Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2023 Vol. 40, No. 11 Published: 2023-11-26 Original Articles          Original Articles 1617 Clinical Characteristics and Prognostic Factors Analysis of 121 Children with Neuroblastoma ZHENG Taiqing, WEN Rong, QIN Lei, et al DOI: 10.3969/j.issn.1671-7171.2023.11.001 【Objective】To investigate the clinical characteristics and prognostic factors of neuroblastoma(NB) in children. 【Methods】A retrospective analysis was conducted on the clinical data of 121 children with NB admitted to our hospital from January 2019 to September 2022. The Kaplan Meier method was used for univariate analysis to calculate the average survival time of each group of patients,and the Log-rank test was used to analyze the differences in survival rate among groups. The Cox regression model was used for multivariate analysis to analyze the independent risk factors affecting the survival rate of children,and the correlation between NB clinical factors and survival time and outcome was analyzed. 【Results】Log-rank test analysis showed that gender,LDH,NMYC amplification,MKI index,INSS stage,COG risk group,and histological type were factors affecting the survival time of children(P<0.05). Multivariate analysis using the Cox regression model showed that LDH≥500 U/L,NMYC gene amplification,and INSS stage 4 were independent risk factors affecting the survival prognosis of children(P<0.05). 【Conclusion】NMYC amplification and INSS stage 4 are risk factors affecting the prognosis of children with NB;detecting serum LDH is of great significance for evaluating the prognosis of children with NB. 2023 Vol. 40 (11): 1617-1619 [Abstract] ( 94 ) HTML (1 KB)  PDF (2282 KB)  ( 50 ) 1620 Study on the Effect of Tetracaine Mucilage Combined with Etomidate in the Removal of Double-J Tube ZHANG Long, JIANG Hui, YANG Yiying, et al DOI: 10.3969/j.issn.1671-7171.2023.11.002 【Objective】To investigate the effect of tetracaine mucilage combined with etomidate in the removal of double-J tube. 【Methods】A total of 180 patients undergoing cystoscopy-assisted double-J tube removal were randomly divided into tetracaine mucilage group(group A),tetracaine mucilage combined with etomidate group(group B),and fentanyl combined with etomidate group(group C),with 60 cases in each group.The mean arterial pressure(MAP),heart rate(HR),pulse oximetry(SpO2),respiratory rate(RR),and adverse reactions during the operation were compared at each time point of the patients' lithotomy position(T0),2 minutes after administration(T1),after entering the bladder(T2),and after removing the double-J tube(T3). The operation time and postoperative urethral pain stimulation [visual analog scale(VAS)] scores were also compared. The satisfaction of patients,operating physicians,and anesthesiologists was compared. 【Results】The MAP,RR,and HR at T2 and T3 in group A were higher than those in group B and C(P<0.05);the MAP,RR,and SpO2 at T1 in group C were lower than those in group A and B(P<0.05);the incidence of body movement during the operation in group A was higher than that in group B and C,while the incidence of myoclonus was lower than that in group B and C(both P<0.05);the incidence of respiratory depression,dizziness,nausea,and vomiting in group C was higher than that in group A and B(P<0.05);the operation time and VAS scores at 10 minutes and 1 hour after surgery in group A were higher than those in group B and C(P<0.05);the VAS score at 2 hours after surgery in group B was lower than that in group A and C(P<0.05);the satisfaction of patients,operating physicians,and anesthesiologists in group B was higher than that in group A and C(P<0.05). 【Conclosion】The effect of tetracaine mucilage combined with etomidate in the removal of double-J tube is better,with the advantages of short-term analgesia,sedation,and less adverse reactions. 2023 Vol. 40 (11): 1620-1623 [Abstract] ( 53 ) HTML (1 KB)  PDF (1233 KB)  ( 45 ) 1624 Application of DCE-MRI,DWI,and Multislice Spiral CT Enhancement Scanning in the Differential Diagnosis of Hepatic Hemangioma and Liver Metastatic Carcinoma JIANG Shijie, LI Heng DOI: 10.3969/j.issn.1671-7171.2023.11.003 【Objective】To discuss the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI),diffusion-weighted imaging(DWI),and multislice spiral CT(MSCT) enhancement scanning in the differential diagnosis of hepatic hemangioma and liver metastatic carcinoma. 【Methods】 Thirty-eight patients with liver metastatic carcinoma were enrolled in the metastasis group,and thirty-two patients with hepatic hemangioma were recruited in the hemangioma group. All patients received examination of DCE-MRI,DWI,and MSCT before surgery. According to pathology diagnosis as gold standard,the imaging characteristics of the two groups were compared,and diagnostic value of indicators were calculated by drawing 2×2 contingency tables for each type of examination. 【Results】The proportion of patients in the hemangioma group with arterial enhancement and portal venous enhancement was significantly lower than that in the metastasis group,and the proportion of patients in the hemangioma group with high signal in the delay phase was significantly higher than that in the metastasis group(P<0.05). The ADC value of DWI in the hemangioma group were significantly higher than that in the metastasis group(P<0.05). Preoperative MSCT examination showed that the mean transit time,liver blood volume,and capillary surface permeability measurements of the hemangioma group were higher than those of the metastasis group(P<0.05),while lesion arterial perfusion and liver blood flow measurements in the hemangioma group were lower than those in the metastasis group(P<0.05). The sensitivity and specificity of DCE-MRI for differentiating liver metastatic carcinoma and hemangioma were 76.32% and 87.50%,respectively; The sensitivity and specificity of DWI were 78.95% and 90.63%,respectively; And the sensitivity and specificity of MSCT were 71.05% and 93.75%,respectively. The sensitivity of the three combined differential diagnosis of liver metastatic carcinoma and hemangioma was 92.11% and the specificity was 87.50%. 【Conclusion】The combined application of DCE-MRI,DWI,and MSCT in the differential diagnosis of liver metastatic carcinoma and hepatic hemangioma can significantly improve sensitivity while maintaining high specificity. 2023 Vol. 40 (11): 1624-1627 [Abstract] ( 49 ) HTML (1 KB)  PDF (1227 KB)  ( 41 ) 1628 The Efficacy of Niaoduqing Combined with Beraprost in the Treatment of Chronic Glomerulonephritis and its Impact on Renal Function ZHU Lihong, LIU Huamei DOI: 10.3969/j.issn.1671-7171.2023.11.004 【Objective】To investigate the efficacy of Niaoduqing combined with beraprost in the treatment of chronic glomerulonephritis(CGN) and its impact on patients' renal function. 【Methods】A total of 80 patients with CGN were randomly divided into two groups,with 40 cases in each group.Under routine intervention,patients in the control group were treated with beraprost,while patients in the observation group were additionally treated with Uremic Clearance,with a course of treatment of 90 days.The clinical efficacy,renal function indicators [24 hour urinary protein quantitation(24hUPro),serum creatinine(Scr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG)] levels,and inflammatory factors [interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)] levels,as well as adverse reactions,were observed and compared between the two groups. 【Results】The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). After treatment,the levels of 24hUPro,Scr,BUN,β2-MG,IL-6,TNF-α,and hs-CRP in both groups decreased compared with those before treatment(P<0.05),and the levels of each index in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】Niaoduqing combined with beraprost has significant efficacy in the treatment of CGN,which can effectively improve patients' renal function and reduce the level of inflammatory factors in the body. At the same time,it has high safety and is worthy of clinical application. 2023 Vol. 40 (11): 1628-1630 [Abstract] ( 31 ) HTML (1 KB)  PDF (2285 KB)  ( 74 ) 1631 Scalp Acupuncture and Rehabilitation Therapy Combined with Traditional Chinese Medicine Five Tones for the Treatment of Intellectual Impairment in Children with Autism Clinical Efficacy WANG Tao, LIU Jing, HU Yanying, et al DOI: 10.3969/j.issn.1671-7171.2023.11.005 【Objective】To explore the clinical effect of scalp acupuncture and rehabilitation therapy combined with traditional Chinese medicine five tone therapy on children with autism and intellectual impairment. 【Methods】A total of 124 children with autism and intellectual disabilities admitted to our hospital from August 2020 to February 2022 were selected and randomly divided into a control group(treated with traditional Chinese medicine five tone therapy) and an observation group(treated with scalp acupuncture and intellectual rehabilitation therapy on the basis of the control group) using a random number table method,with 62 cases in each group. Both groups received continuous treatment for 6 months. The behavioral and symptom scores of autism in both groups were compared before and after treatment,as well as the clinical efficacy of the two groups. The changes in emotions,sleep scores,visual and auditory functions,and intelligence levels of the two groups of children were compared before and after treatment.