血清肿瘤标志物和免疫组化指标与胃癌临床病理特征的相关性

doi:10.3969/j.issn.1671-7171.2021.12.029

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摘要【目的】探讨免疫组化指标及肿瘤标志物与胃癌临床病理特征的相关性。【方法】回顾性分析2015年12月至2019年12月于本院就诊的152例胃癌患者的临床资料,分析免疫组化中人类表皮生长因子受体(Her-2)、表皮生长因子受体(EGFR)及抗原ki67(Ki67)的表达及肿瘤标志物癌胚抗原(CEA)、糖链抗原(CA125)及糖链抗原(CA19-9)的水平与胃癌患者临床病理特征的相关性。【结果】Her-2、EGFR、Ki67表达与有淋巴转移、高分化及TNM Ⅲ、Ⅳ期之间存在相关性(P<0.05);有肿瘤淋巴转移患者CEA、CA125、CA19-9水平明显高于无转移患者(P<0.05),以肿瘤2.4 cm为界,肿瘤直径增大患者血清中CEA、CA125、CA19-9水平明显高于肿瘤直径较小者(P<0.05)。CA125水平随患者病理分化程度升高而降低(P<0.05);在胃癌患者中,Ⅱ期、Ⅲ期、Ⅳ期的CEA、CA125、CA199的表达高于I期(P<0.05),Ⅲ期、Ⅳ期的CEA、CA125、CA199的表达高于Ⅱ期(P<0.05),Ⅳ期的CEA、CA125、CA199的表达高于Ⅲ期(P<0.05)。【结论】免疫组化及肿瘤标志物能作为胃癌患者诊断的依据,为胃癌患者早期的诊断及治疗提供理论依据。

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	李继斌
	王瑞
	汤水平

关键词 ：胃肿瘤/病理学, 癌胚抗原/血液, CA-19-9抗原/血液, 生物标记, 肿瘤

Abstract：【Objective】To investigate the correlation of immunohistochemistry and tumor markers with clinicopathological characteristics of gastric cancer. 【Methods】Retrospective analysis of all clinical data of 152 patients with gastric cancer treated in our hospital from December 2015 to December 2019 were studied. The relationship of the expression of human epidermal growth factor receptor (Her-2), epidermal growth factor receptor (EGFR), antigen ki67 (Ki67), tumor markers carcinoembryonic antigen (CEA), sugar chain antigen (CA125 and CA19-9) with the clinicopathological characteristics of patients with gastric cancer. 【Results】The expressions of HER-2, EGFR and Ki67 were correlated with lymphatic metastasis, high differentiation and TNM stages Ⅲ and IV (P<0.05). The levels of CEA, CA125 and CA19-9 in patients with tumor lymphatic metastasis were significantly higher than those in patients without metastasis (P<0.05). Taking the tumor diameter 2.4cm as the boundary,the levels of CEA, CA125 and CA19-9 in serum of patients with increased tumor diameter were significantly higher than those with smaller tumor diameter (P<0.05). The level of CA125 decreased with the increase of pathological differentiation (P<0.05). In patients with gastric cancer, the expression of CEA, CA125 and CA199 in stage Ⅱ, Ⅲ and Ⅳ was higher than that in stage Ⅰ(P<0.05), the expression of CEA, CA125 and CA199 in stage Ⅲ and Ⅳ was higher than that in stage Ⅱ (P<0.05), and the expression of CEA, CA125 and CA199 in stage Ⅳ was higher than that in stage Ⅲ(P<0.05). 【Conclusion】Immunohistochemistry and tumor markers can be used as useful reference for the diagnosis of gastric cancer patients, and provide a theoretical basis for the early diagnosis and treatment of gastric cancer patients.

Key words： Stomach Neoplasms/PA Carcinoembryonic Antigen/BL CA-19-9 Antigen/BL Biomarkers, Tumor

收稿日期: 2020-10-14

中图分类号:

R735.2

基金资助:陕西省重点研发计划项目(2018YBXM-SF-12-1)

通讯作者: **E-mail:664561883@qq.com

引用本文:

李继斌, 王瑞, 汤水平. 血清肿瘤标志物和免疫组化指标与胃癌临床病理特征的相关性[J]. 医学临床研究, 2021, 38(12): 1860-1863.
LI Ji-bin, WANG Rui, TANG Shui-ping. Correlation Analysis of Serum Tumor Markers and Immunohistochemical Indicators with Clinicopathological Features of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(12): 1860-1863.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.12.029 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I12/1860

[1] 樊祥山, 李琳, 黄勤. 胃癌精准病理诊断中的一些值得重视的问题[J].中华病理学杂志, 2018, 47(7):481-485.
[2] 胡丹, 林贤东, 沈武成, 等. HMGB1和RAGE蛋白在胃癌中的表达及其预后意义[J].中华病理学杂志, 2018, 47(7):542-543.
[3] 王玎, 董召刚, 王立水, 等. 血清癌胚抗原和CA19-9对胃间质瘤的临床价值[J].中华检验医学杂志, 2019, 42(2):128-134.
[4] 王勇, 崔红领, 林运智, 等. 多层螺旋计算机断层扫描及胃肠道肿瘤标志物对进展期胃癌和原发性胃淋巴瘤的鉴别诊断价值[J].癌症进展, 2020, 18(15):4.
[5] ENDO M,KANDA M,SAWAKI K, et al. Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer[J].Anticancar Res,2019, 39(11):5903-5910.
[6] 李凤科, 汪亦民, 李春峰,等. 残胃上的癌与胃癌临床病理特征和预后的比较[J].中华胃肠外科杂志, 2018, 21(5):529-534.
[7] 曹一鑫, 李小琴, 王宏宇,等. Tensin1蛋白与胃癌临床病理特征及预后的关系[J].中华消化外科杂志, 2018, 17(6):612-618.
[8] 张云, 姚萍, 崔旻,等. 临床病理特征与早期胃癌分化程度的关系[J].中华实用诊断与治疗杂志, 2019, 33(5):51-52.
[9] 叶欣, 于健春, 康维明, 等. 胃癌患者手术前后血清维生素B₁₂水平的变化及其影响因素[J].中华普通外科杂志, 2017, 32(7):608-611.
[10] YAMASAKI K, KIYOTANI C, TERASHIMA K, et al. Clinical characteristics, treatment, and survival outcome in pediatric patients with atypical teratoid/rhabdoid tumors: a retrospective study by the Japan Children's Cancer Group[J].J Neurosurg Pediatr,2019,32(15):1-10.
[11] 周荣健, 赵骏杰, 束平, 等. 90例青年胃癌患者的临床病理特征及预后分析[J].中华胃肠外科杂志, 2017, 20(11):1288-1292.
[12] 王洁, 张光波, 魏良君, 等. 血浆外泌体中B7同源物3、程序性细胞死亡蛋白1-配体1在胃癌患者中的表达变化及其临床意义[J].中华消化杂志, 2019, 39(3):187-190.