Abstract：【Objective】To investigate the relationship between liver kinase B1 (LKB1) gene expression and the survival rate of gastric cancer. 【Methods】From June 2012 to June 2013, 46 cases of gastric cancer tissue samples were collected and the clinical and pathological data were analyzed retrospectively. The expression of LKB1 protein in gastric cancer tissue was detected by immunohistochemistry, and the relationship between LKB1 gene expression and clinicopathological parameters with survival rate was also analyzed. 【Results】The positive expression rate of LKB1 protein in gastric cancer was 19.57% (9/46), significantly lower than that in normal adjacent tissues (89.13%, P<0.05). There was no significant difference in age, sex, lymph node metastasis and histopathological classification (P>0.05). There was significant difference in tumor size, TNM stage, and serosal infiltration (P<0.05). The average survival time of LKB1 low expression group was 43.9 months and that of high expression group was 52.6 months. The 5-year survival rate of LKB1 low expression group was significantly lower than that of LKB1 high expression group (P<0.05) . 【Conclusion】LKB1 gene plays an important role in inhibiting the occurrence and development of gastric cancer, improving prognosis, and improving survival rate of patients. Therefore, the mechanism of tumor suppressor gene LKB1 in the diagnosis, treatment, and prognosis of gastric cancer deserves attention, which can provide a new breakthrough for the treatment of gastric cancer.
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2021, Vol. 38 