【Results】The difference in scores of the childhood autism rating scale(CARS) and Autism Behavior Rating Scale(ABC) before and after treatment in the observation group was higher than that in the control group(P<0.05). The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05). The difference in scores of the emotional regulation scale(ER) and children's sleep habits questionnaire(CSHQ) before and after treatment in the observation group was higher than that in the control group (P<0.05). The difference in attention quotient(FAQ) and comprehensive response control quotient(FRCQ) scores between the observation group and the control group before and after treatment was higher(P<0.05). The difference in verbal intelligence(VIQ) and operational intelligence(PIQ) before and after treatment in the observation group was higher than that in the control group(P<0.05).【Conclusion】 The combination of scalp acupuncture and rehabilitation therapy with traditional Chinese medicine five tone therapy can improve the symptoms of loneliness in children with autism and intellectual disorders. The clinical efficacy is good,and it can improve the emotional and sleep conditions of children,and help improve their visual and auditory functions and intelligence levels. 2023 Vol. 40 (11): 1631-1634 [Abstract] ( 38 ) HTML (1 KB)  PDF (1223 KB)  ( 134 ) 1635 Diagnostic Value of Thromboelastography and Mean Platelet Volume in Fetal Growth Restriction CHEN Yanmei, WANG Huiling, YANG Baoyan, et al DOI: 10.3969/j.issn.1671-7171.2023.11.006 【Objective】To investigate the clinical significance and diagnostic value of thromboelastography(TEG) and mean platelet volume(MPV) in fetal growth restriction(FGR). 【Methods】Eighty-one pregnant women with FGR in our hospital from January 2019 to January 2022 were selected as the observation group,and eighty normal pregnant women of the same gestational weeks in the same period were selected as the control group. All of them underwent TEG,recorded coagulation time(K value),coagulation reaction time(R value),maximum thrombus amplitude(MA value) and coagulation angle(Angle value),and MPV level. The influencing factors of FGR and the diagnostic value of TEG index and MPV level were analyzed. 【Results】There were no significant differences in women's pregnant age gestational age,body mass index(BMI),production experience,gestational diabetes mellitus,scar uterus and premature rupture of membranes between the two groups(P>0.05). The proportion of gestational hypertension,spontaneous abortion≥2 times and oligohydramnios in FGR pregnant women was higher than that in normal pregnant women(P<0.05). There were no significant differences in both K value and Angle value between the FGR pregnant women and normal pregnant women(P>0.05). The MA value and MPV level of the FGR pregnant women were higher than those of normal pregnant women,while the R value of the observation group was lower than that of normal pregnant women(P<0.05). Logistic regression analysis showed that gestational hypertension,spontaneous abortion≥2 times,oligohydramnios,R value,MA value and MPV level were the risk factors of FGR(P<0.05). ROC analysis showed that the cut off values of R value,MA value and MPV level of TEG index were 6.88 min,67.27 mm and 11.32 fL,respectively,and their AUC values were 0.687,0.758 and 0.794,respectively. 【Conclusion】There are abnormal changes in TEG index R value,MA value and MPV level in the pregnant women with FGR,which has a certain diagnostic value for the occurrence of FGR. 2023 Vol. 40 (11): 1635-1637 [Abstract] ( 53 ) HTML (1 KB)  PDF (2317 KB)  ( 134 ) 1638 The Application Value of Dynamic Electrocardiogram MTWA in Predicting MACE in Patients with Chronic Heart Failure HE Ya, LIU Fenxia DOI: 10.3969/j.issn.1671-7171.2023.11.007 【Objective】To explore the clinical value of microvolt T wave alternation(MTWA) in predicting major adverse cardiovascular events(MACE) in patients with chronic heart failure.【Methods】A total of 100 patients with CHF admitted to Baoji Hospital affiliated to Xi'an Medical College from December 2019 to December 2021 were selected and divided into MACE group(n=28) and non-MACE group(n=72) according to whether they had MACE. All patients underwent ambulatory electrocardiogram examination,and the risk factors for MACE in patients with CHF were analyzed using univariate and multivariate logistic regression analysis. The receiver operating characteristic(ROC) curve was used to evaluate the value of MTWA in predicting MACE in patients with chronic heart failure. 【Results】The age ≥65 years old,BMI ≥25 kg/m2,history of arrhythmia,smoking history,NYHA classification Ⅳ,history of hypertension,overwork history,and the proportion of V1 lead maximum MTWA(MTWAmax),maximum heart rate(MTWApeakhr),and average MTWA(MTWAoverall) in the MACE group were higher than those in the non-MACE group(P<0.05). ROC curve analysis showed that MTWAmax,MTWApeakhr,and MTWAoverall had higher values for predicting MACE in patients with CHF,with areas under the curve of 0.903,0.686,and 0.825,respectively(P<0.05). Logistic regression analysis showed that age ≥65 years old,history of arrhythmia,smoking history,NYHA classification Ⅳ,history of hypertension,overwork history,MTWAmax≥24.706,MTWApeakhr≥1.586,and MTWAoverall≥1.489 were all risk factors for MACE in patients with CHF(P<0.05). 【Conclusion】The application value of ambulatory electrocardiogram MTWA in predicting MACE in patients with chronic heart failure is high,and it is worthy of clinical reference. 2023 Vol. 40 (11): 1638-1641 [Abstract] ( 36 ) HTML (1 KB)  PDF (1250 KB)  ( 29 ) 1642 Application Effect of Modified Postpartum Hemorrhage Prediction Score Scale in Patients with Postpartum Hemorrhage LEI Lili, LIU Hulin DOI: 10.3969/j.issn.1671-7171.2023.11.008 【Objective】To analyze the application effect of modified postpartum hemorrhage prediction score scale in patients with postpartum hemorrhage. 【Methods】A total of 100 patients with postpartum hemorrhage admitted to our hospital from June 2020 to June 2022 were randomly selected and divided into a control group and an observation group using the random envelope method,with 50 cases in each group. The control group received routine care,while the observation group had modified bleeding prediction score in addition to routine care of the control group. Related hemodynamics and postpartum blood loss were compared before and after the intervention,and the delivery outcomes and labor duration were compared between the two groups. 【Results】After the intervention,the BPC and SaO2 of the observation group were higher than those of the control group,and HR,systolic blood pressure,and diastolic blood pressure were lower than those of the control group,and the differences were statistically significant(P<0.05). After the intervention,the amount of postpartum bleeding and labor time in the observation group at different time points were less than those in the control group,the natural delivery rate was higher than that in the control group(P<0.05). and the difference was statistically significant(P<0.05). The natural delivery rate of the observation group was higher than that of the control group. The difference was statistically significant(P<0.05). 【Conclusion】The implementation of modified postpartum bleeding prediction score scale in postpartum hemorrhage patients can improve the postpartum hemodynamic index,reduce the postpartum bleeding volume,increase the natural delivery rate,and shorten the labor time. 2023 Vol. 40 (11): 1642-1644 [Abstract] ( 37 ) HTML (1 KB)  PDF (2287 KB)  ( 49 ) 1645 The Effect of Atomoxetine Hydrochloride Combined with Auditory Integration Training in the Treatment of Attention Deficit Hyperactivity Disorder in Children MOU Chunyan, HAN Bo DOI: 10.3969/j.issn.1671-7171.2023.11.009 【Objective】To explore the efficacy of atomoxetine hydrochloride combined with auditory integration training(AIT) in the treatment of attention deficit hyperactivity disorder(ADHD) in children.【Methods】 A total of 210 children with ADHD admitted to our hospital from April 2021 to August 2022 were selected and randomly divided into a control group and an observation group according to a random number table method,with 105 cases in each group.The control group was treated with atomoxetine hydrochloride,while the observation group was treated with atomoxetine hydrochloride combined with AIT. The response time,error number,and missed report number of the two groups were compared,as well as the scores of the Chinese version of ADHD rating scale-parent version(ADHDRS-Ⅳ-P),combined raven's test(CRT),clinical efficacy,and adverse reactions. 