S相激酶相关蛋白和p27kip1蛋白表达与胃癌临床病理特征的相关性研究

doi:10.3969/j.issn.1671-7171.2021.05.009

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摘要 【目的】 探讨原发性胃癌组织中细胞S相激酶相关蛋白(skp2)、p27kip1蛋白表达强度与肿瘤发生、发展的关系。【方法】 选取本院获取的60例胃癌组织标本作为胃癌组、60例胃癌癌旁组织标本作为对照组,采用免疫组化染色技术检测两组标本skp2蛋白、p27kip1蛋白阳性表达率,分析不同病灶大小、组织学分级、浸润程度、淋巴结转移及TNM分期胃癌组织中skp2蛋白、p27kip1蛋白阳性表达率的差异。【结果】 胃癌组skp2蛋白阳性表达率为68.33%(41/60),高于对照组的23.33%(14/60),p27kip1蛋白阳性表达率为28.33%(17/60),低于对照组的73.33%(44/60),且两组比较差异均有显著性(P<0.05);不同TNM分期、是否发生淋巴结转移、不同组织学分化程度、不同肿瘤浸润程度的胃癌组织中skp2蛋白阳性表达率相比较差异有显著性(P<0.05);不同TNM分期、是否发生淋巴结转移的胃癌组织中p27kip1蛋白阳性表达率差异有显著性(P<0.05)。【结论】 胃癌组织中的skp2蛋白表达上调、p27kip1蛋白表达下调,其可能与胃癌的发生及发展有关。

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	刘甫
	马沛
	魏海

关键词 ：胃肿瘤/病理学, 蛋白激酶类, 肿瘤转移, 肿瘤侵润, 预后

Abstract：【Objective】 To investigate the relationship between the expression of S phase kinase-related protein (skp2) and p27kip1 protein in primary gastric cancer and the development of tumorigenesis. 【Methods】 A total of 60 cases of gastric cancer tissue samples obtained in our hospital were selected as gastric cancer group, and 60 cases of gastric cancer adjacent tissue samples were selected as control group. The positive expression rates of Skp2 and p27kip1 were detected by immunohistochemistry.The positive rates of Skp2 protein and p27kip1 Protein in gastric cancer tissues with different lesion size, histological grade, degree of invasion, lymph node metastasis and TNM stage were analyzed. 【Results】 The positive expression rate of Skp2 protein in the gastric cancer group was 68.33% (41/60), which was higher than 23.33% (14/60) in the control group; the positive expression rate of p27kip1 Protein in the gastric cancer group was 28.33% (17/60), which was lower than 73.33% (44/60) in the control group, and there was significant difference between the two groups (P<0.05); the positive expression rate of Skp2 protein in gastric cancer tissues with different TNM stages, lymph node metastasis, histological differentiation and tumor invasion was significantly different (P<0.05); the positive expression rate of Skp2 protein in gastric cancer tissues with different TNM stages and lymph node metastasis was significantly different (P<0.05).【Conclusion】 The expression of Skp2 protein is up-regulated and p27kip1 Protein is down regulated in gastric cancer, which may be related to the occurrence and development of gastric cancer.

Key words： Stomach Neoplasms/PA Protein Kinases Neoplasm Metastasis Neoplasm Invasiveness Prognosis

收稿日期: 2019-11-17

中图分类号:

R735.2

基金资助:河南省医学科技攻关计划项目(2018020976)

引用本文:

刘甫, 马沛, 魏海. S相激酶相关蛋白和p27kip1蛋白表达与胃癌临床病理特征的相关性研究[J]. 医学临床研究, 2021, 38(5): 670-672.
LIU Fu, MA Pei, WEI Hai. Correlation between Expression of S-phase Kinase Associated Protein,p27kip1 Protein and Clinicopathological Features of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 670-672.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.05.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I5/670