US-FNAC及TSH、TPOAb 、TGAb水平在甲状腺囊实性结节定性诊断中的应用价值

doi:10.3969/j.issn.1671-7171.2023.11.012

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Abstract 【Objective】To explore the application value of ultrasound guided fine needle aspiration cytology(US-FNAC) and levels of thyroid stimulating hormone(TSH),anti thyroid peroxidase antibody(TPOAb),and anti thyroglobulin antibody(TGAb) in the qualitative diagnosis of thyroid cystic and solid nodules.【Methods】A total of 70 patients with thyroid cystic solid nodules admitted to both hospitals underwent US-FNAC examination,and the consistency between the US-FNAC diagnostic results and pathological examination results was analyzed; Using pathological results as the "gold standard" for diagnosis,70 patients were divided into a benign group(n=43) and a malignant group(n=27). The serum levels of TSH,TPOAb,and TGAb were compared between the two groups of patients; The value of the above indicators in the individual and combined diagnosis of malignant thyroid cystic solid nodules was analyzed through the receiver operating characteristic curve(ROC).【Results】The accuracy,sensitivity,and specificity of US-FNAC in qualitative diagnosis of thyroid cystic solid nodules were 88.57%,92.59%,and 86.05%,respectively; The serum TSH,TPOAb,and TGAb levels in the malignant group were higher than those in the benign group(P<0.05); After ROC analysis,it was confirmed that TSH,TPOAb,and TGAb predicted areas under the curve for patients with thyroid cystic solid nodules to be malignant,which were 0.681,0.794,and 0.618,respectively(all P<0.05); Malignant with US-FNAC,TSH ≥ 2.905 μU/mL,TPOAb≥10.050 IU/mL,and TGAb ≥ 32.285 IU/mL were defined as positive. When any result was positive in the combined diagnosis,the combined diagnosis was considered positive. Consistency analysis confirmed that the accuracy,sensitivity,and specificity of the combined diagnosis of the above indicators were 94.29%,96.30%,and 93.02%,significantly higher than those of US-FNAC alone.【Conclusion】The accuracy of the combined use of US-FNAC and TSH,TPOAb,and TGAb levels in the qualitative diagnosis of thyroid cystic solid nodules is significantly higher than that of individual diagnosis,and is worthy of clinical promotion and application.

Key words： Thyroid Nodule/DI Biopsy, Needle Thyrotropin/BL Thyroxine-Binding Globulin/BL

Received: 15 August 2022

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	YANG Hongmei
	WANG Lei

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YANG Hongmei,WANG Lei. Application of US-FNAC and TSH,TPOAb,TGAb Levels in the Qualitative Diagnosis of Thyroid Cystic Solid Nodules[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1656-1659.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.11.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I11/1656

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