【Results】After treatment,the response time,error number,and missed report number of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05). The attention deficit,hyperactivity/impulsivity,oppositional defiance,and total scores of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05). The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05). After treatment,the scores of reasoning ability,similarity comparison ability,perceptual discrimination ability,serial relationship ability,abstract reasoning ability,and IQ number of the two groups were higher than those before treatment(P<0.05),and the observation group was higher than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 Atomoxetine hydrochloride combined with AIT has better clinical efficacy in the treatment of ADHD in children,as well as enhance their cognitive ability,and is safe and reliable. 2023 Vol. 40 (11): 1645-1648 [Abstract] ( 31 ) HTML (1 KB)  PDF (1235 KB)  ( 89 ) 1649 The Correlation between Serotonin Transporter Gene Polymorphism and Adolescent Self-injury and Suicide Behavior WANG Zhikang, HUANG He DOI: 10.3969/j.issn.1671-7171.2023.11.010 【Objective】To investigate the association between the polymorphism of serotonin transporter (5-HTT) gene and adolescent self-injury and suicide behavior. 【Methods】 A total of 226 adolescents in the region from November 2020 to October 2021 were selected as the research subjects. According to whether the subjects had self-injury or suicide behavior,they were divided into the occurrence group and the non-occurrence group. Peripheral venous blood was collected to extract blood genomic DNA,and the 5-HTT gene polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).The Hardy-weinberg genetic equilibrium law was used to verify whether the genotype frequency of the subjects was representative. The 5-HTT genotype distribution and allele frequency were compared between the occurrence group and the non-occurrence group,and the risk factors affecting adolescent self-injury and suicide behavior were analyzed using logistic regression.【Results】 The genotype frequency of 5-HTT gene in the subjects of this study was tested by Hardy-weinberg genetic equilibrium,and the difference was not statistically significant(P>0.05). The occurrence group had a higher proportion of single-parent families,drunkenness,running away from home,loneliness,lovelorn,and learning pressure than the non-occurrence group(P<0.05). The frequency of SS genotype and S allele in the occurrence group was higher than that in the non-occurrence group(P<0.05). The logistic regression analysis showed that drunkenness,lovelorn,learning pressure,5-HTT genotype as SS/SL,and 5-HTT allele as S were all risk factors affecting the occurrence of adolescent self-injury and suicide behavior(P<0.05). 【Conclusions】The polymorphism of 5-HTT gene is associated with adolescent self-injury and suicide behavior.The SS genotype of 5-HTT gene may be a susceptibility gene for adolescent self-injury and suicide,and the S allele may be a risk allele for adolescent self-injury and suicide. 2023 Vol. 40 (11): 1649-1652 [Abstract] ( 39 ) HTML (1 KB)  PDF (1229 KB)  ( 66 ) 1653 Factors Influencing Early Neurological Deterioration in Acute Large Artery Atherosclerotic Stroke WANG Tao, LIU Huifang, CHEN Xiaohua DOI: 10.3969/j.issn.1671-7171.2023.11.011 【Objective】To investigate the factors influencing early neurological deterioration(END) in acute large artery atherosclerotic(LAA) stroke. 【Methods】A total of 194 LAA stroke patients admitted to the two hospitals were enrolled in the study. Based on whether END occurred during hospitalization,patients were divided into the END group(n=68) and the non-END group(n=126). Clinical data and relevant laboratory test indicators of both groups were compared between the two groups. Multivariate logistic regression was used to analyze the factors related to END,and the receiver operating characteristic(ROC) curve was applied to evaluate the predictive value of clinical indicators for END. 【Results】The systolic and diastolic blood pressures as well as the National Institutes of Health Stroke Scale(NIHSS) scores upon admission in the END group were significantly higher than those in the non-END group(P<0.05).The low-density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbA1c),and homocysteine(Hcy) levels in the END group were significantly higher than those in the non-END group(P<0.05).Multivariate logistic regression analysis showed that the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c were correlated with END. Their odds ratios (OR) were 3.22,1.03,1.08 and 1.83,respectively.ROC analysis indicated that the predictive value areas under the curve(AUC) for the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c for END were 0.89,0.76,0.71,and 0.81,respectively. 【Conclusion】Factors influencing END in acute LAA stroke include the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c. These factors possess predictive value for END. 2023 Vol. 40 (11): 1653-1655 [Abstract] ( 34 ) HTML (1 KB)  PDF (2312 KB)  ( 23 ) 1656 Application of US-FNAC and TSH,TPOAb,TGAb Levels in the Qualitative Diagnosis of Thyroid Cystic Solid Nodules YANG Hongmei, WANG Lei DOI: 10.3969/j.issn.1671-7171.2023.11.012 【Objective】To explore the application value of ultrasound guided fine needle aspiration cytology(US-FNAC) and levels of thyroid stimulating hormone(TSH),anti thyroid peroxidase antibody(TPOAb),and anti thyroglobulin antibody(TGAb) in the qualitative diagnosis of thyroid cystic and solid nodules.【Methods】A total of 70 patients with thyroid cystic solid nodules admitted to both hospitals underwent US-FNAC examination,and the consistency between the US-FNAC diagnostic results and pathological examination results was analyzed; Using pathological results as the "gold standard" for diagnosis,70 patients were divided into a benign group(n=43) and a malignant group(n=27). The serum levels of TSH,TPOAb,and TGAb were compared between the two groups of patients; The value of the above indicators in the individual and combined diagnosis of malignant thyroid cystic solid nodules was analyzed through the receiver operating characteristic curve(ROC).【Results】The accuracy,sensitivity,and specificity of US-FNAC in qualitative diagnosis of thyroid cystic solid nodules were 88.57%,92.59%,and 86.05%,respectively; The serum TSH,TPOAb,and TGAb levels in the malignant group were higher than those in the benign group(P<0.05); After ROC analysis,it was confirmed that TSH,TPOAb,and TGAb predicted areas under the curve for patients with thyroid cystic solid nodules to be malignant,which were 0.681,0.794,and 0.618,respectively(all P<0.05); Malignant with US-FNAC,TSH ≥ 2.905 μU/mL,TPOAb≥10.050 IU/mL,and TGAb ≥ 32.285 IU/mL were defined as positive. When any result was positive in the combined diagnosis,the combined diagnosis was considered positive. Consistency analysis confirmed that the accuracy,sensitivity,and specificity of the combined diagnosis of the above indicators were 94.29%,96.30%,and 93.02%,significantly higher than those of US-FNAC alone.【Conclusion】The accuracy of the combined use of US-FNAC and TSH,TPOAb,and TGAb levels in the qualitative diagnosis of thyroid cystic solid nodules is significantly higher than that of individual diagnosis,and is worthy of clinical promotion and application. 2023 Vol. 40 (11): 1656-1659 [Abstract] ( 29 ) HTML (1 KB)  PDF (1283 KB)  ( 29 ) 1660 Predictive Value of Lipoprotein-associated Phospholipase A2 Combined with Interleukin-10 in the Prognosis of Young Patients with Cerebral Infarction LYU Rilang, LI Xiaoning, REN Chunjuan DOI: 10.3969/j.issn.1671-7171.2023.11.013 【Objective】To analyze the predictive value of interleukin-10(IL-10) combined with lipoprotein-associated phospholipase A2(LP-PLA2) in the prognosis of young patients with cerebral infarction. 【Methods】A total of 86 young patients with cerebral infarction were recruited in the study to analyze the prognostic risk factors. According to the prognosis of 3 months after discharge,the patients were divided into the poor prognosis group and good prognosis group. The value of peripheral blood LP-PLA2 and IL-10 in predicting prognosis of young patients with cerebral infarction was investigated by area under the curve(AUC). 【Results】Among 86 young patients with cerebral infarction,21 cases(24.42%) had the poor prognosis at 3 months after discharge. The level of uric acid(UA) in the poor prognosis group was lower than that in the good prognosis group(P<0.05),while the levels of tumor necrosis factor-α(TNF-α),IL-10 and LP-PLA2 of peripheral blood in the poor prognosis group were higher than those in the good prognosis group(P<0.05). IL-10,LP-PLA2 and TNF-α in peripheral blood were risk factors for the poor prognosis in young patients with cerebral infarction(OR=3.374,3.010,and 2.740,P<0.05). The AUC values of peripheral blood LP-PLA2,IL-10 and their combination in predicting poor prognosis of young patients with cerebral infarction were 0.755,0.752 and 0.884(P<0.05),respectively,which showed the AUC value of the combination of LP-PLA2 and IL-10 were higher(P<0.05). 【Conclusion】Peripheral blood LP-PLA2 and IL-10 play an important role in predicting the prognosis of young patients with cerebral infarction,and their combination has even higher predictive value. 