林松荣, 赵玉军, 温建燔, 罗金现, 卢冠坤. Mucin 5AC蛋白对胃息肉恶变患者病情发生发展的影响[J]. 医学临床研究, 2020, 37(9): 1306-1308.
YU Zhi-tao, ZHANG Lei, LIN Song-rong, et al. Effect of Mucin 5AC Protein on the Occurrence and Development of Malignant Gastric Polyps. JOURNAL OF CLINICAL RESEARCH, 2020, 37(9): 1306-1308.
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2020, Vol. 37 
