Abstract：【Objective】To investigate the relationship of Lysine (K)-specific demethylase 2B (KDM2B) expression with gastric cancer recurrence. 【Methods】Three hundred gastric cancer patients who received surgical treatment in our hospital were included in this study. The expression of KDM2B in gastric cancer tissues was detected and follow-up was conducted to determine the recurrence. Kaplan-Meier and log-rank test were used for univariate analysis, and significant factors in univariate analysis were introduced into Cox regression model. 【Results】According to TNM staging, among the 300 patients selected, 75 cases were categorized into stage Ⅰ, 63 cases were in stage Ⅱ, and 123 cases were in stage Ⅲ. Follow-up was completed in 278 patients, While 22 cases were lost to follow-up. The follow-up rate was 92.7%. KDM2B positive expression was shown in 123 patients (41%) . Recurrence and metastasis occurred in 142 patients. Univariate analysis showed that larger tumors, higher T stage, higher N stage, later TNM stage and positive KDM2B expression increased the risk of recurrence in patients with gastric cancer after surgery. Cox regression analysis showed that, compared to patients with negative KDM2B expression, patients with positive KDM2B expression increased risk of gastric cancer recurrence by 98% [HR:1.98;95%CI: 1.23-3.32]. 【Conclusion】Positive KDM2B expression increases the risk of postoperative recurrence in patients with gastric cancer and patients with positive KDM2B expression have a worse prognosis.
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2020, Vol. 37 