2023 Vol. 40 (11): 1660-1662 [Abstract] ( 30 ) HTML (1 KB)  PDF (2314 KB)  ( 27 ) 1663 Clinical Efficacy of GnRH-a Combined with BREA in the Treatment of Perimenopausal Abnormal Uterine Bleeding LEI Xiaojuan, LI Hongyan, GUO Tianbao DOI: 10.3969/j.issn.1671-7171.2023.11.014 【Objective】To investigate the efficacy of gonadotropin-releasing hormone agonist(GnRH-a) combined with bipolar radiofrequency endometrial ablation(BREA) in the treatment of patients with perimenopausal abnormal uterine bleeding. 【Methods】From June 2019 to June 2021,86 patients with perimenopausal abnormal uterine bleeding treated in our hospital were selected and randomly divided into the observation group and the control group,with 43 cases in each group. The control group was treated with BREA,while the observation group received GnRH-a combined with BREA treatment. The efficacy rate,as well as changes in the Pictorial Blood Assessment Chart(PBAC) score,uterine volume,endometrial thickness,and levels of sex hormones [estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),progesterone(P)] before and after treatment were compared between the two groups. 【Results】Before treatment,there was no significant difference in PBAC scores between the two groups(P>0.05). Three months,six months,and twelve months after treatment,PBAC scores of both groups showed a downward trend,and the PBAC scores of the observation group were consistently lower than those of the control group(P<0.05). The effective rate of the observation group was higher than that of the control group at three months,six months,and twelve months after treatment(P<0.05). Before treatment,there was no significant difference in the levels of E2,LH,FSH,and P between the two groups(P>0.05). After treatment,the levels of E2,LH,FSH,and P decreased in both groups,with the observation group showing lower levels than the control group(P<0.05). Before treatment,there was no significant difference in uterine volume and endometrial thickness between the two groups(P>0.05). Six months and twelve months after treatment,both uterine volume and endometrial thickness were reduced in both groups,with the observation group having smaller measurements than the control group(P<0.05). 【Conclusion】Pre-treatment with GnRH-a before BREA therapy in patients with perimenopausal abnormal uterine bleeding can improve clinical efficacy,adjust serum sex hormone levels,and reduce PBAC scores,and is of clinical value for widespread promotion. 2023 Vol. 40 (11): 1663-1666 [Abstract] ( 33 ) HTML (1 KB)  PDF (1238 KB)  ( 34 ) 1667 Effect of Simvastatin with Different Doses on Serum sE-Selectin and sICAM-1 Levels in Patients with Hyperlipidemia CHEN Siwen, CHEN Yarong DOI: 10.3969/j.issn.1671-7171.2023.11.015 【Objective】To explore the effects of different doses of simvastatin on the levels of soluble E-selectin(sE-Selectin) and soluble intercellular adhesion molecule-1(sICAM-1) in the serum of patients with hyperlipidemia. 【Methods】A total of 80 patients with hyperlipidemia were divided into two groups based on differently used dosage of simvastatin with each group of 40 patients. The control group was given a conventional dose(20 mg/d),while the observation group received a high dose(40 mg/d) treatment. The clinical efficacy,lipid profiles [total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)],serum levels of sE-Selectin and sICAM-1,and the incidence of adverse reactions were compared between the two groups. 【Results】The total effective rate in the observation group was 92.50%(37/40),which was significantly higher than the 75.00%(30/40) in the control group(P<0.05). After treatment,the TG,TC,LDL-C levels of both groups were lower than before treatment,and HDL-C levels were higher than before treatment(P<0.05). Furthermore,the TG,TC,and LDL-C levels in the observation group were lower,and the HDL-C levels were higher than those in the control group(P<0.05). After treatment,the serum sE-Selectin and sICAM-1 levels in both groups were lower than before treatment(P<0.05),with the levels in the observation group being significantly lower than those in the control group(P<0.05). The overall incidence of adverse reactions in both groups showed no significant difference (P>0.05). 【Conclusion】Compared to the conventional dosage,the high dose of simvastatin treatment for hyperlipidemia has a more remarkable therapeutic effect and better lipid-lowering results. 2023 Vol. 40 (11): 1667-1669 [Abstract] ( 24 ) HTML (1 KB)  PDF (1207 KB)  ( 20 ) 1670 Correlation between Urinary Protein Level and Blood Glucose and Lipid Levels in Elderly Patients with Diabetes ZHANG Yanqing, FAN Xingtao, REN Weijuan DOI: 10.3969/j.issn.1671-7171.2023.11.016 【Objective】To explore the correlation between the level of urinary protein and the level of blood sugar and lipid in elderly patients with diabetes. 【Methods】 The clinical data of 88 elderly patients with diabetes diagnosed and treated in our hospital from June 2020 to June 2022 were retrospectively analyzed. The patients were divided into proteinuria group(n=46) and normal group(n=42) according to their urinary protein level. The general information,blood glucose and blood lipid levels of the two groups were compared. The ROC curve was used to analyze the predictive value of blood glucose and lipid levels on proteinuria in elderly patients with diabetes; Multivariate logistic regression was used to analyze the risk factors of proteinuria in elderly patients with diabetes.【Results】 The proportion of patients with body mass index(BMI) ≥ 24 kg/m2,duration of diabetes ≥ 5 years,hypertension,coronary heart disease,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),triglyceride(TG),and total cholesterol(TC) in the proteinuria group were significantly higher than those in the normal group(P<0.05);ROC curve analysis showed that the area under the curve of FPG,HbA1c,TG and TC predicting proteinuria in elderly diabetes patients was 0.841,0.834,0.797 and 0.717,respectively; Multivariate logistic regression analysis showed that BMI ≥ 24 kg/m2,diabetes duration ≥ 5 years,hypertension,coronary heart disease,FPG ≥ 8.640 mmol/L,HbA1c ≥ 7.475%,TG ≥ 1.365 mmol/L,TC ≥ 4.870 mmol/L were risk factors for proteinuria in elderly diabetes patients(P<0.05). 【Conclusion】The level of urinary protein in elderly patients with diabetes is related to the level of blood sugar and blood lipid,and the level of hyperglycemia and blood lipid is related to diabetes nephropathy. 2023 Vol. 40 (11): 1670-1672 [Abstract] ( 40 ) HTML (1 KB)  PDF (2343 KB)  ( 64 ) 1673 Efficacy of Huotan Xijing Tang Combined with Thrombolysis on Patients with Acute Cerebral Infarction and Effect on Cerebral Hemodynamics WANG Liang, WANG Shenghui DOI: 10.3969/j.issn.1671-7171.2023.11.017 【Objective】To investigate the therapeutic effect of Huotan Xijing Tang combined with thrombolysis on patients with acute cerebral infarction and its impact on cognitive function and cerebral hemodynamics. 【Methods】A total of 108 patients with acute cerebral infarction were randomly divided into an observation group and a control group,with 54 cases in each group. The control group was treated with thrombolysis,while the observation group received Huotan Xijing Tang combined with thrombolysis. The therapeutic effects,adverse reactions,and differences in related indicators before and after treatment were compared between the two groups. 【Results】The overall effectiveness rate of the observation group was 94.44%(51/54),which was significantly higher than the 81.48%(44/54) of the control group,and the difference was statistically significant(P<0.05). After treatment,the scores for Traditional Chinese Medicine(TCM) symptoms such as sudden fainting,hemiplegia,and deviation of the mouth and tongue were lower in both groups compared to before treatment(P<0.05). Moreover,the observation group had a greater reduction in these scores than the control group(P<0.05). After treatment,the National Institutes of Health Stroke Scale(NIHSS) scores in both groups significantly reduced,and the Montreal Cognitive Assessment(MoCA) scores and Activities of Daily Living(ADL) scores increased compared to before treatment(P<0.05). The improvement in scores of the observation group was better than that of the control group(P<0.05). After treatment,the pulsatility index(PI) levels in both groups were lower than before treatment,and the peak flow velocity(VP) and mean flow velocity(Vm) levels of the bilateral middle cerebral artery were higher than before treatment(P<0.05). The improvement in these parameters of the observation group was better than that of the control group(P<0.05). The overall incidence of adverse reactions between the two groups showed no statistically significant difference(P>0.05). 【Conclusion】Huotan Xijing Tang combined with thrombolysis in patients with acute cerebral infarction can significantly improve therapeutic effects,reduce TCM symptom scores,enhance neural function,improve cerebral hemodynamics,and elevate patients' cognitive function and daily living ability with minimal drug adverse reactions. 2023 Vol. 40 (11): 1673-1676 [Abstract] ( 26 ) HTML (1 KB)  PDF (1229 KB)  ( 51 ) 1677 Diagnostic Value of Serum Anti-Mullerian Hormone and Sex Hormone Levels in Polycystic Ovary Syndrome HAN Xinmei, YAN Xianghong DOI: 10.3969/j.issn.1671-7171.2023.11.018 【Objective】To investigate the diagnostic value of serum anti-Mullerian hormone(AMH) and sex hormone levels in the diagnosis of polycystic ovary syndrome(PCOS). 【Methods 】A total of 36 patients with PCOS admitted to our hospital from April 2020 to September 2023 were selected as the observation group,and 39 healthy women who underwent AMH and sex hormone level testing during the same period were selected as the control group.The serum AMH levels and sex hormone levels [follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T)] were compared between the two groups,and the diagnostic value of serum AMH and sex hormone levels for PCOS was analyzed using receiver operating characteristic(ROC) curve. 【Results 】The serum AMH,LH,and T levels in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05). There was no significant difference in serum E2 and FSH levels between the two groups(P>0.05). ROC curve analysis showed that the area under the curve of serum AMH in the diagnosis of PCOS was 0.761(95%CI:0.643-0.878,P<0.001),T was 0.660(95%CI:0.536-0.784,P=0.017),and LH was 0.611(95%CI:0.480-0.742,P=0.067). Serum AMH level had the highest diagnostic value for PCOS. 【Conclusion】The serum AMH,LH,and T levels in patients with PCOS were significantly increased,and both serum AMH and T levels had certain diagnostic value for PCOS,with serum AMH having the highest diagnostic value. 2023 Vol. 40 (11): 1677-1679 [Abstract] ( 27 ) HTML (1 KB)  PDF (1235 KB)  ( 28 ) 1680 Effect of Integrated Management Platform for Patients with Weight Loss Metabolic Surgery in Obesity Type 2 Diabetes GUO Xiaoxia, JIA Lina, LUO Yangui DOI: 10.3969/j.issn.1671-7171.2023.11.019 【Objective】To explore the effect of comprehensive management platform for bariatric and metabolic surgery patients with type 2 diabetes mellitus. 【Methods】A sampling survey method was used to select 65 obese patients with type 2 diabetes who underwent bariatric metabolic surgery at Xi'an People's Hospital(Xi'an Fourth Hospital) from March 2018 to March 2019 as the control group for routine information management. Another 65 obese patients with type 2 diabetes who underwent bariatric metabolic surgery at Xi'an People's Hospital(Xi'an Fourth Hospital) from April 2019 to May 2020 were selected as the observation group for comprehensive management platform for bariatric and metabolic surgery patients. The postoperative body mass index(BMI),duration of postoperative complications,and blood glucose indicators were compared between the two groups.【Results】The BMI level of 6 months and 12 months after operation in the observation group was significantly lower than that in the control group(P<0.01). Compared to the control group,the duration of vomiting,constipation,diarrhea and alopecia was shorter in the observation group(P<0.01). And the levels of FPG,2hPG and HbA1c in the observation group at 12 month after surgery were lower than those in the control group(P<0.05). 【Conclusion】The comprehensive management platform used in obese patients with type 2 diabetes and bariatric and metabolic surgery can lower the patient's BMI,reduce the duration of postoperative complications,and promote postoperative blood sugar to approach normal levels. operation. 2023 Vol. 40 (11): 1680-1682 [Abstract] ( 26 ) HTML (1 KB)  PDF (2265 KB)  ( 61 ) 1683 Analysis of the Correlation between Postoperative CT Cistern Grading and Non-invasive Intracranial Pressure and Cerebrospinal Fluid Lactate in Patients with Severe Traumatic Brain Injury SUN Junfeng, GAO Qiang, CHANG Puying DOI: 10.3969/j.issn.1671-7171.2023.11.020 【Objective】To explore the relationship between postoperative CT cistern grading,non-invasive intracranial pressure(NICP),and cerebrospinal fluid lactate in patients with severe head injury.【Methods】A total of 128 patients with severe traumatic brain injury admitted to Baoji People's Hospital from October 2019 to October 2022 were selected and divided into grade Ⅰ group(n=61),grade Ⅱ group(n=46),and grade Ⅲ group(n=21) based on the preoperative circumferential pool grading of the patient's head CT. We compared the differences in intracranial pressure and cerebrospinal fluid lactate levels among patients with different grades,and used Spearman correlation analysis to investigate the correlation between head CT ring pool grading and non-invasive intracranial pressure and cerebrospinal fluid lactate levels. 【Results】 There was a statistically significant difference in CT annulus grading between patients with different preoperative CT annulus grading at 4 hours and 72 hours after surgery(P<0.001); The CT annular pool grading of patients in the Class Ⅱ and Ⅲ groups showed a decreasing trend at 4 hours and 72 hours after surgery(both P<0.05). At 4 hours and 72 hours after surgery,the NICP of patients with different ring pool grades was lower than before surgery(P<0.05); At 4 hours and 72 hours after surgery,the NICP levels in the grade Ⅱ and Ⅲ groups were lower than those in the grade Ⅰ group,while the NICP levels in the grade Ⅲ group were lower than those in the grade Ⅱ group(P<0.05). At 4 hours and 72 hours after surgery,the cerebrospinal fluid lactate levels in patients with different cistern grading were lower than before surgery(P<0.05); At 4 hours and 72 hours after surgery,the cerebrospinal fluid lactate levels in the grade Ⅱ and Ⅲ groups were lower than those in the grade Ⅰ group(P<0.05). There was a negative correlation between the grading of the cranial CT annulus and postoperative NICP(P<0.05); There was a negative correlation between preoperative CT cistern grading and cerebrospinal fluid lactate levels both before and 72 hours after surgery(P<0.05); The grading of the cistern at 4 hours postoperatively was only negatively correlated with the lactate level in cerebrospinal fluid at 72 hours postoperatively(P<0.01); There was a negative correlation(P<0.01) between the 72 hours postoperative grading of the cistern and the preoperative and 72 hours postoperative cerebrospinal fluid lactate levels.【Conclusion】 Preoperative evaluation of CT cistern grading in patients with severe head injury can reflect postoperative NICP levels and is closely related to preoperative cerebrospinal fluid lactate levels. 2023 Vol. 40 (11): 1683-1686 [Abstract] ( 57 ) HTML (1 KB)  PDF (1230 KB)  ( 36 ) 1687 Efficacy of Radiation Therapy Combined with Acupoint Application in the Treatment of Middle and Late Stage Esophageal Cancer DU Guowei, QIN Chen, WANG Zhihai, et al DOI: 10.3969/j.issn.1671-7171.2023.11.021 【Objective】To explore the clinical efficacy of radiation therapy combined with acupoint application in the treatment of middle and late stage esophageal cancer. 【Methods】A total of 76 patients with middle and late stage esophageal cancer treated in our hospital were randomly divided into two groups,with 38 cases in each group. The control group received radiation therapy,while the observation group received radiation therapy combined with acupoint application. The Chinese medicine symptom scores,clinical efficacy,changes in serum levels of vascular endothelial growth factor(VEGF) and cytokeratin 19 fragment antigen (CYFRA21-1) before and after treatment,as well as the occurrence of adverse drug reactions were compared between the two groups. 【Results】After treatment,the Chinese medicine symptom scores of patients in both groups were lower than before treatment(P<0.05),and the score of the observation group was lower than that of the control group(P<0.05). The total effective rate of the observation group was 86.84%(33/38),which was higher than the 65.79%(25/38) of the control group(P<0.05). After treatment,the levels of CYFRA21-1 and VEGF in both groups were lower than before treatment(P<0.05),and the levels of each indicator in the observation group were lower than those in the control group(P<0.05). The incidence of adverse drug reactions during treatment in the observation group was 7.89%(3/38),which was lower than the 28.95%(11/38) in the control group(P<0.05). 【Conclusion】The combined treatment of radiation therapy and acupoint application in middle and late stage esophageal cancer can relieve patients' symptoms,improve efficacy,improve patients' CYFRA21-1 and VEGF levels,and reduce the incidence of adverse drug reactions,which is worthy of clinical promotion and application. 2023 Vol. 40 (11): 1687-1689 [Abstract] ( 29 ) HTML (1 KB)  PDF (1209 KB)  ( 26 ) 1690 Correlation between Visceral Fat Area and Cardiovascular and Cerebrovascular Complications in Type 2 Diabetes Patients with Normal BMI CHEN Fen, DU Aimin DOI: 10.3969/j.issn.1671-7171.2023.11.022 【Objective】To investigate the correlation between visceral fat area(VFA) and cardiovascular and cerebrovascular complications in type 2 diabetes patients with normal body mass index(BMI). 【Methods】Retrospective analysis was conducted on the clinical data of 110 patients with T2DM with normal BMI admitted to our hospital from February 2019 to January 2023. They were divided into a control group(without cardiovascular and cerebrovascular complications,n=39) and an observation group(with cardiovascular and cerebrovascular complications,n=71) according to the presence or absence of cardiovascular and cerebrovascular complications. The VFA of the two groups of patients was compared,and the logistic multiple regression analysis model was used to analyze the influencing factors of cardiovascular and cerebrovascular complications in T2DM patients with normal BMI. The receiver operating characteristic(ROC) curve was drawn to analyze the predictive value of VFA for cardiovascular and cerebrovascular complications in T2DM patients with normal BMI. 【Results】The VFA level in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001). Age,course of diabetes,diastolic pressure,systolic pressure,triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin,and mean platelet volume in the observation group were higher than those in the control group(P<0.05),while high-density lipoprotein cholesterol,direct bilirubin,and indirect bilirubin were lower than those in the control group(P<0.05). Logistic regression analysis showed that the increase of VFA,the long course of diabetes,the decrease of indirect bilirubin,and the increase of mean platelet volume were the influencing factors of cardiovascular and cerebrovascular complications in T2DM patients with normal BMI(P<0.05). The ROC curve results showed that the AUC value(95%CI) of VFA in predicting the occurrence of cardiovascular and cerebrovascular complications in T2DM patients with normal BMI was 0.793(0.690-0.875)(P<0.05). 【Conclusion】VFA has high predictive value for the risk of cardiovascular and cerebrovascular complications in T2DM patients with normal BMI. 2023 Vol. 40 (11): 1690-1692 [Abstract] ( 32 ) HTML (1 KB)  PDF (2308 KB)  ( 26 ) 1693 Effects of Ear Acupuncture Combined with Shugan Lidan Tang on Oxidative Stress Index,Inflammatory Response and Pain Level in Patients after Laparoscopic Cholecystectomy WAN Xuejiao, HAO Dandan DOI: 10.3969/j.issn.1671-7171.2023.11.023 【Objective】To explore the effect of modified Shugan Lidan Tang combined with auricular acupuncture on pain level,inflammatory response,and oxidative stress response in patients undergoing laparoscopic cholecystectomy. 【Methods】A total of 102 patients undergoing laparoscopic cholecystectomy from January 2019 to July 2022 were selected and randomly divided into a control group and an observation group using a random number table method,with 51 cases in each group. The control group received auricular acupuncture treatment,while the observation group received modified Shugan Lidan Tang in addition to the control group. The relevant indicators,visual analog scale(VAS),serum interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) levels were compared between the two groups,and the incidence of postoperative complications was compared between the two groups.【Results】The time of first getting out of bed,the time of resuming eating,the time of first defecation,and the time of first exhaust after surgery were shorter in the observation group than in the control group(P<0.05). The VAS of both groups on day 5 after surgery was lower than that on day 1 after surgery,and the observation group was lower than the control group(P<0.05). On day 5 after surgery,the levels of serum TNF-α,CRP,IL-6,IL-1β in both groups were lower than those on day 1 before surgery,and the level of IL-10 was higher than that on day 1 before surgery.Compared with the control group,the above indicators in the observation group showed significant differences(P<0.05). The levels of serum SOD and GSH-Px in both groups were lower than those on day 1 before surgery,and the difference was statistically significant(P<0.05),but there was no significant difference between the observation group and the control group(P>0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05).【Conclusion】The use of modified Shugan Lidan Tang combined with auricular acupuncture in patients undergoing laparoscopic cholecystectomy can promote postoperative rehabilitation,alleviate postoperative oxidative stress response and inflammatory response,effectively alleviate pain,and is safe and reliable. 2023 Vol. 40 (11): 1693-1696 [Abstract] ( 34 ) HTML (1 KB)  PDF (1232 KB)  ( 47 ) 1697 Application of Serum 25-Hydroxyvitamin D3 Combined with Bone Metabolism Indicators in the Screening of Osteoporosis in the Elderly LU Jie, LI Qian, LIU Na DOI: 10.3969/j.issn.1671-7171.2023.11.024 【Objective】To explore the application value of serum 25-hydroxyvitamin D3 combined with bone metabolism index in the screening of elderly osteoporosis. 【Methods】A total of 96 elderly osteoporosis patients admitted to our hospital from July 2020 to July 2022 were selected as the observation group,and 96 healthy elderly people who underwent physical examination during the same period were selected as the control group. Patients in both groups underwent lumbar spine bone density,femoral neck bone density measurements,as well as measurements of serum 25-hydroxyvitamin D3 [25-(OH)D3],bone metabolism indices (N-MID,P1NP,β-CTX),and inflammatory factors (TNF-α,IL-6). The test results of the two groups were compared. 【Results】The lumbar spine bone density and femoral neck bone density of the observation group were significantly lower than those of the control group,while levels of N-MID,P1NP and β-CTX in the observation group were higher than those in the control group. The serum 25-(OH)D3 level in the observation group was lower than that in the control group,and levels of inflammatory factors TNF-α and IL-6 in the observation group were significantly higher than those in the control group. The differences were statistically significant(P<0.05). 【Conclusion】The detection of serum 25-(OH)D3 combined with bone metabolism index in the screening of elderly osteoporosis can significantly improve the screening effect and early detection rate,help to assess the patient's condition and quality of life,and has important clinical application value. 2023 Vol. 40 (11): 1697-1699 [Abstract] ( 26 ) HTML (1 KB)  PDF (1204 KB)  ( 38 ) 1700 Efficacy of Magnesium Sulfate in Treating Elderly Patients with Cerebral Hemorrhage Complicated with Hypomagnesemia and its Effect on ET and NO Levels LI Jujun, WANG Yonggang, JI Yuanchao, et al DOI: 10.3969/j.issn.1671-7171.2023.11.025 【Objective】To investigate the efficacy of magnesium sulfate in treating elderly patients with cerebral hemorrhage complicated with hypomagnesemia and its effects on endothelin(ET) and nitric oxide(NO) levels. 【Methods】A total of 93 patients with cerebral hemorrhage complicated with hypomagnesemia admitted to our hospital were randomly divided into the observation group(n=47) and the control group(n=46). Both groups received conventional symptomatic treatments such as intracranial pressure reduction,hemostasis,and oxygen inhalation. The control group was intravenously dripped with Xingnaojing,while the observation group received magnesium sulfate treatment on top of the control group's treatment. The clinical efficacy,serum magnesium,ET,NO levels,and scores from the National Institutes of Health Stroke Scale(NIHSS) and activities of daily living(ADL) were compared before and after treatment. 【Results】The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment,the serum magnesium levels in both groups increased compared to before treatment,while ET and NO levels decreased(P<0.05). The observation group had higher post-treatment serum magnesium levels and lower post-treatment ET and NO levels than the control group(P<0.05). One and two weeks post-treatment,the ADL scores of both groups showed an upward trend,and the NIHSS scores showed a downward trend(P<0.05). Moreover,the post-treatment ADL score of the observation group was higher and the post-treatment NIHSS score was lower in the observation group than those in the control group(P<0.05). 【Conclusion】Magnesium sulfate has a good therapeutic effect on elderly patients with cerebral hemorrhage complicated with hypomagnesemia. It helps to increase serum magnesium,reduce NO and ET levels,promote the recovery of neurological function,and has significant application value. 2023 Vol. 40 (11): 1700-1702 [Abstract] ( 20 ) HTML (1 KB)  PDF (2289 KB)  ( 32 ) 1703 Application of ASPECTS Score and CT Perfusion Imaging Parameters in Prognostic Evaluation of Acute Ischemic Stroke Patients CHANG Hufei, JI Wenjun, LI Xue DOI: 10.3969/j.issn.1671-7171.2023.11.026 【Objective】To explore the value of early CT score(ASPECTS) and CT perfusion imaging parameters(CTP) in the prognosis evaluation of patients with acute ischemic stroke(AIS) in the Alberta Stroke Project. 【Methods】A total of 65 AIS patients were divided into a good prognosis group of 36 cases and a poor prognosis group of 29 cases based on their prognosis. We compared the clinical data, National Institutes of Health Stroke Scale(NIHSS) scores, stroke types, ASPECTS scores, and CTP between two groups of patients, and performed multiple logistic regression analysis on the data with differences between the two groups to identify the factors affecting the prognosis of AIS patients. The value of predicting poor prognosis in AIS patients was predicted by analyzing the receiver operating characteristic(ROC) curve of cerebral blood flow(CBF), cerebral blood volume(CBV), and mean transit time(MTT).【Results】The proportion of patients in the poor prognosis group with NIHSS score>7, multiple stroke, cardioembolic stroke, cerebral arteritis, and ASPECTS score ≤7 was significantly higher than that in the good prognosis group(P<0.05); The CBF, CBV, and MTT of the poor prognosis group were significantly lower than those of the good prognosis group(P<0.05). ROC analysis showed that CBF, CBV, and MTT can all be used for predicting poor prognosis in AIS patients, with areas under the curves of 0.828, 0.992, and 0.754, respectively(all P<0.05). Multivariate logistic regression analysis showed that NIHSS score>7, multiple stroke, cardioembolic stroke, cerebral arteritis, ASPECTS score ≤7, CBF≤12.870 mL/100 g/min, CBV≤8.890 mL/100 g, MTT≤16.425 s were risk factors affecting the prognosis of AIS patients(P<0.05). 【Conclusion】NIHSS score, multiple stroke, cardioembolic stroke, cerebral arteritis, ASPECTS score, and CTP parameters are all factors that affect the prognosis of AIS patients, and should be taken seriously in clinical practice. 2023 Vol. 40 (11): 1703-1706 [Abstract] ( 34 ) HTML (1 KB)  PDF (1253 KB)  ( 29 ) 1707 Clinical Efficacy of Laparoscopic Conservative Surgery for Patients with Ectopic Pregnancy YAN Haiya, LIU Xuejun, YAN Huan, et al DOI: 10.3969/j.issn.1671-7171.2023.11.027 【Objective】To explore the clinical efficacy of laparoscopic conservative surgery for patients with ectopic pregnancy. 【Methods】A total of 82 patients with ectopic pregnancy admitted to Baoji Maternal and Child Health Hospital from March 2020 to July 2022 were selected and divided into a resection group(treated with laparoscopic salpingectomy) and a conservative group(treated with laparoscopic conservative surgery) according to the indications and the patients' own wishes. The clinical efficacy of the two groups was analyzed after treatment. 【Results】 The amount of intraoperative bleeding in the conservative group was less than that in the resection group,and the time for blood β-HCG to return to normal and the length of hospital stay were shorter than those in the resection group(P<0.05). There was no significant difference in the preoperative reproductive hormone levels between the two groups(P>0.05). The levels of estradiol(E2) and anti-Mullerian hormone(AMH) in the conservative group were higher than those in the resection group at 1 month and 3 months after surgery,while the level of follicle stimulating hormone(FSH) was lower than that in the resection group. However,there was no significant difference in the level of luteinizing hormone(LH) between the two groups at the same time point(P>0.05). There was no significant difference in the incidence of complications between the two groups after surgery (P>0.05). The natural pregnancy rate and total pregnancy rate within 3 years after surgery were higher in the conservative group than in the resection group,but there was no significant difference in the rates of assisted reproductive pregnancy and recurrent ectopic pregnancy between the two groups(P>0.05).【Conclusion】 Compared with salpingectomy,laparoscopic conservative surgery has less impact on reproductive hormone levels,can accelerate the recovery of blood β-HCG,shorten the length of hospital stay,and improve the rate of pregnancy again within 3 years after surgery. 2023 Vol. 40 (11): 1707-1709 [Abstract] ( 41 ) HTML (1 KB)  PDF (1206 KB)  ( 28 ) 1710 Clinical Efficacy of Sequential Injection of Triamcinolone Acetonide Combined with Sodium Hyaluronate in the Treatment of Shoulder-hand Syndrome after Stroke YAN Yuanyuan, ZHANG Xueyu DOI: 10.3969/j.issn.1671-7171.2023.11.028 【Objective】To investigate the clinical efficacy of sequential injection of triamcinolone acetonide combined with sodium hyaluronate in the treatment of shoulder-hand syndrome after Stroke. 【Methods】 Ninety-two patients with shoulder-hand syndrome admitted to Weinan First Hospital from July 2019 to February 2021 were selected and divided into observation group(n=47) and control group(n=45) according to different treatment schemes. The control group was treated with intra-articular injection of sodium hyaluronate,while the observation group was treated with sequential intra-articular injection of triamcinolone acetonide combined with sodium hyaluronate. After 7 weeks of treatment,the motor function,shoulder-hand pain score,shoulder joint activity range,wrist edema volume,and adverse reactions were compared between the two groups.【Results】After treatment,the scores of motor function assessment scale(FMA) and comprehensive function assessment scale(FCA) in both groups were higher than those before treatment,while the visual analogue scale(VAS) scores were lower than those before treatment. The FMA and FCA scores in the observation group were higher than those in the control group,while the VAS score was lower than that in the control group(P<0.05). After treatment,the shoulder joint activity range in both groups increased compared with that before treatment,while the wrist edema volume decreased compared with that before treatment. The shoulder joint activity range in the observation group was greater than that in the control group,while the wrist edema volume was less than that in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Sequential intra-articular injection of triamcinolone acetonide combined with sodium hyaluronate can effectively improve the upper limb motor function and relieve pain in patients with shoulder-hand syndrome after stroke,and it is safe and reliable. 2023 Vol. 40 (11): 1710-1712 [Abstract] ( 32 ) HTML (1 KB)  PDF (437 KB)  ( 33 ) 1713 Correlation between Thyroid Peroxidase Antibody Level and Endocrine Metabolism Level in PCOS Patients with Normal Thyroid Function LIU Heng, ZHANG Xiaona DOI: 10.3969/j.issn.1671-7171.2023.11.029 【Objective】To explore the correlation between thyroid peroxidase antibody level(TPO-Ab) and endocrine metabolism in patients with polycystic ovary syndrome(PCOS) with normal thyroid function. 【Methods】The clinical data of 112 patients with PCOS with normal thyroid function treated in our hospital from March 2018 to July 2021 were retrospectively analyzed. According to the test results of serum TPO-Ab,they were divided into 21 cases in the TPO-Ab positive group and 91 cases in the TPO-Ab negative group. The thyroid function indexes [thyroid stimulating hormone(TSH),free thyroxine(FT4),total thyroxine(TT4)],differences in sex hormone indexes [testosterone(T),prolactin(PRL),estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)],and lipid metabolism indexes [high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol (LDL-C),triacylglycerol(TG),total cholesterol(TC)] between the two groups were compared. Pearson correlation analysis was used to analyze the relationship of TPO-Ab level with TSH,PRL,E2,TG,FT4,TT4 and HDL-C. 【Results】The levels of serum TSH,PRL and E2 in the TPO-Ab positive group were higher than those in the TPO-Ab negative group(P<0.05),and the levels of serum FT4 and TT4 were lower than those in the TPO-Ab negative group(P<0.05). The level of HDL-C in the TPO-Ab positive group was lower than that in TPO-Ab negative group,while the level of TG was higher than that in the TPO-Ab negative group(P<0.05). The correlation coefficients between serum TPO-Ab level and TSH,PRL,E2,TG,FT4,TT4 and HDL-C in PCOS patients with normal thyroid function were 0.501,0.634,0.498,0.631,-0.479,-0.663 and -0.689,respectively(P<0.05). 【Conclusion】The level of serum TPO-Ab in PCOS patients with normal thyroid function was positively correlated with TSH,PRL,E2 and TG,while negatively correlated with FT4,TT4 and HDL-C. 2023 Vol. 40 (11): 1713-1716 [Abstract] ( 25 ) HTML (1 KB)  PDF (1233 KB)  ( 39 ) 1717 The Application Value of Different Electrocardiogram Index Scores in the Diagnosis of Left Ventricular Hypertrophy in Hypertensive Patients WANG Chunfang, LI Jing DOI: 10.3969/j.issn.1671-7171.2023.11.030 【Objective】To explore the application value of different electrocardiogram index scores in the diagnosis of left ventricular hypertrophy(LVH) in hypertensive patients. 【Methods】A total of 100 hypertensive patients admitted to Baoji High tech Hospital from January 2020 to January 2022 were selected. The Cornell voltage standard,Sokolow-Lyon voltage standard,Peguero-Lo Presti voltage standard,and the number of cases diagnosed with LVH by echocardiography were compared. The left ventricular mass(LVMI) index displayed by echocardiography was used as the diagnostic criteria for LVH,and the sensitivity and specificity of the three electrocardiogram diagnostic indicators were evaluated.【Results】 Among the 100 patients,41 were diagnosed with LVH by echocardiography,13 with Sokolow-Lyon voltage standard,14 with Cornell voltage standard,and 23 with Peguero-Lo Presti voltage standard. The difference was statistically significant(P<0.05). Using echocardiography as a reference standard,consistency analysis showed that the sensitivity and specificity of Peguero-Lo Presti voltage standard in diagnosing LVH were higher than those of Sokolow-Lyon voltage standard and Cornell voltage standard. The sensitivity and specificity of the Sokolow-Lyon voltage standard,Cornell voltage standard,and Peguero-Lo Presti voltage standard in males are higher than those in females.【Conclusion】 Different electrocardiogram index scores can be used for the preliminary diagnosis of LVH in hypertensive patients,among which the Peguero-Lo Presti voltage standard has higher sensitivity in diagnosing LVH. 2023 Vol. 40 (11): 1717-1719 [Abstract] ( 24 ) HTML (1 KB)  PDF (1206 KB)  ( 26 ) 1720 Clinical Value of Transendoscopic Microprobe Ultrasound in the Diagnosis of Inflammatory Bowel Disease WANG Suling, JIA Honge, DEGN Zhaoliang DOI: 10.3969/j.issn.1671-7171.2023.11.031 【Objective】To explore the role of transendoscopic microprobe ultrasound(MPS) in the classification and diagnosis of inflammatory bowel disease(IBD). 【Methods】 A total of 84 patients with IBD admitted to Meixian People's Hospital from March 2017 to March 2020 were selected as the observation group,including 58 cases of ulcerative colitis(UC)(UC group) and 26 cases of Crohn's disease(CD)(CD group). Another 84 healthy individuals who underwent physical examination during the same period were selected as the control group.All subjects underwent transendoscopic MPS examination,recorded the endoscopic characteristics of IBD,and analyzed the clinical value of MPS in differential diagnosis of IBD.【Results】 The MPS findings of UC patients under endoscopy showed a continuous distribution of mucosal lesions,with a higher incidence of "fish mouth" lesions than CD,and a lower incidence of "ear-like" lesions than CD,with significant statistical differences(P<0.05). The Kappa values of MPS for Tsuga classification and modified Baron classification in UC patients were 0.720 and 0.815,respectively,while the Kappa value for Montreal disease behavior classification in CD patients was 0.716.The comparison of total wall thickness(TWT),muscularis propria(MP),submucosa(SM),and mucosa(M) levels among the three groups showed significant statistical differences(P<0.05). The receiver operating characteristic(ROC) curve analysis showed that the AUC value of M value for UC was 0.753(95%CI=0.641-0.864,P<0.001),with a sensitivity of 0.862 and a specificity of 0.691.The AUC value of MP value for CD was 0.759(95%CI=0.592-0.926,P=0.003).【Conclusion】Transendoscopic MPS for IBD examination is helpful for the classification and diagnosis of CD and UC,which is of great value in guiding early intervention for IBD patients. 2023 Vol. 40 (11): 1720-1722 [Abstract] ( 27 ) HTML (1 KB)  PDF (2330 KB)  ( 267 ) 1723 Clinical Efficacy of Calcium Hydroxide Paste Combined with Minocycline in the Treatment of Patients with Periapical Periodontitis YANG Xiao, CHEN Meng, DONG Jianwei DOI: 10.3969/j.issn.1671-7171.2023.11.032 【Objective】To investigate the clinical efficacy of calcium hydroxide paste combined with minocycline in the treatment of patients with periapical periodontitis. 【Methods】 A total of 210 patients with chronic periapical periodontitis diagnosed in our hospital were selected and divided into a combined group(treated with calcium hydroxide paste combined with minocycline),a calcium hydroxide group(treated with calcium hydroxide paste),and a minocycline group(treated with minocycline),with 70 cases in each group.The clinical efficacy and the clinical symptom scores before and after treatment,as well as the inflammatory factors [tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)] in gingival crevicular fluid were compared among the three groups. 【Results】 Before treatment,there was no significant difference in the symptom scores of gingival redness,pain,and tenderness among the combined group,calcium hydroxide group,and minocycline group(P>0.05). After treatment,the symptom scores of gingival redness,pain,and tenderness in all three groups were significantly lower than those before treatment(P<0.05),and the combined group had lower scores than the calcium hydroxide group and the minocycline group(P<0.05). Before treatment,there was no significant difference in the levels of TNF-α,IL-1β,and IL-6 in gingival crevicular fluid among the combined group,calcium hydroxide group,and minocycline group(P>0.05). After treatment,the levels of TNF-α,IL-1β,and IL-6 in gingival crevicular fluid in all three groups were significantly lower than those before treatment(P<0.05),and the combined group had lower levels than the calcium hydroxide group and the minocycline group(P<0.05). The clinical efficacy among the three groups was compared,and the difference was statistically significant(P<0.05),and the combined group had better clinical efficacy than the calcium hydroxide group and the minocycline group.【Conclusion】Combined treatment with calcium hydroxide paste and minocycline can effectively alleviate the clinical symptoms of patients with chronic periapical periodontitis,reduce the inflammatory response,and improve the clinical efficacy. 2023 Vol. 40 (11): 1723-1726 [Abstract] ( 27 ) HTML (1 KB)  PDF (1230 KB)  ( 148 ) 1727 Efficacy of Estrogen Combined with Medroxyprogesterone Acetate in the Treatment of Acute Abnormal Uterine Bleeding GAO Jia, CHEN Wei DOI: 10.3969/j.issn.1671-7171.2023.11.033 【Objective】To study the efficacy of estrogen combined with medroxyprogesterone acetate in the treatment of acute abnormal uterine bleeding. 【Methods】A total of 118 patients with acute abnormal uterine bleeding from April 2019 to February 2022 were selected and divided into the observation group(n=59) and the control group(n=59) by random number table method. The control group was treated with medroxyprogesterone acetate,while the observation group was treated with estrogen in addition to medroxyprogesterone acetate. Patients in both groups received treatment for 3 months. The clinical efficacy,hemostatic effect,incidence of adverse reactions,serum luteinizing hormone(LH),estradiol(E2),follicle-stimulating hormone(FSH),endometrial thickness,and health-promoting lifestyle scale(HPLP-Ⅱ) scores were compared between the two groups before and after treatment.【Results】The total effective rate of the observation group(94.92%) was higher than that of the control group(79.66%)(P<0.05). The duration of complete hemostasis and the time to control bleeding in the observation group were shorter than those in the control group(P<0.05). Compared to before treatment,the serum levels of FSH,E2,and LH in both groups decreased after treatment,and the thickness of the endometrium became thinner(P<0.05). And the changes in the observation group were more obvious(P<0.05). After treatment,the scores of HPLP-Ⅱ in both groups increased(P<0.05),and the score in the observation group was higher than that in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】Estrogen combined with medroxyprogesterone acetate is effective in the treatment of patients with acute abnormal uterine bleeding,which can reduce the level of sex hormones and endometrial thickness,improve the quality of life of patients,and is safe and reliable. 2023 Vol. 40 (11): 1727-1729 [Abstract] ( 36 ) HTML (1 KB)  PDF (2287 KB)  ( 51 ) 1730 Observation on the Effect of Fenofibrate Combined with Statins on the Cardiac Function and Blood Lipid Levels in Patients with Coronary Heart Disease and Hyperlipidemia HE Haixia, WEI Wangfen DOI: 10.3969/j.issn.1671-7171.2023.11.034 【Objective】To investigate the effect of fenofibrate combined with statins on cardiac function and serum lipid levels in patients with coronary heart disease and hyperlipidemia. 【Methods】A total of 120 patients with CHD and hyperlipidemia admitted to Genertec Universal Xi'an Beihuan Hospital from January 2019 to December 2021 were selected and divided into an observation group and a control group according to a random number table method,with 60 cases in each group. The control group was treated with rosuvastatin,while the observation group was treated with fenofibrate in addition to the control group. The therapeutic effects,changes in cardiac function indicators,serum inflammatory indicators,and serum lipid levels before and after treatment,as well as the incidence of adverse reactions,were compared between the two groups. 【Results】The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05). After treatment,the left ventricular end-diastolic diameter(LVEDD) in both groups was lower than that before treatment,while the left ventricular ejection fraction(LVEF) and cardiac output(CO) were higher than before treatment. The LVEDD in the observation group was lower than that in the control group,while the LVEF and CO were higher than those in the control group,and the differences were statistically significant(P<0.05). The levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6) in both groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05). The total cholesterol(TG),triglyceride(TC),and low-density lipoprotein(LDL-C) levels in both groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】 The clinical application of fenofibrate combined with rosuvastatin in the treatment of coronary heart disease with hyperlipidemia is better than the use of rosuvastatin alone,which can effectively improve the patient's cardiac function,improve serum inflammatory factors,and improve serum lipid levels. 2023 Vol. 40 (11): 1730-1733 [Abstract] ( 30 ) HTML (1 KB)  PDF (1233 KB)  ( 30 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech